LOCUS       NM_005839               3735 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens serine and arginine repetitive matrix 1 (SRRM1),
            transcript variant 2, mRNA.
ACCESSION   NM_005839
VERSION     NM_005839.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3735)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 3735)
  AUTHORS   Buljan,M., Ciuffa,R., van Drogen,A., Vichalkovski,A., Mehnert,M.,
            Rosenberger,G., Lee,S., Varjosalo,M., Pernas,L.E., Spegg,V.,
            Snijder,B., Aebersold,R. and Gstaiger,M.
  TITLE     Kinase Interaction Network Expands Functional and Disease Roles of
            Human Kinases
  JOURNAL   Mol Cell 79 (3), 504-520 (2020)
   PUBMED   32707033
REFERENCE   3  (bases 1 to 3735)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 3735)
  AUTHORS   Chwalenia,K., Qin,F., Singh,S. and Li,H.
  TITLE     A cell-based splicing reporter system to identify regulators of
            cis-splicing between adjacent genes
  JOURNAL   Nucleic Acids Res 47 (4), e24 (2019)
   PUBMED   30590765
  REMARK    GeneRIF: We discovered that two factors, SRRM1 and SF3B1, affect
            not only cis-SAGe chimeras, but also other types of chimeric RNAs
            in a genome-wide fashion.
REFERENCE   5  (bases 1 to 3735)
  AUTHORS   Varjosalo,M., Keskitalo,S., Van Drogen,A., Nurkkala,H.,
            Vichalkovski,A., Aebersold,R. and Gstaiger,M.
  TITLE     The protein interaction landscape of the human CMGC kinase group
  JOURNAL   Cell Rep 3 (4), 1306-1320 (2013)
   PUBMED   23602568
REFERENCE   6  (bases 1 to 3735)
  AUTHORS   Blencowe,B.J., Bauren,G., Eldridge,A.G., Issner,R., Nickerson,J.A.,
            Rosonina,E. and Sharp,P.A.
  TITLE     The SRm160/300 splicing coactivator subunits
  JOURNAL   RNA 6 (1), 111-120 (2000)
   PUBMED   10668804
REFERENCE   7  (bases 1 to 3735)
  AUTHORS   Eldridge,A.G., Li,Y., Sharp,P.A. and Blencowe,B.J.
  TITLE     The SRm160/300 splicing coactivator is required for exon-enhancer
            function
  JOURNAL   Proc Natl Acad Sci U S A 96 (11), 6125-6130 (1999)
   PUBMED   10339552
REFERENCE   8  (bases 1 to 3735)
  AUTHORS   Wilson,K.F., Fortes,P., Singh,U.S., Ohno,M., Mattaj,I.W. and
            Cerione,R.A.
  TITLE     The nuclear cap-binding complex is a novel target of growth factor
            receptor-coupled signal transduction
  JOURNAL   J Biol Chem 274 (7), 4166-4173 (1999)
   PUBMED   9933612
REFERENCE   9  (bases 1 to 3735)
  AUTHORS   Blencowe,B.J., Issner,R., Nickerson,J.A. and Sharp,P.A.
  TITLE     A coactivator of pre-mRNA splicing
  JOURNAL   Genes Dev 12 (7), 996-1009 (1998)
   PUBMED   9531537
REFERENCE   10 (bases 1 to 3735)
  AUTHORS   Wang,H.Y., Lin,W., Dyck,J.A., Yeakley,J.M., Songyang,Z.,
            Cantley,L.C. and Fu,X.D.
  TITLE     SRPK2: a differentially expressed SR protein-specific kinase
            involved in mediating the interaction and localization of pre-mRNA
            splicing factors in mammalian cells
  JOURNAL   J Cell Biol 140 (4), 737-750 (1998)
   PUBMED   9472028
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC036187.1, BC017315.2, AF048977.1 and CX782666.1.
            
            On Nov 22, 2018 this sequence version replaced NM_005839.3.
