LOCUS       NM_182692               3679 bp    mRNA    linear   PRI 20-FEB-2025
DEFINITION  Homo sapiens SRSF protein kinase 2 (SRPK2), transcript variant 1,
            mRNA.
ACCESSION   NM_182692
VERSION     NM_182692.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3679)
  AUTHORS   Khoroshkin,M., Buyan,A., Dodel,M., Navickas,A., Yu,J., Trejo,F.,
            Doty,A., Baratam,R., Zhou,S., Lee,S.B., Joshi,T., Garcia,K.,
            Choi,B., Miglani,S., Subramanyam,V., Modi,H., Carpenter,C.,
            Markett,D., Corces,M.R., Mardakheh,F.K., Kulakovskiy,I.V. and
            Goodarzi,H.
  TITLE     Systematic identification of post-transcriptional regulatory
            modules
  JOURNAL   Nat Commun 15 (1), 7872 (2024)
   PUBMED   39251607
  REMARK    Erratum:[Nat Commun. 2024 Oct 28;15(1):9277. doi:
            10.1038/s41467-024-52903-4.. PMID: 39468017]
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3679)
  AUTHORS   Yip,R.P.H., Kwok,D.C.Y., Lai,L.T.F., Ho,S.M., Wong,I.C.K.,
            Chan,C.P., Lau,W.C.Y. and Ngo,J.C.K.
  TITLE     SRPK2 Mediates HBV Core Protein Phosphorylation and Capsid Assembly
            via Docking Interaction
  JOURNAL   PLoS Pathog 20 (2), e1011978 (2024)
   PUBMED   38324561
  REMARK    GeneRIF: SRPK2 Mediates HBV Core Protein Phosphorylation and Capsid
            Assembly via Docking Interaction.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3679)
  AUTHORS   Yang,Z. and Ding,W.X.
  TITLE     The pre-mRNA alternative splicing regulated by SRPK2: A new player
            in alcohol-associated liver disease?
  JOURNAL   Hepatology 78 (5), 1329-1331 (2023)
   PUBMED   37183907
  REMARK    GeneRIF: The pre-mRNA alternative splicing regulated by SRPK2: A
            new player in alcohol-associated liver disease?
REFERENCE   4  (bases 1 to 3679)
  AUTHORS   Hsu,Y.H., Pintacuda,G., Liu,R., Nacu,E., Kim,A., Tsafou,K.,
            Petrossian,N., Crotty,W., Suh,J.M., Riseman,J., Martin,J.M.,
            Biagini,J.C., Mena,D., Ching,J.K.T., Malolepsza,E., Li,T.,
            Singh,T., Ge,T., Egri,S.B., Tanenbaum,B., Stanclift,C.R.,
            Apffel,A.M., Carr,S.A., Schenone,M., Jaffe,J., Fornelos,N.,
            Huang,H., Eggan,K.C. and Lage,K.
  CONSRTM   Schizophrenia Working Group of the Psychiatric Genomics Consortium;
            Stanley Global Asia Initiatives
  TITLE     Using brain cell-type-specific protein interactomes to interpret
            neurodevelopmental genetic signals in schizophrenia
  JOURNAL   iScience 26 (5), 106701 (2023)
   PUBMED   37207277
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3679)
  AUTHORS   Fonteneau,G., Redding,A., Hoag-Lee,H., Sim,E.S., Heinrich,S.,
            Gaida,M.M. and Grabocka,E.
  TITLE     Stress Granules Determine the Development of Obesity-Associated
            Pancreatic Cancer
  JOURNAL   Cancer Discov 12 (8), 1984-2005 (2022)
   PUBMED   35674408
  REMARK    GeneRIF: Stress Granules Determine the Development of
            Obesity-Associated Pancreatic Cancer.
REFERENCE   6  (bases 1 to 3679)
  AUTHORS   Koizumi,J., Okamoto,Y., Onogi,H., Mayeda,A., Krainer,A.R. and
            Hagiwara,M.
  TITLE     The subcellular localization of SF2/ASF is regulated by direct
            interaction with SR protein kinases (SRPKs)
  JOURNAL   J Biol Chem 274 (16), 11125-11131 (1999)
   PUBMED   10196197
REFERENCE   7  (bases 1 to 3679)
  AUTHORS   Wang,H.Y., Lin,W., Dyck,J.A., Yeakley,J.M., Songyang,Z.,
            Cantley,L.C. and Fu,X.D.
  TITLE     SRPK2: a differentially expressed SR protein-specific kinase
            involved in mediating the interaction and localization of pre-mRNA
            splicing factors in mammalian cells
  JOURNAL   J Cell Biol 140 (4), 737-750 (1998)
   PUBMED   9472028
REFERENCE   8  (bases 1 to 3679)
  AUTHORS   Kuroyanagi,N., Onogi,H., Wakabayashi,T. and Hagiwara,M.
