LOCUS       NM_016333               9044 bp    mRNA    linear   PRI 11-FEB-2025
DEFINITION  Homo sapiens serine/arginine repetitive matrix 2 (SRRM2), mRNA.
ACCESSION   NM_016333
VERSION     NM_016333.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 9044)
  AUTHORS   Guo,J., Zhang,Z., Wang,H., Li,Q., Fan,M., Zhang,W., Tao,Q.,
            Wang,Z., Ling,C., Xiao,H., Gao,Z. and Zhai,Z.
  TITLE     SRRM2 may be a potential biomarker and immunotherapy target for
            multiple myeloma: a real-world study based on flow cytometry
            detection
  JOURNAL   Clin Exp Med 24 (1), 28 (2024)
   PUBMED   38289482
  REMARK    GeneRIF: SRRM2 may be a potential biomarker and immunotherapy
            target for multiple myeloma: a real-world study based on flow
            cytometry detection.
            Erratum:[Clin Exp Med. 2024 Jul 18;24(1):159. doi:
            10.1007/s10238-024-01393-1.. PMID: 39023571]
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 9044)
  AUTHORS   Xu,S., Lai,S.K., Sim,D.Y., Ang,W.S.L., Li,H.Y. and Roca,X.
  TITLE     SRRM2 organizes splicing condensates to regulate alternative
            splicing
  JOURNAL   Nucleic Acids Res 50 (15), 8599-8614 (2022)
   PUBMED   35929045
  REMARK    GeneRIF: SRRM2 organizes splicing condensates to regulate
            alternative splicing.
REFERENCE   3  (bases 1 to 9044)
  AUTHORS   Cuinat,S., Nizon,M., Isidor,B., Stegmann,A., van Jaarsveld,R.H.,
            van Gassen,K.L., van der Smagt,J.J., Volker-Touw,C.M.L.,
            Holwerda,S.J.B., Terhal,P.A., Schuhmann,S., Vasileiou,G.,
            Khalifa,M., Nugud,A.A., Yasaei,H., Ousager,L.B.,
            Brasch-Andersen,C., Deb,W., Besnard,T., Simon,M.E.H.,
            Amsterdam,K.H., Verbeek,N.E., Matalon,D., Dykzeul,N., White,S.,
            Spiteri,E., Devriendt,K., Boogaerts,A., Willemsen,M., Brunner,H.G.,
            Sinnema,M., De Vries,B.B.A., Gerkes,E.H., Pfundt,R., Izumi,K.,
            Krantz,I.D., Xu,Z.L., Murrell,J.R., Valenzuela,I., Cusco,I.,
            Rovira-Moreno,E., Yang,Y., Bizaoui,V., Patat,O., Faivre,L.,
            Tran-Mau-Them,F., Vitobello,A., Denomme-Pichon,A.S., Philippe,C.,
            Bezieau,S. and Cogne,B.
  TITLE     Loss-of-function variants in SRRM2 cause a neurodevelopmental
            disorder
  JOURNAL   Genet Med 24 (8), 1774-1780 (2022)
   PUBMED   35567594
  REMARK    GeneRIF: Loss-of-function variants in SRRM2 cause a
            neurodevelopmental disorder.
REFERENCE   4  (bases 1 to 9044)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   5  (bases 1 to 9044)
  AUTHORS   Fazeli,S., Motovali-Bashi,M., Peymani,M., Hashemi,M.S.,
            Etemadifar,M., Nasr-Esfahani,M.H. and Ghaedi,K.
  TITLE     A compound downregulation of SRRM2 and miR-27a-3p with upregulation
            of miR-27b-3p in PBMCs of Parkinson's patients is associated with
            the early stage onset of disease
  JOURNAL   PLoS One 15 (11), e0240855 (2020)
   PUBMED   33171483
  REMARK    GeneRIF: A compound downregulation of SRRM2 and miR-27a-3p with
            upregulation of miR-27b-3p in PBMCs of Parkinson's patients is
            associated with the early stage onset of disease.
            Erratum:[PLoS One. 2020 Dec 30;15(12):e0244776. doi:
            10.1371/journal.pone.0244776.. PMID: 33378389]
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 9044)
  AUTHORS   Jurica,M.S., Licklider,L.J., Gygi,S.R., Grigorieff,N. and
            Moore,M.J.
