LOCUS       NM_003139               2986 bp    mRNA    linear   PRI 20-FEB-2025
DEFINITION  Homo sapiens SRP receptor subunit alpha (SRPRA), transcript variant
            1, mRNA.
ACCESSION   NM_003139
VERSION     NM_003139.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2986)
  AUTHORS   Linder,M.I., Mizoguchi,Y., Hesse,S., Csaba,G., Tatematsu,M.,
            Lyszkiewicz,M., Zietara,N., Jeske,T., Hastreiter,M., Rohlfs,M.,
            Liu,Y., Grabowski,P., Ahomaa,K., Maier-Begandt,D., Schwestka,M.,
            Pazhakh,V., Isiaku,A.I., Briones Miranda,B., Blombery,P.,
            Saito,M.K., Rusha,E., Alizadeh,Z., Pourpak,Z., Kobayashi,M.,
            Rezaei,N., Unal,E., Hauck,F., Drukker,M., Walzog,B., Rappsilber,J.,
            Zimmer,R., Lieschke,G.J. and Klein,C.
  TITLE     Human genetic defects in SRP19 and SRPRA cause severe congenital
            neutropenia with distinctive proteome changes
  JOURNAL   Blood 141 (6), 645-658 (2023)
   PUBMED   36223592
  REMARK    GeneRIF: Human genetic defects in SRP19 and SRPRA cause severe
            congenital neutropenia with distinctive proteome changes.
REFERENCE   2  (bases 1 to 2986)
  AUTHORS   Juaire,K.D., Lapouge,K., Becker,M.M.M., Kotova,I., Michelhans,M.,
            Carapito,R., Wild,K., Bahram,S. and Sinning,I.
  TITLE     Structural and Functional Impact of SRP54 Mutations Causing Severe
            Congenital Neutropenia
  JOURNAL   Structure 29 (1), 15-28 (2021)
   PUBMED   33053321
REFERENCE   3  (bases 1 to 2986)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   4  (bases 1 to 2986)
  AUTHORS   Lang,S., Benedix,J., Fedeles,S.V., Schorr,S., Schirra,C.,
            Schauble,N., Jalal,C., Greiner,M., Hassdenteufel,S., Tatzelt,J.,
            Kreutzer,B., Edelmann,L., Krause,E., Rettig,J., Somlo,S.,
            Zimmermann,R. and Dudek,J.
  TITLE     Different effects of Sec61alpha, Sec62 and Sec63 depletion on
            transport of polypeptides into the endoplasmic reticulum of
            mammalian cells
  JOURNAL   J Cell Sci 125 (Pt 8), 1958-1969 (2012)
   PUBMED   22375059
REFERENCE   5  (bases 1 to 2986)
  AUTHORS   Gonzalez-Begne,M., Lu,B., Han,X., Hagen,F.K., Hand,A.R.,
            Melvin,J.E. and Yates,J.R.
  TITLE     Proteomic analysis of human parotid gland exosomes by
            multidimensional protein identification technology (MudPIT)
  JOURNAL   J Proteome Res 8 (3), 1304-1314 (2009)
   PUBMED   19199708
REFERENCE   6  (bases 1 to 2986)
  AUTHORS   Schlenker,O., Hendricks,A., Sinning,I. and Wild,K.
  TITLE     The structure of the mammalian signal recognition particle (SRP)
            receptor as prototype for the interaction of small GTPases with
            Longin domains
  JOURNAL   J Biol Chem 281 (13), 8898-8906 (2006)
   PUBMED   16439358
REFERENCE   7  (bases 1 to 2986)
  AUTHORS   Janin,N., Delattre,O. and Lipinski,M.
  TITLE     PCR-assisted localization of the human SRPR gene
  JOURNAL   Hum Genet 88 (5), 583-585 (1992)
   PUBMED   1312991
REFERENCE   8  (bases 1 to 2986)
  AUTHORS   Hortsch,M. and Meyer,D.I.
  TITLE     The human docking protein does not associate with the membrane of
            the rough endoplasmic reticulum via a signal or insertion
            sequence-mediated mechanism
  JOURNAL   Biochem Biophys Res Commun 150 (1), 111-117 (1988)
   PUBMED   2827661
REFERENCE   9  (bases 1 to 2986)
  AUTHORS   Hortsch,M., Labeit,S. and Meyer,D.I.