  TITLE     Novel SR-protein-specific kinase, SRPK2, disassembles nuclear
            speckles
  JOURNAL   Biochem Biophys Res Commun 242 (2), 357-364 (1998)
   PUBMED   9446799
REFERENCE   9  (bases 1 to 3679)
  AUTHORS   Bedford,M.T., Chan,D.C. and Leder,P.
  TITLE     FBP WW domains and the Abl SH3 domain bind to a specific class of
            proline-rich ligands
  JOURNAL   EMBO J 16 (9), 2376-2383 (1997)
   PUBMED   9171351
REFERENCE   10 (bases 1 to 3679)
  AUTHORS   Gui,J.F., Lane,W.S. and Fu,X.D.
  TITLE     A serine kinase regulates intracellular localization of splicing
            factors in the cell cycle
  JOURNAL   Nature 369 (6482), 678-682 (1994)
   PUBMED   8208298
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            HY031357.1, BC035214.1, CR746049.1 and BU632662.1.
            
            On Nov 23, 2018 this sequence version replaced NM_182692.2.
            
            Transcript Variant: This variant (1) encodes isoform a.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660805.145225.1,
                                           SRR1803613.111629.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000393651.8/ ENSP00000377262.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-450               HY031357.1         13-462
            451-3117            BC035214.1         456-3122
            3118-3677           CR746049.1         39-598
            3678-3679           BU632662.1         16-17               c
FEATURES             Location/Qualifiers
     source          1..3679
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q22.3"
     gene            1..3679
                     /gene="SRPK2"
                     /gene_synonym="SFRSK2"
                     /note="SRSF protein kinase 2"
                     /db_xref="GeneID:6733"
                     /db_xref="HGNC:HGNC:11306"
                     /db_xref="MIM:602980"
     exon            1..131
                     /gene="SRPK2"
                     /gene_synonym="SFRSK2"
                     /inference="alignment:Splign:2.1.0"
     CDS             116..2215
                     /gene="SRPK2"
                     /gene_synonym="SFRSK2"
                     /EC_number="2.7.11.1"
                     /note="isoform a is encoded by transcript variant 1; SFRS
                     protein kinase 2; serine/arginine-rich splicing factor
                     kinase 2; SR protein kinase 2; serine/threonine-protein
                     kinase SRPK2; serine kinase SRPK2; SR-protein-specific
                     kinase 2; serine/arginine-rich protein-specific kinase 2"
                     /codon_start=1
                     /product="SRSF protein kinase 2 isoform a"
                     /protein_id="NP_872634.1"
                     /db_xref="CCDS:CCDS34724.1"
                     /db_xref="GeneID:6733"
                     /db_xref="HGNC:HGNC:11306"
                     /db_xref="MIM:602980"
                     /translation="MSSRKVLAIQARKRRPKREKHPKKPEPQQKAPLVPPPPPPPPPP
                     PPPLPDPTPPEPEEEILGSDDEEQEDPADYCKGGYHPVKIGDLFNGRYHVIRKLGWGH
                     FSTVWLCWDMQGKRFVAMKVVKSAQHYTETALDEIKLLKCVRESDPSDPNKDMVVQLI
                     DDFKISGMNGIHVCMVFEVLGHHLLKWIIKSNYQGLPVRCVKSIIRQVLQGLDYLHSK
                     CKIIHTDIKPENILMCVDDAYVRRMAAEATEWQKAGAPPPSGSAVSTAPQQKPIGKIS
                     KNKKKKLKKKQKRQAELLEKRLQEIEELEREAERKIIEENITSAAPSNDQDGEYCPEV
                     KLKTTGLEEAAEAETAKDNGEAEDQEEKEDAEKENIEKDEDDVDQELANIDPTWIESP
                     KTNGHIENGPFSLEQQLDDEDDDEEDCPNPEEYNLDEPNAESDYTYSSSYEQFNGELP
                     NGRHKIPESQFPEFSTSLFSGSLEPVACGSVLSEGSPLTEQEESSPSHDRSRTVSASS
                     TGDLPKAKTRAADLLVNPLDPRNADKIRVKIADLGNACWVHKHFTEDIQTRQYRSIEV
                     LIGAGYSTPADIWSTACMAFELATGDYLFEPHSGEDYSRDEDHIAHIIELLGSIPRHF
                     ALSGKYSREFFNRRGELRHITKLKPWSLFDVLVEKYGWPHEDAAQFTDFLIPMLEMVP
