LOCUS       NM_001128854            2975 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens serrate, RNA effector molecule (SRRT), transcript
            variant 5, mRNA.
ACCESSION   NM_001128854
VERSION     NM_001128854.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2975)
  AUTHORS   Lykke-Andersen,S., Rouviere,J.O. and Jensen,T.H.
  TITLE     ARS2/SRRT: at the nexus of RNA polymerase II transcription,
            transcript maturation and quality control
  JOURNAL   Biochem Soc Trans 49 (3), 1325-1336 (2021)
   PUBMED   34060620
  REMARK    GeneRIF: ARS2/SRRT: at the nexus of RNA polymerase II
            transcription, transcript maturation and quality control.
            Review article
REFERENCE   2  (bases 1 to 2975)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   3  (bases 1 to 2975)
  AUTHORS   Melko,M., Winczura,K., Rouviere,J.O., Oborska-Oplova,M.,
            Andersen,P.K. and Heick Jensen,T.
  TITLE     Mapping domains of ARS2 critical for its RNA decay capacity
  JOURNAL   Nucleic Acids Res 48 (12), 6943-6953 (2020)
   PUBMED   32463452
  REMARK    GeneRIF: Mapping domains of ARS2 critical for its RNA decay
            capacity.
REFERENCE   4  (bases 1 to 2975)
  AUTHORS   Yin,J., Kim,S.S., Choi,E., Oh,Y.T., Lin,W., Kim,T.H., Sa,J.K.,
            Hong,J.H., Park,S.H., Kwon,H.J., Jin,X., You,Y., Kim,J.H., Kim,H.,
            Son,J., Lee,J., Nam,D.H., Choi,K.S., Shi,B., Gwak,H.S., Yoo,H.,
            Iavarone,A., Kim,J.H. and Park,J.B.
  TITLE     ARS2/MAGL signaling in glioblastoma stem cells promotes
            self-renewal and M2-like polarization of tumor-associated
            macrophages
  JOURNAL   Nat Commun 11 (1), 2978 (2020)
   PUBMED   32532977
  REMARK    GeneRIF: ARS2/MAGL signaling in glioblastoma stem cells promotes
            self-renewal and M2-like polarization of tumor-associated
            macrophages.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2975)
  AUTHORS   Machitani,M., Taniguchi,I. and Ohno,M.
  TITLE     ARS2 Regulates Nuclear Paraspeckle Formation through 3'-End
            Processing and Stability of NEAT1 Long Noncoding RNA
  JOURNAL   Mol Cell Biol 40 (4), e00269-19 (2020)
   PUBMED   31818879
  REMARK    GeneRIF: In the present study, the authors demonstrate that ARS2
            regulates both the 3=-end processing and stability of NEAT1.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2975)
  AUTHORS   Beausoleil,S.A., Jedrychowski,M., Schwartz,D., Elias,J.E.,
            Villen,J., Li,J., Cohn,M.A., Cantley,L.C. and Gygi,S.P.
  TITLE     Large-scale characterization of HeLa cell nuclear phosphoproteins
  JOURNAL   Proc Natl Acad Sci U S A 101 (33), 12130-12135 (2004)
   PUBMED   15302935
REFERENCE   7  (bases 1 to 2975)
  AUTHORS   Obuse,C., Yang,H., Nozaki,N., Goto,S., Okazaki,T. and Yoda,K.
  TITLE     Proteomics analysis of the centromere complex from HeLa interphase
            cells: UV-damaged DNA binding protein 1 (DDB-1) is a component of
            the CEN-complex, while BMI-1 is transiently co-localized with the
            centromeric region in interphase
  JOURNAL   Genes Cells 9 (2), 105-120 (2004)
   PUBMED   15009096
REFERENCE   8  (bases 1 to 2975)
  AUTHORS   Di,Y., Li,J., Zhang,Y., He,X., Lu,H., Xu,D., Ling,J., Huo,K.,
            Wan,D., Li,Y.Y. and Gu,J.
  TITLE     HCC-associated protein HCAP1, a variant of GEMIN4, interacts with
            zinc-finger proteins
  JOURNAL   J Biochem 133 (6), 713-718 (2003)
   PUBMED   12869526
REFERENCE   9  (bases 1 to 2975)
  AUTHORS   Wilson,M.D., Riemer,C., Martindale,D.W., Schnupf,P., Boright,A.P.,
            Cheung,T.L., Hardy,D.M., Schwartz,S., Scherer,S.W., Tsui,L.C.,
            Miller,W. and Koop,B.F.
