LOCUS       NM_001110199            3617 bp    mRNA    linear   PRI 03-OCT-2024
DEFINITION  Homo sapiens serine/arginine repetitive matrix 3 (SRRM3),
            transcript variant 2, mRNA.
ACCESSION   NM_001110199 XM_001713635 XM_001713636 XM_001713637 XM_001713638
VERSION     NM_001110199.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3617)
  AUTHORS   Ciampi,L., Mantica,F., Lopez-Blanch,L., Permanyer,J.,
            Rodriguez-Marin,C., Zang,J., Cianferoni,D., Jimenez-Delgado,S.,
            Bonnal,S., Miravet-Verde,S., Ruprecht,V., Neuhauss,S.C.F.,
            Banfi,S., Carrella,S., Serrano,L., Head,S.A. and Irimia,M.
  TITLE     Specialization of the photoreceptor transcriptome by
            Srrm3-dependent microexons is required for outer segment
            maintenance and vision
  JOURNAL   Proc Natl Acad Sci U S A 119 (29), e2117090119 (2022)
   PUBMED   35858306
  REMARK    GeneRIF: Specialization of the photoreceptor transcriptome by
            Srrm3-dependent microexons is required for outer segment
            maintenance and vision.
REFERENCE   2  (bases 1 to 3617)
  AUTHORS   Labrecque,M.P., Brown,L.G., Coleman,I.M., Lakely,B., Brady,N.J.,
            Lee,J.K., Nguyen,H.M., Li,D., Hanratty,B., Haffner,M.C.,
            Rickman,D.S., True,L.D., Lin,D.W., Lam,H.M., Alumkal,J.J.,
            Corey,E., Nelson,P.S. and Morrissey,C.
  TITLE     RNA Splicing Factors SRRM3 and SRRM4 Distinguish Molecular
            Phenotypes of Castration-Resistant Neuroendocrine Prostate Cancer
  JOURNAL   Cancer Res 81 (18), 4736-4750 (2021)
   PUBMED   34312180
  REMARK    GeneRIF: RNA Splicing Factors SRRM3 and SRRM4 Distinguish Molecular
            Phenotypes of Castration-Resistant Neuroendocrine Prostate Cancer.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AI815474.1, BC029292.1, AC005077.5, BE466083.1, AK092590.1 and
            CA502814.1.
            
            On Nov 22, 2018 this sequence version replaced NM_001110199.2.
            
            Transcript Variant: This variant (2) lacks an alternate exon that
            results in a frameshift in the 3' coding region, compared to
            variant 1. The encoded isoform (b) has a distinct C-terminus and is
            shorter than isoform a.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            RNAseq introns :: partial sample support SAMEA2154665, SAMEA2158188
                              [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            MANE Ensembl match        :: ENST00000611745.2/ ENSP00000480851.1
            RefSeq Select criteria    :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-4                 AI815474.1         7-10
            5-289               BC029292.1         1-285
            290-467             AI815474.1         296-473
            468-1266            BC029292.1         464-1262
            1267-1511           AC005077.5         11003-11247         c
            1512-1999           BE466083.1         1-488
            2000-3616           AK092590.1         421-2037
            3617-3617           CA502814.1         23-23               c
FEATURES             Location/Qualifiers
     source          1..3617
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q11.23"
     gene            1..3617
                     /gene="SRRM3"
                     /note="serine/arginine repetitive matrix 3"
                     /db_xref="GeneID:222183"
                     /db_xref="HGNC:HGNC:26729"
     exon            1..172
                     /gene="SRRM3"
                     /inference="alignment:Splign:2.1.0"
     exon            173..444
                     /gene="SRRM3"
                     /inference="alignment:Splign:2.1.0"
     CDS             212..2173
                     /gene="SRRM3"
                     /note="isoform b is encoded by transcript variant 2;
