LOCUS       NM_003137               4348 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens SRSF protein kinase 1 (SRPK1), transcript variant 1,
            mRNA.
ACCESSION   NM_003137
VERSION     NM_003137.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4348)
  AUTHORS   Wang,J.J., Roy,S.K. and Xu,Y.M.
  TITLE     Spatiotemporal expression and coexpression patterns of SRPK1 in the
            human brain: A neurodevelopmental perspective
  JOURNAL   Brain Behav 14 (1), e3341 (2024)
   PUBMED   38376036
  REMARK    GeneRIF: Spatiotemporal expression and coexpression patterns of
            SRPK1 in the human brain: A neurodevelopmental perspective.
REFERENCE   2  (bases 1 to 4348)
  AUTHORS   Huang,J.Q., Duan,L.X., Liu,Q.Y., Li,H.F., Hu,A.P., Song,J.W.,
            Lin,C., Huang,B., Yao,D., Peng,B., Sun,Y., Wen,Y., Yang,L., Xu,X.
            and Gong,L.Y.
  TITLE     Serine-arginine protein kinase 1 (SRPK1) promotes EGFR-TKI
            resistance by enhancing GSK3beta Ser9 autophosphorylation
            independent of its kinase activity in non-small-cell lung cancer
  JOURNAL   Oncogene 42 (15), 1233-1246 (2023)
   PUBMED   36869126
  REMARK    GeneRIF: Serine-arginine protein kinase 1 (SRPK1) promotes EGFR-TKI
            resistance by enhancing GSK3beta Ser9 autophosphorylation
            independent of its kinase activity in non-small-cell lung cancer.
REFERENCE   3  (bases 1 to 4348)
  AUTHORS   Guo,W. and Hu,Z.
  TITLE     SRPK1 promotes sepsis-induced acute lung injury via regulating
            PI3K/AKT/FOXO3 signaling
  JOURNAL   Immunopharmacol Immunotoxicol 45 (2), 203-212 (2023)
   PUBMED   36226860
  REMARK    GeneRIF: SRPK1 promotes sepsis-induced acute lung injury via
            regulating PI3K/AKT/FOXO3 signaling.
REFERENCE   4  (bases 1 to 4348)
  AUTHORS   He,C., Liu,B., Wang,H.Y., Wu,L., Zhao,G., Huang,C., Liu,Y., Shan,B.
            and Liu,L.
  TITLE     Inhibition of SRPK1, a key splicing regulator, exhibits antitumor
            and chemotherapeutic-sensitizing effects on extranodal NK/T-cell
            lymphoma cells
  JOURNAL   BMC Cancer 22 (1), 1100 (2022)
   PUBMED   36303126
  REMARK    GeneRIF: Inhibition of SRPK1, a key splicing regulator, exhibits
            antitumor and chemotherapeutic-sensitizing effects on extranodal
            NK/T-cell lymphoma cells.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4348)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   6  (bases 1 to 4348)
  AUTHORS   Papoutsopoulou,S., Nikolakaki,E. and Giannakouros,T.
  TITLE     SRPK1 and LBR protein kinases show identical substrate
            specificities
  JOURNAL   Biochem Biophys Res Commun 255 (3), 602-607 (1999)
   PUBMED   10049757
REFERENCE   7  (bases 1 to 4348)
  AUTHORS   Wang,H.Y., Lin,W., Dyck,J.A., Yeakley,J.M., Songyang,Z.,
            Cantley,L.C. and Fu,X.D.
  TITLE     SRPK2: a differentially expressed SR protein-specific kinase
            involved in mediating the interaction and localization of pre-mRNA
            splicing factors in mammalian cells
  JOURNAL   J Cell Biol 140 (4), 737-750 (1998)
   PUBMED   9472028
REFERENCE   8  (bases 1 to 4348)
  AUTHORS   Tronchere,H., Wang,J. and Fu,X.D.
