LOCUS       NM_006947               3855 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens signal recognition particle 72 (SRP72), transcript
            variant 1, mRNA.
ACCESSION   NM_006947
VERSION     NM_006947.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3855)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   2  (bases 1 to 3855)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 3855)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 3855)
  AUTHORS   Wild,K., Juaire,K.D., Soni,K., Shanmuganathan,V., Hendricks,A.,
            Segnitz,B., Beckmann,R. and Sinning,I.
  TITLE     Reconstitution of the human SRP system and quantitative and
            systematic analysis of its ribosome interactions
  JOURNAL   Nucleic Acids Res 47 (6), 3184-3196 (2019)
   PUBMED   30649417
  REMARK    GeneRIF: e show that SRP RNA does not bind to the ribosome, while
            SRP binds with nanomolar affinity involving a two-step mechanism of
            the key-player SRP54. Ultrasensitive binding of SRP68/72 indicates
            avidity by multiple binding sites that are dominated by the
            C-terminus of SRP72
REFERENCE   5  (bases 1 to 3855)
  AUTHORS   Prevo,R., Tiwana,G.S., Maughan,T.S., Buffa,F.M., McKenna,W.G. and
            Higgins,G.S.
  TITLE     Depletion of signal recognition particle 72kDa increases
            radiosensitivity
  JOURNAL   Cancer Biol Ther 18 (6), 425-432 (2017)
   PUBMED   28494188
  REMARK    GeneRIF: SRP72 depletion is associated with elevated levels of
            apoptosis after irradiation.
REFERENCE   6  (bases 1 to 3855)
  AUTHORS   Utz,P.J., Hottelet,M., Le,T.M., Kim,S.J., Geiger,M.E., van
            Venrooij,W.J. and Anderson,P.
  TITLE     The 72-kDa component of signal recognition particle is cleaved
            during apoptosis
  JOURNAL   J Biol Chem 273 (52), 35362-35370 (1998)
   PUBMED   9857079
REFERENCE   7  (bases 1 to 3855)
  AUTHORS   Larsen,N., Samuelsson,T. and Zwieb,C.
  TITLE     The Signal Recognition Particle Database (SRPDB)
  JOURNAL   Nucleic Acids Res 26 (1), 177-178 (1998)
   PUBMED   9399828
REFERENCE   8  (bases 1 to 3855)
  AUTHORS   Breen,M.A. and Ashcroft,S.J.
  TITLE     A truncated isoform of Ca2+/calmodulin-dependent protein kinase II
            expressed in human islets of Langerhans may result from
            trans-splicing
  JOURNAL   FEBS Lett 409 (3), 375-379 (1997)
   PUBMED   9224693
REFERENCE   9  (bases 1 to 3855)
  AUTHORS   Lutcke,H., Prehn,S., Ashford,A.J., Remus,M., Frank,R. and
            Dobberstein,B.
  TITLE     Assembly of the 68- and 72-kD proteins of signal recognition
            particle with 7S RNA
  JOURNAL   J Cell Biol 121 (5), 977-985 (1993)
   PUBMED   8388879
REFERENCE   10 (bases 1 to 3855)
  AUTHORS   Siegel,V. and Walter,P.
  TITLE     Each of the activities of signal recognition particle (SRP) is
            contained within a distinct domain: analysis of biochemical mutants
            of SRP
  JOURNAL   Cell 52 (1), 39-49 (1988)
   PUBMED   2830980
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DB487204.2, AF069765.1,
            BX537991.1, AC114766.5, CN270014.1 and BM985419.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On May 21, 2018 this sequence version replaced NM_006947.3.
            
            Summary: This gene encodes the 72 kDa subunit of the signal
            recognition particle (SRP), a ribonucleoprotein complex that
            mediates the targeting of secretory proteins to the endoplasmic
            reticulum (ER). The SRP complex consists of a 7S RNA and 6 protein
            subunits: SRP9, SRP14, SRP19, SRP54, SRP68, and SRP72, that are
            bound to the 7S RNA as monomers or heterodimers. SRP has at least 3
            distinct functions that can be associated with the protein
            subunits: signal recognition, translational arrest, and ER membrane
            targeting by interaction with the docking protein. Mutations in
            this gene are associated with familial bone marrow failure.
            Alternatively spliced transcript variants encoding different
            isoforms have been found for this gene. [provided by RefSeq, Jun
            2012].
