LOCUS       NM_021947               2482 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens serine racemase (SRR), transcript variant 1, mRNA.
ACCESSION   NM_021947
VERSION     NM_021947.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2482)
  AUTHORS   Lan,C., Yamashita,Y.I., Tsukamoto,M., Hayashi,H., Nakagawa,S.,
            Liu,Z., Wu,X., Imai,K., Mima,K., Kaida,T. and Baba,H.
  TITLE     The Prognostic Role of Serine Racemase in Patients With Pancreatic
            Cancer: A New Marker in Cancer Metabolism
  JOURNAL   Pancreas 52 (2), e101-e109 (2023)
   PUBMED   37523600
  REMARK    GeneRIF: The Prognostic Role of Serine Racemase in Patients With
            Pancreatic Cancer: A New Marker in Cancer Metabolism.
REFERENCE   2  (bases 1 to 2482)
  AUTHORS   Raza,W., Guo,J., Qadir,M.I., Bai,B. and Muhammad,S.A.
  TITLE     qPCR Analysis Reveals Association of Differential Expression of
            SRR, NFKB1, and PDE4B Genes With Type 2 Diabetes Mellitus
  JOURNAL   Front Endocrinol (Lausanne) 12, 774696 (2022)
   PUBMED   35046895
  REMARK    GeneRIF: qPCR Analysis Reveals Association of Differential
            Expression of SRR, NFKB1, and PDE4B Genes With Type 2 Diabetes
            Mellitus.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2482)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 2482)
  AUTHORS   Marchesani,F., Gianquinto,E., Autiero,I., Michielon,A.,
            Campanini,B., Faggiano,S., Bettati,S., Mozzarelli,A., Spyrakis,F.
            and Bruno,S.
  TITLE     The allosteric interplay between S-nitrosylation and glycine
            binding controls the activity of human serine racemase
  JOURNAL   FEBS J 288 (9), 3034-3054 (2021)
   PUBMED   33249721
  REMARK    GeneRIF: The allosteric interplay between S-nitrosylation and
            glycine binding controls the activity of human serine racemase.
REFERENCE   5  (bases 1 to 2482)
  AUTHORS   Michielon,A., Marchesani,F., Faggiano,S., Giaccari,R.,
            Campanini,B., Bettati,S., Mozzarelli,A. and Bruno,S.
  TITLE     Human serine racemase is inhibited by glyceraldehyde 3-phosphate,
            but not by glyceraldehyde 3-phosphate dehydrogenase
  JOURNAL   Biochim Biophys Acta Proteins Proteom 1869 (1), 140544 (2021)
   PUBMED   32971286
  REMARK    GeneRIF: Human serine racemase is inhibited by glyceraldehyde
            3-phosphate, but not by glyceraldehyde 3-phosphate dehydrogenase.
REFERENCE   6  (bases 1 to 2482)
  AUTHORS   Chen,Z., Huang,W., Srinivas,S.R., Jones,C.R., Ganapathy,V. and
            Prasad,P.D.
  TITLE     Serine racemase and D-serine transport in human placenta and
            evidence for a transplacental gradient for D-serine in humans
  JOURNAL   J Soc Gynecol Investig 11 (5), 294-303 (2004)
   PUBMED   15219883
  REMARK    GeneRIF: D-serine is synthesized in human placenta by the
            racemization of L-serine by serine racemase.
REFERENCE   7  (bases 1 to 2482)
  AUTHORS   Xia,M., Liu,Y., Figueroa,D.J., Chiu,C.S., Wei,N., Lawlor,A.M.,
            Lu,P., Sur,C., Koblan,K.S. and Connolly,T.M.
  TITLE     Characterization and localization of a human serine racemase
  JOURNAL   Brain Res Mol Brain Res 125 (1-2), 96-104 (2004)
   PUBMED   15193426
  REMARK    GeneRIF: Data report on the isolation of a cDNA encoding a human
            serine racemase (SRR) from a human neuronal like cell line.
REFERENCE   8  (bases 1 to 2482)
  AUTHORS   Cardoso,C., Leventer,R.J., Ward,H.L., Toyo-Oka,K., Chung,J.,
            Gross,A., Martin,C.L., Allanson,J., Pilz,D.T., Olney,A.H.,
            Mutchinick,O.M., Hirotsune,S., Wynshaw-Boris,A., Dobyns,W.B. and
            Ledbetter,D.H.
  TITLE     Refinement of a 400-kb critical region allows genotypic
            differentiation between isolated lissencephaly, Miller-Dieker
            syndrome, and other phenotypes secondary to deletions of 17p13.3
  JOURNAL   Am J Hum Genet 72 (4), 918-930 (2003)
   PUBMED   12621583
REFERENCE   9  (bases 1 to 2482)
  AUTHORS   Strisovsky,K., Jiraskova,J., Barinka,C., Majer,P., Rojas,C.,
            Slusher,B.S. and Konvalinka,J.
