LOCUS       NM_001379313            2576 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens SRP receptor subunit beta (SRPRB), transcript variant
            3, mRNA.
ACCESSION   NM_001379313
VERSION     NM_001379313.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2576)
  AUTHORS   Lee,Y.J., Yoo,M.G., Kim,H.K., Jang,H.B., Park,K.J., Lee,H.J.,
            Kim,S.G. and Park,S.I.
  TITLE     The association between alcohol metabolism and genetic variants of
            ADH1A, SRPRB, and PGM1 in Korea
  JOURNAL   Alcohol 79, 137-145 (2019)
   PUBMED   31002879
  REMARK    GeneRIF: Variation in SRPRB was associated with lower blood alcohol
            content in Korean subjects, suggesting likely involvement in
            alcohol metabolism and possible association with the development of
            alcohol-related diseases in Korea.
REFERENCE   2  (bases 1 to 2576)
  AUTHORS   Ma,Q., Wu,X., Wu,J., Liang,Z. and Liu,T.
  TITLE     SERP1 is a novel marker of poor prognosis in pancreatic ductal
            adenocarcinoma patients via anti-apoptosis and regulating
            SRPRB/NF-kappaB axis
  JOURNAL   Int J Oncol 51 (4), 1104-1114 (2017)
   PUBMED   28902358
  REMARK    GeneRIF: Results show that SRPRB promotes cell apoptosis through
            NF-kappaB activation. Its expression is regulated by SERP1 in
            pancreatic ductal adenocarcinoma.
REFERENCE   3  (bases 1 to 2576)
  AUTHORS   Fong,K.W., Leung,J.W., Li,Y., Wang,W., Feng,L., Ma,W., Liu,D.,
            Songyang,Z. and Chen,J.
  TITLE     MTR120/KIAA1383, a novel microtubule-associated protein, promotes
            microtubule stability and ensures cytokinesis
  JOURNAL   J Cell Sci 126 (Pt 3), 825-837 (2013)
   PUBMED   23264731
REFERENCE   4  (bases 1 to 2576)
  AUTHORS   Lang,S., Benedix,J., Fedeles,S.V., Schorr,S., Schirra,C.,
            Schauble,N., Jalal,C., Greiner,M., Hassdenteufel,S., Tatzelt,J.,
            Kreutzer,B., Edelmann,L., Krause,E., Rettig,J., Somlo,S.,
            Zimmermann,R. and Dudek,J.
  TITLE     Different effects of Sec61alpha, Sec62 and Sec63 depletion on
            transport of polypeptides into the endoplasmic reticulum of
            mammalian cells
  JOURNAL   J Cell Sci 125 (Pt 8), 1958-1969 (2012)
   PUBMED   22375059
REFERENCE   5  (bases 1 to 2576)
  AUTHORS   Kutalik,Z., Benyamin,B., Bergmann,S., Mooser,V., Waeber,G.,
            Montgomery,G.W., Martin,N.G., Madden,P.A., Heath,A.C.,
            Beckmann,J.S., Vollenweider,P., Marques-Vidal,P. and Whitfield,J.B.
  TITLE     Genome-wide association study identifies two loci strongly
            affecting transferrin glycosylation
  JOURNAL   Hum Mol Genet 20 (18), 3710-3717 (2011)
   PUBMED   21665994
REFERENCE   6  (bases 1 to 2576)
  AUTHORS   Girard,A., Sachidanandam,R., Hannon,G.J. and Carmell,M.A.
  TITLE     A germline-specific class of small RNAs binds mammalian Piwi
            proteins
  JOURNAL   Nature 442 (7099), 199-202 (2006)
   PUBMED   16751776
REFERENCE   7  (bases 1 to 2576)
  AUTHORS   Schlenker,O., Hendricks,A., Sinning,I. and Wild,K.
  TITLE     The structure of the mammalian signal recognition particle (SRP)
            receptor as prototype for the interaction of small GTPases with
            Longin domains
  JOURNAL   J Biol Chem 281 (13), 8898-8906 (2006)
   PUBMED   16439358
REFERENCE   8  (bases 1 to 2576)
  AUTHORS   Yan,W., Wang,W.L., Zhu,F., Chen,S.Q., Li,Q.L. and Wang,L.
  TITLE     Isolation of a novel member of small G protein superfamily and its
            expression in colon cancer
  JOURNAL   World J Gastroenterol 9 (8), 1719-1724 (2003)
   PUBMED   12918107
  REMARK    GeneRIF: APMCF1 may be the gene coding human signal recognition
            particle receptor beta and belongs to the small-G protein
            superfamily. Its strong expression pattern in colon cancer suggests
            it may play a role in colon cancer development.
REFERENCE   9  (bases 1 to 2576)
  AUTHORS   Bacher,G., Pool,M. and Dobberstein,B.