            
            Transcript Variant: This variant (1) represents the predominant
            transcript, and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF038851.1, SRR1660807.47424.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000642900.1/ ENSP00000495128.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-9                 DB487204.2         22-30
            10-2084             AF069765.1         1-2075
            2085-2589           BX537991.1         1902-2406
            2590-3263           AC114766.5         60388-61061
            3264-3814           CN270014.1         167-717
            3815-3855           BM985419.1         18-58               c
FEATURES             Location/Qualifiers
     source          1..3855
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4q12"
     gene            1..3855
                     /gene="SRP72"
                     /gene_synonym="BMFF; BMFS1; HEL103"
                     /note="signal recognition particle 72"
                     /db_xref="GeneID:6731"
                     /db_xref="HGNC:HGNC:11303"
                     /db_xref="MIM:602122"
     exon            1..128
                     /gene="SRP72"
                     /gene_synonym="BMFF; BMFS1; HEL103"
                     /inference="alignment:Splign:2.1.0"
     CDS             20..2035
                     /gene="SRP72"
                     /gene_synonym="BMFF; BMFS1; HEL103"
                     /note="isoform 1 is encoded by transcript variant 1;
                     signal recognition particle 72 kDa protein; signal
                     recognition particle subunit SRP72; epididymis luminal
                     protein 103; signal recognition particle 72kD; signal
                     recognition particle 72kDa"
                     /codon_start=1
                     /product="signal recognition particle subunit SRP72
                     isoform 1"
                     /protein_id="NP_008878.3"
                     /db_xref="CCDS:CCDS3506.1"
                     /db_xref="GeneID:6731"
                     /db_xref="HGNC:HGNC:11303"
                     /db_xref="MIM:602122"
                     /translation="MASGGSGGVSVPALWSEVNRYGQNGDFTRALKTVNKILQINKDD
                     VTALHCKVVCLIQNGSFKEALNVINTHTKVLANNSLSFEKAYCEYRLNRIENALKTIE
                     SANQQTDKLKELYGQVLYRLERYDECLAVYRDLVRNSQDDYDEERKTNLSAVVAAQSN
                     WEKVVPENLGLQEGTHELCYNTACALIGQGQLNQAMKILQKAEDLCRRSLSEDTDGTE
                     EDPQAELAIIHGQMAYILQLQGRTEEALQLYNQIIKLKPTDVGLLAVIANNIITINKD
                     QNVFDSKKKVKLTNAEGVEFKLSKKQLQAIEFNKALLAMYTNQAEQCRKISASLQSQS
                     PEHLLPVLIQAAQLCREKQHTKAIELLQEFSDQHPENAAEIKLTMAQLKISQGNISKA
                     CLILRSIEELKHKPGMVSALVTMYSHEEDIDSAIEVFTQAIQWYQNHQPKSPAHLSLI
                     REAANFKLKYGRKKEAISDLQQLWKQNPKDIHTLAQLISAYSLVDPEKAKALSKHLPS
                     SDSMSLKVDVEALENSAGATYIRKKGGKVTGDSQPKEQGQGDLKKKKKKKKGKLPKNY
                     DPKVTPDPERWLPMRERSYYRGRKKGKKKDQIGKGTQGATAGASSELDASKTVSSPPT
                     SPRPGSAATVSASTSNIIPPRHQKPAGAPATKKKQQQKKKKGGKGGW"
     exon            129..249
                     /gene="SRP72"
                     /gene_synonym="BMFF; BMFS1; HEL103"
                     /inference="alignment:Splign:2.1.0"
     exon            250..373
                     /gene="SRP72"
                     /gene_synonym="BMFF; BMFS1; HEL103"
                     /inference="alignment:Splign:2.1.0"
     exon            374..517
                     /gene="SRP72"
                     /gene_synonym="BMFF; BMFS1; HEL103"
                     /inference="alignment:Splign:2.1.0"
     exon            518..629
                     /gene="SRP72"
                     /gene_synonym="BMFF; BMFS1; HEL103"
                     /inference="alignment:Splign:2.1.0"
     exon            630..661
                     /gene="SRP72"
                     /gene_synonym="BMFF; BMFS1; HEL103"
