LOCUS       NM_014370               1960 bp    mRNA    linear   PRI 20-FEB-2025
DEFINITION  Homo sapiens SRSF protein kinase 3 (SRPK3), transcript variant 1,
            mRNA.
ACCESSION   NM_014370
VERSION     NM_014370.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1960)
  AUTHORS   Roychaudhury,A., Lee,Y.R., Choi,T.I., Thomas,M.G., Khan,T.N.,
            Yousaf,H., Skinner,C., Maconachie,G., Crosier,M., Horak,H.,
            Constantinescu,C.S., Kim,T.Y., Lee,K.H., Kyung,J.J., Wang,T.,
            Ku,B., Chodirker,B.N., Hammer,M.F., Gottlob,I., Norton,W.H.J.,
            Gerlai,R., Kim,H.G., Graziano,C., Pippucci,T., Iovino,E.,
            Montanari,F., Severi,G., Toro,C., Boerkoel,C.F., Cha,H.S.,
            Choi,C.Y., Kim,S., Yoon,J.H., Gilmore,K., Vora,N.L., Davis,E.E.,
            Chudley,A.E., Schwartz,C.E. and Kim,C.H.
  TITLE     SRPK3 Is Essential for Cognitive and Ocular Development in Humans
            and Zebrafish, Explaining X-Linked Intellectual Disability
  JOURNAL   Ann Neurol 96 (5), 914-931 (2024)
   PUBMED   39073169
REFERENCE   2  (bases 1 to 1960)
  AUTHORS   Segal,D., Maier,S., Mastromarco,G.J., Qian,W.W., Nabeel-Shah,S.,
            Lee,H., Moore,G., Lacoste,J., Larsen,B., Lin,Z.Y.,
            Selvabaskaran,A., Liu,K., Smibert,C., Zhang,Z., Greenblatt,J.,
            Peng,J., Lee,H.O., Gingras,A.C. and Taipale,M.
  TITLE     A central chaperone-like role for 14-3-3 proteins in human cells
  JOURNAL   Mol Cell 83 (6), 974-993 (2023)
   PUBMED   36931259
REFERENCE   3  (bases 1 to 1960)
  AUTHORS   Buljan,M., Ciuffa,R., van Drogen,A., Vichalkovski,A., Mehnert,M.,
            Rosenberger,G., Lee,S., Varjosalo,M., Pernas,L.E., Spegg,V.,
            Snijder,B., Aebersold,R. and Gstaiger,M.
  TITLE     Kinase Interaction Network Expands Functional and Disease Roles of
            Human Kinases
  JOURNAL   Mol Cell 79 (3), 504-520 (2020)
   PUBMED   32707033
REFERENCE   4  (bases 1 to 1960)
  AUTHORS   Wang,Y. and Tatakis,D.N.
  TITLE     Human gingiva transcriptome during wound healing
  JOURNAL   J Clin Periodontol 44 (4), 394-402 (2017)
   PUBMED   28005267
  REMARK    GeneRIF: SRPK3 expression is significantly downregulated in human
            masticatory mucosa during wound healing
REFERENCE   5  (bases 1 to 1960)
  AUTHORS   Zhang,M., Zhu,B. and Davie,J.
  TITLE     Alternative splicing of MEF2C pre-mRNA controls its activity in
            normal myogenesis and promotes tumorigenicity in rhabdomyosarcoma
            cells
  JOURNAL   J Biol Chem 290 (1), 310-324 (2015)
   PUBMED   25404735
  REMARK    GeneRIF: Alternative splicing of the alpha-exon of MEF2C regulates
            myogenesis. Loss of SRPK3 in rhabdomyosarcoma cells inhibits this
            splicing and blocks differentiation.
REFERENCE   6  (bases 1 to 1960)
  AUTHORS   Varjosalo,M., Keskitalo,S., Van Drogen,A., Nurkkala,H.,
            Vichalkovski,A., Aebersold,R. and Gstaiger,M.
