LOCUS       NM_014467               6646 bp    mRNA    linear   PRI 12-FEB-2025
DEFINITION  Homo sapiens sushi repeat containing protein X-linked 2 (SRPX2),
            mRNA.
ACCESSION   NM_014467
VERSION     NM_014467.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6646)
  AUTHORS   Guo,H., Liu,R., Wu,J., Li,S., Yao,W., Xu,J., Zheng,C., Lu,Y. and
            Zhang,H.
  TITLE     SRPX2 promotes cancer cell proliferation and migration of papillary
            thyroid cancer
  JOURNAL   Clin Exp Med 23 (8), 4825-4834 (2023)
   PUBMED   37306872
  REMARK    GeneRIF: SRPX2 promotes cancer cell proliferation and migration of
            papillary thyroid cancer.
REFERENCE   2  (bases 1 to 6646)
  AUTHORS   Wang,Q., Liu,J., Hu,Y., Pan,T., Xu,Y., Yu,J., Xiong,W., Zhou,Q. and
            Wang,Y.
  TITLE     Local administration of liposomal-based Srpx2 gene therapy reverses
            pulmonary fibrosis by blockading fibroblast-to-myofibroblast
            transition
  JOURNAL   Theranostics 11 (14), 7110-7125 (2021)
   PUBMED   34093874
  REMARK    GeneRIF: Local administration of liposomal-based Srpx2 gene therapy
            reverses pulmonary fibrosis by blockading
            fibroblast-to-myofibroblast transition.
            Erratum:[Theranostics. 2022 Jul 8;12(12):5330-5331. doi:
            10.7150/thno.74512.. PMID: 35910799]
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 6646)
  AUTHORS   Li,X., Liu,J., Sun,H., Zou,Y., Chen,J., Chen,Y., Chen,C. and Wu,X.
  TITLE     SRPX2 promotes cell proliferation and invasion via activating
            FAK/SRC/ERK pathway in non-small cell lung cancer
  JOURNAL   Acta Biochim Pol 67 (2), 165-172 (2020)
   PUBMED   32550700
  REMARK    GeneRIF: SRPX2 promotes cell proliferation and invasion via
            activating FAK/SRC/ERK pathway in non-small cell lung cancer.
REFERENCE   4  (bases 1 to 6646)
  AUTHORS   Sasahira,T., Kurihara-Shimomura,M., Nishiguchi,Y., Shimomura,H. and
            Kirita,T.
  TITLE     Sushi Repeat Containing Protein X-linked 2 Is a Downstream Signal
            of LEM Domain Containing 1 and Acts as a Tumor-Promoting Factor in
            Oral Squamous Cell Carcinoma
  JOURNAL   Int J Mol Sci 21 (10), 3655 (2020)
   PUBMED   32455867
  REMARK    GeneRIF: Sushi Repeat Containing Protein X-linked 2 Is a Downstream
            Signal of LEM Domain Containing 1 and Acts as a Tumor-Promoting
            Factor in Oral Squamous Cell Carcinoma.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 6646)
  AUTHORS   He,F., Wang,H., Li,Y., Liu,W., Gao,X., Chen,D., Wang,Q. and Shi,G.
  TITLE     SRPX2 knockdown inhibits cell proliferation and metastasis and
            promotes chemosensitivity in esophageal squamous cell carcinoma
  JOURNAL   Biomed Pharmacother 109, 671-678 (2019)
   PUBMED   30551519
  REMARK    GeneRIF: Knockdown of SRPX2 inhibits cell proliferation and
            metastasis, and promotes chemosensitivity in esophageal squamous
            cell carcinoma cells.
REFERENCE   6  (bases 1 to 6646)
  AUTHORS   Royer,B., Soares,D.C., Barlow,P.N., Bontrop,R.E., Roll,P.,
            Robaglia-Schlupp,A., Blancher,A., Levasseur,A., Cau,P.,
            Pontarotti,P. and Szepetowski,P.