  TITLE     Comparative analysis of the gene-dense ACHE/TFR2 region on human
            chromosome 7q22 with the orthologous region on mouse chromosome 5
  JOURNAL   Nucleic Acids Res 29 (6), 1352-1365 (2001)
   PUBMED   11239002
REFERENCE   10 (bases 1 to 2975)
  AUTHORS   Rossman,T.G. and Wang,Z.
  TITLE     Expression cloning for arsenite-resistance resulted in isolation of
            tumor-suppressor fau cDNA: possible involvement of the ubiquitin
            system in arsenic carcinogenesis
  JOURNAL   Carcinogenesis 20 (2), 311-316 (1999)
   PUBMED   10069470
  REMARK    GeneRIF: Nomenclature. Original paper and GenBank submission by
            Rossman and Wang (1999) called the gene Asr2 (arsenite resistance
            protein 2) as opposed to Ars2 (arsenate resistance protein 2).
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA611314.1, BC109117.1 and AF248955.1.
            
            On May 31, 2019 this sequence version replaced NM_001128854.1.
            
            Transcript Variant: This variant (5) uses alternate in-frame splice
            junctions at the ends of a 5' and 3' exon compared to variant 1.
            The resulting isoform (e) has the same N- and C-termini but is 5 aa
            shorter compared to isoform a.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC109117.1, SRR1803613.105571.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-82                DA611314.1         26-107
            83-2974             BC109117.1         1-2892
            2975-2975           AF248955.1         2965-2965
FEATURES             Location/Qualifiers
     source          1..2975
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q22.1"
     gene            1..2975
                     /gene="SRRT"
                     /gene_synonym="ARS2; ASR2; serrate"
                     /note="serrate, RNA effector molecule"
                     /db_xref="GeneID:51593"
                     /db_xref="HGNC:HGNC:24101"
                     /db_xref="MIM:614469"
     exon            1..226
                     /gene="SRRT"
                     /gene_synonym="ARS2; ASR2; serrate"
                     /inference="alignment:Splign:2.1.0"
     exon            227..366
                     /gene="SRRT"
                     /gene_synonym="ARS2; ASR2; serrate"
                     /inference="alignment:Splign:2.1.0"
     CDS             245..2860
                     /gene="SRRT"
                     /gene_synonym="ARS2; ASR2; serrate"
                     /note="isoform e is encoded by transcript variant 5;
                     arsenite resistance protein; arsenate resistance protein
                     ARS2; arsenate resistance protein 2; arsenite-resistance
                     protein 2; serrate RNA effector molecule homolog"
                     /codon_start=1
                     /product="serrate RNA effector molecule homolog isoform e"
                     /protein_id="NP_001122326.1"
                     /db_xref="CCDS:CCDS47667.1"
                     /db_xref="GeneID:51593"
                     /db_xref="HGNC:HGNC:24101"
                     /db_xref="MIM:614469"
                     /translation="MGDSDDEYDRRRRDKFRRERSDYDRSRERDERRRGDDWNDREWD
                     RGRERRSRGEYRDYDRNRRERFSPPRHELSPPQKRMRRDWDEHSSDPYHSGYEMPYAG
                     GGGGPTYGPPQPWGHPDVHIMQHHVLPIQARLGSIAEIDLGVPPPVMKTFKEFLLSLD
                     DSVDETEAVKRYNDYKLDFRRQQMQDFFLAHKDEEWFRSKYHPDEVGKRRQEARGALQ
                     NRLRVFLSLMETGWFDNLLLDIDKADAIVKMLDAAVIKMEGGTENDLRILEQEEEEEQ
                     AGKPGEPSKKEEGRAGAGLGDGERKTNDKDEKKEDGKQAENDSSNDDKTKKSEGDGDK
                     EEKKEDSEKEAKKSSKKRNRKHSGDDSFDEGSVSESESESESGQAEEEKEEAEALKEK
                     EKPKEEEWEKPKDAAGLECKPRPLHKTCSLFMRNIAPNISRAEIISLCKRYPGFMRVA
                     LSEPQPERRFFRRGWVTFDRSVNIKEICWNLQNIRLRECELSPGVNRDLTRRVRNING
                     ITQHKQIVRNDIKLAAKLIHTLDDRTQLWASEPGTPPLPTSLPSQNPILKNITDYLIE
