LOCUS       NP_003130                638 aa            linear   PRI 27-APR-2025
DEFINITION  signal recognition particle receptor subunit alpha isoform 1 [Homo
            sapiens].
ACCESSION   NP_003130
VERSION     NP_003130.2
DBSOURCE    REFSEQ: accession NM_003139.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 638)
  AUTHORS   Linder,M.I., Mizoguchi,Y., Hesse,S., Csaba,G., Tatematsu,M.,
            Lyszkiewicz,M., Zietara,N., Jeske,T., Hastreiter,M., Rohlfs,M.,
            Liu,Y., Grabowski,P., Ahomaa,K., Maier-Begandt,D., Schwestka,M.,
            Pazhakh,V., Isiaku,A.I., Briones Miranda,B., Blombery,P.,
            Saito,M.K., Rusha,E., Alizadeh,Z., Pourpak,Z., Kobayashi,M.,
            Rezaei,N., Unal,E., Hauck,F., Drukker,M., Walzog,B., Rappsilber,J.,
            Zimmer,R., Lieschke,G.J. and Klein,C.
  TITLE     Human genetic defects in SRP19 and SRPRA cause severe congenital
            neutropenia with distinctive proteome changes
  JOURNAL   Blood 141 (6), 645-658 (2023)
   PUBMED   36223592
  REMARK    GeneRIF: Human genetic defects in SRP19 and SRPRA cause severe
            congenital neutropenia with distinctive proteome changes.
REFERENCE   2  (residues 1 to 638)
  AUTHORS   Juaire,K.D., Lapouge,K., Becker,M.M.M., Kotova,I., Michelhans,M.,
            Carapito,R., Wild,K., Bahram,S. and Sinning,I.
  TITLE     Structural and Functional Impact of SRP54 Mutations Causing Severe
            Congenital Neutropenia
  JOURNAL   Structure 29 (1), 15-28 (2021)
   PUBMED   33053321
REFERENCE   3  (residues 1 to 638)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   4  (residues 1 to 638)
  AUTHORS   Lang,S., Benedix,J., Fedeles,S.V., Schorr,S., Schirra,C.,
            Schauble,N., Jalal,C., Greiner,M., Hassdenteufel,S., Tatzelt,J.,
            Kreutzer,B., Edelmann,L., Krause,E., Rettig,J., Somlo,S.,
            Zimmermann,R. and Dudek,J.
  TITLE     Different effects of Sec61alpha, Sec62 and Sec63 depletion on
            transport of polypeptides into the endoplasmic reticulum of
            mammalian cells
  JOURNAL   J Cell Sci 125 (Pt 8), 1958-1969 (2012)
   PUBMED   22375059
REFERENCE   5  (residues 1 to 638)
  AUTHORS   Gonzalez-Begne,M., Lu,B., Han,X., Hagen,F.K., Hand,A.R.,
            Melvin,J.E. and Yates,J.R.
  TITLE     Proteomic analysis of human parotid gland exosomes by
            multidimensional protein identification technology (MudPIT)
  JOURNAL   J Proteome Res 8 (3), 1304-1314 (2009)
   PUBMED   19199708
REFERENCE   6  (residues 1 to 638)
  AUTHORS   Schlenker,O., Hendricks,A., Sinning,I. and Wild,K.
  TITLE     The structure of the mammalian signal recognition particle (SRP)
            receptor as prototype for the interaction of small GTPases with
            Longin domains
  JOURNAL   J Biol Chem 281 (13), 8898-8906 (2006)
   PUBMED   16439358
REFERENCE   7  (residues 1 to 638)
  AUTHORS   Janin,N., Delattre,O. and Lipinski,M.
  TITLE     PCR-assisted localization of the human SRPR gene
  JOURNAL   Hum Genet 88 (5), 583-585 (1992)
   PUBMED   1312991
REFERENCE   8  (residues 1 to 638)
  AUTHORS   Hortsch,M. and Meyer,D.I.
  TITLE     The human docking protein does not associate with the membrane of
            the rough endoplasmic reticulum via a signal or insertion
            sequence-mediated mechanism
  JOURNAL   Biochem Biophys Res Commun 150 (1), 111-117 (1988)
   PUBMED   2827661
REFERENCE   9  (residues 1 to 638)
  AUTHORS   Hortsch,M., Labeit,S. and Meyer,D.I.
  TITLE     Complete cDNA sequence coding for human docking protein
  JOURNAL   Nucleic Acids Res 16 (1), 361-362 (1988)
   PUBMED   3340536
REFERENCE   10 (residues 1 to 638)
  AUTHORS   Tajima,S., Lauffer,L., Rath,V.L. and Walter,P.
  TITLE     The signal recognition particle receptor is a complex that contains
            two distinct polypeptide chains
  JOURNAL   J Cell Biol 103 (4), 1167-1178 (1986)
   PUBMED   3021779
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK303379.1 and BC009110.1.