  TITLE     Molecular evolution of the human SRPX2 gene that causes brain
            disorders of the Rolandic and Sylvian speech areas
  JOURNAL   BMC Genet 8, 72 (2007)
   PUBMED   17942002
  REMARK    GeneRIF: The R75K human-specific variation occurred in an important
            functional loop of the first sushi domain of SRPX2, indicating that
            this evolutionary mutation may have functional importance
            Publication Status: Online-Only
REFERENCE   7  (bases 1 to 6646)
  AUTHORS   Roll,P., Rudolf,G., Pereira,S., Royer,B., Scheffer,I.E.,
            Massacrier,A., Valenti,M.P., Roeckel-Trevisiol,N., Jamali,S.,
            Beclin,C., Seegmuller,C., Metz-Lutz,M.N., Lemainque,A.,
            Delepine,M., Caloustian,C., de Saint Martin,A., Bruneau,N.,
            Depetris,D., Mattei,M.G., Flori,E., Robaglia-Schlupp,A., Levy,N.,
            Neubauer,B.A., Ravid,R., Marescaux,C., Berkovic,S.F., Hirsch,E.,
            Lathrop,M., Cau,P. and Szepetowski,P.
  TITLE     SRPX2 mutations in disorders of language cortex and cognition
  JOURNAL   Hum Mol Genet 15 (7), 1195-1207 (2006)
   PUBMED   16497722
  REMARK    GeneRIF: The involvement of SRPX2 in these disorders suggests an
            important role for SRPX2 in the perisylvian region critical for
            language and cognitive development.
REFERENCE   8  (bases 1 to 6646)
  AUTHORS   Villard,L., Nguyen,K., Cardoso,C., Martin,C.L., Weiss,A.M.,
            Sifry-Platt,M., Grix,A.W., Graham,J.M. Jr., Winter,R.M.,
            Leventer,R.J. and Dobyns,W.B.
  TITLE     A locus for bilateral perisylvian polymicrogyria maps to Xq28
  JOURNAL   Am J Hum Genet 70 (4), 1003-1008 (2002)
   PUBMED   11822025
REFERENCE   9  (bases 1 to 6646)
  AUTHORS   Kurosawa,H., Goi,K., Inukai,T., Inaba,T., Chang,K.S., Shinjyo,T.,
            Rakestraw,K.M., Naeve,C.W. and Look,A.T.
  TITLE     Two candidate downstream target genes for E2A-HLF
  JOURNAL   Blood 93 (1), 321-332 (1999)
   PUBMED   9864177
REFERENCE   10 (bases 1 to 6646)
  AUTHORS   Arlotta,P., Santori,L. and de Vecchi,A.
  TITLE     [A case of mixed tumor of the palate]
  JOURNAL   Acta Biol Med Ger 2 (3), 34 (1976)
   PUBMED   209648
  REMARK    GeneRIF: The SRPX2 protein contains the P-DUDES structural domain
            in its C-terminal region. This domain has significant albeit remote
            sequence similarity to thioredoxin-like domains, and is predicted
            to possess an oxidoreductase function.
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL035608.11 and AL390040.9.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_014467.2.
            
            Summary: This gene encodes a secreted protein that contains three
            sushi repeat motifs. The encoded protein may play a role in the
            development of speech and language centers in the brain. This
            protein may also be involved in angiogenesis. Mutations in this
            gene are the cause of bilateral perisylvian polymicrogyria,
            rolandic epilepsy, speech dyspraxia and cognitive disability.