                     EKRASAGECLRHPWLNS"
     exon            132..186
                     /gene="SRPK2"
                     /gene_synonym="SFRSK2"
                     /inference="alignment:Splign:2.1.0"
     exon            187..344
                     /gene="SRPK2"
                     /gene_synonym="SFRSK2"
                     /inference="alignment:Splign:2.1.0"
     exon            345..453
                     /gene="SRPK2"
                     /gene_synonym="SFRSK2"
                     /inference="alignment:Splign:2.1.0"
     exon            454..541
                     /gene="SRPK2"
                     /gene_synonym="SFRSK2"
                     /inference="alignment:Splign:2.1.0"
     exon            542..629
                     /gene="SRPK2"
                     /gene_synonym="SFRSK2"
                     /inference="alignment:Splign:2.1.0"
     exon            630..736
                     /gene="SRPK2"
                     /gene_synonym="SFRSK2"
                     /inference="alignment:Splign:2.1.0"
     exon            737..902
                     /gene="SRPK2"
                     /gene_synonym="SFRSK2"
                     /inference="alignment:Splign:2.1.0"
     exon            903..928
                     /gene="SRPK2"
                     /gene_synonym="SFRSK2"
                     /inference="alignment:Splign:2.1.0"
     exon            929..1175
                     /gene="SRPK2"
                     /gene_synonym="SFRSK2"
                     /inference="alignment:Splign:2.1.0"
     exon            1176..1658
                     /gene="SRPK2"
                     /gene_synonym="SFRSK2"
                     /inference="alignment:Splign:2.1.0"
     exon            1659..1759
                     /gene="SRPK2"
                     /gene_synonym="SFRSK2"
                     /inference="alignment:Splign:2.1.0"
     exon            1760..1867
                     /gene="SRPK2"
                     /gene_synonym="SFRSK2"
                     /inference="alignment:Splign:2.1.0"
     exon            1868..1937
                     /gene="SRPK2"
                     /gene_synonym="SFRSK2"
                     /inference="alignment:Splign:2.1.0"
     exon            1938..2030
                     /gene="SRPK2"
                     /gene_synonym="SFRSK2"
                     /inference="alignment:Splign:2.1.0"
     exon            2031..3679
                     /gene="SRPK2"
                     /gene_synonym="SFRSK2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2720..2725
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SRPK2"
                     /gene_synonym="SFRSK2"
                     /note="hexamer: ATTAAA"
     polyA_site      2754
                     /gene="SRPK2"
                     /gene_synonym="SFRSK2"
     regulatory      3649..3654
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SRPK2"
                     /gene_synonym="SFRSK2"
                     /note="hexamer: ATTAAA"
     polyA_site      3679
                     /gene="SRPK2"
                     /gene_synonym="SFRSK2"
                     /note="major polyA site"
ORIGIN      
        1 aggcgcggtt ctcgtctcct cccggccggc ggagcgagtg gaggctgcag cccagctcgt
       61 ctcggcgccc gcgtcgccgt cgcgaagccc cccgccccgc ttccgccgcg tcggaatgag
      121 ctcccggaaa gtgctggcca ttcaggcccg aaagcggagg ccgaaaagag agaaacatcc
      181 gaaaaagccg gagcctcaac agaaagctcc tttagttcct cctcctccac cgccaccacc
      241 accaccaccg ccacctttgc cagaccccac acccccggag ccagaggagg agatcctggg
      301 atcagatgat gaggagcaag aggaccctgc ggactactgc aaaggtggat atcatccagt
      361 gaaaattgga gacctcttca atggccggta tcatgttatt agaaagcttg gatgggggca
      421 cttctctact gtctggctgt gctgggatat gcaggggaaa agatttgttg caatgaaagt
      481 tgtaaaaagt gcccagcatt atacggagac agccttggat gaaataaaat tgctcaaatg
      541 tgttcgagaa agtgatccca gtgacccaaa caaagacatg gtggtccagc tcattgacga
