LOCUS       NM_001013694            4020 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens SRR1 domain containing (SRRD), mRNA.
ACCESSION   NM_001013694 XM_377713
VERSION     NM_001013694.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4020)
  AUTHORS   Sweeney,K.M., Chantarawong,S., Barbieri,E.M., Cajka,G., Liu,M.,
            Spruce,L., Fazelinia,H., Portz,B., Copley,K., Lapidot,T.,
            Duhamel,L., Greenwald,P., Saida,N., Shalgi,R., Shorter,J. and
            Shalem,O.
  TITLE     CRISPR screen for protein inclusion formation uncovers a role for
            SRRD in the regulation of intermediate filament dynamics and
            aggresome assembly
  JOURNAL   PLoS Genet 20 (2), e1011138 (2024)
   PUBMED   38315730
  REMARK    GeneRIF: CRISPR screen for protein inclusion formation uncovers a
            role for SRRD in the regulation of intermediate filament dynamics
            and aggresome assembly.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4020)
  AUTHORS   Dunham,I., Shimizu,N., Roe,B.A., Chissoe,S., Hunt,A.R.,
            Collins,J.E., Bruskiewich,R., Beare,D.M., Clamp,M., Smink,L.J.,
            Ainscough,R., Almeida,J.P., Babbage,A., Bagguley,C., Bailey,J.,
            Barlow,K., Bates,K.N., Beasley,O., Bird,C.P., Blakey,S.,
            Bridgeman,A.M., Buck,D., Burgess,J., Burrill,W.D., O'Brien,K.P. et
            al.
  TITLE     The DNA sequence of human chromosome 22
  JOURNAL   Nature 402 (6761), 489-495 (1999)
   PUBMED   10591208
  REMARK    Erratum:[Nature 2000 Apr 20;404(6780):904]
REFERENCE   3  (bases 1 to 4020)
  AUTHORS   Kedar,V., Fletcher,L. and Powell,L.
  TITLE     Molecular cloning of a novel mRNA highly expressed in
            haemochromatotic human liver and proliferating cells
  JOURNAL   Biochem Biophys Res Commun 226 (2), 461-466 (1996)
   PUBMED   8806657
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            Z99714.2, BC066962.1, DA325985.1, BQ189353.1 and KF457388.1.
            
            On Nov 22, 2018 this sequence version replaced NM_001013694.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660805.164899.1,
                                           SRR1660803.231108.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000215917.11/ ENSP00000215917.6
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-7                 Z99714.2           68891-68897
            8-142               BC066962.1         5-139
            143-580             DA325985.1         131-568
            581-1224            BC066962.1         557-1200
            1225-1300           BQ189353.1         355-430
            1301-2681           Z99714.2           76953-78333
            2682-2975           KF457388.1         1-294
            2976-4020           Z99714.2           78628-79672
FEATURES             Location/Qualifiers
     source          1..4020
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="22"
                     /map="22q12.1"
     gene            1..4020
                     /gene="SRRD"
                     /gene_synonym="HC/HCC; SRR1L"
                     /note="SRR1 domain containing"
                     /db_xref="GeneID:402055"
                     /db_xref="HGNC:HGNC:33910"
                     /db_xref="MIM:602254"
     exon            1..223
                     /gene="SRRD"
                     /gene_synonym="HC/HCC; SRR1L"
                     /inference="alignment:Splign:2.1.0"
     CDS             15..1034
                     /gene="SRRD"
                     /gene_synonym="HC/HCC; SRR1L"
                     /note="hepatocellular carcinoma complicating
                     hemochromatosis; SRR1 domain-containing protein"
                     /codon_start=1
                     /product="SRR1-like protein"
                     /protein_id="NP_001013716.2"
                     /db_xref="CCDS:CCDS42995.1"