  TITLE     The ribosome regulates the GTPase of the beta-subunit of the signal
            recognition particle receptor
  JOURNAL   J Cell Biol 146 (4), 723-730 (1999)
   PUBMED   10459008
REFERENCE   10 (bases 1 to 2576)
  AUTHORS   Miller,J.D., Tajima,S., Lauffer,L. and Walter,P.
  TITLE     The beta subunit of the signal recognition particle receptor is a
            transmembrane GTPase that anchors the alpha subunit, a peripheral
            membrane GTPase, to the endoplasmic reticulum membrane
  JOURNAL   J Cell Biol 128 (3), 273-282 (1995)
   PUBMED   7844142
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC080128.21.
            
            Summary: The protein encoded by this gene has similarity to mouse
            protein which is a subunit of the signal recognition particle
            receptor (SR). This subunit is a transmembrane GTPase belonging to
            the GTPase superfamily. It anchors alpha subunit, a peripheral
            membrane GTPase, to the ER membrane. SR is required for the
            cotranslational targeting of both secretory and membrane proteins
            to the ER membrane. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: Variants 1 and 3 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR11853559.23710.1,
                                           SRR11853566.20149.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000678299.1/ ENSP00000503923.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-188               AC080128.21        133036-133223       c
            189-283             AC080128.21        132335-132429       c
            284-361             AC080128.21        131215-131292       c
            362-444             AC080128.21        127839-127921       c
            445-581             AC080128.21        123312-123448       c
            582-636             AC080128.21        122106-122160       c
            637-2576            AC080128.21        117546-119485       c
FEATURES             Location/Qualifiers
     source          1..2576
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q22.1"
     gene            1..2576
                     /gene="SRPRB"
                     /gene_synonym="APMCF1; SR-beta"
                     /note="SRP receptor subunit beta"
                     /db_xref="GeneID:58477"
                     /db_xref="HGNC:HGNC:24085"
                     /db_xref="MIM:616883"
     exon            1..188
                     /gene="SRPRB"
                     /gene_synonym="APMCF1; SR-beta"
                     /inference="alignment:Splign:2.1.0"
     CDS             35..850
                     /gene="SRPRB"
                     /gene_synonym="APMCF1; SR-beta"
                     /note="signal recognition particle receptor, beta subunit;
                     signal recognition particle receptor, B subunit; SRP
                     receptor beta subunit"
                     /codon_start=1
                     /product="signal recognition particle receptor subunit
                     beta"
                     /protein_id="NP_001366242.1"
                     /db_xref="CCDS:CCDS3081.1"
                     /db_xref="GeneID:58477"
                     /db_xref="HGNC:HGNC:24085"
                     /db_xref="MIM:616883"
                     /translation="MASADSRRVADGGGAGGTFQPYLDTLRQELQQTDPTLLSVVVAV
                     LAVLLTLVFWKLIRSRRSSQRAVLLVGLCDSGKTLLFVRLLTGLYRDTQTSITDSCAV
                     YRVNNNRGNSLTLIDLPGHESLRLQFLERFKSSARAIVFVVDSAAFQREVKDVAEFLY
                     QVLIDSMGLKNTPSFLIACNKQDIAMAKSAKLIQQQLEKELNTLRVTRSAAPSTLDSS
                     STAPAQLGKKGKEFEFSQLPLKVEFLECSAKGGRGDVGSADIQDLEKWLAKIA"
     exon            189..283
                     /gene="SRPRB"
                     /gene_synonym="APMCF1; SR-beta"
                     /inference="alignment:Splign:2.1.0"
     exon            284..361
                     /gene="SRPRB"
                     /gene_synonym="APMCF1; SR-beta"
                     /inference="alignment:Splign:2.1.0"
     exon            362..444
                     /gene="SRPRB"
                     /gene_synonym="APMCF1; SR-beta"
                     /inference="alignment:Splign:2.1.0"
     exon            445..581
                     /gene="SRPRB"
                     /gene_synonym="APMCF1; SR-beta"
                     /inference="alignment:Splign:2.1.0"
     exon            582..636
                     /gene="SRPRB"
                     /gene_synonym="APMCF1; SR-beta"