  TITLE     Mouse brain serine racemase catalyzes specific elimination of
            L-serine to pyruvate
  JOURNAL   FEBS Lett 535 (1-3), 44-48 (2003)
   PUBMED   12560076
REFERENCE   10 (bases 1 to 2482)
  AUTHORS   De Miranda,J., Santoro,A., Engelender,S. and Wolosker,H.
  TITLE     Human serine racemase: moleular cloning, genomic organization and
            functional analysis
  JOURNAL   Gene 256 (1-2), 183-188 (2000)
   PUBMED   11054547
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AY743706.1, AK023169.1 and AL834378.1.
            
            On Nov 23, 2018 this sequence version replaced NM_021947.2.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.84471.1,
                                           SRR1660809.56672.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000344595.10/ ENSP00000339435.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-4                 AY743706.1         8-11
            5-1408              AK023169.1         1-1404
            1409-2482           AL834378.1         1181-2254
FEATURES             Location/Qualifiers
     source          1..2482
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17p13.3"
     gene            1..2482
                     /gene="SRR"
                     /gene_synonym="ILV1; ISO1"
                     /note="serine racemase"
                     /db_xref="GeneID:63826"
                     /db_xref="HGNC:HGNC:14398"
                     /db_xref="MIM:606477"
     exon            1..68
                     /gene="SRR"
                     /gene_synonym="ILV1; ISO1"
                     /inference="alignment:Splign:2.1.0"
     exon            69..240
                     /gene="SRR"
                     /gene_synonym="ILV1; ISO1"
                     /inference="alignment:Splign:2.1.0"
     CDS             73..1095
                     /gene="SRR"
                     /gene_synonym="ILV1; ISO1"
                     /EC_number="4.3.1.17"
                     /EC_number="5.1.1.18"
                     /EC_number="4.3.1.18"
                     /note="isoform a is encoded by transcript variant 1;
                     D-serine dehydratase; L-serine dehydratase; D-serine
                     ammonia-lyase; L-serine ammonia-lyase"
                     /codon_start=1
                     /product="serine racemase isoform a"
                     /protein_id="NP_068766.1"
                     /db_xref="CCDS:CCDS11017.1"
                     /db_xref="GeneID:63826"
                     /db_xref="HGNC:HGNC:14398"
                     /db_xref="MIM:606477"
                     /translation="MCAQYCISFADVEKAHINIRDSIHLTPVLTSSILNQLTGRNLFF
                     KCELFQKTGSFKIRGALNAVRSLVPDALERKPKAVVTHSSGNHGQALTYAAKLEGIPA
                     YIVVPQTAPDCKKLAIQAYGASIVYCEPSDESRENVAKRVTEETEGIMVHPNQEPAVI
                     AGQGTIALEVLNQVPLVDALVVPVGGGGMLAGIAITVKALKPSVKVYAAEPSNADDCY
                     QSKLKGKLMPNLYPPETIADGVKSSIGLNTWPIIRDLVDDIFTVTEDEIKCATQLVWE
                     RMKLLIEPTAGVGVAAVLSQHFQTVSPEVKNICIVLSGGNVDLTSSITWVKQAERPAS
                     YQSVSV"
     exon            241..367
                     /gene="SRR"
                     /gene_synonym="ILV1; ISO1"
                     /inference="alignment:Splign:2.1.0"
     exon            368..471
                     /gene="SRR"
                     /gene_synonym="ILV1; ISO1"
                     /inference="alignment:Splign:2.1.0"
     exon            472..591
                     /gene="SRR"
                     /gene_synonym="ILV1; ISO1"
                     /inference="alignment:Splign:2.1.0"
     exon            592..666
                     /gene="SRR"
                     /gene_synonym="ILV1; ISO1"
                     /inference="alignment:Splign:2.1.0"
     exon            667..876
                     /gene="SRR"
                     /gene_synonym="ILV1; ISO1"
                     /inference="alignment:Splign:2.1.0"