                     /db_xref="GeneID:402055"
                     /db_xref="HGNC:HGNC:33910"
                     /db_xref="MIM:602254"
                     /translation="MAAAAAAALESWQAAAPRKRRSAARRPRRREAAPRGREAAPRGR
                     EAAPRGPEAEFESDSGVVLRRIWEAEKDLFISDFWSSALETINRCLTKHLEQLKAPVG
                     TLSDIFGNLHLDSLPEESDVATDSIPREILVTGTCHLKCVCYGIGNFATCIVARNQLT
                     FLLLLLEKCQIPRSHCWVYDPLFSQLEIEVLNTLGVTVLSENEEGKRSIRGEPTIFYM
                     LHCGTALYNNLLWSNWSVDALSKMVIIGNSFKGLEERLLARILQKNYPYIAKILKGLE
                     ELEFPQTSQYMDIFNDTSVHWFPVQKLEQLSIDIWEFREEPDYQDCEDLEIIRNKRED
                     PSATD"
     exon            224..264
                     /gene="SRRD"
                     /gene_synonym="HC/HCC; SRR1L"
                     /inference="alignment:Splign:2.1.0"
     exon            265..524
                     /gene="SRRD"
                     /gene_synonym="HC/HCC; SRR1L"
                     /inference="alignment:Splign:2.1.0"
     exon            525..623
                     /gene="SRRD"
                     /gene_synonym="HC/HCC; SRR1L"
                     /inference="alignment:Splign:2.1.0"
     exon            624..778
                     /gene="SRRD"
                     /gene_synonym="HC/HCC; SRR1L"
                     /inference="alignment:Splign:2.1.0"
     exon            779..824
                     /gene="SRRD"
                     /gene_synonym="HC/HCC; SRR1L"
                     /inference="alignment:Splign:2.1.0"
     exon            825..4020
                     /gene="SRRD"
                     /gene_synonym="HC/HCC; SRR1L"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1273..1278
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SRRD"
                     /gene_synonym="HC/HCC; SRR1L"
                     /note="hexamer: AGTAAA"
     polyA_site      1300
                     /gene="SRRD"
                     /gene_synonym="HC/HCC; SRR1L"
                     /note="major polyA site"
     regulatory      3957..3962
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SRRD"
                     /gene_synonym="HC/HCC; SRR1L"
                     /note="hexamer: AATAAA"
     polyA_site      3982
                     /gene="SRRD"
                     /gene_synonym="HC/HCC; SRR1L"
                     /note="major polyA site"
     regulatory      3999..4004
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SRRD"
                     /gene_synonym="HC/HCC; SRR1L"
                     /note="hexamer: AATAAA"
     polyA_site      4020
                     /gene="SRRD"
                     /gene_synonym="HC/HCC; SRR1L"
                     /note="major polyA site"
ORIGIN      
        1 gacgtcagag accaatggct gcggccgcag ctgcggcgct ggaatcctgg caggcggcgg
       61 ctccgcggaa gaggcgctcc gcggctcgac ggccgcggcg gagggaggcg gcgccccggg
      121 ggagagaggc ggcgccccgg gggagagagg cggcgccccg gggccccgag gcggagttcg
      181 agtctgacag cggagtcgtg cttcgtcgca tctgggaggc tgagaaggac ctgtttatct
      241 ctgatttctg gagttcagca ctagaaacca tcaatagatg tctcacaaaa catctggaac
      301 aactgaaggc ccctgtgggg actctttcag acatctttgg aaacctgcat cttgactcat
      361 tgccagagga gtcagatgtg gccactgatt ctatcccaag agagatcttg gtcacaggaa
      421 cctgccattt gaagtgtgtg tgttacggca ttgggaactt tgccacctgc atcgtagcta
      481 gaaaccagct aacgtttttg ctgcttttgt tggaaaagtg ccagattccc agaagtcact
      541 gttgggtata tgaccctctg tttagccaac ttgaaattga agtccttaac acccttggtg
      601 tgactgttct cagtgagaac gaggaaggga aacggagtat tcgcggggag cctaccatct
      661 tttacatgct ccattgtggg acggccttgt acaacaatct tttatggagt aactggtcag
      721 tagatgccct ttctaagatg gtcatcattg ggaacagttt caaaggactt gaggagaggt
      781 tgttggcaag gattctgcag aaaaattatc cctacattgc aaagatttta aaaggactgg
      841 aggagcttga gtttcctcag acttcacaat acatggacat atttaatgat acctctgtcc
      901 actggttccc tgtgcaaaag ctagaacagc tctccataga tatttgggag tttcgggaag