  TITLE     A protein related to splicing factor U2AF35 that interacts with
            U2AF65 and SR proteins in splicing of pre-mRNA
  JOURNAL   Nature 388 (6640), 397-400 (1997)
   PUBMED   9237760
REFERENCE   9  (bases 1 to 4348)
  AUTHORS   Colwill,K., Feng,L.L., Yeakley,J.M., Gish,G.D., Caceres,J.F.,
            Pawson,T. and Fu,X.D.
  TITLE     SRPK1 and Clk/Sty protein kinases show distinct substrate
            specificities for serine/arginine-rich splicing factors
  JOURNAL   J Biol Chem 271 (40), 24569-24575 (1996)
   PUBMED   8798720
REFERENCE   10 (bases 1 to 4348)
  AUTHORS   Gui,J.F., Lane,W.S. and Fu,X.D.
  TITLE     A serine kinase regulates intracellular localization of splicing
            factors in the cell cycle
  JOURNAL   Nature 369 (6482), 678-682 (1994)
   PUBMED   8208298
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC038292.1, AK299591.1,
            Z99128.1 and BX648697.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_003137.4.
            
            Summary: This gene encodes a serine/arginine protein kinase
            specific for the SR (serine/arginine-rich domain) family of
            splicing factors. The protein localizes to the nucleus and the
            cytoplasm. It is thought to play a role in regulation of both
            constitutive and alternative splicing by regulating intracellular
            localization of splicing factors. Alternative splicing of this gene
            results in multiple transcript variants. Additional alternatively
            spliced transcript variants have been described for this gene, but
            their full length nature have not been determined.[provided by
            RefSeq, Jul 2010].
            
            Transcript Variant: This variant (1) represents the shorter
            transcript.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803614.85279.1,
                                           SRR1803613.123013.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000373825.7/ ENSP00000362931.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-670               BC038292.1         48-717
            671-2272            AK299591.1         741-2342
            2273-4054           Z99128.1           6868-8649           c
            4055-4280           BX648697.1         4054-4279
            4281-4348           Z99128.1           6574-6641           c
FEATURES             Location/Qualifiers
     source          1..4348
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6p21.31"
     gene            1..4348
                     /gene="SRPK1"
                     /gene_synonym="SFRSK1"
                     /note="SRSF protein kinase 1"
                     /db_xref="GeneID:6732"
                     /db_xref="HGNC:HGNC:11305"
                     /db_xref="MIM:601939"
     exon            1..55
                     /gene="SRPK1"
                     /gene_synonym="SFRSK1"
                     /inference="alignment:Splign:2.1.0"
     CDS             43..2010
                     /gene="SRPK1"
                     /gene_synonym="SFRSK1"
                     /EC_number="2.7.11.1"
                     /note="SFRS protein kinase 1; serine/arginine-rich
                     splicing factor kinase 1; serine/threonine-protein kinase