                     EVSAEEEELLGSSGGAPPEEPPKEGNPAEINVERDEKLIKVLDKLLLYLRIVHSLDYY
                     NTCEYPNEDEMPNRCGIIHVRGPMPPNRISHGEVLEWQKTFEEKLTPLLSVRESLSEE
                     EAQKMGRKDPEQEVEKFVTSNTQELGKDKWLCPLSGKKFKGPEFVRKHIFNKHAEKIE
                     EVKKEVAFFNNFLTDAKRPALPEIKPAQPPGPAQSLTPGLPYPHQTPQGLMPYGQPRP
                     PILGYGAGAVRPAVPTGGPPYPHAPYGAGRGNYDAFRGQGGYPGKPRNRMVRGDPRAI
                     VEYRDLDAPDDVDFF"
     exon            367..495
                     /gene="SRRT"
                     /gene_synonym="ARS2; ASR2; serrate"
                     /inference="alignment:Splign:2.1.0"
     exon            496..642
                     /gene="SRRT"
                     /gene_synonym="ARS2; ASR2; serrate"
                     /inference="alignment:Splign:2.1.0"
     exon            643..831
                     /gene="SRRT"
                     /gene_synonym="ARS2; ASR2; serrate"
                     /inference="alignment:Splign:2.1.0"
     exon            832..1001
                     /gene="SRRT"
                     /gene_synonym="ARS2; ASR2; serrate"
                     /inference="alignment:Splign:2.1.0"
     exon            1002..1186
                     /gene="SRRT"
                     /gene_synonym="ARS2; ASR2; serrate"
                     /inference="alignment:Splign:2.1.0"
     exon            1187..1285
                     /gene="SRRT"
                     /gene_synonym="ARS2; ASR2; serrate"
                     /inference="alignment:Splign:2.1.0"
     exon            1286..1403
                     /gene="SRRT"
                     /gene_synonym="ARS2; ASR2; serrate"
                     /inference="alignment:Splign:2.1.0"
     exon            1404..1558
                     /gene="SRRT"
                     /gene_synonym="ARS2; ASR2; serrate"
                     /inference="alignment:Splign:2.1.0"
     exon            1559..1620
                     /gene="SRRT"
                     /gene_synonym="ARS2; ASR2; serrate"
                     /inference="alignment:Splign:2.1.0"
     exon            1621..1699
                     /gene="SRRT"
                     /gene_synonym="ARS2; ASR2; serrate"
                     /inference="alignment:Splign:2.1.0"
     exon            1700..1888
                     /gene="SRRT"
                     /gene_synonym="ARS2; ASR2; serrate"
                     /inference="alignment:Splign:2.1.0"
     exon            1889..2062
                     /gene="SRRT"
                     /gene_synonym="ARS2; ASR2; serrate"
                     /inference="alignment:Splign:2.1.0"
     exon            2063..2216
                     /gene="SRRT"
                     /gene_synonym="ARS2; ASR2; serrate"
                     /inference="alignment:Splign:2.1.0"
     exon            2217..2410
                     /gene="SRRT"
                     /gene_synonym="ARS2; ASR2; serrate"
                     /inference="alignment:Splign:2.1.0"
     exon            2411..2567
                     /gene="SRRT"
                     /gene_synonym="ARS2; ASR2; serrate"
                     /inference="alignment:Splign:2.1.0"
     exon            2568..2657
                     /gene="SRRT"
                     /gene_synonym="ARS2; ASR2; serrate"
                     /inference="alignment:Splign:2.1.0"
     exon            2658..2784
                     /gene="SRRT"
                     /gene_synonym="ARS2; ASR2; serrate"
                     /inference="alignment:Splign:2.1.0"
     exon            2785..2975
                     /gene="SRRT"
                     /gene_synonym="ARS2; ASR2; serrate"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2955..2960
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SRRT"
                     /gene_synonym="ARS2; ASR2; serrate"
                     /note="hexamer: AATAAA"
     polyA_site      2975