  TITLE     The protein interaction landscape of the human CMGC kinase group
  JOURNAL   Cell Rep 3 (4), 1306-1320 (2013)
   PUBMED   23602568
REFERENCE   7  (bases 1 to 1960)
  AUTHORS   Nakagawa,O., Arnold,M., Nakagawa,M., Hamada,H., Shelton,J.M.,
            Kusano,H., Harris,T.M., Childs,G., Campbell,K.P., Richardson,J.A.,
            Nishino,I. and Olson,E.N.
  TITLE     Centronuclear myopathy in mice lacking a novel muscle-specific
            protein kinase transcriptionally regulated by MEF2
  JOURNAL   Genes Dev 19 (17), 2066-2077 (2005)
   PUBMED   16140986
REFERENCE   8  (bases 1 to 1960)
  AUTHORS   Grunau,C., Hindermann,W. and Rosenthal,A.
  TITLE     Large-scale methylation analysis of human genomic DNA reveals
            tissue-specific differences between the methylation profiles of
            genes and pseudogenes
  JOURNAL   Hum Mol Genet 9 (18), 2651-2663 (2000)
   PUBMED   11063724
  REMARK    Erratum:[Hum Mol Genet 2001 Jan 1;10(1):85-7]
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from U52111.3 and BC092416.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_014370.3.
            
            Summary: This gene encodes a protein kinase similar to a protein
            kinase which is specific for the SR (serine/arginine-rich domain)
            family of splicing factors. A highly similar protein has been shown
            to play a role in muscle development in mice. Multiple transcript
            variants encoding different isoforms have been found for this gene.
            [provided by RefSeq, Dec 2009].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK301749.1, BC092416.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968832, SAMEA2151741
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000370101.8/ ENSP00000359119.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-14                U52111.3           164250-164263
            15-1059             BC092416.1         1-1045
            1060-1060           U52111.3           167289-167289
            1061-1960           BC092416.1         1047-1946
FEATURES             Location/Qualifiers
     source          1..1960
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xq28"
     gene            1..1960
                     /gene="SRPK3"
                     /gene_synonym="MSSK-1; MSSK1; STK23; XLID114"
                     /note="SRSF protein kinase 3"
                     /db_xref="GeneID:26576"
                     /db_xref="HGNC:HGNC:11402"
                     /db_xref="MIM:301002"
     exon            1..105
                     /gene="SRPK3"
                     /gene_synonym="MSSK-1; MSSK1; STK23; XLID114"
                     /inference="alignment:Splign:2.1.0"
     CDS             47..1750
                     /gene="SRPK3"
                     /gene_synonym="MSSK-1; MSSK1; STK23; XLID114"
                     /EC_number="2.7.11.1"
                     /note="isoform 1 is encoded by transcript variant 1; SFRS
                     protein kinase 3; serine/threonine kinase 23;
                     muscle-specific serine kinase 1; serine arginine rich
                     protein-specific kinase 3; serine/threonine-protein kinase
                     SRPK3; SR-protein-specific kinase 3;
                     serine/threonine-protein kinase 23"
