LOCUS       NP_056992                876 aa            linear   PRI 27-APR-2025
DEFINITION  serrate RNA effector molecule homolog isoform a [Homo sapiens].
ACCESSION   NP_056992
VERSION     NP_056992.4
DBSOURCE    REFSEQ: accession NM_015908.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 876)
  AUTHORS   Lykke-Andersen,S., Rouviere,J.O. and Jensen,T.H.
  TITLE     ARS2/SRRT: at the nexus of RNA polymerase II transcription,
            transcript maturation and quality control
  JOURNAL   Biochem Soc Trans 49 (3), 1325-1336 (2021)
   PUBMED   34060620
  REMARK    GeneRIF: ARS2/SRRT: at the nexus of RNA polymerase II
            transcription, transcript maturation and quality control.
            Review article
REFERENCE   2  (residues 1 to 876)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   3  (residues 1 to 876)
  AUTHORS   Melko,M., Winczura,K., Rouviere,J.O., Oborska-Oplova,M.,
            Andersen,P.K. and Heick Jensen,T.
  TITLE     Mapping domains of ARS2 critical for its RNA decay capacity
  JOURNAL   Nucleic Acids Res 48 (12), 6943-6953 (2020)
   PUBMED   32463452
  REMARK    GeneRIF: Mapping domains of ARS2 critical for its RNA decay
            capacity.
REFERENCE   4  (residues 1 to 876)
  AUTHORS   Yin,J., Kim,S.S., Choi,E., Oh,Y.T., Lin,W., Kim,T.H., Sa,J.K.,
            Hong,J.H., Park,S.H., Kwon,H.J., Jin,X., You,Y., Kim,J.H., Kim,H.,
            Son,J., Lee,J., Nam,D.H., Choi,K.S., Shi,B., Gwak,H.S., Yoo,H.,
            Iavarone,A., Kim,J.H. and Park,J.B.
  TITLE     ARS2/MAGL signaling in glioblastoma stem cells promotes
            self-renewal and M2-like polarization of tumor-associated
            macrophages
  JOURNAL   Nat Commun 11 (1), 2978 (2020)
   PUBMED   32532977
  REMARK    GeneRIF: ARS2/MAGL signaling in glioblastoma stem cells promotes
            self-renewal and M2-like polarization of tumor-associated
            macrophages.
            Publication Status: Online-Only
REFERENCE   5  (residues 1 to 876)
  AUTHORS   Machitani,M., Taniguchi,I. and Ohno,M.
  TITLE     ARS2 Regulates Nuclear Paraspeckle Formation through 3'-End
            Processing and Stability of NEAT1 Long Noncoding RNA
  JOURNAL   Mol Cell Biol 40 (4), e00269-19 (2020)
   PUBMED   31818879
  REMARK    GeneRIF: In the present study, the authors demonstrate that ARS2
            regulates both the 3=-end processing and stability of NEAT1.
            Publication Status: Online-Only
REFERENCE   6  (residues 1 to 876)
  AUTHORS   Beausoleil,S.A., Jedrychowski,M., Schwartz,D., Elias,J.E.,
            Villen,J., Li,J., Cohn,M.A., Cantley,L.C. and Gygi,S.P.
  TITLE     Large-scale characterization of HeLa cell nuclear phosphoproteins
  JOURNAL   Proc Natl Acad Sci U S A 101 (33), 12130-12135 (2004)
   PUBMED   15302935
REFERENCE   7  (residues 1 to 876)
  AUTHORS   Obuse,C., Yang,H., Nozaki,N., Goto,S., Okazaki,T. and Yoda,K.
  TITLE     Proteomics analysis of the centromere complex from HeLa interphase
            cells: UV-damaged DNA binding protein 1 (DDB-1) is a component of
            the CEN-complex, while BMI-1 is transiently co-localized with the
            centromeric region in interphase
  JOURNAL   Genes Cells 9 (2), 105-120 (2004)
   PUBMED   15009096
REFERENCE   8  (residues 1 to 876)
  AUTHORS   Di,Y., Li,J., Zhang,Y., He,X., Lu,H., Xu,D., Ling,J., Huo,K.,
            Wan,D., Li,Y.Y. and Gu,J.