            [provided by RefSeq, May 2010].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803617.201156.1,
                                           SRR5189664.175439.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1966682, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000373004.5/ ENSP00000362095.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-317               AL035608.11        89358-89674
            318-529             AL035608.11        91352-91563
            530-610             AL035608.11        95944-96024
            611-802             AL390040.9         10246-10437
            803-979             AL390040.9         12844-13020
            980-1106            AL390040.9         13313-13439
            1107-1228           AL390040.9         13606-13727
            1229-1408           AL390040.9         14824-15003
            1409-1542           AL390040.9         15344-15477
            1543-1664           AL390040.9         17318-17439
            1665-6646           AL390040.9         18877-23858
FEATURES             Location/Qualifiers
     source          1..6646
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xq22.1"
     gene            1..6646
                     /gene="SRPX2"
                     /gene_synonym="BPP; CBPS; PMGX; RESDX; SRPUL"
                     /note="sushi repeat containing protein X-linked 2"
                     /db_xref="GeneID:27286"
                     /db_xref="HGNC:HGNC:30668"
                     /db_xref="MIM:300642"
     exon            1..317
                     /gene="SRPX2"
                     /gene_synonym="BPP; CBPS; PMGX; RESDX; SRPUL"
                     /inference="alignment:Splign:2.1.0"
     exon            318..529
                     /gene="SRPX2"
                     /gene_synonym="BPP; CBPS; PMGX; RESDX; SRPUL"
                     /inference="alignment:Splign:2.1.0"
     CDS             448..1845
                     /gene="SRPX2"
                     /gene_synonym="BPP; CBPS; PMGX; RESDX; SRPUL"
                     /note="sushi-repeat protein up-regulated in leukemia;
                     sushi repeat-containing protein SRPX2; sushi-repeat
                     protein upregulated in leukemia"
                     /codon_start=1
                     /product="sushi repeat-containing protein SRPX2 precursor"
                     /protein_id="NP_055282.1"
                     /db_xref="CCDS:CCDS14471.1"
                     /db_xref="GeneID:27286"
                     /db_xref="HGNC:HGNC:30668"
                     /db_xref="MIM:300642"
                     /translation="MASQLTQRGALFLLFFLTPAVTPTWYAGSGYYPDESYNEVYAEE
                     VPQAPALDYRVPRWCYTLNIQDGEATCYSPKGGNYHSSLGTRCELSCDRGFRLIGRRS
                     VQCLPSRRWSGTAYCRQMRCHALPFITSGTYTCTNGVLLDSRCDYSCSSGYHLEGDRS
                     RICMEDGRWSGGEPVCVDIDPPKIRCPHSREKMAEPEKLTARVYWDPPLVKDSADGTI
                     TRVTLRGPEPGSHFPEGEHVIRYTAYDRAYNRASCKFIVKVQVRRCPTLKPPQHGYLT
                     CTSAGDNYGATCEYHCDGGYDRQGTPSRVCQSSRQWSGSPPICAPMKINVNVNSAAGL
                     LDQFYEKQRLLIISAPDPSNRYYKMQISMLQQSTCGLDLRHVTIIELVGQPPQEVGRI
                     REQQLSANIIEELRQFQRLTRSYFNMVLIDKQGIDRDRYMEPVTPEEIFTFIDDYLLS
                     NQELTQRREQRDICE"
     exon            530..610
                     /gene="SRPX2"
                     /gene_synonym="BPP; CBPS; PMGX; RESDX; SRPUL"
                     /inference="alignment:Splign:2.1.0"
     exon            611..802
                     /gene="SRPX2"