                     /codon_start=1
                     /product="SRSF protein kinase 3 isoform 1"
                     /protein_id="NP_055185.2"
                     /db_xref="CCDS:CCDS35441.1"
                     /db_xref="GeneID:26576"
                     /db_xref="HGNC:HGNC:11402"
                     /db_xref="MIM:301002"
                     /translation="MSASTGGGGDSGGSGGSSSSSQASCGPESSGSELALATPVPQML
                     QGLLGSDDEEQEDPKDYCKGGYHPVKIGDVFNGRYHVVRKLGWGHFSTVWLCWDIQRK
                     RFVALKVVKSAGHYTETAVDEIKLLKCVRDSDPSDPKRETIVQLIDDFRISGVNGVHV
                     CMVLEVLGHQLLKWIIKSNYQGLPVPCVKSIVRQVLHGLDYLHTKCKIIHTDIKPENI
                     LLCVGDAYIRRLAAEATEWQQAGAPPPSRSIVSTAPQEVLQTGKLSKNKRKKMRRKRK
                     QQKRLLEERLRDLQRLEAMEAATQAEDSGLRLDGGSGSTSSSGCHPGGARAGPSPASS
                     SPAPGGGRSLSAGSQTSGFSGSLFSPASCSILSGSSNQRETGGLLSPSTPFGASNLLV
                     NPLEPQNADKIKIKIADLGNACWVHKHFTEDIQTRQYRAVEVLIGAEYGPPADIWSTA
                     CMAFELATGDYLFEPHSGEDYSRDEDHIAHIVELLGDIPPAFALSGRYSREFFNRRGE
                     LRHIHNLKHWGLYEVLMEKYEWPLEQATQFSAFLLPMMEYIPEKRASAADCLQHPWLN
                     P"
     exon            106..236
                     /gene="SRPK3"
                     /gene_synonym="MSSK-1; MSSK1; STK23; XLID114"
                     /inference="alignment:Splign:2.1.0"
     exon            237..345
                     /gene="SRPK3"
                     /gene_synonym="MSSK-1; MSSK1; STK23; XLID114"
                     /inference="alignment:Splign:2.1.0"
     exon            346..433
                     /gene="SRPK3"
                     /gene_synonym="MSSK-1; MSSK1; STK23; XLID114"
                     /inference="alignment:Splign:2.1.0"
     exon            434..521
                     /gene="SRPK3"
                     /gene_synonym="MSSK-1; MSSK1; STK23; XLID114"
                     /inference="alignment:Splign:2.1.0"
     exon            522..628
                     /gene="SRPK3"
                     /gene_synonym="MSSK-1; MSSK1; STK23; XLID114"
                     /inference="alignment:Splign:2.1.0"
     exon            629..794
                     /gene="SRPK3"
                     /gene_synonym="MSSK-1; MSSK1; STK23; XLID114"
                     /inference="alignment:Splign:2.1.0"
     exon            795..820
                     /gene="SRPK3"
                     /gene_synonym="MSSK-1; MSSK1; STK23; XLID114"
                     /inference="alignment:Splign:2.1.0"
     exon            821..953
                     /gene="SRPK3"
                     /gene_synonym="MSSK-1; MSSK1; STK23; XLID114"
                     /inference="alignment:Splign:2.1.0"
     exon            954..1193
                     /gene="SRPK3"
                     /gene_synonym="MSSK-1; MSSK1; STK23; XLID114"
                     /inference="alignment:Splign:2.1.0"
     exon            1194..1294
                     /gene="SRPK3"
                     /gene_synonym="MSSK-1; MSSK1; STK23; XLID114"
                     /inference="alignment:Splign:2.1.0"
     exon            1295..1402
                     /gene="SRPK3"
                     /gene_synonym="MSSK-1; MSSK1; STK23; XLID114"
                     /inference="alignment:Splign:2.1.0"
     exon            1403..1472
                     /gene="SRPK3"
                     /gene_synonym="MSSK-1; MSSK1; STK23; XLID114"