  TITLE     Purification and characterization of native spliceosomes suitable
            for three-dimensional structural analysis
  JOURNAL   RNA 8 (4), 426-439 (2002)
   PUBMED   11991638
REFERENCE   7  (bases 1 to 9044)
  AUTHORS   McGarvey,T., Rosonina,E., McCracken,S., Li,Q., Arnaout,R.,
            Mientjes,E., Nickerson,J.A., Awrey,D., Greenblatt,J., Grosveld,G.
            and Blencowe,B.J.
  TITLE     The acute myeloid leukemia-associated protein, DEK, forms a
            splicing-dependent interaction with exon-product complexes
  JOURNAL   J Cell Biol 150 (2), 309-320 (2000)
   PUBMED   10908574
REFERENCE   8  (bases 1 to 9044)
  AUTHORS   Sawada,Y., Miura,Y., Umeki,K., Tamaoki,T., Fujinaga,K. and
            Ohtaki,S.
  TITLE     Cloning and characterization of a novel RNA-binding protein SRL300
            with RS domains
  JOURNAL   Biochim Biophys Acta 1492 (1), 191-195 (2000)
   PUBMED   11004489
REFERENCE   9  (bases 1 to 9044)
  AUTHORS   Blencowe,B.J., Bauren,G., Eldridge,A.G., Issner,R., Nickerson,J.A.,
            Rosonina,E. and Sharp,P.A.
  TITLE     The SRm160/300 splicing coactivator subunits
  JOURNAL   RNA 6 (1), 111-120 (2000)
   PUBMED   10668804
REFERENCE   10 (bases 1 to 9044)
  AUTHORS   Blencowe,B.J., Issner,R., Nickerson,J.A. and Sharp,P.A.
  TITLE     A coactivator of pre-mRNA splicing
  JOURNAL   Genes Dev 12 (7), 996-1009 (1998)
   PUBMED   9531537
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC092117.4, AB016092.1, AB002322.3 and AI083775.1.
            
            On Nov 22, 2018 this sequence version replaced NM_016333.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB016092.1, AB002322.3 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA1970526
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000301740.13/ ENSP00000301740.8
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-209               AC092117.4         143709-143917
            210-2595            AB016092.1         195-2580
            2596-7973           AC092117.4         153955-159332
            7974-9014           AB002322.3         7935-8975
            9015-9044           AI083775.1         27-56               c
FEATURES             Location/Qualifiers
     source          1..9044
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16p13.3"
     gene            1..9044
                     /gene="SRRM2"
                     /gene_synonym="300-KD; Cwc21; CWF21; HSPC075; MRD72;
                     SRL300; SRm300"
                     /note="serine/arginine repetitive matrix 2"
                     /db_xref="GeneID:23524"
                     /db_xref="HGNC:HGNC:16639"
                     /db_xref="MIM:606032"
     exon            1..209
                     /gene="SRRM2"
                     /gene_synonym="300-KD; Cwc21; CWF21; HSPC075; MRD72;
                     SRL300; SRm300"
                     /inference="alignment:Splign:2.1.0"
     exon            210..482
                     /gene="SRRM2"
                     /gene_synonym="300-KD; Cwc21; CWF21; HSPC075; MRD72;
                     SRL300; SRm300"
                     /inference="alignment:Splign:2.1.0"
     CDS             241..8499
                     /gene="SRRM2"
                     /gene_synonym="300-KD; Cwc21; CWF21; HSPC075; MRD72;
