LOCUS       NM_015908               2990 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens serrate, RNA effector molecule (SRRT), transcript
            variant 1, mRNA.
ACCESSION   NM_015908
VERSION     NM_015908.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2990)
  AUTHORS   Lykke-Andersen,S., Rouviere,J.O. and Jensen,T.H.
  TITLE     ARS2/SRRT: at the nexus of RNA polymerase II transcription,
            transcript maturation and quality control
  JOURNAL   Biochem Soc Trans 49 (3), 1325-1336 (2021)
   PUBMED   34060620
  REMARK    GeneRIF: ARS2/SRRT: at the nexus of RNA polymerase II
            transcription, transcript maturation and quality control.
            Review article
REFERENCE   2  (bases 1 to 2990)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   3  (bases 1 to 2990)
  AUTHORS   Melko,M., Winczura,K., Rouviere,J.O., Oborska-Oplova,M.,
            Andersen,P.K. and Heick Jensen,T.
  TITLE     Mapping domains of ARS2 critical for its RNA decay capacity
  JOURNAL   Nucleic Acids Res 48 (12), 6943-6953 (2020)
   PUBMED   32463452
  REMARK    GeneRIF: Mapping domains of ARS2 critical for its RNA decay
            capacity.
REFERENCE   4  (bases 1 to 2990)
  AUTHORS   Yin,J., Kim,S.S., Choi,E., Oh,Y.T., Lin,W., Kim,T.H., Sa,J.K.,
            Hong,J.H., Park,S.H., Kwon,H.J., Jin,X., You,Y., Kim,J.H., Kim,H.,
            Son,J., Lee,J., Nam,D.H., Choi,K.S., Shi,B., Gwak,H.S., Yoo,H.,
            Iavarone,A., Kim,J.H. and Park,J.B.
  TITLE     ARS2/MAGL signaling in glioblastoma stem cells promotes
            self-renewal and M2-like polarization of tumor-associated
            macrophages
  JOURNAL   Nat Commun 11 (1), 2978 (2020)
   PUBMED   32532977
  REMARK    GeneRIF: ARS2/MAGL signaling in glioblastoma stem cells promotes
            self-renewal and M2-like polarization of tumor-associated
            macrophages.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2990)
  AUTHORS   Machitani,M., Taniguchi,I. and Ohno,M.
  TITLE     ARS2 Regulates Nuclear Paraspeckle Formation through 3'-End
            Processing and Stability of NEAT1 Long Noncoding RNA
  JOURNAL   Mol Cell Biol 40 (4), e00269-19 (2020)
   PUBMED   31818879
  REMARK    GeneRIF: In the present study, the authors demonstrate that ARS2
            regulates both the 3=-end processing and stability of NEAT1.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2990)
  AUTHORS   Beausoleil,S.A., Jedrychowski,M., Schwartz,D., Elias,J.E.,
            Villen,J., Li,J., Cohn,M.A., Cantley,L.C. and Gygi,S.P.
  TITLE     Large-scale characterization of HeLa cell nuclear phosphoproteins
  JOURNAL   Proc Natl Acad Sci U S A 101 (33), 12130-12135 (2004)
   PUBMED   15302935
REFERENCE   7  (bases 1 to 2990)
  AUTHORS   Obuse,C., Yang,H., Nozaki,N., Goto,S., Okazaki,T. and Yoda,K.
  TITLE     Proteomics analysis of the centromere complex from HeLa interphase
            cells: UV-damaged DNA binding protein 1 (DDB-1) is a component of
            the CEN-complex, while BMI-1 is transiently co-localized with the
            centromeric region in interphase
  JOURNAL   Genes Cells 9 (2), 105-120 (2004)
   PUBMED   15009096
REFERENCE   8  (bases 1 to 2990)
  AUTHORS   Di,Y., Li,J., Zhang,Y., He,X., Lu,H., Xu,D., Ling,J., Huo,K.,
            Wan,D., Li,Y.Y. and Gu,J.
  TITLE     HCC-associated protein HCAP1, a variant of GEMIN4, interacts with
            zinc-finger proteins
  JOURNAL   J Biochem 133 (6), 713-718 (2003)
   PUBMED   12869526
REFERENCE   9  (bases 1 to 2990)
  AUTHORS   Wilson,M.D., Riemer,C., Martindale,D.W., Schnupf,P., Boright,A.P.,
            Cheung,T.L., Hardy,D.M., Schwartz,S., Scherer,S.W., Tsui,L.C.,
            Miller,W. and Koop,B.F.
