LOCUS       NM_003135               2776 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens signal recognition particle 19 (SRP19), transcript
            variant 1, mRNA.
ACCESSION   NM_003135
VERSION     NM_003135.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2776)
  AUTHORS   Linder,M.I., Mizoguchi,Y., Hesse,S., Csaba,G., Tatematsu,M.,
            Lyszkiewicz,M., Zietara,N., Jeske,T., Hastreiter,M., Rohlfs,M.,
            Liu,Y., Grabowski,P., Ahomaa,K., Maier-Begandt,D., Schwestka,M.,
            Pazhakh,V., Isiaku,A.I., Briones Miranda,B., Blombery,P.,
            Saito,M.K., Rusha,E., Alizadeh,Z., Pourpak,Z., Kobayashi,M.,
            Rezaei,N., Unal,E., Hauck,F., Drukker,M., Walzog,B., Rappsilber,J.,
            Zimmer,R., Lieschke,G.J. and Klein,C.
  TITLE     Human genetic defects in SRP19 and SRPRA cause severe congenital
            neutropenia with distinctive proteome changes
  JOURNAL   Blood 141 (6), 645-658 (2023)
   PUBMED   36223592
  REMARK    GeneRIF: Human genetic defects in SRP19 and SRPRA cause severe
            congenital neutropenia with distinctive proteome changes.
REFERENCE   2  (bases 1 to 2776)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   3  (bases 1 to 2776)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 2776)
  AUTHORS   Becker,M.M., Lapouge,K., Segnitz,B., Wild,K. and Sinning,I.
  TITLE     Structures of human SRP72 complexes provide insights into SRP RNA
            remodeling and ribosome interaction
  JOURNAL   Nucleic Acids Res 45 (1), 470-481 (2017)
   PUBMED   27899666
  REMARK    GeneRIF: The crystal structures of the SRP68 protein-binding domain
            (PBD) in complex with SRP72-PBD and of the SRP72-RBD bound to the
            SRP S domain (SRP RNA, SRP19 and SRP68) detailing all interactions
            of SRP72 within SRP have been presented.
REFERENCE   5  (bases 1 to 2776)
  AUTHORS   Wang,Q., Duan,F., Liu,P., Wang,P.F. and Wang,M.X.
  TITLE     Expression of anti-SRP19 antibody in muscle tissues from patients
            with autoimmune necrotizing myopathy
  JOURNAL   Genet Mol Res 15 (3) (2016)
   PUBMED   27525944
  REMARK    GeneRIF: anti-SRP19 antibody is highly expressed in muscle tissues
            of patients with autoimmune necrotizing myopathy.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2776)
  AUTHORS   Politz,J.C., Yarovoi,S., Kilroy,S.M., Gowda,K., Zwieb,C. and
            Pederson,T.
  TITLE     Signal recognition particle components in the nucleolus
  JOURNAL   Proc Natl Acad Sci U S A 97 (1), 55-60 (2000)
   PUBMED   10618370
REFERENCE   7  (bases 1 to 2776)
  AUTHORS   Gowda,K., Chittenden,K. and Zwieb,C.
  TITLE     Binding site of the M-domain of human protein SRP54 determined by
            systematic site-directed mutagenesis of signal recognition particle
            RNA
  JOURNAL   Nucleic Acids Res 25 (2), 388-394 (1997)
   PUBMED   9016569
REFERENCE   8  (bases 1 to 2776)
  AUTHORS   Joslyn,G., Carlson,M., Thliveris,A., Albertsen,H., Gelbert,L.,
            Samowitz,W., Groden,J., Stevens,J., Spirio,L., Robertson,M. et al.
  TITLE     Identification of deletion mutations and three new genes at the
            familial polyposis locus
  JOURNAL   Cell 66 (3), 601-613 (1991)
   PUBMED   1678319
REFERENCE   9  (bases 1 to 2776)
  AUTHORS   Groden,J., Thliveris,A., Samowitz,W., Carlson,M., Gelbert,L.,
            Albertsen,H., Joslyn,G., Stevens,J., Spirio,L., Robertson,M. et al.
  TITLE     Identification and characterization of the familial adenomatous
            polyposis coli gene
  JOURNAL   Cell 66 (3), 589-600 (1991)
   PUBMED   1651174
REFERENCE   10 (bases 1 to 2776)
  AUTHORS   Lingelbach,K., Zwieb,C., Webb,J.R., Marshallsay,C., Hoben,P.J.,
            Walter,P. and Dobberstein,B.