                     SRL300; SRm300"
                     /note="splicing coactivator subunit SRm300; RNA binding
                     protein; taxREB803; 300 kDa nuclear matrix antigen;
                     testicular secretory protein Li 53; SR-related nuclear
                     matrix protein of 300 kDa; ser/Arg-related nuclear matrix
                     protein of 300 kDa; tax-responsive enhancer
                     element-binding protein 803; serine/arginine-rich splicing
                     factor-related nuclear matrix protein of 300 kDa"
                     /codon_start=1
                     /product="serine/arginine repetitive matrix protein 2"
                     /protein_id="NP_057417.3"
                     /db_xref="CCDS:CCDS32373.1"
                     /db_xref="GeneID:23524"
                     /db_xref="HGNC:HGNC:16639"
                     /db_xref="MIM:606032"
                     /translation="MYNGIGLPTPRGSGTNGYVQRNLSLVRGRRGERPDYKGEEELRR
                     LEAALVKRPNPDILDHERKRRVELRCLELEEMMEEQGYEEQQIQEKVATFRLMLLEKD
                     VNPGGKEETPGQRPAVTETHQLAELNEKKNERLRAAFGISDSYVDGSSFDPQRRAREA
                     KQPAPEPPKPYSLVRESSSSRSPTPKQKKKKKKKDRGRRSESSSPRRERKKSSKKKKH
                     RSESESKKRKHRSPTPKSKRKSKDKKRKRSRSTTPAPKSRRAHRSTSADSASSSDTSR
                     SRSRSAAAKTHTTALAGRSPSPASGRRGEGDAPFSEPGTTSTQRPSSPETATKQPSSP
                     YEDKDKDKKEKSATRPSPSPERSSTGPEPPAPTPLLAERHGGSPQPLATTPLSQEPVN
                     PPSEASPTRDRSPPKSPEKLPQSSSSESSPPSPQPTKVSRHASSSPESPKPAPAPGSH
                     REISSSPTSKNRSHGRAKRDKSHSHTPSRRMGRSRSPATAKRGRSRSRTPTKRGHSRS
                     RSPQWRRSRSAQRWGRSRSPQRRGRSRSPQRPGWSRSRNTQRRGRSRSARRGRSHSRS
                     PATRGRSRSRTPARRGRSRSRTPARRRSRSRTPTRRRSRSRTPARRGRSRSRTPARRR
                     SRTRSPVRRRSRSRSPARRSGRSRSRTPARRGRSRSRTPARRGRSRSRTPARRSGRSR
                     SRTPARRGRSRSRTPRRGRSRSRSLVRRGRSHSRTPQRRGRSGSSSERKNKSRTSQRR
                     SRSNSSPEMKKSRISSRRSRSLSSPRSKAKSRLSLRRSLSGSSPCPKQKSQTPPRRSR
                     SGSSQPKAKSRTPPRRSRSSSSPPPKQKSKTPSRQSHSSSSPHPKVKSGTPPRQGSIT
                     SPQANEQSVTPQRRSCFESSPDPELKSRTPSRHSCSGSSPPRVKSSTPPRQSPSRSSS
                     PQPKVKAIISPRQRSHSGSSSPSPSRVTSRTTPRRSRSVSPCSNVESRLLPRYSHSGS
                     SSPDTKVKPETPPRQSHSGSISPYPKVKAQTPPGPSLSGSKSPCPQEKSKDSLVQSCP
                     GSLSLCAGVKSSTPPGESYFGVSSLQLKGQSQTSPDHRSDTSSPEVRQSHSESPSLQS
                     KSQTSPKGGRSRSSSPVTELASRSPIRQDRGEFSASPMLKSGMSPEQSRFQSDSSSYP
                     TVDSNSLLGQSRLETAESKEKMALPPQEDATASPPRQKDKFSPFPVQDRPESSLVFKD
                     TLRTPPRERSGAGSSPETKEQNSALPTSSQDEELMEVVEKSEEPAGQILSHLSSELKE
                     MSTSNFESSPEVEERPAVSLTLDQSQSQASLEAVEVPSMASSWGGPHFSPEHKELSNS
                     PLRENSFGSPLEFRNSGPLGTEMNTGFSSEVKEDLNGPFLNQLETDPSLDMKEQSTRS
                     SGHSSSELSPDAVEKAGMSSNQSISSPVLDAVPRTPSRERSSSASSPEMKDGLPRTPS
                     RRSRSGSSPGLRDGSGTPSRHSLSGSSPGMKDIPRTPSRGRSECDSSPEPKALPQTPR
                     PRSRSPSSPELNNKCLTPQRERSGSESSVDQKTVARTPLGQRSRSGSSQELDVKPSAS
                     PQERSESDSSPDSKAKTRTPLRQRSRSGSSPEVDSKSRLSPRRSRSGSSPEVKDKPRA
                     APRAQSGSDSSPEPKAPAPRALPRRSRSGSSSKGRGPSPEGSSSTESSPEHPPKSRTA
                     RRGSRSSPEPKTKSRTPPRRRSSRSSPELTRKARLSRRSRSASSSPETRSRTPPRHRR