            
            Transcript Variant: This variant (2) lacks an alternate in-frame
            exon in the central coding region compared to variant 1. The
            encoded isoform (2) is shorter than isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC036187.1, AF419855.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000323848.14/ ENSP00000326261.8
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-533               BC036187.1         28-560
            534-2457            BC017315.2         514-2437
            2458-3082           BC036187.1         2485-3109
            3083-3412           AF048977.1         3056-3385
            3413-3648           BC036187.1         3439-3674
            3649-3721           AF048977.1         3621-3693
            3722-3735           CX782666.1         25-38               c
FEATURES             Location/Qualifiers
     source          1..3735
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p36.11"
     gene            1..3735
                     /gene="SRRM1"
                     /gene_synonym="160-KD; POP101; SRM160"
                     /note="serine and arginine repetitive matrix 1"
                     /db_xref="GeneID:10250"
                     /db_xref="HGNC:HGNC:16638"
                     /db_xref="MIM:605975"
     exon            1..46
                     /gene="SRRM1"
                     /gene_synonym="160-KD; POP101; SRM160"
                     /inference="alignment:Splign:2.1.0"
     CDS             26..2740
                     /gene="SRRM1"
                     /gene_synonym="160-KD; POP101; SRM160"
                     /note="isoform 2 is encoded by transcript variant 2;
                     serine/arginine repetitive matrix protein 1;
                     Ser/Arg-related nuclear matrix protein; SR-related nuclear
                     matrix protein of 160 kDa"
                     /codon_start=1
                     /product="serine/arginine repetitive matrix protein 1
                     isoform 2"
                     /protein_id="NP_005830.2"
                     /db_xref="CCDS:CCDS255.1"
                     /db_xref="GeneID:10250"
                     /db_xref="HGNC:HGNC:16638"
                     /db_xref="MIM:605975"
                     /translation="MDAGFFRGTSAEQDNRFSNKQKKLLKQLKFAECLEKKVDMSKVN
                     LEVIKPWITKRVTEILGFEDDVVIEFIFNQLEVKNPDSKMMQINLTGFLNGKNAREFM
                     GELWPLLLSAQENIAGIPSAFLELKKEEIKQRQIEQEKLASMKKQDEDKDKRDKEEKE
                     SSREKRERSRSPRRRKSRSPSPRRRSSPVRRERKRSHSRSPRHRTKSRSPSPAPEKKE
                     KTPELPEPSVKVKEPSVQEATSTSDILKVPKPEPIPEPKEPSPEKNSKKEKEKEKTRP
                     RSRSRSKSRSRTRSRSPSHTRPRRRHRSRSRSYSPRRRPSPRRRPSPRRRTPPRRMPP
                     PPRHRRSRSPVRRRRRSSASLSGSSSSSSSSRSRSPPKKPPKRTSSPPRKTRRLSPSA
                     SPPRRRHRPSPPATPPPKTRHSPTPQQSNRTRKSRVSVSPGRTSGKVTKHKGTEKRES
                     PSPAPKPRKVELSESEEDKGGKMAAADSVQQRRQYRRQNQQSSSDSGSSSSSEDERPK
                     RSHVKNGEVGRRRRHSPSRSASPSPRKRQKETSPRGRRRRSPSPPPTRRRRSPSPAPP
                     PRRRRTPTPPPRRRTPSPPPRRRSPSPRRYSPPIQRRYSPSPPPKRRTASPPPPPKRR
                     ASPSPPPKRRVSHSPPPKQRSSPVTKRRSPSLSSKHRKGSSPSRSTREARSPQPNKRH
                     SPSPRPRAPQTSSSPPPVRRGASSSPQRRQSPSPSTRPIRRVSRTPEPKKIKKAASPS
                     PQSVRRVSSSRSVSGSPEPAAKKPPAPPSPVQSQSPSTNWSPAVPVKKAKSPTPSPSP
                     PRNSDQEGGGKKKKKKKDKKHKKDKKHKKHKKHKKEKAVAAAAAAAVTPAAIAAATTT
                     LAQEEPVAAPEPKKETESEAEDNLDDLEKHLREKALRSMRKAQVSPQS"
     exon            47..136
                     /gene="SRRM1"
                     /gene_synonym="160-KD; POP101; SRM160"
                     /inference="alignment:Splign:2.1.0"
     exon            137..259
                     /gene="SRRM1"
                     /gene_synonym="160-KD; POP101; SRM160"
                     /inference="alignment:Splign:2.1.0"