  TITLE     Complete cDNA sequence coding for human docking protein
  JOURNAL   Nucleic Acids Res 16 (1), 361-362 (1988)
   PUBMED   3340536
REFERENCE   10 (bases 1 to 2986)
  AUTHORS   Tajima,S., Lauffer,L., Rath,V.L. and Walter,P.
  TITLE     The signal recognition particle receptor is a complex that contains
            two distinct polypeptide chains
  JOURNAL   J Cell Biol 103 (4), 1167-1178 (1986)
   PUBMED   3021779
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK303379.1 and BC009110.1.
            
            On Nov 23, 2018 this sequence version replaced NM_003139.3.
            
            Summary: The gene encodes a subunit of the endoplasmic reticulum
            signal recognition particle receptor that, in conjunction with the
            signal recognition particle, is involved in the targeting and
            translocation of signal sequence tagged secretory and membrane
            proteins across the endoplasmic reticulum. Alternative splicing
            results in multiple transcript variants. [provided by RefSeq, Apr
            2010].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC013583.1, X06272.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000332118.11/ ENSP00000328023.5
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-70                AK303379.1         88-157
            71-2986             BC009110.1         1-2916
FEATURES             Location/Qualifiers
     source          1..2986
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q24.2"
     gene            1..2986
                     /gene="SRPRA"
                     /gene_synonym="DP; Sralpha; SRPR"
                     /note="SRP receptor subunit alpha"
                     /db_xref="GeneID:6734"
                     /db_xref="HGNC:HGNC:11307"
                     /db_xref="MIM:182180"
     exon            1..208
                     /gene="SRPRA"
                     /gene_synonym="DP; Sralpha; SRPR"
                     /inference="alignment:Splign:2.1.0"
     CDS             92..2008
                     /gene="SRPRA"
                     /gene_synonym="DP; Sralpha; SRPR"
                     /note="isoform 1 is encoded by transcript variant 1;
                     docking protein alpha; signal recognition particle
                     receptor subunit alpha; SRP-alpha; DP-alpha; SR-alpha;
                     signal recognition particle receptor (docking protein);
                     SRP receptor alpha subunit"
                     /codon_start=1
                     /product="signal recognition particle receptor subunit
                     alpha isoform 1"
                     /protein_id="NP_003130.2"
                     /db_xref="CCDS:CCDS31717.1"
                     /db_xref="GeneID:6734"
                     /db_xref="HGNC:HGNC:11307"
                     /db_xref="MIM:182180"
                     /translation="MLDFFTIFSKGGLVLWCFQGVSDSCTGPVNALIRSVLLQERGGN
                     NSFTHEALTLKYKLDNQFELVFVVGFQKILTLTYVDKLIDDVHRLFRDKYRTEIQQQS
                     ALSLLNGTFDFQNDFLRLLREAEESSKIRAPTTMKKFEDSEKAKKPVRSMIETRGEKP
                     KEKAKNSKKKGAKKEGSDGPLATSKPVPAEKSGLPVGPENGVELSKEELIRRKREEFI
                     QKHGRGMEKSNKSTKSDAPKEKGKKAPRVWELGGCANKEVLDYSTPTTNGTPEAALSE
                     DINLIRGTGSGGQLQDLDCSSSDDEGAAQNSTKPSATKGTLGGMFGMLKGLVGSKSLS
                     REDMESVLDKMRDHLIAKNVAADIAVQLCESVANKLEGKVMGTFSTVTSTVKQALQES