                     SPSVSSPEPAEKSRSSRRRRSASSPRTKTTSRRGRSPSPKPRGLQRSRSRSRREKTRT
                     TRRRDRSGSSQSTSRRRQRSRSRSRVTRRRRGGSGYHSRSPARQESSRTSSRRRRGRS
                     RTPPTSRKRSRSRTSPAPWKRSRSRASPATHRRSRSRTPLISRRRSRSRTSPVSRRRS
                     RSRTSVTRRRSRSRASPVSRRRSRSRTPPVTRRRSRSRTPTTRRRSRSRTPPVTRRRS
                     RSRTPPVTRRRSRSRTSPITRRRSRSRTSPVTRRRSRSRTSPVTRRRSRSRTSPVTRR
                     RSRSRTPPAIRRRSRSRTPLLPRKRSRSRSPLAIRRRSRSRTPRTARGKRSLTRSPPA
                     IRRRSASGSSSDRSRSATPPATRNHSGSRTPPVALNSSRMSCFSRPSMSPTPLDRCRS
                     PGMLEPLGSSRTPMSVLQQAGGSMMDGPGPRIPDHQRTSVPENHAQSRIALALTAISL
                     GTARPPPSMSAAGLAARMSQVPAPVPLMSLRTAPAANLASRIPAASAAAMNLASARTP
                     AIPTAVNLADSRTPAAAAAMNLASPRTAVAPSAVNLADPRTPTAPAVNLAGARTPAAL
                     AALSLTGSGTPPTAANYPSSSRTPQAPASANLVGPRSAHATAPVNIAGSRTAAALAPA
                     SLTSARMAPALSGANLTSPRVPLSAYERVSGRTSPPLLDRARSRTPPSAPSQSRMTSE
                     RAPSPSSRMGQAPSQSLLPPAQDQPRSPVPSAFSDQSRCLIAQTTPVAGSQSLSSGAV
                     ATTTSSAGDHNGMLSVPAPGVPHSDVGEPPASTGAQQPSALAALQPAKERRSSSSSSS
                     SSSSSSSSSSSSSSSSSSGSSSSDSEGSSLPVQPEVALKRVPSPTPAPKEAVREGRPP
                     EPTPAKRKRRSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSPSPAKP
                     GPQALPKPASPKKPPPGERRSRSPRKPIDSLRDSRSLSYSPVERRRPSPQPSPRDQQS
                     SSSERGSRRGQRGDSRSPSHKRRRETPSPRPMRHRSSRSP"
     exon            483..590
                     /gene="SRRM2"
                     /gene_synonym="300-KD; Cwc21; CWF21; HSPC075; MRD72;
                     SRL300; SRm300"
                     /inference="alignment:Splign:2.1.0"
     exon            591..755
                     /gene="SRRM2"
                     /gene_synonym="300-KD; Cwc21; CWF21; HSPC075; MRD72;
                     SRL300; SRm300"
                     /inference="alignment:Splign:2.1.0"
     exon            756..833
                     /gene="SRRM2"
                     /gene_synonym="300-KD; Cwc21; CWF21; HSPC075; MRD72;
                     SRL300; SRm300"
                     /inference="alignment:Splign:2.1.0"
     exon            834..896
                     /gene="SRRM2"
                     /gene_synonym="300-KD; Cwc21; CWF21; HSPC075; MRD72;
                     SRL300; SRm300"
                     /inference="alignment:Splign:2.1.0"
     exon            897..929
                     /gene="SRRM2"
                     /gene_synonym="300-KD; Cwc21; CWF21; HSPC075; MRD72;
                     SRL300; SRm300"
                     /inference="alignment:Splign:2.1.0"
     exon            930..980
                     /gene="SRRM2"
                     /gene_synonym="300-KD; Cwc21; CWF21; HSPC075; MRD72;
                     SRL300; SRm300"
                     /inference="alignment:Splign:2.1.0"
     exon            981..1073
                     /gene="SRRM2"
                     /gene_synonym="300-KD; Cwc21; CWF21; HSPC075; MRD72;
                     SRL300; SRm300"
                     /inference="alignment:Splign:2.1.0"
     exon            1074..1272
                     /gene="SRRM2"
                     /gene_synonym="300-KD; Cwc21; CWF21; HSPC075; MRD72;
                     SRL300; SRm300"