                     SRPK1; SR-protein-specific kinase 1"
                     /codon_start=1
                     /product="SRSF protein kinase 1"
                     /protein_id="NP_003128.3"
                     /db_xref="CCDS:CCDS47415.1"
                     /db_xref="GeneID:6732"
                     /db_xref="HGNC:HGNC:11305"
                     /db_xref="MIM:601939"
                     /translation="MERKVLALQARKKRTKAKKDKAQRKSETQHRGSAPHSESDLPEQ
                     EEEILGSDDDEQEDPNDYCKGGYHLVKIGDLFNGRYHVIRKLGWGHFSTVWLSWDIQG
                     KKFVAMKVVKSAEHYTETALDEIRLLKSVRNSDPNDPNREMVVQLLDDFKISGVNGTH
                     ICMVFEVLGHHLLKWIIKSNYQGLPLPCVKKIIQQVLQGLDYLHTKCRIIHTDIKPEN
                     ILLSVNEQYIRRLAAEATEWQRSGAPPPSGSAVSTAPQPKPADKMSKNKKKKLKKKQK
                     RQAELLEKRMQEIEEMEKESGPGQKRPNKQEESESPVERPLKENPPNKMTQEKLEESS
                     TIGQDQTLMERDTEGGAAEINCNGVIEVINYTQNSNNETLRHKEDLHNANDCDVQNLN
                     QESSFLSSQNGDSSTSQETDSCTPITSEVSDTMVCQSSSTVGQSFSEQHISQLQESIR
                     AEIPCEDEQEQEHNGPLDNKGKSTAGNFLVNPLEPKNAEKLKVKIADLGNACWVHKHF
                     TEDIQTRQYRSLEVLIGSGYNTPADIWSTACMAFELATGDYLFEPHSGEEYTRDEDHI
                     ALIIELLGKVPRKLIVAGKYSKEFFTKKGDLKHITKLKPWGLFEVLVEKYEWSQEEAA
                     GFTDFLLPMLELIPEKRATAAECLRHPWLNS"
     exon            56..116
                     /gene="SRPK1"
                     /gene_synonym="SFRSK1"
                     /inference="alignment:Splign:2.1.0"
     exon            117..235
                     /gene="SRPK1"
                     /gene_synonym="SFRSK1"
                     /inference="alignment:Splign:2.1.0"
     exon            236..344
                     /gene="SRPK1"
                     /gene_synonym="SFRSK1"
                     /inference="alignment:Splign:2.1.0"
     exon            345..432
                     /gene="SRPK1"
                     /gene_synonym="SFRSK1"
                     /inference="alignment:Splign:2.1.0"
     exon            433..520
                     /gene="SRPK1"
                     /gene_synonym="SFRSK1"
                     /inference="alignment:Splign:2.1.0"
     exon            521..627
                     /gene="SRPK1"
                     /gene_synonym="SFRSK1"
                     /inference="alignment:Splign:2.1.0"
     exon            628..793
                     /gene="SRPK1"
                     /gene_synonym="SFRSK1"
                     /inference="alignment:Splign:2.1.0"
     exon            794..819
                     /gene="SRPK1"
                     /gene_synonym="SFRSK1"
                     /inference="alignment:Splign:2.1.0"
     exon            820..1033
                     /gene="SRPK1"
                     /gene_synonym="SFRSK1"
                     /inference="alignment:Splign:2.1.0"
     exon            1034..1453
                     /gene="SRPK1"
                     /gene_synonym="SFRSK1"
                     /inference="alignment:Splign:2.1.0"
     exon            1454..1554
                     /gene="SRPK1"
                     /gene_synonym="SFRSK1"
                     /inference="alignment:Splign:2.1.0"
     exon            1555..1662
                     /gene="SRPK1"
                     /gene_synonym="SFRSK1"
                     /inference="alignment:Splign:2.1.0"
