LOCUS       NM_006307               1846 bp    mRNA    linear   PRI 05-APR-2024
DEFINITION  Homo sapiens sushi repeat containing protein X-linked (SRPX),
            transcript variant 1, mRNA.
ACCESSION   NM_006307
VERSION     NM_006307.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1846)
  AUTHORS   Jiao,Y., Geng,R., Zhong,Z., Ni,S., Liu,W., He,Z., Gan,S., Huang,Q.,
            Liu,J. and Bai,J.
  TITLE     A Hypoxia Molecular Signature-Based Prognostic Model for
            Endometrial Cancer Patients
  JOURNAL   Int J Mol Sci 24 (2), 1675 (2023)
   PUBMED   36675190
  REMARK    GeneRIF: A Hypoxia Molecular Signature-Based Prognostic Model for
            Endometrial Cancer Patients.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1846)
  AUTHORS   Liu,C.L., Pan,H.W., Torng,P.L., Fan,M.H. and Mao,T.L.
  TITLE     SRPX and HMCN1 regulate cancer-associated fibroblasts to promote
            the invasiveness of ovarian carcinoma
  JOURNAL   Oncol Rep 42 (6), 2706-2715 (2019)
   PUBMED   31638245
  REMARK    GeneRIF: the findings of the present study suggest that targeting
            the Cancerassociated fibroblasts genes, SRPX and HMCN1, can inhibit
            ovarian cancer migration and invasion.
REFERENCE   3  (bases 1 to 1846)
  AUTHORS   Inoue,Y., Ueda,M., Tasaki,M., Takeshima,A., Nagatoshi,A.,
            Masuda,T., Misumi,Y., Kosaka,T., Nomura,T., Mizukami,M.,
            Matsumoto,S., Yamashita,T., Takahashi,H., Kakita,A. and Ando,Y.
  TITLE     Sushi repeat-containing protein 1: a novel disease-associated
            molecule in cerebral amyloid angiopathy
  JOURNAL   Acta Neuropathol 134 (4), 605-617 (2017)
   PUBMED   28478503
  REMARK    GeneRIF: SRPX1 co-accumulated with Abeta deposits in cerebral blood
            vessels of all autopsied cases with severe cerebral amyloid
            angiopathy (CAA); no SRPX1 co-accumulated with Abeta deposits in
            senile plaques. Furthermore, we demonstrated that both Abeta40 and
            Abeta42 bound to SRPX1 in vitro and enhanced SRPX1 expression in
            primary cultures of cerebrovascular smooth muscle cells. SRPX1
            enhanced caspase activity induced by Abeta40.
REFERENCE   4  (bases 1 to 1846)
  AUTHORS   Naba,A., Clauser,K.R., Whittaker,C.A., Carr,S.A., Tanabe,K.K. and
            Hynes,R.O.
  TITLE     Extracellular matrix signatures of human primary metastatic colon
            cancers and their metastases to liver
  JOURNAL   BMC Cancer 14, 518 (2014)
   PUBMED   25037231
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1846)
  AUTHORS   Burnicka-Turek,O., Kata,A., Buyandelger,B., Ebermann,L.,
            Kramann,N., Burfeind,P., Hoyer-Fender,S., Engel,W. and Adham,I.M.
  TITLE     Pelota interacts with HAX1, EIF3G and SRPX and the resulting
            protein complexes are associated with the actin cytoskeleton
  JOURNAL   BMC Cell Biol 11, 28 (2010)
   PUBMED   20406461
  REMARK    GeneRIF: PELO is subcellularly localized at the actin cytoskeleton,
            interacts with HAX1, EIF3G and SRPX proteins and that this
            interaction occurs at the cytoskeleton; this interaction may
            facilitate PELO to detect and degrade aberrant mRNAs.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1846)
  AUTHORS   Shimakage,M., Takami,K., Kodama,K., Mano,M., Yutsudo,M. and
            Inoue,H.
  TITLE     Expression of drs mRNA in human lung adenocarcinomas
  JOURNAL   Hum Pathol 33 (6), 615-619 (2002)
   PUBMED   12152160
  REMARK    GeneRIF: expression of drs mRNA in well-differentiated, moderately
            differentiated, and poorly differentiated lung adenocarcinoma
            tissues (drs; down-regulated by v-scr)
REFERENCE   7  (bases 1 to 1846)
  AUTHORS   Nangaku,M., Shankland,S.J., Kurokawa,K., Bomsztyk,K., Johnson,R.J.
            and Couser,W.G.
  TITLE     Cloning of a new human gene with short consensus repeats using the
            EST database
  JOURNAL   Immunogenetics 46 (2), 99-103 (1997)
   PUBMED   9162095
REFERENCE   8  (bases 1 to 1846)
  AUTHORS   Dry,K.L., Aldred,M.A., Edgar,A.J., Brown,J., Manson,F.D., Ho,M.F.,
            Prosser,J., Hardwick,L.J., Lennon,A.A., Thomson,K. et al.