                     /inference="alignment:Splign:2.1.0"
     exon            1273..7973
                     /gene="SRRM2"
                     /gene_synonym="300-KD; Cwc21; CWF21; HSPC075; MRD72;
                     SRL300; SRm300"
                     /inference="alignment:Splign:2.1.0"
     exon            7974..8261
                     /gene="SRRM2"
                     /gene_synonym="300-KD; Cwc21; CWF21; HSPC075; MRD72;
                     SRL300; SRm300"
                     /inference="alignment:Splign:2.1.0"
     exon            8262..8375
                     /gene="SRRM2"
                     /gene_synonym="300-KD; Cwc21; CWF21; HSPC075; MRD72;
                     SRL300; SRm300"
                     /inference="alignment:Splign:2.1.0"
     exon            8376..8489
                     /gene="SRRM2"
                     /gene_synonym="300-KD; Cwc21; CWF21; HSPC075; MRD72;
                     SRL300; SRm300"
                     /inference="alignment:Splign:2.1.0"
     exon            8490..9044
                     /gene="SRRM2"
                     /gene_synonym="300-KD; Cwc21; CWF21; HSPC075; MRD72;
                     SRL300; SRm300"
                     /inference="alignment:Splign:2.1.0"
     regulatory      9022..9027
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SRRM2"
                     /gene_synonym="300-KD; Cwc21; CWF21; HSPC075; MRD72;
                     SRL300; SRm300"
                     /note="hexamer: AATAAA"
     polyA_site      9044
                     /gene="SRRM2"
                     /gene_synonym="300-KD; Cwc21; CWF21; HSPC075; MRD72;
                     SRL300; SRm300"
                     /note="major polyA site"
ORIGIN      
        1 gtgctgacgt gcagcgcggc ccaggcgggg tgcgagtggc gcagttggag cccgttgcgg
       61 cccctgagga agcgaggagg cgtcggcgtc ggctgaggcg ggcggaccgg cgaggcgagg
      121 cggcggcccc aggcccgagg gactcgggag ctcgagcagc ggcggcggca agacctctcc
      181 ccctcggagg cggcgggcgg aggcggcggg agcggtggtg ccccccccgg gcacggggcc
      241 atgtacaacg ggatcgggct gccgacgccc cggggcagcg gcaccaacgg ctacgtccag
      301 cgcaacctgt ccctggtgcg gggccgccgg ggtgagcggc ctgactacaa gggagaggag
      361 gaactgcggc gcctggaggc tgccctggtg aagcggccta atcctgacat cctggaccac
      421 gagcgcaagc ggcgcgtcga gctgcgatgc ctcgagctgg aggagatgat ggaagagcag
      481 gggtacgagg aacagcaaat tcaggaaaaa gtggcgacct ttcgactcat gttgctggag
      541 aaggatgtga accctggggg caaggaggag accccagggc agaggccagc ggtcacggag
      601 actcaccagt tggcagaatt aaatgagaag aagaatgaaa gactccgtgc tgcctttggc
      661 atcagtgatt cttacgtaga tggcagctct tttgatcctc agcgtcgtgc ccgagaagct
      721 aaacaaccag ctcctgagcc tcccaaacct tacagccttg ttcgggagtc tagcagttct
      781 cgctcaccaa ccccaaagca gaagaagaag aaaaagaaga aagatagagg acgcaggtca
      841 gagagcagct ctcctcgacg ggagagaaag aaaagctcaa agaagaagaa gcacaggtca
      901 gaatctgagt ccaagaaacg taagcatagg tctcccactc caaagagcaa acgtaaatct
      961 aaggacaaaa agcgaaagcg gtctcgaagt acaacaccag cccccaagag ccgccgggcc
     1021 caccgttcaa cttctgctga ctctgcttcc tcctccgata cttcccgcag tcggtctcga
     1081 agtgctgcag ctaaaactca tacaactgcc ttggctgggc gaagtccttc ccctgcttca
     1141 gggcgacgcg gggagggaga tgcgcctttc agtgaaccag gtactaccag cacacaacgg
     1201 cctagtagcc cggagactgc tacgaaacag cctagcagcc cttatgaaga caaagataaa