  TITLE     HCC-associated protein HCAP1, a variant of GEMIN4, interacts with
            zinc-finger proteins
  JOURNAL   J Biochem 133 (6), 713-718 (2003)
   PUBMED   12869526
REFERENCE   9  (residues 1 to 876)
  AUTHORS   Wilson,M.D., Riemer,C., Martindale,D.W., Schnupf,P., Boright,A.P.,
            Cheung,T.L., Hardy,D.M., Schwartz,S., Scherer,S.W., Tsui,L.C.,
            Miller,W. and Koop,B.F.
  TITLE     Comparative analysis of the gene-dense ACHE/TFR2 region on human
            chromosome 7q22 with the orthologous region on mouse chromosome 5
  JOURNAL   Nucleic Acids Res 29 (6), 1352-1365 (2001)
   PUBMED   11239002
REFERENCE   10 (residues 1 to 876)
  AUTHORS   Rossman,T.G. and Wang,Z.
  TITLE     Expression cloning for arsenite-resistance resulted in isolation of
            tumor-suppressor fau cDNA: possible involvement of the ubiquitin
            system in arsenic carcinogenesis
  JOURNAL   Carcinogenesis 20 (2), 311-316 (1999)
   PUBMED   10069470
  REMARK    GeneRIF: Nomenclature. Original paper and GenBank submission by
            Rossman and Wang (1999) called the gene Asr2 (arsenite resistance
            protein 2) as opposed to Ars2 (arsenate resistance protein 2).
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA611314.1, BC109116.1, AC011895.4 and AF248955.1.
            
            On Jan 29, 2005 this sequence version replaced NP_056992.3.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC109116.1, SRR1803611.208790.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000611405.5/ ENSP00000480421.1
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..876
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q22.1"
     Protein         1..876
                     /product="serrate RNA effector molecule homolog isoform a"
                     /note="arsenite resistance protein; arsenate resistance
                     protein ARS2; arsenate resistance protein 2;
                     arsenite-resistance protein 2; serrate RNA effector
                     molecule homolog"
                     /calculated_mol_wt=100536
     Region          1..90
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9BXP5.1)"
     Site            2
                     /site_type="acetylation"
                     /note="N-acetylglycine.
                     /evidence=ECO:0007744|PubMed:20068231,
                     ECO:0007744|PubMed:21406692; propagated from
                     UniProtKB/Swiss-Prot (Q9BXP5.1)"
     Site            4
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:20068231,
                     ECO:0007744|PubMed:21406692; propagated from
                     UniProtKB/Swiss-Prot (Q9BXP5.1)"
     Site            8
                     /site_type="phosphorylation"
                     /note="Phosphotyrosine.