                     /inference="alignment:Splign:2.1.0"
     exon            637..2576
                     /gene="SRPRB"
                     /gene_synonym="APMCF1; SR-beta"
                     /inference="alignment:Splign:2.1.0"
     regulatory      974..979
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SRPRB"
                     /gene_synonym="APMCF1; SR-beta"
                     /note="hexamer: AACAAA"
     polyA_site      994
                     /gene="SRPRB"
                     /gene_synonym="APMCF1; SR-beta"
                     /note="major polyA site"
     regulatory      1738..1743
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SRPRB"
                     /gene_synonym="APMCF1; SR-beta"
                     /note="hexamer: AAGAAA"
     polyA_site      1765
                     /gene="SRPRB"
                     /gene_synonym="APMCF1; SR-beta"
                     /note="major polyA site"
     regulatory      2540..2545
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SRPRB"
                     /gene_synonym="APMCF1; SR-beta"
                     /note="hexamer: AATAAA"
     polyA_site      2576
                     /gene="SRPRB"
                     /gene_synonym="APMCF1; SR-beta"
ORIGIN      
        1 gcttttgctg taccggggac cacgcgtctc atccatggct tccgcggact cgcgccgggt
       61 ggcagatggc ggcggtgccg ggggcacctt ccagccctac ctagacacct tgcggcagga
      121 gctgcagcag acggacccaa cgctgttgtc agtagtggtg gcggttcttg cggtgctgct
      181 gacgctagtc ttctggaagt taatccggag cagaaggagc agtcagagag ctgttcttct
      241 tgttggcctt tgtgattccg ggaaaacgtt gctctttgtc aggttgttaa caggccttta
      301 tagagacact cagacgtcca ttactgacag ctgtgctgta tacagagtca acaataacag
      361 gggcaatagt ctgaccttga ttgaccttcc cggccatgag agtttgaggc ttcagttctt
      421 agagcggttt aagtcttcag ccagggctat tgtgtttgtt gtggatagtg cagcattcca
      481 gcgagaggtg aaagatgtgg ctgagtttct gtatcaagtc ctcattgaca gtatgggtct
      541 gaagaataca ccatcattct taatagcctg caataagcaa gatattgcaa tggcaaaatc
      601 agcaaagtta attcaacagc agctggagaa agaactcaac accttacgag ttacccgttc
      661 tgctgccccc agcacactgg acagttccag cactgcccct gctcagctgg ggaagaaagg
      721 caaagagttt gaattctcac agttgcccct caaagtggag ttcctggagt gcagtgccaa
      781 gggtggaaga ggggacgtgg gctctgctga catccaggac ttggagaaat ggctggctaa
      841 aattgcctga gaggcagctc taaagcacaa gacctggatg tgtgacacac agttttggaa
      901 aaaggtctgt ggtagtctgg agttgatgag gaaggggtac aagatgtggt tagaaacatt
      961 tctttgttct ggaaacaaag tactgttgaa accagcttgg aatttttttt tttttttttt
     1021 ttaagttcag ttctccctta tggctgcctt tcaaacaagt accttttatc tgatgcctgt
     1081 atcttccctt tgttaaggtg taacttgatg tagggtcaag gtttttgtga caacaggcag
     1141 actccacaca gagaggatat gatgagaata tggccatcac ctgaaaagtt ttcttatctt
     1201 ctgtgctttt ggtccctgga aacaaatccg cctatgtatg aagctagttg atttccagtt
     1261 gcactatttc cagttgcctc tgaagttcac aggcaataca ttgtctagtc ctttgcgaat
     1321 ttctctgatt tgtgggcaca gttatgaagt ttccccacat gtgaagacag gtacaaaata
     1381 gcagagccaa gcagacagtg ggtctattct tcattagctc agtgacttgt ccacactcgt
     1441 cttagcactt acgtttcaaa agcttgtcac aaacccttgg agtcattccc agataataga
     1501 actggaaatg ataaatcccc taatgccaag ggtctagtgt gttcttagtg gttatactgg
     1561 gaagtgtgtg gagatttagg tgctgctctg ctgctctgga tggctgaagg ctcctgggcc
     1621 atcttcatgt gctgcttgaa gagctcctat tttgtactcc tggctagaat gctgtggaac
     1681 aaatacaaag tgaaaaaagt tctctgtaga tttctgaagt gcatattcat tgatgccaag
     1741 aaaaaaaaaa agttgccttt ttgaagtgat gttttttgct gtcttcttaa acacaaggct
     1801 tttttgaatg attagtatat ttcatggtaa agaaaacagc ctgtctggct caaagcaatt
     1861 aaatagaatg taatggtgag tacaaatgag tgcacatgtc aggactcagg tctaactcct
     1921 tgtctcctga gcctaaagat tgcaacatac acaagaacac actcctattc ctaccccaca
     1981 cactcaggga caagcccaac taaagcttac aaggagacca gggtggctct gtccagggga
     2041 gaagccagtt atggaacagt gcattgagag ccatggtagg agaggcccac agttctctgg
     2101 agcatgcagc aggggcaccc cacctggcct tgaggatcag ggggagtcaa aggataaagc
     2161 atggggctga tgacgtctga gggagtgtga tcctccatgt atggcctctg cctgctgtct
     2221 cacatgtccc ttctggtggt cacttgggct ctaggagtat acgtcacctc agaccatctg
     2281 gcagaaatac tccaggctcc taccccaaag cacatgtcag ccttgctgct ggagcacgaa
     2341 gacaatgtaa atgaaacatg aaatggagga gttgtgagac cctgaccctg agtccttact
     2401 tgaaagctgc tgctggtgtt ctgagtgtct tttggactct tatttcttgc ccttttcctt
     2461 attaggcaag cagtaactta ggaagtaggt aagagcaata aatgtgacat gttatgtcat
     2521 catagtagga gctcatggga ataaaagtca gtggcttgat gcttctgtta gaggca
//