                     /inference="alignment:Splign:2.1.0"
     exon            662..786
                     /gene="SRP72"
                     /gene_synonym="BMFF; BMFS1; HEL103"
                     /inference="alignment:Splign:2.1.0"
     exon            787..844
                     /gene="SRP72"
                     /gene_synonym="BMFF; BMFS1; HEL103"
                     /inference="alignment:Splign:2.1.0"
     exon            845..976
                     /gene="SRP72"
                     /gene_synonym="BMFF; BMFS1; HEL103"
                     /inference="alignment:Splign:2.1.0"
     exon            977..1105
                     /gene="SRP72"
                     /gene_synonym="BMFF; BMFS1; HEL103"
                     /inference="alignment:Splign:2.1.0"
     exon            1106..1178
                     /gene="SRP72"
                     /gene_synonym="BMFF; BMFS1; HEL103"
                     /inference="alignment:Splign:2.1.0"
     exon            1179..1243
                     /gene="SRP72"
                     /gene_synonym="BMFF; BMFS1; HEL103"
                     /inference="alignment:Splign:2.1.0"
     exon            1244..1339
                     /gene="SRP72"
                     /gene_synonym="BMFF; BMFS1; HEL103"
                     /inference="alignment:Splign:2.1.0"
     exon            1340..1443
                     /gene="SRP72"
                     /gene_synonym="BMFF; BMFS1; HEL103"
                     /inference="alignment:Splign:2.1.0"
     exon            1444..1521
                     /gene="SRP72"
                     /gene_synonym="BMFF; BMFS1; HEL103"
                     /inference="alignment:Splign:2.1.0"
     exon            1522..1659
                     /gene="SRP72"
                     /gene_synonym="BMFF; BMFS1; HEL103"
                     /inference="alignment:Splign:2.1.0"
     exon            1660..1697
                     /gene="SRP72"
                     /gene_synonym="BMFF; BMFS1; HEL103"
                     /inference="alignment:Splign:2.1.0"
     exon            1698..1857
                     /gene="SRP72"
                     /gene_synonym="BMFF; BMFS1; HEL103"
                     /inference="alignment:Splign:2.1.0"
     exon            1858..3855
                     /gene="SRP72"
                     /gene_synonym="BMFF; BMFS1; HEL103"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3240..3245
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SRP72"
                     /gene_synonym="BMFF; BMFS1; HEL103"
                     /note="hexamer: AATAAA"
     polyA_site      3281
                     /gene="SRP72"
                     /gene_synonym="BMFF; BMFS1; HEL103"
                     /note="major polyA site"
     regulatory      3828..3833
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SRP72"
                     /gene_synonym="BMFF; BMFS1; HEL103"
                     /note="hexamer: AATAAA"
     polyA_site      3855
                     /gene="SRP72"
                     /gene_synonym="BMFF; BMFS1; HEL103"
ORIGIN      
        1 gcccctcgtc tcctccaaga tggcgagcgg cggcagcggg ggggtgtcag tacctgcgct
       61 gtggagtgaa gtgaaccggt atggccagaa cggcgacttc acgcgcgctc tcaagaccgt
      121 caataagata ctacagatca acaaagatga cgtaactgcc ctgcattgta aagtggtatg
      181 ccttatccag aatggaagtt tcaaggaagc tttgaatgtc atcaatactc acaccaaagt
      241 gttagccaat aactctctct cctttgaaaa ggcatattgc gagtacaggc tgaacagaat
      301 tgagaatgcc ttgaagacaa tagaaagtgc caaccagcag acagacaaac tgaaggagct
      361 ttatggacaa gtgttatacc gtttggaacg ctatgatgaa tgcttagcag tgtatagaga
      421 tctcgtccga aactcccaag atgattatga tgaggagagg aaaacaaacc tttcagcagt
      481 tgttgcagct caaagcaatt gggaaaaagt ggttccagag aacctgggcc tccaagaagg
      541 cacacatgag ctgtgctaca acactgcatg tgcactgata ggccaaggcc agctgaacca
      601 ggccatgaaa atcctacaaa aagctgaaga tctttgccgc cgttcattat cagaagacac
      661 tgatgggact gaggaagacc cacaggcaga actggccatc attcatggtc agatggctta