                     serine/arginine repetitive matrix protein 3; SRRM2-like
                     protein"
                     /codon_start=1
                     /product="serine/arginine repetitive matrix protein 3
                     isoform b"
                     /protein_id="NP_001103669.1"
                     /db_xref="GeneID:222183"
                     /db_xref="HGNC:HGNC:26729"
                     /translation="MSSTVNNGAASMQSTPDAANGFPQPSSSSGTWPRAEEELRAAEP
                     GLVKRAHREILDHERKRRVELKCMELQEMMEEQGYSEEEIRQKVGTFRQMLMEKEGVL
                     TREDRPGGHIVAETPRLTEGAEPGLEYAPFDDDDGPVDCDCPASCYRGHRGYRTKHWS
                     SSSASPPPKKKKKKKGGHRRSRKKRRLESECSCGSSSPLRKKKKSVKKHRRDRSDSGS
                     RRKRRHRSRSSKCKRKEKNKEKKRPHTESPGRRSHRHSSGSSHSPSLSSHYSDSRSPS
                     RLSPKHRDEGRKTGSQRSSGSRSPSPSGGSGWGSPQRNGGSGQRSGAHGGRPGSAHSP
                     PDKPSSPSPRVRDKAAAAAPTPPARGKESPSPRSAPSSQGRGGRAAGGAGRRRRRRRR
                     RRRSRSSASAPRRRGRRRPRPAPPRGSSRSLSRARSSSDSGSGRGAPGPGPEPGSERG
                     HGGHGKRAKERPPRARPASTSPSPGAHGRRGGPEGKSSSRSPGPHPRSWSSSRSPSKS
                     RSRSAEKRPHSPSRSPSPKKPLSRDKDGEGRARHSEAEATRARRRSRSYSPIRKRRRD
                     SPSFMEPRRITSARKRPIPYYRPSPSSSSSCLSSDYSTRSHSRSPSPGHSHGSYSSRS
                     HGTRSRTRSPSRTPSPSYHSRSSSESGGF"
     exon            445..546
                     /gene="SRRM3"
                     /inference="alignment:Splign:2.1.0"
     exon            547..675
                     /gene="SRRM3"
                     /inference="alignment:Splign:2.1.0"
     exon            676..756
                     /gene="SRRM3"
                     /inference="alignment:Splign:2.1.0"
     exon            757..786
                     /gene="SRRM3"
                     /inference="alignment:Splign:2.1.0"
     exon            787..849
                     /gene="SRRM3"
                     /inference="alignment:Splign:2.1.0"
     exon            850..885
                     /gene="SRRM3"
                     /inference="alignment:Splign:2.1.0"
     exon            886..936
                     /gene="SRRM3"
                     /inference="alignment:Splign:2.1.0"
     exon            937..1041
                     /gene="SRRM3"
                     /inference="alignment:Splign:2.1.0"
     exon            1042..1219
                     /gene="SRRM3"
                     /inference="alignment:Splign:2.1.0"
     exon            1220..1581
                     /gene="SRRM3"
                     /inference="alignment:Splign:2.1.0"
     exon            1582..1806
                     /gene="SRRM3"
                     /inference="alignment:Splign:2.1.0"
     exon            1807..1944
                     /gene="SRRM3"
                     /inference="alignment:Splign:2.1.0"
     exon            1945..3617
                     /gene="SRRM3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3596..3601
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SRRM3"
                     /note="hexamer: AATAAA"
     polyA_site      3617
                     /gene="SRRM3"
                     /note="major polyA site"
ORIGIN      
        1 gtccagcatt tcagcaagcg gcggcagcac ccgcggggag gcagagggtg cggggccgtg
       61 ggggccgcgg agctgccctg cccaactcag cccagactag gcggcagccc ggaccggcgg
      121 gacccgaggg cctggcccca gcgcccggta gatcgcggcg gtcagcggtg agggccagcg
      181 gcccaggcca gcggctccag ggccagccac gatgtcctcc accgtgaaca acggggcggc
      241 cagcatgcag tccacacccg acgccgcgaa cggcttcccg cagcccagct cctcctcggg
      301 gacctggccg cgggcggaag aggagctgcg cgccgcggag ccgggcctgg tgaagcgcgc
      361 gcaccgcgag atcctggacc acgagcgcaa gcggcgggtg gagctcaagt gcatggagct
      421 gcaggagatg atggaggagc aggggtattc ggaggaggag attcggcaga aagtggggac
      481 attccggcag atgctgatgg agaaggaggg agtgctcacc agggaggacc ggcctggggg
      541 ccacattgtg gcggagaccc cgcggctgac cgagggcgct gagccgggcc tggagtacgc