     1261 gacaagaagg agaaatctgc aactcgacct agcccctctc cggaaaggag cagcacaggc
     1321 ccagaaccac ctgctcccac tccgctcctt gctgagcgac atggcggctc cccacaaccc
     1381 cttgcaacca cccccttaag ccaggagcca gtgaaccccc catctgaggc ctctccaact
     1441 cgggaccgtt caccacctaa gtctcccgag aaacttcccc agtcttcttc ctcagagagc
     1501 agcccaccat cccctcaacc taccaaagtt tctcggcatg ccagctcttc cccagaaagt
     1561 cctaaacctg ctccagctcc agggtcccac cgagagattt cttcttctcc cacatctaag
     1621 aatcgctcac atggccgagc aaaacgggat aaatcacatt ctcatacccc ctcccgtagg
     1681 atggggaggt cccgtagccc tgccaccgct aagagagggc gatctcggtc tcgaacccct
     1741 accaagagag gtcattctcg atcccgatct ccccagtggc gtaggtccag gtctgcacag
     1801 aggtggggaa gatctagaag cccccagcga cgtggccgct ctaggtctcc tcagcgacca
     1861 ggctggtcta ggagcagaaa tacccagaga agaggcaggt ctaggtcagc aaggcgaggg
     1921 aggtcccact ctagatcccc agccactagg ggtagatctc gttctagaac accagcccgc
     1981 cggggcaggt cccgctctag aacacctgcc aggcggagat cacgatccag aactcccacc
     2041 aggcgtaggt ctcggtctag aacaccagcc cggaggggca ggtctcggtc tagaacacct
     2101 gctaggcgca gatctaggac ccgatcacca gtacgacgca ggtctcgtag tagatcacca
     2161 gccaggagaa gtggcaggtc acgctctaga accccagcta gacgtggccg ctcacgctcc
     2221 agaaccccag ccagacgtgg ccgctcacgc tctagaaccc cagctagacg cagtggtcgc
     2281 tcacgctcca gaacaccagc caggagaggg aggtctcggt ctaggacacc aagacgagga
     2341 agatcccgca gtagaagctt agttagacgt ggaagatctc actctagaac acctcaaaga
     2401 agaggcagat ctggctcatc ttcagagcgg aaaaacaaat ccagaacatc tcaaagaaga
     2461 agcaggtcca attcaagccc agaaatgaag aaatctcgca tttcttcaag gcggagcagg
     2521 tctctctctt caccacggtc caaagcaaaa tctcgcttgt ctttgaggcg cagcctttca
     2581 gggtcttccc catgccctaa acaaaagtca cagacaccac ccaggcgcag tcgctctgga
     2641 tcctcccaac ctaaagctaa atctagaacg ccacccagac gcagtcgctc cagttcttct
     2701 ccgccaccta aacagaaatc taagacacca tcaagacaaa gtcattccag ttcatctcct
     2761 catcctaaag tgaaatctgg aacaccaccg aggcaagggt ccataacaag tccccaggcc
     2821 aatgagcaat ctgtaacgcc acagagacgg agctgttttg aatcatcacc tgaccctgag
     2881 ttgaaatcta ggaccccttc tagacatagc tgctcagggt cctctcctcc tagagtgaaa
     2941 tctagcacac ctcccagaca gagcccatct aggtcatcat ctccacaacc caaagtgaag
     3001 gcaataatat caccaagaca aagaagccat tctggctcct cttctccaag tcctagtagg
     3061 gtgacgtcga gaacaactcc acggcgaagc agatcagtat ctccctgctc caatgtggaa
     3121 tccagattgt tgccaagata cagtcattct gggtcctcct caccagatac caaagtgaaa
     3181 cctgaaacac cgccaagaca aagtcactca gggtctattt caccataccc caaagtaaag
     3241 gcccaaactc caccggggcc aagtctttct ggatcaaagt caccatgtcc ccaagagaag
     3301 tctaaagact cactagttca aagttgccct ggatccctct ctctctgtgc aggagtaaaa
     3361 tctagcacac caccaggcga gagctatttt ggtgtctcat ctctgcaact gaaaggacaa
     3421 tctcaaactt caccagacca cagatctgat acttcaagtc cagaagtgag acagagtcat
     3481 tcagaatcac catctctgca gagcaaatct caaacatcac ctaagggagg tcggtccagg
     3541 tcttcatctc cagtcactga gctggcatcc agatctccaa taagacaaga tagaggtgag
     3601 ttctcagcga gtcctatgtt gaaatctgga atgtctcctg agcagagcag gttccagtct
     3661 gactcttctt catatcctac agtggactcg aattctctct tggggcagag tagattggag
     3721 actgctgaat caaaagagaa aatggcctta ccccctcagg aggatgctac tgcatcacct
     3781 cctagacaga aagacaaatt tagtcccttt ccagtacagg ataggcctga gtcttcactg