                     LVQILQPQRRVDMLRDIMDAQRRQRPYVVTFCGVNGVGKSTNLAKISFWLLENGFSVL
                     IAACDTFRAGAVEQLRTHTRRLSALHPPEKHGGRTMVQLFEKGYGKDAAGIAMEAIAF
                     ARNQGFDVVLVDTAGRMQDNAPLMTALAKLITVNTPDLVLFVGEALVGNEAVDQLVKF
                     NRALADHSMAQTPRLIDGIVLTKFDTIDDKVGAAISMTYITSKPIVFVGTGQTYCDLR
                     SLNAKAVVAALMKA"
     exon            209..292
                     /gene="SRPRA"
                     /gene_synonym="DP; Sralpha; SRPR"
                     /inference="alignment:Splign:2.1.0"
     exon            293..456
                     /gene="SRPRA"
                     /gene_synonym="DP; Sralpha; SRPR"
                     /inference="alignment:Splign:2.1.0"
     exon            457..617
                     /gene="SRPRA"
                     /gene_synonym="DP; Sralpha; SRPR"
                     /inference="alignment:Splign:2.1.0"
     exon            618..777
                     /gene="SRPRA"
                     /gene_synonym="DP; Sralpha; SRPR"
                     /inference="alignment:Splign:2.1.0"
     exon            778..931
                     /gene="SRPRA"
                     /gene_synonym="DP; Sralpha; SRPR"
                     /inference="alignment:Splign:2.1.0"
     exon            932..1023
                     /gene="SRPRA"
                     /gene_synonym="DP; Sralpha; SRPR"
                     /inference="alignment:Splign:2.1.0"
     exon            1024..1142
                     /gene="SRPRA"
                     /gene_synonym="DP; Sralpha; SRPR"
                     /inference="alignment:Splign:2.1.0"
     exon            1143..1229
                     /gene="SRPRA"
                     /gene_synonym="DP; Sralpha; SRPR"
                     /inference="alignment:Splign:2.1.0"
     exon            1230..1402
                     /gene="SRPRA"
                     /gene_synonym="DP; Sralpha; SRPR"
                     /inference="alignment:Splign:2.1.0"
     exon            1403..1616
                     /gene="SRPRA"
                     /gene_synonym="DP; Sralpha; SRPR"
                     /inference="alignment:Splign:2.1.0"
     exon            1617..1780
                     /gene="SRPRA"
                     /gene_synonym="DP; Sralpha; SRPR"
                     /inference="alignment:Splign:2.1.0"
     exon            1781..1879
                     /gene="SRPRA"
                     /gene_synonym="DP; Sralpha; SRPR"
                     /inference="alignment:Splign:2.1.0"
     exon            1880..2986
                     /gene="SRPRA"
                     /gene_synonym="DP; Sralpha; SRPR"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2968..2973
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SRPRA"
                     /gene_synonym="DP; Sralpha; SRPR"
                     /note="hexamer: AATAAA"
     polyA_site      2986
                     /gene="SRPRA"
                     /gene_synonym="DP; Sralpha; SRPR"
                     /note="major polyA site"
ORIGIN      
        1 gtgacgtgtc ccgcgcttgg cgcagcagga agcggcggcg aacgcggcct gaattcccgg
       61 cgccggcccc agctcctctg ccgctgccgc catgctcgac ttcttcacca ttttctccaa
      121 gggcgggctt gtgctctggt gcttccaggg cgttagcgac tcatgcaccg gacccgttaa
      181 cgcgttgatt cgttccgtgc tgctgcagga acggggaggt aacaactcct tcacccatga
      241 ggcactcaca ctcaagtata aactggacaa ccagtttgag ctggtgtttg tggttggttt