      961 aaccagatta tcaggactgt gaggaccttg aaatcatcag gaacaagaga gaagatcctt
     1021 ctgctactga ctgaactcgt tgtgaggtac tcagtgttgg ctgaggtaga agctgccacc
     1081 agagactaaa gggaaggctg ctatggagga actacagaga actcctttgc caggaaagaa
     1141 catcaacttg gctgtcctgt tttgaggacg ataccccaca tgaggacttg gtataaagat
     1201 tcctgcccta cgtggcattg tcccatttta catccttccc tcatgacctg gcctgatgtg
     1261 gagtagctcc tgagtaaaga agttaccctt ttgaaggtga tctaaaaata ctgtttattt
     1321 acagtacatc cctcttaggg gcaagtctct gactggttct ggacctgcca cagttcactt
     1381 ggccatgtcg atcaggctct gcagtgaggt gggcacccac gtcttctcgc cctggacaaa
     1441 gaccactccc cggtcgatgt agatcacaat gcggccaaag gtgtagagct gcttcccttc
     1501 gtgtcgcttc ccaatgacgg gcatgaagac aatgttgtgc tcctcagcct tggtctcaat
     1561 gaggtcctta aagttcatgg gcacagagct agcggccacg ccaatgcccc tctgagccat
     1621 gttctcagcc tcccgcctct cctgcatggc ctcgtactgg aagtccttcc tccgctccgt
     1681 gtgggtgaga taggcaatgt tctcccgtgc tcctggctgc atgtaggcac ctaagataca
     1741 ggaggacagg gcggtgagga gaggtgtttc caggtgtatg gaagttgaca ctgtggcttg
     1801 gcccaggtct tgggtgtgcc agagtgcttg tgactcactg aagggcagct ctgcctcaaa
     1861 gatacaactt tggaggaagt ttagacgact ggccagtatc acataaaaac tgttcagaag
     1921 gttcctggct agtatctagt aaccagatta ttaatattca acattttaaa atgaagtatc
     1981 tgcaagggat ttcttccttc agagctggaa acattaacag agagtcctca gccactcttc
     2041 tgttcccacc ttgctctgta gagtttccat ttcccaccac caaagaggca gcttttagta
     2101 ccttgaaaac atagggccca tactggcttt atttttaacc tacccacaca gggcccccat
     2161 cctgaaagaa gttcacatat atttagggag ctgaaatgag tgtttaaagg ataataccaa
     2221 gaccataaat gctaagtgct aattgagggg tatattcagg gaacagtttt ggaaacatga
     2281 ggccaagggt agctaaggaa gagtttttag aaaaaacttg ataattacag aagcagagaa
     2341 gtatatttgc cttattactt aatctctgtt ttcacagaat aggctatttt tctttttttt
     2401 tttttgagac cgagtctcgc tcttgtcacc taggctggag tgcagtgctt gcaatctcgg
     2461 ctcactacaa cctctgcctc ccaggtttaa gcgattcttc tgcctcagcc tcctaagtag
     2521 ctggcattac aggcatgtgc caccgcgccc ggctaatttt tgcattttta gtagagacgg
     2581 ggtttcacca tgttggtcag gctggtctcg aactcctgac ctcgtgatct acccgcctcg
     2641 gcctcccaaa gtgctaggat tacaggcgtg agccaccgtg cctggcctag gctattaaat
     2701 aacaagaatt aaagactcag gaaatagaaa ttccagttct aactgccacc ctttaactat
     2761 gtgaccttga acaggctctc agcctcgctg ggcttatctg taaaacacag actagacgat
     2821 cccatttcaa tgctgcgaat cggctaatga gcaacactgg agcacaggac tggttgaaat
     2881 aggctcccaa atgtagaaac ataaatatac tctcacttac ttatgatcta ggcagaatga
     2941 cttacctaga acttgggaac agatatagta cacgaacagt gaactgcctg tttttgacaa
     3001 cacagacacc acctattgaa ggctatacac aagcatgaac tcactctccc ttttagccta
     3061 taaagtagat cttactgttt aacaggtaaa atggggctga ttaaggctga gcaatcacca
     3121 agtgtcagac cgcgtgccaa actccacact gtaagatgcg tcacctaagc agcatgctca
     3181 ggcatgaatg agccttaaaa ggccacacag cacagtggtt aagagggcgg ggcctggggt
     3241 tagactgaca tcatctgaat ccagcttaag tcagtctcca ctcagggaag atgcccctct
     3301 cagtcatggt agacctgggc agtgggtgcc agctgaccat gtaccccagt cagcagggtg
     3361 agagtctgtt gctatgtgca aaagtgtgac ctaaggttta ggctgcctac aggaaccaga
     3421 aaactctgat tctgtgtcat ttacatgtgt aaaatctgaa acttggggcc aggacatcca
     3481 aaatgggaat cctcacttac caacgttgga ggacaccgcc cggttcatga tatcaagtgc
     3541 ctcattaaat ttgtccttga cagatggatg tgccagcact tggtctgaga acatcgactt
     3601 ccaacccagg taccacttgg tgatctcctc ataatttggg ctgttactga gccaagagca
     3661 cagcacctgc caaaaagaaa aattacttgc atccatcgtg gcaacaaatg aaggcaagat
     3721 ttctgaagtg gccatttgtt ttgttttgat cctggtccta caggctagtg acactacttt
     3781 acagggattt atagtagcta aacagtctag cacttatgaa tatggatttt ggagtcagcc
     3841 tggtagctaa agtgcccttg catgtaaact ctctgagcct cagcttccat gtctacacaa
     3901 cagggatacc atatccccta ccccataggg ttgctgagag gagctgagat aaagcaaata
     3961 aagtgcttgg aacagcttct gatacatggc aaatgtccaa taaatggtgc ccactatgaa
//