                     /inference="alignment:Splign:2.1.0"
     exon            1473..1565
                     /gene="SRPK3"
                     /gene_synonym="MSSK-1; MSSK1; STK23; XLID114"
                     /inference="alignment:Splign:2.1.0"
     exon            1566..1960
                     /gene="SRPK3"
                     /gene_synonym="MSSK-1; MSSK1; STK23; XLID114"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1943..1948
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SRPK3"
                     /gene_synonym="MSSK-1; MSSK1; STK23; XLID114"
                     /note="hexamer: AATAAA"
     polyA_site      1960
                     /gene="SRPK3"
                     /gene_synonym="MSSK-1; MSSK1; STK23; XLID114"
                     /note="major polyA site"
ORIGIN      
        1 aggagcagcc gcccggggca ccggagctgc gggctgcgtg gccgggatga gcgccagcac
       61 gggcggtggt ggggacagcg gcggcagcgg cggcagtagc agcagctcac aggcctcctg
      121 cgggcccgag tcctcgggct ccgaactagc cctggccaca ccggtgcctc agatgctgca
      181 gggccttctg ggctccgacg acgaggaaca ggaagacccc aaagactact gcaagggcgg
      241 ctaccaccct gtgaagatcg gcgacgtgtt caatgggcgg taccacgtgg tgcgcaaact
      301 gggctggggc cacttctcca ccgtctggct ctgctgggac atccagcgca agcgctttgt
      361 ggccctcaaa gtggtgaaga gtgcggggca ttacacggag acagctgtgg atgagatcaa
      421 gctcctgaaa tgtgtccggg acagcgaccc cagtgacccc aaaagagaga ccattgtcca
      481 gctcattgat gacttcagga tctcaggagt caatggagtc catgtgtgca tggtgctgga
      541 ggtgctgggc caccagctcc tcaaatggat catcaagtcc aactaccagg gcctgcccgt
      601 gccctgcgtg aagagcatcg tgaggcaggt gctgcacggc ctggactacc tccacaccaa
      661 gtgcaagatc atccacacgg acatcaagcc cgagaacatc ttgctgtgtg tgggggacgc
      721 ttacatcagg cgcctggctg ccgaggccac ggagtggcaa caggcagggg cgccgccccc
      781 ctcccgctcc atagtcagca ctgcccccca ggaggtcttg cagaccggta agctgtccaa
      841 aaacaagagg aagaagatga ggcgcaaacg gaaacagcag aagcggctgc tggaggagcg
      901 gctgcgggac ctgcagaggc tggaggccat ggaggctgcc acccaggctg aggactctgg
      961 cttgagacta gacgggggca gcggctccac atcctcttca ggctgtcacc ccgggggcgc
     1021 cagagcaggt ccctccccag cctcttcctc ccccgcccca gggggcggcc gtagcctcag
     1081 cgcgggctca cagacctcag gcttctccgg ctccctcttc tctcctgcct cctgctccat
     1141 cctctccggc tcgtccaatc agcgagagac cgggggcctc ctgtcgccta gcacaccatt
     1201 cggtgcctcg aacctcctgg tgaaccccct ggagccccaa aatgcagata agatcaagat
     1261 caagatcgca gacctgggca acgcctgctg ggtgcacaag cacttcacgg aagacatcca
     1321 gactcggcag taccgggccg tcgaggtgct gatcggcgcc gaatacggcc ccccggcaga
     1381 catctggagc acagcctgca tggccttcga gctggccact ggtgactacc tgttcgagcc
     1441 gcattctgga gaagactaca gtcgtgatga ggaccacatc gctcacatag tggagcttct
     1501 gggggacatc cccccagcct tcgccctctc aggccgctat tcccgggagt tcttcaaccg
     1561 gagaggagag ctgcggcaca tccacaatct caagcactgg ggcctgtacg aggtactcat
     1621 ggaaaagtac gagtggcccc tagagcaggc cacacagttc agcgcctttc tgctgcccat
     1681 gatggagtac atccccgaaa agcgggccag tgccgctgac tgcctccagc acccctggct
     1741 caacccctag gcccggctgt ggctccacct ccagctctcc gtgccttaag ggaaaagcgg
     1801 gacagctccc accaccctgc tgggcgccag ttctccacaa ccacagggca gagagacgct
     1861 ggagccaggc ccggctctca gagcgtgttc tgcctgagac ccccgtgagg gctctcggag
     1921 aaagtgtgtg tattcctttc ttaataaagt gtggactgaa
//
