LOCUS       NM_003133               1481 bp    mRNA    linear   PRI 12-NOV-2024
DEFINITION  Homo sapiens signal recognition particle 9 (SRP9), transcript
            variant 2, mRNA.
ACCESSION   NM_003133
VERSION     NM_003133.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1481)
  AUTHORS   Sato,H., Meng,S., Sasaki,K., Kobayashi,S., Kido,K., Tsuji,Y.,
            Arao,Y., Saito,Y., Iwagami,Y., Yamada,D., Tomimaru,Y., Noda,T.,
            Takahashi,H., Motooka,D., Uchida,S., Ofusa,K., Satoh,T., Doki,Y.,
            Eguchi,H., Hara,T. and Ishii,H.
  TITLE     Significance of signal recognition particle 9 nuclear
            translocation: Implications for pancreatic cancer prognosis and
            functionality
  JOURNAL   Int J Oncol 65 (1) (2024)
   PUBMED   38847231
  REMARK    GeneRIF: Significance of signal recognition particle 9 nuclear
            translocation: Implications for pancreatic cancer prognosis and
            functionality.
REFERENCE   2  (bases 1 to 1481)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   3  (bases 1 to 1481)
  AUTHORS   Erdogan,G., Trabulus,D.C., Talu,C.K. and Guven,M.
  TITLE     Investigation of SRP9 protein expression in breast cancer
  JOURNAL   Mol Biol Rep 49 (1), 531-537 (2022)
   PUBMED   34727289
  REMARK    GeneRIF: Investigation of SRP9 protein expression in breast cancer.
REFERENCE   4  (bases 1 to 1481)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   5  (bases 1 to 1481)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   6  (bases 1 to 1481)
  AUTHORS   Andersen,J.S., Lam,Y.W., Leung,A.K., Ong,S.E., Lyon,C.E.,
            Lamond,A.I. and Mann,M.
  TITLE     Nucleolar proteome dynamics
  JOURNAL   Nature 433 (7021), 77-83 (2005)
   PUBMED   15635413
REFERENCE   7  (bases 1 to 1481)
  AUTHORS   Weichenrieder,O., Wild,K., Strub,K. and Cusack,S.
  TITLE     Structure and assembly of the Alu domain of the mammalian signal
            recognition particle
  JOURNAL   Nature 408 (6809), 167-173 (2000)
   PUBMED   11089964
REFERENCE   8  (bases 1 to 1481)
  AUTHORS   Hsu,K., Chang,D.Y. and Maraia,R.J.
  TITLE     Human signal recognition particle (SRP) Alu-associated protein also
            binds Alu interspersed repeat sequence RNAs. Characterization of
            human SRP9
  JOURNAL   J Biol Chem 270 (17), 10179-10186 (1995)
   PUBMED   7730321
REFERENCE   9  (bases 1 to 1481)
  AUTHORS   Bovia,F., Bui,N. and Strub,K.
  TITLE     The heterodimeric subunit SRP9/14 of the signal recognition
            particle functions as permuted single polypeptide chain
  JOURNAL   Nucleic Acids Res 22 (11), 2028-2035 (1994)
   PUBMED   7518078
REFERENCE   10 (bases 1 to 1481)
  AUTHORS   Strub,K. and Walter,P.
  TITLE     Assembly of the Alu domain of the signal recognition particle
            (SRP): dimerization of the two protein components is required for
            efficient binding to SRP RNA
  JOURNAL   Mol Cell Biol 10 (2), 777-784 (1990)
   PUBMED   2153922
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA983529.1, BC008443.1 and BC021995.1.
            
            On Feb 27, 2020 this sequence version replaced NM_003133.5.