      301 tcagaagatc ctgacactga catatgtaga caaattgata gatgacgtgc atcggctgtt
      361 tcgggacaag taccgcacag agatccaaca gcaaagtgct ttaagtttat taaatggcac
      421 ttttgatttc caaaatgact tcctgcggct ccttcgtgaa gcagaggaga gcagtaagat
      481 ccgtgctccc actaccatga agaaatttga agattctgaa aaggccaaga aacctgtgag
      541 gtccatgatt gagacacggg gggaaaagcc caaggaaaaa gcaaagaata gcaaaaaaaa
      601 gggggccaag aaggaaggtt ctgatggtcc tttggctacc agcaaaccag tccctgcaga
      661 aaagtcaggt cttccagtgg gtcctgagaa cggagtagaa ctttccaaag aggagctgat
      721 ccgcaggaag cgcgaggagt tcattcagaa gcatgggagg ggtatggaga agtccaacaa
      781 gtccacgaag tcagatgctc caaaggagaa gggcaaaaaa gcaccccggg tgtgggaact
      841 gggtggctgt gctaacaaag aagtgttgga ttacagtact cccaccacca atggaacccc
      901 tgaggctgcc ttgtctgagg acatcaacct gattcgaggg actgggtctg gggggcagct
      961 tcaggatctg gactgcagca gctctgatga cgaaggggct gctcaaaact ctaccaaacc
     1021 tagtgcgacc aagggaacac tgggtggcat gtttggtatg ctgaagggcc ttgtgggttc
     1081 aaagagcttg agtcgtgaag acatggaatc tgtgctggac aagatgcgtg atcatctcat
     1141 tgctaagaac gtggctgcag acattgccgt ccagctctgt gaatctgttg ccaacaagtt
     1201 ggaagggaag gtgatgggga cgttcagcac ggtgacttcc acagtaaagc aagccctaca
     1261 ggagtccctg gtgcagattc tgcagccaca gcgtcgtgta gacatgctcc gggacatcat
     1321 ggatgcccag cgtcgccagc gcccttatgt cgtcaccttc tgcggcgtta atggagtggg
     1381 gaaatctact aatcttgcca agatttcctt ctggttgtta gagaatggct tcagtgtcct
     1441 cattgctgcc tgtgatacat ttcgtgctgg ggccgtggag cagctgcgta cacacacccg
     1501 gcgtttgagt gccctacacc ctccagagaa gcatggtggc cgcaccatgg tgcagttgtt
     1561 tgaaaagggc tatggcaagg atgctgctgg cattgccatg gaagccattg cttttgcacg
     1621 taaccaaggc tttgacgtgg tgctggtgga cacggcaggc cgcatgcaag acaatgcccc
     1681 tctgatgact gccctggcca aactcattac tgtcaataca cctgatttgg tgctgtttgt
     1741 aggagaagcc ttagtaggca atgaagccgt ggaccagctg gtcaagttca acagagcctt
     1801 ggctgaccat tctatggctc agacacctcg gctcattgat ggcattgttc ttaccaaatt
     1861 tgataccatt gatgacaagg tgggagctgc tatttctatg acgtacatca caagcaaacc
     1921 catcgtcttt gtgggcaccg gccagaccta ctgtgaccta cgcagcctca atgccaaggc
     1981 tgtggtggct gccctcatga aggcttaacg tggctcttgc ccaataccaa atcgccgctt
     2041 tccccacaag cccttcttcc tgtatcaaga atgtgcttta gagtatgtga gcaacctgtc
     2101 ttcagtgtag tacaaaggca gagtgagggg gcttgtggct ccttccaacc ccactccccg
     2161 ttcagcacag ccgccatctg caaggaaggc ctaatcatgt tacaatcact gcccactgac
     2221 cctctcccag cgggcctccc ccttcctact caggcacccc cttcactctg cctacagact
     2281 cagtcttatt acagctttga ccaatggttg gaacccaaca ccagagcttt gctaataatt
     2341 agtgtggtca agagccgtct gagcctaatg agtcccagct gcattaggtt aagagactct
     2401 tccagagcca gcgccaggtc ttgaatggca cctctcccta ggatacacag cctgcaggtc
     2461 cccaggacct ggatgacacc cgcctcactg tggcagtgta ttgcctgtta attgctgcta
     2521 attctaattc tgatgatgac tcctactcca ttgtttaccc caaagcatca gctaggctgg
     2581 agtgatttgt tacaaatgag caaaagatga gtccttgctt ccctcagaaa taaaaggagc
     2641 tcagctgcag cgttgcattg ggcttcttgg cctcccaact cttcccactc ccagaatcca
     2701 gaagtaagct ctgcatgttc cccttcctgg gaggaaacca attgtcagaa ggatgtatga
     2761 tgaccccctc ccctcccatc cttcacctcc taagcagtcc tggcttttcc tcatcactcc
     2821 cctctacagt gcctggtaga caagtgctac attgaagaac acaaacctct tgttaagact
     2881 tgtcctgtag cttgatatta cagatgtgct attagtgcaa taaggtgaag gctgtctgcc
     2941 cagagaaata agtaatttat ataagaaaat aaatttcata aataaa
//