  TITLE     Comparative analysis of the gene-dense ACHE/TFR2 region on human
            chromosome 7q22 with the orthologous region on mouse chromosome 5
  JOURNAL   Nucleic Acids Res 29 (6), 1352-1365 (2001)
   PUBMED   11239002
REFERENCE   10 (bases 1 to 2990)
  AUTHORS   Rossman,T.G. and Wang,Z.
  TITLE     Expression cloning for arsenite-resistance resulted in isolation of
            tumor-suppressor fau cDNA: possible involvement of the ubiquitin
            system in arsenic carcinogenesis
  JOURNAL   Carcinogenesis 20 (2), 311-316 (1999)
   PUBMED   10069470
  REMARK    GeneRIF: Nomenclature. Original paper and GenBank submission by
            Rossman and Wang (1999) called the gene Asr2 (arsenite resistance
            protein 2) as opposed to Ars2 (arsenate resistance protein 2).
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA611314.1, BC109116.1, AC011895.4 and AF248955.1.
            
            On Nov 23, 2018 this sequence version replaced NM_015908.5.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC109116.1, SRR1803611.208790.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000611405.5/ ENSP00000480421.1
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-85                DA611314.1         26-110
            86-554              BC109116.1         1-469
            555-555             AC011895.4         123850-123850
            556-2989            BC109116.1         470-2903
            2990-2990           AF248955.1         2965-2965
FEATURES             Location/Qualifiers
     source          1..2990
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q22.1"
     gene            1..2990
                     /gene="SRRT"
                     /gene_synonym="ARS2; ASR2; serrate"
                     /note="serrate, RNA effector molecule"
                     /db_xref="GeneID:51593"
                     /db_xref="HGNC:HGNC:24101"
                     /db_xref="MIM:614469"
     exon            1..226
                     /gene="SRRT"
                     /gene_synonym="ARS2; ASR2; serrate"
                     /inference="alignment:Splign:2.1.0"
     exon            227..366
                     /gene="SRRT"
                     /gene_synonym="ARS2; ASR2; serrate"
                     /inference="alignment:Splign:2.1.0"
     CDS             245..2875
                     /gene="SRRT"
                     /gene_synonym="ARS2; ASR2; serrate"
                     /note="isoform a is encoded by transcript variant 1;
                     arsenite resistance protein; arsenate resistance protein
                     ARS2; arsenate resistance protein 2; arsenite-resistance
                     protein 2; serrate RNA effector molecule homolog"
                     /codon_start=1
                     /product="serrate RNA effector molecule homolog isoform a"
                     /protein_id="NP_056992.4"
                     /db_xref="CCDS:CCDS34709.1"
                     /db_xref="GeneID:51593"
                     /db_xref="HGNC:HGNC:24101"
                     /db_xref="MIM:614469"
                     /translation="MGDSDDEYDRRRRDKFRRERSDYDRSRERDERRRGDDWNDREWD
                     RGRERRSRGEYRDYDRNRRERFSPPRHELSPPQKRMRRDWDEHSSDPYHSGYEMPYAG
                     GGGGPTYGPPQPWGHPDVHIMQHHVLPIQARLGSIAEIDLGVPPPVMKTFKEFLLSLD
                     DSVDETEAVKRYNDYKLDFRRQQMQDFFLAHKDEEWFRSKYHPDEVGKRRQEARGALQ
                     NRLRVFLSLMETGWFDNLLLDIDKADAIVKMLDAAVIKMEGGTENDLRILEQEEEEEQ
                     AGKPGEPSKKEEGRAGAGLGDGERKTNDKDEKKEDGKQAENDSSNDDKTKKSEGDGDK
                     EEKKEDSEKEAKKSSKKRNRKHSGDDSFDEGSVSESESESESGQAEEEKEEAEEALKE
                     KEKPKEEEWEKPKDAAGLECKPRPLHKTCSLFMRNIAPNISRAEIISLCKRYPGFMRV
                     ALSEPQPERRFFRRGWVTFDRSVNIKEICWNLQNIRLRECELSPGVNRDLTRRVRNIN
                     GITQHKQIVRNDIKLAAKLIHTLDDRTQLWASEPGTPPLPTSLPSQNPILKNITDYLI