  TITLE     Isolation and characterization of a cDNA clone encoding the 19 kDa
            protein of signal recognition particle (SRP): expression and
            binding to 7SL RNA
  JOURNAL   Nucleic Acids Res 16 (20), 9431-9442 (1988)
   PUBMED   2460823
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC008575.7, X12791.1, AW890522.1, CN265235.1 and AA845342.1.
            
            On May 17, 2019 this sequence version replaced NM_003135.2.
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803612.134293.1,
                                           SRR1660807.128387.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000505459.6/ ENSP00000424870.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-9                 AC008575.7         150667-150675
            10-854              X12791.1           1-845
            855-898             AW890522.1         42-85               c
            899-903             CN265235.1         96-100
            904-1380            AA845342.1         28-504              c
            1381-2776           AC008575.7         157773-159168
FEATURES             Location/Qualifiers
     source          1..2776
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q22.2"
     gene            1..2776
                     /gene="SRP19"
                     /note="signal recognition particle 19"
                     /db_xref="GeneID:6728"
                     /db_xref="HGNC:HGNC:11300"
                     /db_xref="MIM:182175"
     exon            1..131
                     /gene="SRP19"
                     /inference="alignment:Splign:2.1.0"
     CDS             91..525
                     /gene="SRP19"
                     /EC_number="3.6.5.4"
                     /note="isoform 1 is encoded by transcript variant 1;
                     signal recognition particle 19 kDa protein; signal
                     recognition particle 19kD; signal recognition particle
                     19kDa"
                     /codon_start=1
                     /product="signal recognition particle 19 kDa protein
                     isoform 1"
                     /protein_id="NP_003126.1"
                     /db_xref="CCDS:CCDS4108.1"
                     /db_xref="GeneID:6728"
                     /db_xref="HGNC:HGNC:11300"
                     /db_xref="MIM:182175"
                     /translation="MACAAARSPADQDRFICIYPAYLNNKKTIAEGRRIPISKAVENP
                     TATEIQDVCSAVGLNVFLEKNKMYSREWNRDVQYRGRVRVQLKQEDGSLCLVQFPSRK
                     SVMLYAAEMIPKLKTRTQKTGGADQSLQQGEGSKKGKGKKKK"
     exon            132..207
                     /gene="SRP19"
                     /inference="alignment:Splign:2.1.0"
     exon            208..279
                     /gene="SRP19"
                     /inference="alignment:Splign:2.1.0"
     exon            280..391
                     /gene="SRP19"
                     /inference="alignment:Splign:2.1.0"
     exon            392..2776
                     /gene="SRP19"
                     /inference="alignment:Splign:2.1.0"
     regulatory      878..883
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SRP19"
                     /note="hexamer: AATAAA"
     polyA_site      895
                     /gene="SRP19"
                     /note="major polyA site"
     regulatory      1069..1074
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SRP19"
                     /note="hexamer: AATATA"
     polyA_site      1088
                     /gene="SRP19"
     regulatory      1363..1368
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SRP19"
                     /note="hexamer: AGTAAA"
     polyA_site      1383
                     /gene="SRP19"
     regulatory      2085..2090