     exon            1663..1732
                     /gene="SRPK1"
                     /gene_synonym="SFRSK1"
                     /inference="alignment:Splign:2.1.0"
     exon            1733..1825
                     /gene="SRPK1"
                     /gene_synonym="SFRSK1"
                     /inference="alignment:Splign:2.1.0"
     exon            1826..4348
                     /gene="SRPK1"
                     /gene_synonym="SFRSK1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4260..4265
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SRPK1"
                     /gene_synonym="SFRSK1"
                     /note="hexamer: AACAAA"
     polyA_site      4280
                     /gene="SRPK1"
                     /gene_synonym="SFRSK1"
                     /note="major polyA site"
     regulatory      4331..4336
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SRPK1"
                     /gene_synonym="SFRSK1"
                     /note="hexamer: AGTAAA"
     polyA_site      4348
                     /gene="SRPK1"
                     /gene_synonym="SFRSK1"
ORIGIN      
        1 gccactcgag tgcgcaggcg cctggcgatt accggtctca ccatggagcg gaaagtgctt
       61 gcgctccagg cccgaaagaa aaggaccaag gccaagaagg acaaagccca aaggaaatct
      121 gaaactcagc accgaggctc tgctccccac tctgagagtg atctaccaga gcaggaagag
      181 gagattctgg gatctgatga tgatgagcaa gaagatccta atgattattg taaaggaggt
      241 tatcatcttg tgaaaattgg agatctattc aatgggagat accatgtgat ccgaaagtta
      301 ggctggggac acttttcaac agtatggtta tcatgggata ttcaggggaa gaaatttgtg
      361 gcaatgaaag tagttaaaag tgctgaacat tacactgaaa cagcactaga tgaaatccgg
      421 ttgctgaagt cagttcgcaa ttcagaccct aatgatccaa atagagaaat ggttgttcaa
      481 ctactagatg actttaaaat atcaggagtt aatggaacac atatctgcat ggtatttgaa
      541 gttttggggc atcatctgct caagtggatc atcaaatcca attatcaggg gcttccactg
      601 ccttgtgtca aaaaaattat tcagcaagtg ttacagggtc ttgattattt acataccaag
      661 tgccgtatca tccacactga cattaaacca gagaacatct tattgtcagt gaatgagcag
      721 tacattcgga ggctggctgc agaagcaaca gaatggcagc gatctggagc tcctccgcct
      781 tccggatctg cagtcagtac tgctccccag cctaaaccag ctgacaaaat gtcaaagaat
      841 aagaagaaga aattgaagaa gaagcagaag cgccaggcag aattactaga gaagcgaatg
      901 caggaaattg aggaaatgga gaaagagtcg ggccctgggc aaaaaagacc aaacaagcaa
      961 gaagaatcag agagtcctgt tgaaagaccc ttgaaagaga acccacctaa taaaatgacc
     1021 caagaaaaac ttgaagagtc aagtaccatt ggccaggatc aaacgcttat ggaacgtgat
     1081 acagagggtg gtgcagcaga aattaattgc aatggagtga ttgaagtcat taattatact
     1141 cagaacagta ataatgaaac attgagacat aaagaggatc tacataatgc taatgactgt
     1201 gatgtccaaa atttgaatca ggaatctagt ttcctaagct cccaaaatgg agacagcagc
     1261 acatctcaag aaacagactc ttgtacacct ataacatctg aggtgtcaga caccatggtg
     1321 tgccagtctt cctcaactgt aggtcagtca ttcagtgaac aacacattag ccaacttcaa
     1381 gaaagcattc gggcagagat accctgtgaa gatgaacaag agcaagaaca taacggacca
     1441 ctggacaaca aaggaaaatc cacggctgga aattttcttg ttaatcccct tgagccaaaa
     1501 aatgcagaaa agctcaaggt gaagattgct gaccttggaa atgcttgttg ggtgcacaaa
     1561 catttcactg aagatattca aacaaggcaa tatcgttcct tggaagttct aatcggatct
     1621 ggctataata cccctgctga catttggagc acggcatgca tggcctttga actggccaca
     1681 ggtgactatt tgtttgaacc tcattcaggg gaagagtaca ctcgagatga agatcacatt