     exon            260..430
                     /gene="SRRM1"
                     /gene_synonym="160-KD; POP101; SRM160"
                     /inference="alignment:Splign:2.1.0"
     exon            431..546
                     /gene="SRRM1"
                     /gene_synonym="160-KD; POP101; SRM160"
                     /inference="alignment:Splign:2.1.0"
     exon            547..750
                     /gene="SRRM1"
                     /gene_synonym="160-KD; POP101; SRM160"
                     /inference="alignment:Splign:2.1.0"
     exon            751..945
                     /gene="SRRM1"
                     /gene_synonym="160-KD; POP101; SRM160"
                     /inference="alignment:Splign:2.1.0"
     exon            946..1065
                     /gene="SRRM1"
                     /gene_synonym="160-KD; POP101; SRM160"
                     /inference="alignment:Splign:2.1.0"
     exon            1066..1340
                     /gene="SRRM1"
                     /gene_synonym="160-KD; POP101; SRM160"
                     /inference="alignment:Splign:2.1.0"
     exon            1341..1421
                     /gene="SRRM1"
                     /gene_synonym="160-KD; POP101; SRM160"
                     /inference="alignment:Splign:2.1.0"
     exon            1422..1508
                     /gene="SRRM1"
                     /gene_synonym="160-KD; POP101; SRM160"
                     /inference="alignment:Splign:2.1.0"
     exon            1509..1653
                     /gene="SRRM1"
                     /gene_synonym="160-KD; POP101; SRM160"
                     /inference="alignment:Splign:2.1.0"
     exon            1654..1764
                     /gene="SRRM1"
                     /gene_synonym="160-KD; POP101; SRM160"
                     /inference="alignment:Splign:2.1.0"
     exon            1765..2229
                     /gene="SRRM1"
                     /gene_synonym="160-KD; POP101; SRM160"
                     /inference="alignment:Splign:2.1.0"
     exon            2230..2425
                     /gene="SRRM1"
                     /gene_synonym="160-KD; POP101; SRM160"
                     /inference="alignment:Splign:2.1.0"
     exon            2426..2635
                     /gene="SRRM1"
                     /gene_synonym="160-KD; POP101; SRM160"
                     /inference="alignment:Splign:2.1.0"
     exon            2636..3735
                     /gene="SRRM1"
                     /gene_synonym="160-KD; POP101; SRM160"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      3506
                     /gene="SRRM1"
                     /gene_synonym="160-KD; POP101; SRM160"
     regulatory      3700..3705
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SRRM1"
                     /gene_synonym="160-KD; POP101; SRM160"
                     /note="hexamer: AATAAA"
     polyA_site      3735
                     /gene="SRRM1"
                     /gene_synonym="160-KD; POP101; SRM160"
                     /note="major polyA site"
ORIGIN      
        1 agcgatctcc gagcgaggcg gcaagatgga cgcgggattt ttccgcggaa caagtgcaga
       61 acaggataat cggttcagca acaaacagaa gaaactactg aagcagctga aatttgcaga
      121 atgcctagaa aaaaaggtgg acatgagcaa agtaaatttg gaggttataa agccttggat
      181 aacaaaaaga gtaacggaaa tccttgggtt tgaagatgat gttgtgattg agtttatatt
      241 caaccagctg gaagtgaaga atccagactc caaaatgatg caaatcaacc tgactggatt
      301 tttgaatgga aaaaatgctc gagaatttat gggagaactg tggcccctgc tgctaagtgc
      361 acaagaaaac atcgcgggaa tcccttctgc tttcctagaa ctgaagaaag aagaaataaa
      421 acaaagacag attgaacaag aaaaactggc atctatgaaa aagcaagatg aagacaaaga
      481 taaaagagat aaggaagaaa aagaaagcag cagagaaaaa agggagcggt ctcgtagccc
      541 aagaagacgc aaatccagat ctccttcccc tagaagacga tcttcccctg tcaggagaga
      601 gagaaagcgc agtcattctc gatctccccg tcacagaacc aagagccgga gtccttcccc