                     /gene_synonym="BPP; CBPS; PMGX; RESDX; SRPUL"
                     /inference="alignment:Splign:2.1.0"
     exon            803..979
                     /gene="SRPX2"
                     /gene_synonym="BPP; CBPS; PMGX; RESDX; SRPUL"
                     /inference="alignment:Splign:2.1.0"
     exon            980..1106
                     /gene="SRPX2"
                     /gene_synonym="BPP; CBPS; PMGX; RESDX; SRPUL"
                     /inference="alignment:Splign:2.1.0"
     exon            1107..1228
                     /gene="SRPX2"
                     /gene_synonym="BPP; CBPS; PMGX; RESDX; SRPUL"
                     /inference="alignment:Splign:2.1.0"
     exon            1229..1408
                     /gene="SRPX2"
                     /gene_synonym="BPP; CBPS; PMGX; RESDX; SRPUL"
                     /inference="alignment:Splign:2.1.0"
     exon            1409..1542
                     /gene="SRPX2"
                     /gene_synonym="BPP; CBPS; PMGX; RESDX; SRPUL"
                     /inference="alignment:Splign:2.1.0"
     exon            1543..1664
                     /gene="SRPX2"
                     /gene_synonym="BPP; CBPS; PMGX; RESDX; SRPUL"
                     /inference="alignment:Splign:2.1.0"
     exon            1665..6646
                     /gene="SRPX2"
                     /gene_synonym="BPP; CBPS; PMGX; RESDX; SRPUL"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2133..2138
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SRPX2"
                     /gene_synonym="BPP; CBPS; PMGX; RESDX; SRPUL"
                     /note="hexamer: AGTAAA"
     polyA_site      2157
                     /gene="SRPX2"
                     /gene_synonym="BPP; CBPS; PMGX; RESDX; SRPUL"
                     /note="major polyA site"
     regulatory      6623..6628
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SRPX2"
                     /gene_synonym="BPP; CBPS; PMGX; RESDX; SRPUL"
                     /note="hexamer: AATAAA"
     polyA_site      6646
                     /gene="SRPX2"
                     /gene_synonym="BPP; CBPS; PMGX; RESDX; SRPUL"
                     /note="major polyA site"
ORIGIN      
        1 acacttcccc ctcttctgca gcagacggac tgagttcctc taatccctgt gttccttctc
       61 ccccatcttt ctaaaaccct tctctgagag aggaataact atagcttcag ggataatata
      121 gctttaagga aacttttggc agatgtggac gtcgtaacat ctgggcagtg ttaacagaat
      181 cccggaggcc gggacagacc aggagccact cgttctagga atgttaaagt agaaggtttt
      241 ttccaattga tgagaggagc agagaggaag gagaaagagg aggagagaga aaaagggcac
      301 aaaataccat aaaacagatc ccatatttct gcttcccctc acttttagaa gttaattgat
      361 ggctgacttc tgaaagtcac tttcctttgc cctggtactt caggccatat acatcttttc
      421 ttgtctccat aatcctccct ttcaaggatg gccagtcagc taactcaaag aggagctctc
      481 tttctgctgt tcttcctaac tccggcagtg acaccaacat ggtatgcagg ttctggctac
      541 tatccggatg aaagctacaa tgaagtatat gcagaggagg tcccacaggc tcctgccctg
      601 gactaccgag tcccccgatg gtgttataca ttaaatatcc aggatggaga agccacatgc
      661 tactcaccga agggaggaaa ttatcacagc agcctgggca cgcgttgtga gctctcctgt
      721 gaccggggct ttcgattgat tggaaggagg tcggtgcaat gcctgccaag ccgtcgttgg
      781 tctggaactg cctactgcag gcagatgaga tgccacgcac taccattcat cactagtggc
      841 acttacacct gcacaaatgg agtgcttctt gactctcgct gtgactacag ctgttccagt
      901 ggctaccacc tggaaggtga tcgcagccga atctgcatgg aagatgggag atggagtgga
      961 ggcgagcctg tatgtgtaga catagatccc cccaagatcc gctgtcccca ctcacgtgag
     1021 aagatggcag agccagagaa attgactgct cgagtatact gggacccacc gttggtgaaa