                     EEVSAEEEELLGSSGGAPPEEPPKEGNPAEINVERDEKLIKVLDKLLLYLRIVHSLDY
                     YNTCEYPNEDEMPNRCGIIHVRGPMPPNRISHGEVLEWQKTFEEKLTPLLSVRESLSE
                     EEAQKMGRKDPEQEVEKFVTSNTQELGKDKWLCPLSGKKFKGPEFVRKHIFNKHAEKI
                     EEVKKEVAFFNNFLTDAKRPALPEIKPAQPPGPAQILPPGLTPGLPYPHQTPQGLMPY
                     GQPRPPILGYGAGAVRPAVPTGGPPYPHAPYGAGRGNYDAFRGQGGYPGKPRNRMVRG
                     DPRAIVEYRDLDAPDDVDFF"
     exon            367..495
                     /gene="SRRT"
                     /gene_synonym="ARS2; ASR2; serrate"
                     /inference="alignment:Splign:2.1.0"
     exon            496..642
                     /gene="SRRT"
                     /gene_synonym="ARS2; ASR2; serrate"
                     /inference="alignment:Splign:2.1.0"
     exon            643..831
                     /gene="SRRT"
                     /gene_synonym="ARS2; ASR2; serrate"
                     /inference="alignment:Splign:2.1.0"
     exon            832..1001
                     /gene="SRRT"
                     /gene_synonym="ARS2; ASR2; serrate"
                     /inference="alignment:Splign:2.1.0"
     exon            1002..1186
                     /gene="SRRT"
                     /gene_synonym="ARS2; ASR2; serrate"
                     /inference="alignment:Splign:2.1.0"
     exon            1187..1285
                     /gene="SRRT"
                     /gene_synonym="ARS2; ASR2; serrate"
                     /inference="alignment:Splign:2.1.0"
     exon            1286..1403
                     /gene="SRRT"
                     /gene_synonym="ARS2; ASR2; serrate"
                     /inference="alignment:Splign:2.1.0"
     exon            1404..1561
                     /gene="SRRT"
                     /gene_synonym="ARS2; ASR2; serrate"
                     /inference="alignment:Splign:2.1.0"
     exon            1562..1623
                     /gene="SRRT"
                     /gene_synonym="ARS2; ASR2; serrate"
                     /inference="alignment:Splign:2.1.0"
     exon            1624..1702
                     /gene="SRRT"
                     /gene_synonym="ARS2; ASR2; serrate"
                     /inference="alignment:Splign:2.1.0"
     exon            1703..1891
                     /gene="SRRT"
                     /gene_synonym="ARS2; ASR2; serrate"
                     /inference="alignment:Splign:2.1.0"
     exon            1892..2065
                     /gene="SRRT"
                     /gene_synonym="ARS2; ASR2; serrate"
                     /inference="alignment:Splign:2.1.0"
     exon            2066..2219
                     /gene="SRRT"
                     /gene_synonym="ARS2; ASR2; serrate"
                     /inference="alignment:Splign:2.1.0"
     exon            2220..2413
                     /gene="SRRT"
                     /gene_synonym="ARS2; ASR2; serrate"
                     /inference="alignment:Splign:2.1.0"
     exon            2414..2570
                     /gene="SRRT"
                     /gene_synonym="ARS2; ASR2; serrate"
                     /inference="alignment:Splign:2.1.0"
     exon            2571..2672
                     /gene="SRRT"
                     /gene_synonym="ARS2; ASR2; serrate"
                     /inference="alignment:Splign:2.1.0"
     exon            2673..2799
                     /gene="SRRT"
                     /gene_synonym="ARS2; ASR2; serrate"
                     /inference="alignment:Splign:2.1.0"
     exon            2800..2990
                     /gene="SRRT"
                     /gene_synonym="ARS2; ASR2; serrate"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2970..2975
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SRRT"
                     /gene_synonym="ARS2; ASR2; serrate"
                     /note="hexamer: AATAAA"
     polyA_site      2990
                     /gene="SRRT"