                     /gene="SRRT"
                     /gene_synonym="ARS2; ASR2; serrate"
                     /note="major polyA site"
ORIGIN      
        1 ggagctttgt gcctcggagg cgtgggtgac gcaggcgcag cgcgggctgc gcgcgctact
       61 gcccatcccc ggttgtccca cttttgttcg cctctcttcg gccctctact caagagctcc
      121 gtctccgtct cgccctcctc gaagtcctcg tcgcgcgccc gcgacccagg tcgccctgaa
      181 atctagcccg tccgagcgcg agtccaacgg ccgcggccgc accaaggccc cctcagaccg
      241 tgccatgggt gacagtgatg acgagtacga tcgaaggcgc agggacaagt tcagaagaga
      301 gcgcagcgac tacgaccgtt cccgcgagag agatgaaaga cgtcgagggg acgattggaa
      361 tgacagagag tgggaccgtg gccgtgagcg ccgtagtcgg ggtgaatatc gggactatga
      421 ccggaatcgg cgagagcgct tctcgccacc tcgccacgaa ctcagcccgc cacagaagcg
      481 catgaggaga gactgggatg agcacagctc tgacccatac cacagtggct atgagatgcc
      541 ctatgctggg gggggtgggg gcccaactta tggcccccct cagccctggg gccaccctga
      601 cgtccacatc atgcagcacc atgtcctgcc tatccaggcc aggctgggca gcattgcaga
      661 gattgacctg ggtgtgccgc cgcccgtgat gaagaccttc aaggagtttc tcctctccct
      721 ggatgactcg gtggatgaga cggaggccgt caagcgctat aatgactaca agctggattt
      781 ccggaggcaa cagatgcagg atttcttcct ggcgcacaaa gatgaggagt ggtttcggtc
      841 taagtaccac ccagatgagg tggggaagcg tcggcaggag gcccgggggg ccctgcaaaa
      901 ccgactgagg gtcttcctgt ccctcatgga gactggctgg tttgataacc ttctcctgga
      961 catagacaaa gctgatgcca ttgtcaagat gctggatgca gccgtgatta agatggaagg
     1021 aggcacggag aatgatcttc gcatcctgga gcaggaggag gaggaggagc aggcaggaaa
     1081 gcctggggag cccagcaaga aagaagaagg acgggctgga gcaggcctag gggacgggga
     1141 gcgcaaaacc aacgacaagg atgagaagaa ggaagacggc aagcaggctg agaatgacag
     1201 ttctaatgat gacaaaacaa agaagtcgga gggtgatggg gacaaggaag agaagaaaga
     1261 agactccgag aaggaagcca aaaagagtag caagaagcgg aaccggaagc acagtggtga
     1321 cgacagcttt gacgagggca gcgtgtcaga gtctgagtcg gagtcagaga gcggccaggc
     1381 tgaggaggag aaggaggagg ccgaagcgct caaggagaag gagaagccca aggaagaaga
     1441 atgggagaag cccaaggacg ccgcggggct ggagtgcaag ccgcggccgc tgcataagac
     1501 ctgctccctc ttcatgcgca acatcgcgcc caacatctcc cgggccgaga tcatctccct
     1561 ttgtaaaagg tacccaggct ttatgcgggt ggcgctctca gagccccagc cagagaggag
     1621 gtttttccgt cgtggctggg tgaccttcga ccgcagtgtt aacattaaag agatctgttg
     1681 gaacctgcag aacatccgtc tccgggagtg tgagctgagc cctggtgtga acagggacct
     1741 gacccggcgc gttcgcaaca tcaacggcat cacccagcac aagcagattg tgcgcaacga
     1801 catcaagctg gcggccaagc tgatccacac gctggatgac aggacacagc tttgggcctc
     1861 agaaccaggg acgcctcccc tgcccacgag cctgccctcg caaaacccga tcttgaagaa
     1921 tatcaccgac tacctgatcg aggaagtaag cgccgaggag gaggagctgc tggggagcag
     1981 cgggggcgct cctcctgagg agcctcctaa ggaagggaac ccggcagaga tcaacgtgga
     2041 gcgggatgag aagttgatta aggtcttgga caagctcctc ctttacctgc gcatcgtgca
     2101 ttccttggat tattacaaca cctgtgagta ccccaacgag gacgagatgc ccaatcgctg
     2161 tgggatcatc cacgttcggg ggcccatgcc acccaaccgc atcagtcacg gggaagtgct
     2221 ggagtggcag aagacttttg aggagaagct cacgccgttg ctgagtgtgc gggagtcact
     2281 ctcagaggaa gaggcccaga agatggggcg caaagaccca gagcaggaag tggagaagtt
     2341 cgtcacctcc aacacgcagg aactgggcaa ggataagtgg ctgtgtcctc tcagtggcaa
     2401 gaaattcaag ggtcctgagt ttgtgcgcaa acatatcttc aacaagcatg cagagaaaat
     2461 tgaggaagtg aaaaaggaag tcgcgttttt taacaacttc ctcactgatg ctaagcgccc
     2521 agctctgcct gagatcaagc cagcccagcc acctggcccc gcccagagtt tgaccccagg
     2581 actcccctac ccacaccaga ctccccaggg cctgatgccc tatggtcagc cccggccccc
     2641 gatcttgggc tatggagctg gtgctgtccg ccctgcagtc cccacaggag gccctccata
     2701 cccccatgcc ccgtatggtg ctggtcgagg gaactatgat gccttccgag gccagggagg
     2761 ttatcctggg aaacctcgca acaggatggt tcgtggagac ccaagggcca ttgtggaata
     2821 tcgggacctg gatgccccag acgatgttga tttcttttga gccgtccccc gttcctcagt
     2881 cctgtatcat ccatacttgt actaccttgt cctatgaagc tctgagaatt ttttgtacga
     2941 tcagccttac tgctaataaa agcacttcca caggg
//