      661 tgctccagaa aagaaggaaa aaactccaga gctcccagaa ccttcagtga aagtaaaaga
      721 accttcagta caagaggcta cttctactag tgacattctg aaagttccca aacctgaacc
      781 tataccagag cctaaagaac cttctccgga aaaaaattcc aaaaaagaaa aggagaagga
      841 gaagacccga ccacgatctc ggtcacgctc caaatcaaga tcccggacgc ggtcccgctc
      901 tccttctcac actcgaccta gacggcgcca tagatcccga tcaagatcgt attcacctag
      961 aaggcggcca agcccaagaa ggcggccatc tcctcgaaga agaactccgc caagaagaat
     1021 gcctcctcca ccaaggcata gaaggagtag atctccagta agacgaagaa gacgttcgtc
     1081 agcatccttg tctgggagta gctcatcatc ctcttcatct cgttcacggt caccaccaaa
     1141 gaagcctccc aagaggacat ccagcccccc tcggaaaact cgtaggttat ctccttcagc
     1201 aagtcctcca aggcgaaggc acaggccatc acctcctgca actccaccac ccaaaactcg
     1261 gcattcccct acaccccagc agtcaaaccg tacaagaaaa agtcgtgttt ctgtgtctcc
     1321 agggagaact tcaggtaaag tgacaaaaca taaaggtact gagaaaagag aatccccttc
     1381 accagcaccg aagcctagaa aagtagagtt atctgaatcg gaagaagata aaggtggcaa
     1441 aatggctgca gcagattctg tgcagcagag acgccaatac agacgacaaa accagcagtc
     1501 ttcatctgac tctggctcct cctcctcctc agaagatgaa cgacccaaga gatcccatgt
     1561 gaagaatggt gaggttggca ggcggcggag acattcccct tcccggagtg cttctccatc
     1621 accacgaaag cgccaaaaag agacttcccc tcgtggtaga cggaggagaa gtccatcccc
     1681 accacccacc agaaggcgac ggtctccttc tcccgcccct cctcctcgac ggcgcaggac
     1741 tcccacacca ccaccacgac gaaggactcc ttctcctccc ccacgtcggc gctcaccttc
     1801 tcctagaaga tactctcctc caatacagag gagatactct ccttctccac ctccaaagag
     1861 aagaacggct tcacctcctc cccctcctaa acgaagagca tcaccatctc caccaccaaa
     1921 gcggcgggtc tcccattctc cacctcccaa acaaagaagc tccccagtca ccaagagacg
     1981 ttcaccttca ttatcatcca agcataggaa agggtcttcc ccaagccgct ctacccggga
     2041 ggcccgatca ccacaaccaa acaaacggca ttcgccctca ccacggcctc gagctcctca
     2101 gacctcctca agtcctccac ccgttcgaag aggagcgtcg tcatcacccc aaagaaggca
     2161 gtccccgtct ccaagtacta ggcccattag gagagtctcc aggactccgg aacctaaaaa
     2221 gataaaaaag gctgcttccc caagcccaca gtctgtaaga agggtctcat cctcccgatc
     2281 tgtctccggg tctcctgagc cagcagctaa aaagccccca gcacctccat cccccgtcca
     2341 gtctcagtca ccgtctacaa actggtcacc agctgtaccg gtcaaaaagg ccaaaagccc
     2401 aacaccgagc ccatcaccgc caagaaattc agatcaggaa ggaggtggaa agaaaaagaa
     2461 gaaaaagaag gacaagaaac acaaaaagga taagaagcac aagaagcaca aaaaacacaa
     2521 gaaggaaaag gctgtggctg cagctgctgc agctgctgtg acccctgcag ccattgcagc
     2581 tgccacaacc acattagcac aggaagagcc agtggcagcg ccagagccga agaaggagac
     2641 tgaaagtgaa gctgaagata accttgatga tttagaaaag cacctgcgtg aaaaggccct
     2701 gagatcaatg aggaaggccc aagtgtcccc acagtcttag ggggaaatgt ttgttatgat
     2761 gtaaatttta tttggtttgt acgcagttca atttcaaaat tgctaaaatg tgtttgagct
     2821 ttagactata acatttgttg taataattgc taggttgaag ttcaacatgt aaaaaaaggg
     2881 ggcatggatt tacattgcaa aaggtgtcca cagtgtatta gtgacattct ttcattgaca
     2941 gctgacataa ttcattgagt gaaatatttt aagccaaaaa aaaattccct ttttaaaaaa
     3001 gggggtttaa atactgttgg catttttatg gttcctttaa atgccctagc tattcccaga
     3061 ggggtttttt tgtttgtttt tttggttttg attttctttt tgtttttctt tcttcttctt
     3121 atttttttca tttgagtctt agctcccatt taagttatgc ttctgacctt gtatggtctg
     3181 taagcttgcc cagaaataag accactgttt tgaactacca caaaagtata aatgaatatt
     3241 ttaatgccac aatctttcct gttgcctgtg gagtctctgc tgaaatgaat caggattcga
     3301 gctctaggat gagacagaaa atgaaagcat gttgtttgcc aggacactgt gggtttatat
     3361 tgatgtgtaa caagttgatt tggaacactg gactctcatt ctgttattct ggttttgttt
     3421 tttttgtttt gttttttttc ttttgtaaag gcaatgagct agtcccagaa aggatccttc
     3481 agttacatac aatttgttta atgaaatgtc atggctctgt tcatattttt gtcttgttct
     3541 tccaattggt atatacaact ttcagagcct cttgtatttg gaaggctgga agggcccaga
     3601 ctttggaata gtgtcttggt ttcactgttt ttgttttgat tttttttttg ttttgatttt
     3661 ttttaaacta aagctatata aagcttgtgg attaaacaga ataaatttct aaatttaaaa
     3721 attttgccac tctta
//