                     /gene_synonym="ARS2; ASR2; serrate"
                     /note="major polyA site"
ORIGIN      
        1 ggagctttgt gcctcggagg cgtgggtgac gcaggcgcag cgcgggctgc gcgcgctact
       61 gcccatcccc ggttgtccca cttttgttcg cctctcttcg gccctctact caagagctcc
      121 gtctccgtct cgccctcctc gaagtcctcg tcgcgcgccc gcgacccagg tcgccctgaa
      181 atctagcccg tccgagcgcg agtccaacgg ccgcggccgc accaaggccc cctcagaccg
      241 tgccatgggt gacagtgatg acgagtacga tcgaaggcgc agggacaagt tcagaagaga
      301 gcgcagcgac tacgaccgtt cccgcgagag agatgaaaga cgtcgagggg acgattggaa
      361 tgacagagag tgggaccgtg gccgtgagcg ccgtagtcgg ggtgaatatc gggactatga
      421 ccggaatcgg cgagagcgct tctcgccacc tcgccacgaa ctcagcccgc cacagaagcg
      481 catgaggaga gactgggatg agcacagctc tgacccatac cacagtggct atgagatgcc
      541 ctatgctggg gggggtgggg gcccaactta tggcccccct cagccctggg gccaccctga
      601 cgtccacatc atgcagcacc atgtcctgcc tatccaggcc aggctgggca gcattgcaga
      661 gattgacctg ggtgtgccgc cgcccgtgat gaagaccttc aaggagtttc tcctctccct
      721 ggatgactcg gtggatgaga cggaggccgt caagcgctat aatgactaca agctggattt
      781 ccggaggcaa cagatgcagg atttcttcct ggcgcacaaa gatgaggagt ggtttcggtc
      841 taagtaccac ccagatgagg tggggaagcg tcggcaggag gcccgggggg ccctgcaaaa
      901 ccgactgagg gtcttcctgt ccctcatgga gactggctgg tttgataacc ttctcctgga
      961 catagacaaa gctgatgcca ttgtcaagat gctggatgca gccgtgatta agatggaagg
     1021 aggcacggag aatgatcttc gcatcctgga gcaggaggag gaggaggagc aggcaggaaa
     1081 gcctggggag cccagcaaga aagaagaagg acgggctgga gcaggcctag gggacgggga
     1141 gcgcaaaacc aacgacaagg atgagaagaa ggaagacggc aagcaggctg agaatgacag
     1201 ttctaatgat gacaaaacaa agaagtcgga gggtgatggg gacaaggaag agaagaaaga
     1261 agactccgag aaggaagcca aaaagagtag caagaagcgg aaccggaagc acagtggtga
     1321 cgacagcttt gacgagggca gcgtgtcaga gtctgagtcg gagtcagaga gcggccaggc
     1381 tgaggaggag aaggaggagg ccgaagaagc gctcaaggag aaggagaagc ccaaggaaga
     1441 agaatgggag aagcccaagg acgccgcggg gctggagtgc aagccgcggc cgctgcataa
     1501 gacctgctcc ctcttcatgc gcaacatcgc gcccaacatc tcccgggccg agatcatctc
     1561 cctttgtaaa aggtacccag gctttatgcg ggtggcgctc tcagagcccc agccagagag
     1621 gaggtttttc cgtcgtggct gggtgacctt cgaccgcagt gttaacatta aagagatctg
     1681 ttggaacctg cagaacatcc gtctccggga gtgtgagctg agccctggtg tgaacaggga
     1741 cctgacccgg cgcgttcgca acatcaacgg catcacccag cacaagcaga ttgtgcgcaa
     1801 cgacatcaag ctggcggcca agctgatcca cacgctggat gacaggacac agctttgggc
     1861 ctcagaacca gggacgcctc ccctgcccac gagcctgccc tcgcaaaacc cgatcttgaa
     1921 gaatatcacc gactacctga tcgaggaagt aagcgccgag gaggaggagc tgctggggag
     1981 cagcgggggc gctcctcctg aggagcctcc taaggaaggg aacccggcag agatcaacgt
     2041 ggagcgggat gagaagttga ttaaggtctt ggacaagctc ctcctttacc tgcgcatcgt
     2101 gcattccttg gattattaca acacctgtga gtaccccaac gaggacgaga tgcccaatcg
     2161 ctgtgggatc atccacgttc gggggcccat gccacccaac cgcatcagtc acggggaagt
     2221 gctggagtgg cagaagactt ttgaggagaa gctcacgccg ttgctgagtg tgcgggagtc
     2281 actctcagag gaagaggccc agaagatggg gcgcaaagac ccagagcagg aagtggagaa
     2341 gttcgtcacc tccaacacgc aggaactggg caaggataag tggctgtgtc ctctcagtgg
     2401 caagaaattc aagggtcctg agtttgtgcg caaacatatc ttcaacaagc atgcagagaa
     2461 aattgaggaa gtgaaaaagg aagtcgcgtt ttttaacaac ttcctcactg atgctaagcg
     2521 cccagctctg cctgagatca agccagccca gccacctggc cccgcccaga tactcccccc
     2581 aggtttgacc ccaggactcc cctacccaca ccagactccc cagggcctga tgccctatgg
     2641 tcagccccgg cccccgatct tgggctatgg agctggtgct gtccgccctg cagtccccac
     2701 aggaggccct ccataccccc atgccccgta tggtgctggt cgagggaact atgatgcctt
     2761 ccgaggccag ggaggttatc ctgggaaacc tcgcaacagg atggttcgtg gagacccaag
     2821 ggccattgtg gaatatcggg acctggatgc cccagacgat gttgatttct tttgagccgt
     2881 cccccgttcc tcagtcctgt atcatccata cttgtactac cttgtcctat gaagctctga
     2941 gaattttttg tacgatcagc cttactgcta ataaaagcac ttccacaggg
//