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SRP19"
                     /note="hexamer: AATGAA"
     polyA_site      2104
                     /gene="SRP19"
ORIGIN      
        1 gggctgtctc ggaaactcag agccgggttc ctcccgggtt tctgccgggt ttctccctgc
       61 ggctcctggg ttgttgagac tcttgtgaag atggcttgcg ctgccgcgcg gtccccggcc
      121 gaccaggaca ggtttatttg tatctatcct gcttatttaa ataataagaa gaccatcgca
      181 gagggaaggc gaatccccat aagtaaggct gttgaaaatc ctacagctac agagattcaa
      241 gatgtatgtt cagcagttgg acttaacgta tttcttgaga aaaataaaat gtactctaga
      301 gaatggaatc gtgatgtcca atacagaggc agagtccggg tccagctcaa acaggaagat
      361 gggagcctct gccttgtaca gttcccatca cgtaagtcag taatgttgta tgcagcagaa
      421 atgataccta aactaaaaac aaggacacaa aaaacaggag gtgctgacca aagtcttcaa
      481 caaggagagg gaagtaaaaa agggaaagga aagaaaaaga agtaacctag tatcagcatc
      541 aagtatgtgg tactactgta agagacatga atggagactt ctaatttgta tcggagggaa
      601 acagaagctt tttgtttgca tcatttaact gaactgtgaa cccttgtgcc tctcatcttt
      661 atcatcggag ttgacagtga aacaaattta catcagaagt ttgcatctcg cgtatatgcc
      721 gtataaaaga atttttttgt ctttcaatgc agttttttgg aagaaaatat ttttaaatgg
      781 acaatggact gtacaataag ttacttgaaa taagttgttt cagataaatt tcaattagat
      841 ttaaaataaa cattttgtcc accttttaag ttaatgaaat aaaatttgaa actgactttt
      901 gcagcttttg cttatatact aatgctagga gaggagggat aattaagaat aaaatatgta
      961 gtgaaagttt ccatagtgtg aggctaaaac tagaagaaac tgtggtaggt ccttttgtgg
     1021 gtgggggaca ggggagtctg taaaaagcca gtctgtagat gatattttaa tatattattg
     1081 taatcgaatc gttcagttgt tttttgacat ggaaagtcct ggattttaag ctttaaattt
     1141 gcttattttg taggtttaag aacatgattt tcatgggagt tgtaaaatta actgtgcttt
     1201 agcaccttga ggtacacttt ccttcaacaa atgaaattgg attggtgctc cagaatttca
     1261 gagcggtttc tgaaagtagt gattttgagc tatcccaatt cctgttcttc ctgaggcctg
     1321 gtttagctct tccttgaatt ctgcaagcta tctcatattt tcagtaaatt ccattttttt
     1381 taagtttgtt tgtttgtttg tttttgagat ggagtttcac tcttgttgcc taggctggag
     1441 tgcaatggca cgatatcggc gtaccacaac ctctgcatcc caggttcaag agattctcct
     1501 gcctcagcct ccctaggagc tgggattaca ggcatgtgcc accacacccg gctaattttg
     1561 tatttttagt agagacaggg tttttccatg ttggtcaggc tggtctcgaa ctcccgacct
     1621 caggtgatct gcccacctca gcctcccaaa gtgctgggat tacaggcatg agccaccgtg
     1681 cccggccttc tttacatttt tattgctcac agtcaaacat tcctattgat tgtaaaataa
     1741 gcaaacctag agttgtggag atttatatgt atttatttat ttgaattgag acagggtctt
     1801 aaactcccag gctcaagtga tcctcctgcc tcaacctccc aaagtgctgg gattacaggc
     1861 atgagctagc tggcctgttg actttttttt tttaactcta acaatttctg ttttatagtg
     1921 aacataatag tataagactt agtttatata tttgacttac aaataaatcc tggggagagg
     1981 ggagtatgtg taaaacataa ttcagagcag ccttctttga gaaagtgggt gtgtttggct
     2041 gtgtaacaaa acaataaggg gatgtgtttg ctgtgtaaca aaacaatgaa ggatttaagc
     2101 aggatatttt tgcctcatat gttaaatcca agtgaggttg ctgtggtggt tggtttagct
     2161 ctcagtgatg ccttttttgt atttttccgc tctgctgtcc atgacatatt tctaacacct
     2221 ttatgattat tgttcctgct tgtaaaaggg ctgatattta catgagtgca aggcaggaag
     2281 aaaaggtagc tgtgccagcc acttctggca agcagttctc ccaccttagc ctcccaagta
     2341 gctgagacca taggcatgag atttctcaaa attcctccca gcaggctttc acttagtttc
     2401 attgttgaga actgtgacag gtccatctct agctgcaaag gaggctgaga aagtgaacac
     2461 agcagtcctc cttatccttg gggaatacat tccaagagtg gatccctgaa acagcagata
     2521 gtactgaacc ctatatatac tatgtttttg cctatgtata tatacttgat atggtttggc
     2581 tgctacccaa cccaaaatct catcttgaat tataatcccc aaatccctat gtgttaaggg
     2641 tgggaccagg tggagataat tggatcatgg gggcaatttc ccctgtgctg ttcttgagat
     2701 aatgagtgac tctcaggaga tctgttggtt ttataagtgc ctggcgtttc ccctgcttgc
     2761 agtcactcca tcttgc
//