  TITLE     Identification of a novel gene, ETX1 from Xp21.1, a candidate gene
            for X-linked retintis pigmentosa (RP3)
  JOURNAL   Hum Mol Genet 4 (12), 2347-2353 (1995)
   PUBMED   8634709
REFERENCE   9  (bases 1 to 1846)
  AUTHORS   Meindl,A., Carvalho,M.R., Herrmann,K., Lorenz,B., Achatz,H.,
            Lorenz,B., Apfelstedt-Sylla,E., Wittwer,B., Ross,M. and
            Meitinger,T.
  TITLE     A gene (SRPX) encoding a sushi-repeat-containing protein is deleted
            in patients with X-linked retinitis pigmentosa
  JOURNAL   Hum Mol Genet 4 (12), 2339-2346 (1995)
   PUBMED   8634708
REFERENCE   10 (bases 1 to 1846)
  AUTHORS   Arlotta,P., Santori,L. and de Vecchi,A.
  TITLE     [A case of mixed tumor of the palate]
  JOURNAL   Acta Biol Med Ger 2 (3), 34 (1976)
   PUBMED   209648
  REMARK    GeneRIF: The SRPX protein contains the P-DUDES structural domain in
            its C-terminal region. This domain has significant albeit remote
            sequence similarity to thioredoxin-like domains, and is predicted
            to possess an oxidoreductase function.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC020684.1, AL121578.1 and BM672597.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_006307.4.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC020684.1, SRR3476690.775677.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000378533.4/ ENSP00000367794.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1710              BC020684.1         9-1718
            1711-1711           AL121578.1         315794-315794       c
            1712-1846           BM672597.1         22-156              c
FEATURES             Location/Qualifiers
     source          1..1846
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xp11.4"
     gene            1..1846
                     /gene="SRPX"
                     /gene_synonym="DRS; ETX1; HEL-S-83p; SRPX1"
                     /note="sushi repeat containing protein X-linked"
                     /db_xref="GeneID:8406"
                     /db_xref="HGNC:HGNC:11309"
                     /db_xref="MIM:300187"
     exon            1..176
                     /gene="SRPX"
                     /gene_synonym="DRS; ETX1; HEL-S-83p; SRPX1"
                     /inference="alignment:Splign:2.1.0"
     CDS             80..1474
                     /gene="SRPX"
                     /gene_synonym="DRS; ETX1; HEL-S-83p; SRPX1"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; sushi-repeat-containing protein, X chromosome;
                     sushi repeat-containing protein SRPX; epididymis secretory
                     sperm binding protein Li 83p"
                     /codon_start=1
                     /product="sushi repeat-containing protein SRPX isoform 1
                     precursor"
                     /protein_id="NP_006298.1"
                     /db_xref="CCDS:CCDS14245.1"
                     /db_xref="GeneID:8406"
                     /db_xref="HGNC:HGNC:11309"
                     /db_xref="MIM:300187"
                     /translation="MGSPAHRPALLLLLPPLLLLLLLRVPPSRSFPGSGDSPLEDDEV
                     GYSHPRYKDTPWCSPIKVKYGDVYCRAPQGGYYKTALGTRCDIRCQKGYELHGSSLLI
                     CQSNKRWSDKVICKQKRCPTLAMPANGGFKCVDGAYFNSRCEYYCSPGYTLKGERTVT
                     CMDNKAWSGRPASCVDMEPPRIKCPSVKERIAEPNKLTVRVSWETPEGRDTADGILTD
                     VILKGLPPGSNFPEGDHKIQYTVYDRAENKGTCKFRVKVRVKRCGKLNAPENGYMKCS
                     SDGDNYGATCEFSCIGGYELQGSPARVCQSNLAWSGTEPTCAAMNVNVGVRTAAALLD
                     QFYEKRRLLIVSTPTARNLLYRLQLGMLQQAQCGLDLRHITVVELVGVFPTLIGRIGA
                     KIMPPALALQLRLLLRIPLYSFSMVLVDKHGMDKERYVSLVMPVALFNLIDTFPLRKE
                     EMVLQAEMSQTCNT"
     exon            177..236
                     /gene="SRPX"
                     /gene_synonym="DRS; ETX1; HEL-S-83p; SRPX1"
                     /inference="alignment:Splign:2.1.0"
     exon            237..428
                     /gene="SRPX"
                     /gene_synonym="DRS; ETX1; HEL-S-83p; SRPX1"
                     /inference="alignment:Splign:2.1.0"
     exon            429..605
                     /gene="SRPX"
                     /gene_synonym="DRS; ETX1; HEL-S-83p; SRPX1"