     1081 gattctgctg atggtaccat caccagggtg acacttcggg gccctgagcc tggctctcac
     1141 tttcccgaag gagagcatgt gattcgttac actgcctatg accgagccta caaccgggcc
     1201 agctgcaagt tcattgtgaa agtacaagtg agacgctgcc caactctgaa acctccgcag
     1261 cacggctacc tcacctgcac ctcagcgggg gacaactatg gtgccacctg tgaataccac
     1321 tgtgatggcg gttatgatcg ccaggggaca ccctcccggg tctgtcagtc cagccgccag
     1381 tggtcaggtt caccaccaat ctgtgctcct atgaagatta acgtcaacgt caactcagct
     1441 gctggtctct tggatcaatt ctatgagaaa cagcgactcc tcatcatctc agctcctgat
     1501 ccttccaacc gatattataa aatgcagatc tctatgctac agcaatccac ctgtggactg
     1561 gatttgcggc atgtgaccat cattgaactg gtgggacagc cacctcagga ggtggggcgc
     1621 atccgggagc aacagctgtc agccaacatc atcgaggagc tcaggcaatt tcagcgcctc
     1681 actcgctcct acttcaacat ggtgttgatt gacaagcagg gtattgaccg agaccgctac
     1741 atggaacctg tcacccccga ggaaatcttc acattcattg atgactacct actgagcaat
     1801 caggagttga cccagcgtcg ggagcaaagg gacatatgcg agtgaacttg agccagggca
     1861 tggttaaagt caagggaaaa gctcctctag ttagctgaaa ctgggaccta ataaaaggag
     1921 gaaatgtttt cccacagttc tagggacagg actctgaggt gggtgagttt gacaaatcct
     1981 gcggtgtttc caggcatcct tttaggactg tgtaatagtt tccctagaag ctaggtaggg
     2041 actgaggaca ggccttgggc agtgggttgg gggtagaagt tcttcctttc ctaacccggg
     2101 cccctgccca gctctccaaa gtctttcaga aaagtaaatc ctaaattcag tgatgaactg
     2161 gctgttttaa ctggttcctc taccctgagg tgacagcaga gggcagcacg agcacaacag
     2221 aaaccagctt acactttaag caagtgtagc tggattttcc ttacaggatg aggggtgggt
     2281 agcagggtac aaaacatcct tttttttttt tttttgagac ggagtcttgc cttgcgccca
     2341 ggctggagtg cagtggcgcg atcttggctc accgcaagct ccgtctcctg ggttcatgcc
     2401 attctcctgc ctcagcctcc cgagaagctg ggactacagg cgcccaccac cacacccggc
     2461 taacgttttg tatttttagt agagacgggt tttgaccatg ttagccagga tggtctctat
     2521 ctcctgacct cgcgatccac ccgcctcggc ctcccaaagt gctgggatta caggcgtgag
     2581 ccaccacgcc cagcccaaaa cattcttgaa cttgtttgtc atttcccctt ctagggcact
     2641 gggcagcaaa tgttatctga accattgctt cactgttaga aaaaccctgc agtgggagag
     2701 agcttggtaa gatgtatcca atcagagcag aatgttctct ggggccctcc agctggctca
     2761 cgggcaagaa ccccttcttc ctgaggcctc ccgtttctgt agcagaaggc aaacgattct
     2821 ctcccttcct cagaggagtc cccagcttgt tacttaggaa acttcaaaac caccactgca
     2881 ggtcgtaggg aaagaaaaga aaaacagact cagcctcatg tattaacttc ttcagatact
     2941 tgtccccttt tgagagatga gcacagagca ggtgggagct atagcagcac aaaatcaagc
     3001 cttaccaggc ctaaaattcg aggtggagcc acacacagat ccctgctctg actgcagtcc
     3061 ctctcaatgg tgtgccagtg tctgaaagac aagtgttctc tcccttgctg ctgagagcct
     3121 tctttcatac agtcatggaa cccagagtca tagctaagac tcagcagcct ctctccttca
     3181 gctttactca gggggtcatc agtggatgac ttgaggggag aaggaagcag gctgggtggg
     3241 gaggcagagc tcataatgct caagcactat gtgccaggtg ctgttctaaa cactctactg
     3301 attgactccg aagccttcac aagaacccta tgaggtaggt actgttatta accccatttt
     3361 acagatgagg aaattgaagc tgagtgagat taggtaattt gcctaagatc agacagctag
     3421 taagtggcag agtcaggatt tcaacaccag cagcctggct ctagaggcaa tgttcttctt
     3481 agacattatg ccatcctgac gctacttctt ttcctacttt ccatttaaag acaactgaaa
     3541 gctgtaagca aggagaaact ttccatgttc tataatccta cccagacaca aggctcagag
     3601 tgggctcagg aggaaagagg gaaatggaaa tgaaagggtc tcaacctgag aaaattcagt
     3661 cttgaaagcg gagtgatggg acataaatca tgagcccaga acaaattggg ggagcagtga
     3721 gtcagagaga atctccttcc actgggattt tagtggaaat ctcattttta aaatgcaata
     3781 taaaaaatta gggagttgct gggtagaatg gaacatggag gaaatgttca aagttggagc