      601 gccctttgac gatgacgacg gcccagtgga ctgtgactgc ccggcctcct gctaccgcgg
      661 ccaccgcggg tacaggacca agcattggtc tagcagctcg gcatcgcccc ctcccaagaa
      721 aaagaagaaa aagaaaggcg gccaccggag aagccgcaaa aagaggagac tggagtccga
      781 atgcagctgt gggagctcct cacccctccg caagaagaag aagagtgtga agaagcatcg
      841 ccgagacagg tctgattctg ggtcccggag gaagagacgg cacagatctc gaagctccaa
      901 gtgcaaaaga aaagagaaga acaaagagaa gaagaggcct cacacagagt ccccaggccg
      961 gaggtctcat cgccatagca gtggcagctc ccacagcccc tccctctcct cccactacag
     1021 tgattccaga tctcccagca ggctgagccc caagcaccga gacgaagggc gaaagacggg
     1081 cagccagcgg tccagcggaa gccggtcgcc ttccccgtcg ggcggcagcg gatgggggtc
     1141 gccccagcgg aacggcggca gcgggcagcg gagcggagcg cacgggggcc gccccggctc
     1201 ggcgcacagc ccgcccgata agcccagctc gccctcgccc agggtccgtg acaaggcggc
     1261 ggccgccgca cccacgccgc ccgcgcgggg gaaggagagc ccgagcccgc gctcggcgcc
     1321 gtcgtcccaa ggtcgcggag gccgcgcggc gggcggggcg ggcaggcggc ggcggcggcg
     1381 gcgtaggcgg cggcgctcgc ggtcctcggc gtccgcgccc cgccgcaggg gtcgccggcg
     1441 cccccggccc gcgccccccc ggggctcgtc gcgctcgctc agcagggccc gctccagcag
     1501 cgactccggc agcggccgcg gcgcccccgg ccccgggccc gagcccggct ctgagcgagg
     1561 ccacggcgga cacgggaaac gggccaagga gcggcccccg cgcgcgcggc ccgccagcac
     1621 ctctccgtcc ccgggcgcgc acggccggcg cggcggccca gaagggaaga gctcgtcgcg
     1681 cagccccggc ccgcaccccc gctcctggag ctccagccgc tcgccctcca aatctcgctc
     1741 gcgctctgcg gagaagcggc cccacagccc cagccgctcg ccgtcgccca agaagcccct
     1801 cagccgggac aaggacggcg agggccgcgc aaggcactct gaggccgagg ccacccgcgc
     1861 ccggcgccgc tcccgcagct actcgcccat ccgcaagcgg cgccgggact cgccaagctt
     1921 catggagccg cggcgcatca ccagcgcccg caagcgtcct attccatact accggcccag
     1981 cccctcttcc tcctccagct gcttgagcag cgactactcg acccggagcc acagccgcag
     2041 ccccagcccc ggccacagcc acgggagcta cagcagtcgc agccatggga cccgcagccg
     2101 gacacgcagc ccctcgagga cccccagtcc cagctaccac agccggagca gctctgagag
     2161 cgggggcttc tgagcccaga cagactcagc ttggtgcccc cctggcactg ggagaggcga
     2221 ggggcgggcc ccaggacccc agtggggagg gggctatatc tccttgcccc caaggctaca
     2281 aagaggtctc agggccagtg cacgggcaga tgggaccggg gaagactttg agggtgggca
     2341 tccagtggac aaggagaagc cagatgtgct gcttctacgg gtgtcctctc ccacctcctg
     2401 tccacccact gtgcccgggg aacaaagagc cgttacgaac acaggaatct ccccatcccc
     2461 cttcctgctg atgccaactc accaggcttg ggactgctgc cggtggatgg taccagagtc
     2521 catgatctgc tctgtcactt caccttagct cagtgcagcc agggacacct tgcaaggtgc
     2581 cagccctggg agcccctctt ccgcactaca cagctccctc cactcctctc ttatcactgg
     2641 gcagacgagg aggtggtaca gcacatgggt ttggagctag acagaaggaa gaacagccta
     2701 acccttggtg cacccccatc caagctgggg agctgcatcc ttttgagctg gctgcaggag
     2761 gaccctggct gagggctggt ggctggcccc acagcctccc ccaagctcct ccactgaccc
     2821 aggagtgccc agacgggtgg cccccaaaat cccagcctgg ggagctaggc acctcactct
     2881 tggtctgacc tctccaggcc aggctctcct caccccatgc cctgggccaa ggtcctacca
     2941 gccatgacta ctgcatgaca agaggtgggg ggtacagacc tcaggtacat ttgaccctga
     3001 ggttaaaagg ggttcaggtc aagaggtggg agaggaaagg ggtagatggg aggtggaatc
     3061 tgtaggaaag agaaaaagca aagtcgttca ctgactgagt agcccccagg gagtggagac
     3121 gggtccctgg ggagggagca gctgacaggt cagcagtgcc cccagcccca cccaagagga
     3181 gggcagcgtg tgcctgtggt ctgggacgtg ggctggatgg cagcccaggg tcacaggcat
     3241 aggataacat gtgctttgga cctgacaagg gagtaccttg ggggtctgat ggggtcatgg
     3301 ccagccgagc ctctgtagag atggaggcta cagccctcag aagggagggg aggaaagaga
     3361 ctgagggccc tggcctgggg cgtcgatggg gaagcggtgg cccccagtcc tcttctgctg
     3421 ctcccagccc cctcctcctg gggccctcag ggatctcatg aagtcttcct tggcccaacc
     3481 aggcagatgc cccgggctcc agtgggggga ggggtctggg gtctggtccg ggttccccgc
     3541 tttctctatg tcccccctcc ctctttctcc gcagtgcgga taaaaattgg actcgaataa
     3601 aacccttggt gcccgga
//