                     /evidence=ECO:0007744|PubMed:17081983; propagated from
                     UniProtKB/Swiss-Prot (Q9BXP5.1)"
     Site            67
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:23186163,
                     ECO:0007744|PubMed:24275569; propagated from
                     UniProtKB/Swiss-Prot (Q9BXP5.1)"
     Site            74
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:20068231,
                     ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569;
                     propagated from UniProtKB/Swiss-Prot (Q9BXP5.1)"
     Site            136
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:23186163; propagated from
                     UniProtKB/Swiss-Prot (Q9BXP5.1)"
     Region          153..262
                     /region_name="SERRATE_Ars2_N"
                     /note="SERRATE/Ars2, N-terminal domain; pfam12066"
                     /db_xref="CDD:463453"
     Region          271..412
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9BXP5.1)"
     Site            493
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:17081983,
                     ECO:0007744|PubMed:18220336, ECO:0007744|PubMed:20068231,
                     ECO:0007744|PubMed:23186163; propagated from
                     UniProtKB/Swiss-Prot (Q9BXP5.1)"
     Site            540
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:16964243,
                     ECO:0007744|PubMed:18669648; propagated from
                     UniProtKB/Swiss-Prot (Q9BXP5.1)"
     Site            544
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0007744|PubMed:17081983,
                     ECO:0007744|PubMed:17693683, ECO:0007744|PubMed:17924679,
                     ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:19690332,
                     ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692,
                     ECO:0007744|PubMed:23186163; propagated from
                     UniProtKB/Swiss-Prot (Q9BXP5.1)"
     Site            570
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:24275569; propagated from
                     UniProtKB/Swiss-Prot (Q9BXP5.1)"
     Region          575..598
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9BXP5.1)"
     Region          646..851
                     /region_name="ARS2"
                     /note="Arsenite-resistance protein 2; pfam04959"
                     /db_xref="CDD:461498"
     Site            671
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0007744|PubMed:23186163; propagated from
                     UniProtKB/Swiss-Prot (Q9BXP5.1)"
     Site            679
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:23186163; propagated from
                     UniProtKB/Swiss-Prot (Q9BXP5.1)"
     Site            833
                     /site_type="methylation"
                     /note="Omega-N-methylarginine.
                     /evidence=ECO:0007744|PubMed:24129315; propagated from
                     UniProtKB/Swiss-Prot (Q9BXP5.1)"
     Region          835..854
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9BXP5.1)"
     Site            840
                     /site_type="methylation"
                     /note="Omega-N-methylarginine.
                     /evidence=ECO:0007744|PubMed:24129315; propagated from
                     UniProtKB/Swiss-Prot (Q9BXP5.1)"
     Site            850
                     /site_type="methylation"
                     /note="Omega-N-methylarginine.
                     /evidence=ECO:0007744|PubMed:24129315; propagated from
                     UniProtKB/Swiss-Prot (Q9BXP5.1)"
     CDS             1..876
                     /gene="SRRT"
                     /gene_synonym="ARS2; ASR2; serrate"
                     /coded_by="NM_015908.6:245..2875"
                     /note="isoform a is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS34709.1"
                     /db_xref="GeneID:51593"
                     /db_xref="HGNC:HGNC:24101"
                     /db_xref="MIM:614469"
ORIGIN      
        1 mgdsddeydr rrrdkfrrer sdydrsrerd errrgddwnd rewdrgrerr srgeyrdydr
       61 nrrerfsppr helsppqkrm rrdwdehssd pyhsgyempy agggggptyg ppqpwghpdv
      121 himqhhvlpi qarlgsiaei dlgvpppvmk tfkefllsld dsvdeteavk ryndykldfr
      181 rqqmqdffla hkdeewfrsk yhpdevgkrr qeargalqnr lrvflslmet gwfdnllldi
      241 dkadaivkml daavikmegg tendlrileq eeeeeqagkp gepskkeegr agaglgdger
      301 ktndkdekke dgkqaendss nddktkkseg dgdkeekked sekeakkssk krnrkhsgdd
      361 sfdegsvses esesesgqae eekeeaeeal kekekpkeee wekpkdaagl eckprplhkt
      421 cslfmrniap nisraeiisl ckrypgfmrv alsepqperr ffrrgwvtfd rsvnikeicw
      481 nlqnirlrec elspgvnrdl trrvrningi tqhkqivrnd iklaakliht lddrtqlwas
      541 epgtpplpts lpsqnpilkn itdylieevs aeeeellgss ggappeeppk egnpaeinve
      601 rdeklikvld klllylrivh sldyyntcey pnedempnrc giihvrgpmp pnrishgevl
      661 ewqktfeekl tpllsvresl seeeaqkmgr kdpeqevekf vtsntqelgk dkwlcplsgk
      721 kfkgpefvrk hifnkhaeki eevkkevaff nnfltdakrp alpeikpaqp pgpaqilppg
      781 ltpglpyphq tpqglmpygq prppilgyga gavrpavptg gppyphapyg agrgnydafr
      841 gqggypgkpr nrmvrgdpra iveyrdldap ddvdff
//