            
            On Sep 25, 2002 this sequence version replaced NP_003130.1.
            
            Summary: The gene encodes a subunit of the endoplasmic reticulum
            signal recognition particle receptor that, in conjunction with the
            signal recognition particle, is involved in the targeting and
            translocation of signal sequence tagged secretory and membrane
            proteins across the endoplasmic reticulum. Alternative splicing
            results in multiple transcript variants. [provided by RefSeq, Apr
            2010].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC013583.1, X06272.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000332118.11/ ENSP00000328023.5
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..638
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q24.2"
     Protein         1..638
                     /product="signal recognition particle receptor subunit
                     alpha isoform 1"
                     /note="docking protein alpha; signal recognition particle
                     receptor subunit alpha; SRP-alpha; DP-alpha; SR-alpha;
                     signal recognition particle receptor (docking protein);
                     SRP receptor alpha subunit"
                     /calculated_mol_wt=69680
     Region          28..296
                     /region_name="SRP-alpha_N"
                     /note="Signal recognition particle, alpha subunit,
                     N-terminal; pfam04086"
                     /db_xref="CDD:461165"
     Region          132..244
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P08240.2)"
     Site            177
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:23186163; propagated from
                     UniProtKB/Swiss-Prot (P08240.2)"
     Region          283..316
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P08240.2)"
     Site            284
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0007744|PubMed:24275569; propagated from
                     UniProtKB/Swiss-Prot (P08240.2)"
     Site            296
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:18669648,
                     ECO:0007744|PubMed:24275569; propagated from
                     UniProtKB/Swiss-Prot (P08240.2)"
     Site            297
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:18669648,
                     ECO:0007744|PubMed:24275569; propagated from
                     UniProtKB/Swiss-Prot (P08240.2)"
     Site            298
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:18669648,
                     ECO:0007744|PubMed:24275569; propagated from
                     UniProtKB/Swiss-Prot (P08240.2)"
     Region          <301..523
                     /region_name="FlhF"
                     /note="flagellar biosynthetic protein FlhF; TIGR03499"
                     /db_xref="CDD:274609"
     Region          419..636
                     /region_name="NG domain.
                     /evidence=ECO:0000303|PubMed:34020957"
                     /note="propagated from UniProtKB/Swiss-Prot (P08240.2)"
     Region          419..635
                     /region_name="SRalpha_C"
                     /note="C-terminal domain of signal recognition particle
                     receptor alpha subunit; cd17876"
                     /db_xref="CDD:349785"
     Site            order(426..433,437,455,458,464,523,589,591,615..618)
                     /site_type="active"
                     /db_xref="CDD:349785"
     Site            order(427..428,457..460,463..464,467..468,494,523,
                     525..527,552,554..558,561,589,591..592,594,618)
                     /site_type="other"
                     /note="heterodimer interface [polypeptide binding]"
                     /db_xref="CDD:349785"
     Site            473
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:23186163; propagated from
                     UniProtKB/Swiss-Prot (P08240.2)"
     Site            578
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0007744|PubMed:23186163; propagated from
                     UniProtKB/Swiss-Prot (P08240.2)"
     CDS             1..638
                     /gene="SRPRA"
                     /gene_synonym="DP; Sralpha; SRPR"
                     /coded_by="NM_003139.4:92..2008"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS31717.1"
                     /db_xref="GeneID:6734"
                     /db_xref="HGNC:HGNC:11307"
                     /db_xref="MIM:182180"
ORIGIN      
        1 mldfftifsk gglvlwcfqg vsdsctgpvn alirsvllqe rggnnsfthe altlkykldn
       61 qfelvfvvgf qkiltltyvd kliddvhrlf rdkyrteiqq qsalsllngt fdfqndflrl
      121 lreaeesski rapttmkkfe dsekakkpvr smietrgekp kekaknskkk gakkegsdgp
      181 latskpvpae ksglpvgpen gvelskeeli rrkreefiqk hgrgmeksnk stksdapkek
      241 gkkaprvwel ggcankevld ystpttngtp eaalsedinl irgtgsggql qdldcsssdd
      301 egaaqnstkp satkgtlggm fgmlkglvgs kslsredmes vldkmrdhli aknvaadiav
      361 qlcesvankl egkvmgtfst vtstvkqalq eslvqilqpq rrvdmlrdim daqrrqrpyv
      421 vtfcgvngvg kstnlakisf wllengfsvl iaacdtfrag aveqlrthtr rlsalhppek
      481 hggrtmvqlf ekgygkdaag iameaiafar nqgfdvvlvd tagrmqdnap lmtalaklit
      541 vntpdlvlfv gealvgneav dqlvkfnral adhsmaqtpr lidgivltkf dtiddkvgaa
      601 ismtyitskp ivfvgtgqty cdlrslnaka vvaalmka
//