     3841 gtattcaaag acacacttag aaccccgcca agggaaagaa gtggtgctgg gtcatctcca
     3901 gaaacaaaag agcaaaatag tgcattgcct acgtcaagcc aagatgaaga gttaatggag
     3961 gtggtagaga agtctgaaga acccgcaggc caaatcctgt ctcatttgtc ttcagaactt
     4021 aaagaaatgt ccacaagtaa ctttgaatca tctcctgaag tagaagaaag gcctgctgtg
     4081 tctttgactc ttgatcagag ccagtcacag gcttctttgg aagcagtaga agtcccttca
     4141 atggcctcat cttggggtgg gccacatttt tctccagaac ataaagaact gtctaactcc
     4201 ccactcaggg agaacagctt tggatcacct ttagaattta gaaactcagg cccacttggt
     4261 acagaaatga atactggatt ttcttctgag gttaaagaag atttgaatgg accgtttctt
     4321 aatcagctgg aaacagatcc atctctagac atgaaagaac aatcgacaag atcctctgga
     4381 cacagcagtt ctgagttatc cccagatgca gtggaaaagg cagggatgtc ttcaaatcag
     4441 agcatctctt cacctgtgct tgatgctgta cccagaacac cctcgagaga aagaagtagt
     4501 tctgcatctt ctcctgaaat gaaagatggt ttacccagaa ctccatcaag gagaagcagg
     4561 tctgggtctt ctccaggact tagagatggg tctgggactc cctcgaggca cagcctgtct
     4621 gggtcctctc ctggaatgaa agatatacct agaacgccat ctagagggag aagcgaatgt
     4681 gattcttccc cagaaccgaa agctttgcct cagactccta ggccgaggag tcgttctcca
     4741 tcatccccag agctcaacaa caagtgtctt accccccaga gagaaagaag cgggtcagaa
     4801 tcatcagttg atcagaaaac tgtggctcgg actcccctgg ggcagagaag tcgttcggga
     4861 tcctctcaag aacttgatgt gaaacccagt gcatcccctc aggaaagaag tgagtcagac
     4921 tcttctccag attctaaagc caagacaaga accccacttc ggcagaggag tcggtctgga
     4981 tcatctccag aggttgacag caaatctcga ctatcccctc ggcgcagtag gtctggttcc
     5041 tcccctgaag tgaaagataa gccaagagca gcacccaggg cacagagtgg ttctgattcc
     5101 tctcctgaac ctaaagctcc agcccctcgg gcccttccca gacgaagcag atcaggttca
     5161 tcaagcaaag gcagaggccc ttctcctgaa ggaagcagca gtaccgagtc ctctcctgaa
     5221 catccgccca aatccagaac tgctcgcaga ggttccaggt catcaccaga gcccaagacc
     5281 aagtctcgta caccacctcg acgtcgcagc tctcgatcat ctccggagct aacaaggaag
     5341 gccagactgt cccgtagaag ccgctctgcc tcatcctcac cagaaactcg ctctagaact
     5401 cccccaaggc accggagaag tccctcagtg tcttccccgg agccagccga aaaatcgagg
     5461 tcttcacgcc gacggcgctc agcttcatct ccacgcacta agacaacctc aaggagaggc
     5521 cgctctcctt cgccaaagcc tcgtggactc cagaggtccc gttcccgctc aaggagagag
     5581 aaaacaagaa caacccgacg tcgagatagg tctggatctt ctcagtcaac ctctcggcga
     5641 agacagcgga gccggtcaag gtcgcgggtt actcggcggc ggaggggagg ctctggttat
     5701 cactcaaggt cacctgcccg gcaggaaagt tcccggacct cctctcgacg ccgaagaggc
     5761 cgctctcgga cacccccaac cagtcggaag cgttctcgct cacgcacatc accagccccg
     5821 tggaaacgct ctagatctcg agcctctcca gccactcacc ggcgatccag gtccagaacc
     5881 cccctgataa gccgacgtag gtccagatct cgaacttcac cagtcagccg gagacggtca
     5941 aggtccagga cttcagtgac tcgacgaaga tcccggtcaa gagcatcccc agtgagcaga
     6001 aggcgatcca gatccagaac gccaccagta acccgccgtc gttcaaggtc tagaacgcca
     6061 acaacacgcc gccgctcccg ttctagaact ccaccagtga ctcgcagaag gtccagatcc
     6121 aggactccac cagtaaccag gaggcgatct cgaagcagaa cttcgcctat cactcgcaga
     6181 agatcaagat ccagaacatc tccggtcacc cgaaggagat ctcgatctcg cacatctcca
     6241 gtaactcgaa gaaggtcccg ctctcgaacc tcaccagtga cacgccgccg ctctaggtcc
     6301 cggacacctc cagctattcg gcgccgctct agatctcgaa cgccactgtt accacgcaaa
     6361 cgttctcgaa gtcgctcacc acttgctatc cgccgccgct ccagatcccg tactccacga
     6421 acagctcggg gtaaacggtc cttaacaaga tctcctccag ccatccgcag gcgttctgca