            
            Transcript Variant: This variant (2) lacks an internal exon, as
            compared to variant 1. The resulting isoform (2) has a longer and
            distinct C-terminus, as compared to isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC066957.1, AF070649.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000304786.12/ ENSP00000305230.7
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3                 DA983529.1         14-16
            4-1479              BC008443.1         1-1476
            1480-1481           BC021995.1         1597-1598
FEATURES             Location/Qualifiers
     source          1..1481
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q42.12"
     gene            1..1481
                     /gene="SRP9"
                     /gene_synonym="ALURBP"
                     /note="signal recognition particle 9"
                     /db_xref="GeneID:6726"
                     /db_xref="HGNC:HGNC:11304"
                     /db_xref="MIM:600707"
     exon            1..187
                     /gene="SRP9"
                     /gene_synonym="ALURBP"
                     /inference="alignment:Splign:2.1.0"
     CDS             116..376
                     /gene="SRP9"
                     /gene_synonym="ALURBP"
                     /EC_number="3.6.5.4"
                     /note="isoform 2 is encoded by transcript variant 2;
                     signal recognition particle 9 kDa protein; signal
                     recognition particle 9kD; signal recognition particle
                     9kDa"
                     /codon_start=1
                     /product="signal recognition particle 9 kDa protein
                     isoform 2"
                     /protein_id="NP_003124.1"
                     /db_xref="CCDS:CCDS1546.1"
                     /db_xref="GeneID:6726"
                     /db_xref="HGNC:HGNC:11304"
                     /db_xref="MIM:600707"
                     /translation="MPQYQTWEEFSRAAEKLYLADPMKARVVLKYRHSDGNLCVKVTD
                     DLVCLVYKTDQAQDVKKIEKFHSQLMRLMVAKEARNVTMETE"
     exon            188..256
                     /gene="SRP9"
                     /gene_synonym="ALURBP"
                     /inference="alignment:Splign:2.1.0"
     exon            257..1481
                     /gene="SRP9"
                     /gene_synonym="ALURBP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      811..816
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SRP9"
                     /gene_synonym="ALURBP"
                     /note="hexamer: TATAAA"
     polyA_site      840
                     /gene="SRP9"
                     /gene_synonym="ALURBP"
     regulatory      1461..1466
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SRP9"
                     /gene_synonym="ALURBP"
                     /note="hexamer: AATAAA"
     polyA_site      1481
                     /gene="SRP9"
                     /gene_synonym="ALURBP"
                     /note="major polyA site"
ORIGIN      
        1 gccgccatct tggggctgct gggactcgcg tcggttggcg actcccggac gtaggtagtt
       61 tgttgggccg ggttctgagg ccttgcttct ctttactttt ccactctagg ccacgatgcc
      121 gcagtaccag acctgggagg agttcagccg cgctgccgag aagctttacc tcgctgaccc
      181 tatgaaggca cgtgtggttc tcaaatatag gcattctgat gggaacttgt gtgttaaagt
      241 aacagatgat ttagtttgtt tggtgtataa aacagaccaa gctcaagatg taaagaagat
      301 tgagaaattc cacagtcaac taatgcgact tatggtagcc aaggaagccc gcaatgttac
      361 catggaaact gagtgaatgg tttgaaatga agactttgtc gtgtacttag gaagtaaata
      421 tcttttgaat tagagaaagt gttgggacag aaagtacttt atgtaactaa gtgggctgtt
      481 cagaagctta gaggtcattt tttgtaattt tctttttaat tactttagag agctagggat
      541 gcaaatgttt tcagttagaa agcctttatt tacttttgga aattgaacaa gaaatgcatc
      601 tgtcttagaa actggagatt atttgatgtt aggtaaaaca tgtaattgtt tctctggcaa
      661 atttgtatca gtaatttgaa aatgagatat taggaaaaac caattcttct taaatttagt
      721 tcatctttct ttaaaagaac attaaatgta accattttgt cagatccatg tattttggag
      781 cataaaatgt atgctgttgt gaccaataaa tataaaatat ggtaattgga attaactcca
      841 caccatagta tgcattgtta tacatactgt gtacctaatt atgtatagca gtgtagtctc
      901 aattatatct gaaagtaatt gtgactaaca agtatgcttt gccttatttc cacatttaaa
      961 ctacctgtta atataaggga tttgtagtat cagcttgttg agcaatgact ttgaatctag
     1021 ttttcagtga tcagaagcag cagttatttg agtgtatgaa tggaatgatg atcactgtgc
     1081 tataatgtac tgaaaccacc atattacaga aatatttact acatattttc catctgtagt
     1141 ttctcagaag ggctatggat tagtttgaac tgtcaaatcc ttgcatactt ctgtgacacc
     1201 cctgcccatt ttctgtcttt aattaaccaa ggtgttaggt gtgactgtca caactgttat
     1261 gttttccagt aaactagaag tacgatattt gataattata tttgtatttc accacctaaa
     1321 tgtaatgttg attcctcaag aatgaaatga aggcactaca ttgaaatatg ttttgtataa
     1381 atttgtcatg ttgaacagca ttttagcatg gtaagttccc ttagctatat gaattttggc
     1441 atgtttcaga gagatcagta aataaaatat tagataaaat a
//