     1741 gcattgatca tagaacttct ggggaaggtg cctcgcaagc tcattgtggc aggaaaatat
     1801 tccaaggaat ttttcaccaa aaaaggtgac ctgaaacata tcacgaagct gaaaccttgg
     1861 ggcctttttg aggttctagt ggagaagtat gagtggtcgc aggaagaggc agctggcttc
     1921 acagatttct tactgcccat gttggagctg atccctgaga agagagccac tgccgccgag
     1981 tgtctccggc acccttggct taactcctaa gcccctgccc agcaccacag cagagatcac
     2041 acactgaccc tccgcccttc cccttcaagc attttcctct tcccttttca gggtgaagct
     2101 cttccttcaa gagtttctag atcttgtttt ttttttaatc caacatgttc atttgggttt
     2161 gcttacttga ccctgtggag atccccacag ccattgggca tcctaggtga atttggcctt
     2221 ggttgggctc tgccaaagac taatggacta aaatgtgaaa cagcctcttg ccctgtacct
     2281 ttccttccca ttaggacatc ctttaaatta taagcatcct ttttgaaaag agctatgaag
     2341 gtgtatgagc ccatcctttt attcattgac tctaagagtc aaattttcta gtgcatatcc
     2401 tattgccagc ataaggatga ggagggggaa agggtcttaa ttctatgtac agcagagaca
     2461 ttaaacttgc tgtgtccggg ctgcatcatc ttcctggact gtttctgttg ttctctgtgt
     2521 tcacattttt tcctgcaact tttaagctac tgtctttttt aaatagctat atgaacacca
     2581 aatttgggta ccattttatc actgttcaaa gcactgtcaa attcctttca tcctttaata
     2641 gttaagatct ttgaatcttc agtctgattt ttaatgtaag caaaaacaga accattgaat
     2701 agtaatttct tgagaacctc aggtgttcta taaacagtcc tttcctgtat gtcttctatt
     2761 accctaagac cagagttatt ttggttggtt gttttgtttt attttttgtt tttgtatcca
     2821 tggctggcac tttactcatt gcacttgagt ttattgcccc ataactaaag gatcaggatg
     2881 atggtagaac ggagatctgg gtttcagagc tttcccattt aagaaaaata gatcttgaga
     2941 ttctgattct tttccaaaca gtcccctgct ttcatgtaca gctttttctt taccttaccc
     3001 aaaattctgg ccttgaagca gttttcctct atggctttgc ctttctgatt ttctcagagg
     3061 ctcgagtctt taatataacc ccaaatgaaa gaaccaaggg gaggggtggg atggcacttt
     3121 tttttgttgg tcttgttttg ttttgttttt tggttggttg gttcgttatt ttttaagatt
     3181 agccattctc tgctgctatt tccctacata atgtcaattt ttaaccataa ttttgacatg
     3241 attgagatgt acttgaggct tttttgtttt aattgagaaa agactttgca attttttttt
     3301 taggatgagc ctctcctaga cttgacctag aatattacat attcctccag taagtaatac
     3361 tgaagagcaa aagagaggca ggattggggt cacagccgct tcttcagcat ggaccaagtg
     3421 ggccttgggg attgcagcgt tctcgaagtg gctgtaggac tcgaatttac agaaagccac
     3481 agaggtgcaa cttgaggctc tgctagcaag ccaccagtga ggctattggg taaccacctt
     3541 tctatacagg agattggaat ctactttgtc atttatccac cacagtgaca aaggaaaagt
     3601 ggtgccgtta tgcaatccat ttaactcata aacatattac tctgagtaac tggccagcca
     3661 ttcatcggat ccttcattgg gtactcctga aatcagacat gttcctgtag aaagaatttt
     3721 aagttaggct ttctatgcac ctatcaagaa tcaagagaat agattgtatc aaacaacggc
     3781 agggaaatcc ttcagcaatt ctaatccact ttgggttttc agctgttttt acatctaaag
     3841 caatagacta gaactgaatt atcttctaca tagtaaaatc acaattgtgg aattacagga
     3901 attctggtga tattaaggtg aaataacaaa acacaaaagg ccctatttta acagttgatg
     3961 tgacagtaag ttttaataga acctgtaact tcattttgga aatgcttctc caccaaataa
     4021 gggctttttc ccctatttaa ggagccagat ggattgaaag atgtggaaat aggcagctgt
     4081 agatcttgat cttccaggta ccccatgtac ctttattgag cttaattata atactgtcaa
     4141 attgccacga tctcactaaa ggatttctat ttgctgtcag ttaaaaataa agccctaaat
     4201 acatttttat tctttctact gagggcattg tctgttttct ttgtaaatgc cgtacaataa
     4261 acaaattatt taataaccta catgtttcca aaaatctctg ttcatttgtt gtccaaattg
     4321 ctctgccctg agtaaaagga ggaaaaga
//