     6481 tctggaagta gttctgatcg ttcacgatct gctactcctc cagcaacaag aaatcattct
     6541 ggttcacgga cacctccagt agcactcaac agttccagaa tgagctgctt cagtcgtcct
     6601 agcatgtccc caacacctct tgatcgctgc agatcacctg gaatgcttga accccttggc
     6661 agctctagaa cacccatgtc tgtcctgcag caagccggcg gctccatgat ggatggtcca
     6721 ggtccccgaa tacctgacca ccagagaaca tctgtgccag aaaatcatgc tcagtccagg
     6781 attgcacttg ccctgacagc tatcagtctt ggcaccgctc ggcctcctcc gtccatgtct
     6841 gctgctggcc ttgctgcaag aatgtcccag gttccagccc cggtgcctct catgagtctc
     6901 agaaccgcac cagcagccaa ccttgccagc aggattcctg cagcctctgc ggcagccatg
     6961 aacctagcca gcgccaggac acctgccatt ccaacagcag tgaacctggc tgactctcga
     7021 acgccagctg cagcagcggc catgaacttg gccagcccca gaacagcggt ggcaccttcg
     7081 gctgtgaacc tggctgaccc tcgcactccc acagccccag ctgtgaacct agcaggggcc
     7141 agaaccccag ctgccttggc agctctgagt ctcacaggct ctggcacacc accaactgct
     7201 gcaaactatc cctccagctc cagaacacca caggctccag cctctgcaaa cctggtgggt
     7261 cctcggtctg cacatgccac agctcctgtg aatattgccg gctccagaac cgccgcagcc
     7321 ttggcccccg cgagcctcac cagtgctagg atggctccag cattgtctgg tgcaaacctc
     7381 accagcccca gggtgcccct ttctgcctac gagcgtgtca gtggcagaac ctcaccaccg
     7441 ctccttgacc gagctaggtc cagaacacca ccgtctgccc caagccaatc taggatgacc
     7501 tctgaacggg ctccctcccc ttcctctaga atgggccagg ctccttcaca gtctcttctc
     7561 cctccagcac aggatcagcc gaggtctcct gtgccttctg ctttttcaga ccaatcccgt
     7621 tgtttgattg cccagaccac ccctgtagca gggtctcagt ccctttcctc tggggcagtg
     7681 gcaacgacca cgtcctctgc tggtgatcac aatggcatgc tctctgtccc tgcccctggg
     7741 gtgccccact ctgatgtggg ggagccacct gcctctactg gggcccagca gccttctgca
     7801 ttagccgccc tgcagccagc aaaggagcgg cggagttcct cctcgtcgtc gtcgtcctct
     7861 agctcctcct cttcttcatc atcgtcgtcg tcgtcctcct cctcctctgg ctccagttct
     7921 agtgactcag agggctctag ccttcctgtg caacctgagg tggcactgaa gagggtcccc
     7981 agccccaccc cagccccaaa ggaggctgtt cgagagggac gtcctccgga gccaacccca
     8041 gccaaacgga agaggcgctc tagcagttcc agttccagct cctcctcttc atcttcctcc
     8101 tcctcctcct cctcctcttc ttcctcctcc tcttcctctt cttcttcttc ctcctcatct
     8161 tcctcctcct cgtcgtcttc ctccccttcc cctgctaagc ctggccctca ggccttgccc
     8221 aaacctgcaa gccccaagaa gccaccccct ggcgagcgga ggtcccgcag cccccggaag
     8281 ccaatagact ccctcaggga ctctcggtcc ctcagctact cgcctgtgga gcgtcgccgt
     8341 ccctcgcccc agccctcacc acgggaccag cagagcagca gcagtgagcg gggttcccgg
     8401 agaggccagc gtggggacag ccgctccccc agccacaagc gcaggaggga gacacctagc
     8461 cctcggccca tgagacaccg ctcctccagg tctccataaa ttgtctttgg gggattccac
     8521 cacacccaat gctctggagc cacaaggagt gtcccttctt ccccagcaga gccgtgggag
     8581 ggtccttgtc tgctctcctt tgaaccttgg cagcccttgg atggagggct ccctttccct
     8641 cccctttttt ttttctttgt tcctgtgaaa tgttaatctc cgtgagttct tcctggttca
     8701 tgtgttctgg ggggtttggg gtgggaggga atgcagatgg gagttggggg aggggaggat
     8761 acagttcagg ataccccagc ctggagtcag ggccagggag gcatggcccc acttgtatcc
     8821 agaagttccc aggggtgatt gtgatggtgg ttgggactgg aggttgtata aggtgttctt
     8881 ggaaggaagg ggcaggagtt ggaattagtt ggtccctact gtcccccatg aggttgtgaa
     8941 cccctccccc caacttttca tgtttcttaa aggcattttg gttttttaaa atctgtacag
     9001 caagagcaac tttttctgtc aaataaaaat gagaaatgca ggaa
//