     exon            877..2482
                     /gene="SRR"
                     /gene_synonym="ILV1; ISO1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1334..1339
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SRR"
                     /gene_synonym="ILV1; ISO1"
                     /note="hexamer: AATAAA"
     polyA_site      1355
                     /gene="SRR"
                     /gene_synonym="ILV1; ISO1"
                     /note="major polyA site"
     regulatory      2454..2459
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SRR"
                     /gene_synonym="ILV1; ISO1"
                     /note="hexamer: AATAAA"
     polyA_site      2482
                     /gene="SRR"
                     /gene_synonym="ILV1; ISO1"
ORIGIN      
        1 gtgcgcagag gtgcggccgg ggaggcgcgc ggaggctgga gctggaggcg cggcgccggt
       61 gagctgagaa ccatgtgtgc tcagtattgc atctcctttg ctgatgttga aaaagctcat
      121 atcaacattc gagattctat ccacctcaca ccagtgctaa caagctccat tttgaatcaa
      181 ctaacagggc gcaatctttt cttcaaatgt gaactcttcc agaaaacagg atcttttaag
      241 attcgtggtg ctctcaatgc cgtcagaagc ttggttcctg atgctttaga aaggaagccg
      301 aaagctgttg ttactcacag cagtggaaac catggccagg ctctcaccta tgctgccaaa
      361 ttggaaggaa ttcctgctta tattgtggtg ccccagacag ctccagactg taaaaaactt
      421 gcaatacaag cctacggagc gtcaattgta tactgtgaac ctagtgatga gtccagagaa
      481 aatgttgcaa aaagagttac agaagaaaca gaaggcatca tggtacatcc caaccaggag
      541 cctgcagtga tagctggaca agggacaatt gccctggaag tgctgaacca ggttcctttg
      601 gtggatgcac tggtggtacc tgtaggtgga ggaggaatgc ttgctggaat agcaattaca
      661 gttaaggctc tgaaacctag tgtgaaggta tatgctgctg aaccctcaaa tgcagatgac
      721 tgctaccagt ccaagctgaa ggggaaactg atgcccaatc tttatcctcc agaaaccata
      781 gcagatggtg tcaaatccag cattggcttg aacacctggc ctattatcag ggaccttgtg
      841 gatgatatct tcactgtcac agaggatgaa attaagtgtg caacccagct ggtgtgggag
      901 aggatgaaac tactcattga acctacagct ggtgttggag tggctgctgt gctgtctcaa
      961 cattttcaaa ctgtttcccc agaagtaaag aacatttgta ttgtgctcag tggtggaaat
     1021 gtagacttaa cctcctccat aacttgggtg aagcaggctg aaaggccagc ttcttatcag
     1081 tctgtttctg tttaatttac agaaaaggaa atggtgggaa ttcagtgtct ttagatactg
     1141 aagacatttt gtttcctagt attgtcaact cttagttatc agattcttaa tggagagtgg
     1201 ctatttcatt aagatttaat agtttttttt ggactaagta gtggaaaaac ttttatactt
     1261 aactgagaca ttttgtcaag gctaaaaaaa agtcttgcaa aatggggcag tggactgaca
     1321 ggctgacata gaaaataaac tttgcccaat cacaacttgt gcctcccatc cctggagtac
     1381 tgactggcac cggtaagaca gaatctcttt gaatccatta ctccatgccc ccttgaggca
     1441 ctgttgaaga aatctcactt ttcagccagg gtactggttc tggtacatat ggatcataag
     1501 tccatttggg gaagactcgt ttatacaggt tcatcagtac tgtgtcttga gattttagct
     1561 tcccatcaaa gctgcatttc atgtggccat gggtacctag aaagacatca gaacaagtcg
     1621 gtcaaattaa aagtagaaaa ttttaaagca atgacttcca acccaacagt catttagcaa
     1681 cactgcagaa atgcagacat ggtctcaaat cccgtgtttc cttacctaaa ggttccttga
     1741 tatgtcctct ccggccccac ttcgttctca gttccactgg tttaaaccac agcacatcct
     1801 cttagaatca aacacattaa agaccaagat gaaacattta cccacaaaat gtaaacccaa
     1861 cctttatacc acaaaggcaa tcagatccca tcctcctcct tcatacccac ctctgttgaa
     1921 gaacatgtaa cgtactactg ccatcttagt aaaaattttg aaaggatgac cactcagaac
     1981 aactctcttg atgaccattc tgtctggatc tactgacata agatggcctg tagcaatgag
     2041 gctgtgcatt cctaaaggac aaaagcaaag aagctattta ggaatttaca ggccaaagtc
     2101 ttcatttatt gcccagtcca tttaaagacc catgcaagag cctggtttgt catccctgcc
     2161 ctagcccaat ctgaggctaa gattggtaaa ctgtaagccc acacttaacc ttgtcaatag
     2221 gttcttgaaa acttgtactt caagagaaat gatgtataac aaaaccatac tttttctcat
     2281 cagttgttac aaggaaagga tgttgaacaa aaggcagtta tttgaggact ggctatacac
     2341 tgtttcacgt aaaagttgga gttttcattg ttctattaac aatgttaaat gaagacttac
     2401 tgtattttga aaaccatcat taccttctcc ataccatttg gctcccaaat ttaaataaac
     2461 aagagaaaac ggtgttcatc ta
//