                     /inference="alignment:Splign:2.1.0"
     exon            606..732
                     /gene="SRPX"
                     /gene_synonym="DRS; ETX1; HEL-S-83p; SRPX1"
                     /inference="alignment:Splign:2.1.0"
     exon            733..854
                     /gene="SRPX"
                     /gene_synonym="DRS; ETX1; HEL-S-83p; SRPX1"
                     /inference="alignment:Splign:2.1.0"
     exon            855..1034
                     /gene="SRPX"
                     /gene_synonym="DRS; ETX1; HEL-S-83p; SRPX1"
                     /inference="alignment:Splign:2.1.0"
     exon            1035..1168
                     /gene="SRPX"
                     /gene_synonym="DRS; ETX1; HEL-S-83p; SRPX1"
                     /inference="alignment:Splign:2.1.0"
     exon            1169..1290
                     /gene="SRPX"
                     /gene_synonym="DRS; ETX1; HEL-S-83p; SRPX1"
                     /inference="alignment:Splign:2.1.0"
     exon            1291..1846
                     /gene="SRPX"
                     /gene_synonym="DRS; ETX1; HEL-S-83p; SRPX1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1821..1826
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SRPX"
                     /gene_synonym="DRS; ETX1; HEL-S-83p; SRPX1"
                     /note="hexamer: AATAAA"
     regulatory      1826..1831
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SRPX"
                     /gene_synonym="DRS; ETX1; HEL-S-83p; SRPX1"
                     /note="hexamer: AACAAA"
     polyA_site      1841
                     /gene="SRPX"
                     /gene_synonym="DRS; ETX1; HEL-S-83p; SRPX1"
                     /note="major polyA site"
     polyA_site      1846
                     /gene="SRPX"
                     /gene_synonym="DRS; ETX1; HEL-S-83p; SRPX1"
                     /note="major polyA site"
ORIGIN      
        1 agtcccttgg tctcttcggt ctcctgccgc ccccgggaag cgcgctgcgc tgccgaggcg
       61 agctaagcgc ccgctcgcca tggggagccc cgcacatcgg cccgcgctgc tgctgctgct
      121 gccgcctctg ctgctgctgc tgctgctgcg cgtcccgccc agccgcagct tcccaggatc
      181 gggagactca ccactagaag acgatgaagt cgggtattca caccctagat ataaagatac
      241 cccgtggtgc tcccccatca aggtgaagta tggggatgtg tactgcaggg cccctcaagg
      301 aggatactac aaaacagccc tgggaaccag gtgcgacatt cgctgccaga agggctacga
      361 gctgcatggc tcttccctac tgatctgcca gtcaaacaaa cgatggtctg acaaggtcat
      421 ctgcaaacaa aagcgatgtc ctacccttgc catgccagca aatggagggt ttaagtgtgt
      481 agatggtgcc tactttaact cccggtgtga gtattattgt tcaccaggat acacgttgaa
      541 aggggagcgg accgtcacat gtatggacaa caaggcctgg agcggccggc cagcctcctg
      601 tgtggatatg gaacctccta gaatcaagtg cccaagtgtg aaggaacgca ttgcagaacc
      661 caacaaactg acagtccggg tgtcctggga gacacccgaa ggaagagaca cagcagatgg
      721 aattcttact gatgtcattc taaaaggcct ccccccaggc tccaactttc cagaaggaga
      781 ccacaagatc cagtacacag tctatgacag agctgagaat aagggcactt gcaaatttcg
      841 agttaaagta agagtcaaac gctgtggcaa actcaatgcc ccagagaatg gttacatgaa
      901 gtgctccagc gacggtgata attatggagc cacctgtgag ttctcctgca tcggcggcta
      961 tgagctccag ggtagccctg cccgagtatg tcaatccaac ctggcttggt ctggcacgga
     1021 gcccacctgt gcagccatga acgtcaatgt gggtgtcaga acggcagctg cacttctgga
     1081 tcagttttat gagaaaagga gactcctcat tgtgtccaca cccacagccc gaaacctcct
     1141 ttaccggctc cagctaggaa tgctgcagca agcacagtgt ggccttgatc ttcgacacat
     1201 caccgtggtg gagctggtgg gtgtgttccc gactctcatt ggcaggatag gagcaaagat
     1261 tatgcctcca gccctagcgc tgcagctcag gctgttgctg cgaatcccac tctactcctt
     1321 cagtatggtg ctagtggata agcatggcat ggacaaagag cgctatgtct ccctggtgat
     1381 gcctgtggcc ctgttcaacc tgattgacac ttttcccttg agaaaagaag agatggtcct
     1441 acaagccgaa atgagccaga cctgtaacac ctgacatgat ggttcctctc ttggcaattc
     1501 ctcttcattg tctacatagt gacatgcaca cgggaaagcc ttaaaaatat ccttgatgta
     1561 cagattttat ttgtaatttt aaaagtctat tttattatga gctttctttg cacttaaaaa
     1621 ttagcatgct gctttttgta cttggaagtg tttcaaaaaa ttatatgacc atatttactc
     1681 tttctaactt tctttactcc atcatggctg cttgattttg tagagaaatt agaacccata
     1741 accatacaca ggctatcaac atgttattca atgtgacacc taactctttt ctattttgtt
     1801 ttttaagtaa gacttttatt aataaaacaa aatgttttgg agcaaa
//