      721 tattctgcag cttcagggtc gaacagagga ggctttgcaa ctttacaatc aaataataaa
      781 actaaaacca acagatgtgg gattactagc tgtaattgca aataacatca ttaccattaa
      841 caaggaccaa aatgtctttg actccaagaa gaaagtgaaa ttaaccaatg cggaaggagt
      901 agagtttaag ctttccaaga aacaactaca agctatagaa tttaacaaag ctttacttgc
      961 tatgtacaca aaccaggctg aacaatgccg caaaatatct gccagtttac agtcccaaag
     1021 tcccgagcat ctcttacctg tgttaatcca agctgcccag ctctgccgtg aaaagcagca
     1081 cacaaaagca atagagctgc ttcaggaatt ttcagatcag catccagaaa atgcagctga
     1141 aattaagctg accatggcac agttgaaaat ttctcaaggt aatatttcta aagcatgtct
     1201 aatattgaga agcatagagg agttaaagca taaaccaggc atggtatctg cattagttac
     1261 catgtatagc catgaagaag atattgatag tgccattgag gtcttcacac aagctatcca
     1321 gtggtatcaa aaccatcagc caaaatctcc tgctcatttg tccttgataa gagaagctgc
     1381 aaacttcaaa ctcaaatatg ggcggaagaa ggaggcaatt agtgacctac aacagctgtg
     1441 gaaacaaaat ccaaaagata ttcacaccct ggcacagctt atttctgctt actcacttgt
     1501 agatccagag aaagccaaag ctcttagtaa acacttgcca tcgtcagata gtatgtctct
     1561 aaaagtagat gttgaggctc ttgaaaattc tgctggtgct acatacattc ggaagaaggg
     1621 tggaaaagtt actggagata gtcaaccaaa ggaacaagga cagggagatt tgaaaaagaa
     1681 gaaaaagaaa aagaagggaa aattgcctaa gaattatgac ccaaaagtta ccccagatcc
     1741 agaaagatgg ctgccaatgc gagaacgttc ttactaccgg ggaagaaaga agggtaaaaa
     1801 gaaggatcag attggaaaag ggacccaggg agcaactgca ggagcttcat ctgaactgga
     1861 tgccagtaaa actgtgagca gcccacccac ctccccaaga cctggcagtg ctgcaacagt
     1921 atctgcctct acaagtaaca tcataccccc aagacaccag aaacctgcag gggctccagc
     1981 aacaaaaaag aaacagcaac agaaaaagaa gaaaggtgga aaaggtggct ggtgatgaga
     2041 atattcttgt tgcaggctgt ttttaaacta gtgtcagtga cactaggaat ataataaagg
     2101 taacacagca agaagcacag aactactccc tcttcatctc catattttca taatttcttg
     2161 tgtttcaaat agggaaacat cttcctcaaa gtctgcctag tgagatatgg cctactggtt
     2221 gcctcatagc tttgtacaga ttatgaggac tgaaaataat tgggcattta cccatcttgg
     2281 tatctgttgt atcctttatc tgtgtgtgct gatttgatct tttttcagtt tcacatacct
     2341 tatctaaggt ttcccaggat ttaaacagaa actacttcta tgatttcagc tggagtctga
     2401 agatacttgt ttctgttcaa gtcccacttt aaattatgtc ttaggagact gaaagtggaa
     2461 tcttctgagc attcctaaat atctgcttag aaatatcatg tgataaagag ggaccttctt
     2521 aatacactga tgttcttcac taaatggatg gccacaagaa aaataaagta aatgtcttaa
     2581 ataatttaac cataaatttt ctgtcatgtg atactggaat atgggatact tttcatgttt
     2641 atatatatat atatatgtat atatatatac atatatatat atatataaac atgaaatata
     2701 tatatatggc tcctttgtgc cccatgtcat tttcagatta tggtagcatg ctgatacagc
     2761 accatgaaag aactcaagga aaatatatca atgtaagaag ttcactctta gacccagtgt
     2821 tctgaggtca catgggtttg gactgtctca atcagaaaga ttaatgactg ttatcaagaa
     2881 catgaacatt ggcttcctcc atagagaaga aatcagtatc tgagttgcat accaggcagt
     2941 attaaaatct aacaggtctg tttggcccat tgatagatac tcaaatggtg tctccttctg
     3001 gttatggatt ttgaccattg attacctttc tcaatgtaat gaagtatttt acagtcaatt
     3061 tgtggtgtaa atgttgctct tgtctttcct tgcttacaaa ctactttcac attgaacagc
     3121 tgtgagacag acatattgag atgcctgccc ttgttagtat tcattttatg ctgcccaaga
     3181 tatcatttaa tttagactta acaagtattt ccttgtgatt atattactct gtccttgtta
     3241 ataaagtgct gctgtgtttg actctgaaca tactaccaaa acttcttcaa agagtttttt
     3301 atgaaagact ttcctccttt acaagaaaga aatggggtgc tgcctttctg tttagtaaaa
     3361 gcagaatttg cagtggcatc taaagagatc ttttttaaat aaaaattatg tattgtggca
     3421 taatcctttt tttgagctct acagagaaca gtcttttggt aatagtggca ggtatttatt
     3481 ccttctgaat atatacccca ttataggaat aactgttact tatttaggat tccatcattg
     3541 aaaattttga cccaaggcac agcagtgaaa tttatagttc tcaatttagt tgtcattatt
     3601 gacaggcatt ggtattatta gtcattgcta agcaactaaa acttcatcag ttcaaataag
     3661 ttttaattgt caaatgaagt ataaacacat gaactttcta gaaatatttc ctcttttgga
     3721 taggtcttta accagttcat atatatactt tgtcaaatat atggatgtgt atgtgtacat
     3781 ttataagaac cagtatggat acatccattc actgtggtac attttaaaat aaaatatttt
     3841 agcagtgaat atgga
//