      601 cttcaagatt tcaggcatga atgggataca tgtctgcatg gtcttcgaag tacttggcca
      661 ccatctcctc aagtggatca tcaaatccaa ctatcaaggc ctcccagtac gttgtgtgaa
      721 gagtatcatt cgacaggtcc ttcaagggtt agattactta cacagtaagt gcaagatcat
      781 tcatactgac ataaagccgg aaaatatctt gatgtgtgtg gatgatgcat atgtgagaag
      841 aatggcagct gaggccactg agtggcagaa agcaggtgct cctcctcctt cagggtctgc
      901 agtgagtacg gctccacagc agaaacctat aggaaaaata tctaaaaaca aaaagaaaaa
      961 actgaaaaag aaacagaaga ggcaggctga gttattggag aagcgcctgc aggagataga
     1021 agaattggag cgagaagctg aaaggaaaat aatagaagaa aacatcacct cagctgcacc
     1081 ttccaatgac caggatggcg aatactgccc agaggtgaaa ctaaaaacaa caggattaga
     1141 ggaggcggct gaggcagaga ctgcaaagga caatggtgaa gctgaggacc aggaagagaa
     1201 agaagatgct gagaaagaaa acattgaaaa agatgaagat gatgtagatc aggaacttgc
     1261 gaacatagac cctacgtgga tagaatcacc taaaaccaat ggccatattg agaatggccc
     1321 attctcactg gagcagcaac tggacgatga agatgatgat gaagaagact gcccaaatcc
     1381 tgaggaatat aatcttgatg agccaaatgc agaaagtgat tacacatata gcagctccta
     1441 tgaacaattc aatggtgaat tgccaaatgg acgacataaa attcccgagt cacagttccc
     1501 agagttttcc acctcgttgt tctctggatc cttagaacct gtggcctgcg gctctgtgct
     1561 ttctgaggga tcaccactta ctgagcaaga ggagagcagt ccatcccatg acagaagcag
     1621 aacggtttca gcctccagta ctggggattt gccaaaagca aaaacccggg cagctgactt
     1681 gttggtgaat cccctggatc cgcggaatgc agataaaatt agagtaaaaa ttgctgacct
     1741 gggaaatgct tgttgggtgc ataaacactt cacggaagac atccagacgc gtcagtaccg
     1801 ctccatagag gttttaatag gagcggggta cagcacccct gcggacatct ggagcacggc
     1861 gtgtatggca tttgagctgg caacgggaga ttatttgttt gaaccacatt ctggggaaga
     1921 ctattccaga gacgaagacc acatagccca catcatagag ctgctaggca gtattccaag
     1981 gcactttgct ctatctggaa aatattctcg ggaattcttc aatcgcagag gagaactgcg
     2041 acacatcacc aagctgaagc cctggagcct ctttgatgta cttgtggaaa agtatggctg
     2101 gccccatgaa gatgctgcac agtttacaga tttcctgatc ccgatgttag aaatggttcc
     2161 agaaaaacga gcctcagctg gcgaatgcct tcggcatcct tggttgaatt cttagcaaat
     2221 tctaccaata ttgcattctg agctagcaaa tgttcccagt acattggacc taaacggtga
     2281 ctctcattct ttaacaggat tacaagtgag ctggcttcat cctcagacct ttattttgct
     2341 ttgaggtact gttgtttgac attttgcttt ttgtgcactg tgatcctggg gaagggtagt
     2401 cttttgtctt cagctaagta gtttactgac cattttcttc tggaaacaat aacatgtctc
     2461 taagcattgt ttcttgtgtt gtgtgacatt caaatgtcat ttttttgaat gaaaaatact
     2521 ttcccctttg tgttttggca ggttttgtaa ctatttatga agaaatattt tagctgagta
     2581 ctatataatt tacaatctta agaaattatc aagttggaac caagaaatag caaggaaatg
     2641 tacaatttta tcttctggca aagggacatc attcctgtat tatagtgtat gtaaatgcac
     2701 cctgtaaatg ttactttcca ttaaatatgg gagggggact caaatttcag aaaagctacc
     2761 aagtcttgag tgctttgtag cctatgttgc atgtagcgga ctttaactgc tccaaggagt
     2821 tgtgcaaact tttcattcca taacagtctt ttcacattgg attttaaaca aagtggctct
     2881 gggttataag atgtcattct ctatatggca ctttaaagga agaaaagata tgtttctcat
     2941 tctaaaatat gcattataat ttagcagtcc catttgtgat tttgcatatt tttaaaagta
     3001 cttttaaaga agagcaattt ccctttaaaa atgtgatggc tcagtaccat gtcatgttgc
     3061 ctcctctggg cgctgtaagt taagctctac atagattaaa ttggagaaac gtgttaattg
     3121 tgtggaatga aaaaatacat atatttttgg aaaagcatga tcatgcttgt ctagaacaca
     3181 aggtatggta tatacaattt gcagtgcagt gggcagaata cttctcacag ctcaaagata
     3241 acagtgatca cattcattcc ataggtagct ttacgtgtgg ctacaacaaa ttttactagc
     3301 tttttcattg tctttccatg aaacgaagtt gagaaaatga ttttcccttt gcaggttgca
     3361 cacagttttg tttatgcatt tccttaaaat taattgtaga ctccaggata caaaccatag
     3421 taggcaatac aattttagaa tgtaatatat agaggtatat ttagcctctt ttagaagtca
     3481 gtggattgaa tgtcttttta ttttaaattt tacattcatt aaggtgcctc gtttttgact
     3541 ttgtccatta acatttatcc atatgccttt gcaataacta gattgtgaaa agctaacaag
     3601 tgttgtaaca ataatccatt gtttgaggtg cttgcagttg tcttaaaaat taaagtgttt
     3661 tggttttttt ttttccaga
//