     3841 aaaaaggtcc cttctccctc ttccctccag ggaaatatgg gaactgtgag aggcagcagg
     3901 caagttatgg gcagaggcag atacaatgag ttcatgtggg aaatttctgg tcagactagc
     3961 tctgtggttc caaaggcaaa gactgcacct tgggcgagat gaatgccctt cgttgtcttt
     4021 atcactaaca cttcaaatgg ggcaagccag gacatactag caggtcaaag gcccaaacag
     4081 cggaggccta ctacctcctg aacagagctc cacctggacc tgactcaagg aacatttata
     4141 tgcaactgag gagcttttgt ttcatttcat tttgaatagt caagtcagtc ttgctttctt
     4201 taggtaaagt tttacagtaa cctcctttgt agtcctttga agatgaggat ttgagaaatc
     4261 ccaactccta aagtagggga gagacagcag cagaatatga cccacagcca gacccaaagg
     4321 ggctagcccg acccctgtat atattgtacc tctctctctg cccacctctc ccccacttct
     4381 ccccactgcc ccattctctc ttatcctgcc tattcctctc ccctatttct ctgtctctct
     4441 ctctctcaca tacacacaca ctcactcaca agcagtacag tcactaagtt ggctaggtaa
     4501 tatccaaagc attctgattg tcctactttt tgtaaattga acttatttaa gatattttag
     4561 aagagatgag tcacgtcttc ctttgaccct tcacccataa cacacatacc attctcacag
     4621 gaggccacat ggtgcagtag agtcagactt tgattcaaag cccaactctg tcacgtgaca
     4681 gtaggcttga gtttcctcat ctgtaaaaag ggaagatttc ctacttcata aagtggttgg
     4741 agaaattaaa gaaatagtat atgaagcctt gcacataaaa agcatttgat atatattaat
     4801 gcccttttgc acaagaggtc aagaattgct tgggttctac ctagaaatca agagccttat
     4861 ttctgagctg ggttacttgg cacctgtgtt atttctctct caaaactaca taatggtagg
     4921 aggagtaaaa gaaaaagtcc ccgcctccca gagaaattga aggatccaga aagaagtgct
     4981 tatagcaggg aatgtctccc ctcacctcct gtatgaacat ctctctcctt cctccagtat
     5041 aggagggtct gcaaagctaa aggaagagtt cctttgttac aagatagaaa agtggtgcca
     5101 ctttaaagat gatttctcag tgttctcctt agataccaaa tacaaaggac gagggatcaa
     5161 gctcagcgaa agtatcaggc atttaaggta tcaggcagca atgcggggaa aggtgaattt
     5221 tcttcaatca gcataggatg gttagggaag agcatttatc actttggttc ttatccttca
     5281 agccagggga aaagcaacag tgaggacatc agagacaaaa gcatttatag aactaacaaa
     5341 cacaaacgtt tgacaagtga gaaagcttta ttaaagcaca catacatgtc aggggggtgg
     5401 gaaacaaaag agcaagttac agcccgggat cccaagttat gccttccatt acaattgcaa
     5461 tccacaccaa atcaatcttt gaaaacattc ctccattcgg ttcatacata cagtagaaac
     5521 cactgtggct gcccttaatc cagtgtgctt ataggaaatc agttagcagc tgactctgtt
     5581 gaaagggatt tcctctctgc tatacactcc ttccacacac aactttgggt agaaacgctt
     5641 atgagaatag aaaggtcagt ttgatcaatg agtaccagaa gatgaaactt agctcactag
     5701 acccttcttt gaaaagcctc aacacactac acccatgtaa tatgtaggtc aaatttagga
     5761 aacaatagca aaaacaggaa ctgaaagctc atcaagcagg aagtcagaat aacagggaga
     5821 ctctgtctac attcccttag agcccttaac agtccccagc ctggagaaac actgggccaa
     5881 ttgagataac acttggctct tctggttgac acagtgggat gtagaccatg ctctgtttga
     5941 taacacaccc cagacgcaaa cactaagaca gatgtggtac atgaggatga atatatctca
     6001 tctttcattc gagaaatgag gagctctctc tccaatgact gcagtatcag tttaaaatgc
     6061 agaaaattca gcatgggctg tgagacactt taccctcagt cactctggtc ctctgagatc
     6121 agctagaagc tctcactggg catcctcgtg atttagtcaa aatacattat ctaattaaag
     6181 tgcttttcaa aagcagctcc attataagag tcccccaaag gtctagtaaa gatatctaga
     6241 actggaaaaa gcttgggaat tctgttagca tttcaaagaa aagcattaga ccaaagcaag
     6301 gtggaaactg cttaaaaact agaaaagtta aatttaaaag ccaagttcca gaagtttatc
     6361 caggtagaaa ataagttaaa agcataaatt ggagaggaga aagaggaagg aactactcac
     6421 ctctccccaa cattcctgtc tttactaacc aaccctgctt cccagagcct taaaacccag
     6481 actggtccta atgcgaaagg tagccagggc ttcctaggga agtaggaaca atgatagcaa
     6541 gacagaagat aaaaagttgt tttaaaagct gtttttaagt taagtgaacc ttataaagac
     6601 ataagaaaaa atggactctg aaaataaact agattataca cagaaa
//
