LOCUS       NM_003134               1119 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens signal recognition particle 14 (SRP14), transcript
            variant 1, mRNA.
ACCESSION   NM_003134
VERSION     NM_003134.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1119)
  AUTHORS   Tian,H., Tang,D., Ma,M. and Fu,X.
  TITLE     Expression of signal recognition particle 14 in hepatocellular
            carcinoma and its relationship with disease progression and patient
            survival
  JOURNAL   Zhejiang Da Xue Xue Bao Yi Xue Ban 53 (4), 460-471 (2024)
   PUBMED   39183055
  REMARK    GeneRIF: Expression of signal recognition particle 14 in
            hepatocellular carcinoma and its relationship with disease
            progression and patient survival.
REFERENCE   2  (bases 1 to 1119)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   3  (bases 1 to 1119)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 1119)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 1119)
  AUTHORS   Fasci,D., van Ingen,H., Scheltema,R.A. and Heck,A.J.R.
  TITLE     Histone Interaction Landscapes Visualized by Crosslinking Mass
            Spectrometry in Intact Cell Nuclei
  JOURNAL   Mol Cell Proteomics 17 (10), 2018-2033 (2018)
   PUBMED   30021884
REFERENCE   6  (bases 1 to 1119)
  AUTHORS   Bovia,F., Wolff,N., Ryser,S. and Strub,K.
  TITLE     The SRP9/14 subunit of the human signal recognition particle binds
            to a variety of Alu-like RNAs and with higher affinity than its
            mouse homolog
  JOURNAL   Nucleic Acids Res 25 (2), 318-326 (1997)
   PUBMED   9016560
REFERENCE   7  (bases 1 to 1119)
  AUTHORS   Bovia,F., Fornallaz,M., Leffers,H. and Strub,K.
  TITLE     The SRP9/14 subunit of the signal recognition particle (SRP) is
            present in more than 20-fold excess over SRP in primate cells and
            exists primarily free but also in complex with small cytoplasmic
            Alu RNAs
  JOURNAL   Mol Biol Cell 6 (4), 471-484 (1995)
   PUBMED   7542942
REFERENCE   8  (bases 1 to 1119)
  AUTHORS   Chang,D.Y., Nelson,B., Bilyeu,T., Hsu,K., Darlington,G.J. and
            Maraia,R.J.
  TITLE     A human Alu RNA-binding protein whose expression is associated with
            accumulation of small cytoplasmic Alu RNA
  JOURNAL   Mol Cell Biol 14 (6), 3949-3959 (1994)
   PUBMED   8196634
REFERENCE   9  (bases 1 to 1119)
  AUTHORS   Strub,K. and Walter,P.
  TITLE     Assembly of the Alu domain of the signal recognition particle
            (SRP): dimerization of the two protein components is required for
            efficient binding to SRP RNA
  JOURNAL   Mol Cell Biol 10 (2), 777-784 (1990)
   PUBMED   2153922
REFERENCE   10 (bases 1 to 1119)
  AUTHORS   Strub,K. and Walter,P.
  TITLE     Isolation of a cDNA clone of the 14-kDa subunit of the signal
            recognition particle by cross-hybridization of differently primed
            polymerase chain reactions
  JOURNAL   Proc Natl Acad Sci U S A 86 (24), 9747-9751 (1989)
   PUBMED   2557625
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA338824.1, BC035495.2 and CV575824.1.
            
            On May 17, 2019 this sequence version replaced NM_003134.5.
            
            Transcript Variant: This variant (1) represents the shorter
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803614.253584.1,
                                           SRR1803613.107874.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1966682, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000267884.11/ ENSP00000267884.6
            RefSeq Select criteria :: based on expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-193               DA338824.1         22-214
            194-768             BC035495.2         171-745
            769-1119            CV575824.1         77-427
FEATURES             Location/Qualifiers
     source          1..1119
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="15"
                     /map="15q15.1"
     gene            1..1119
                     /gene="SRP14"
                     /gene_synonym="ALURBP"
                     /note="signal recognition particle 14"
                     /db_xref="GeneID:6727"
                     /db_xref="HGNC:HGNC:11299"
                     /db_xref="MIM:600708"
     exon            1..89
                     /gene="SRP14"
                     /gene_synonym="ALURBP"
                     /inference="alignment:Splign:2.1.0"
     CDS             66..476
                     /gene="SRP14"
                     /gene_synonym="ALURBP"
                     /note="isoform 1 is encoded by transcript variant 1;
                     homologous Alu RNA binding protein; 18 kDa Alu RNA-binding
                     protein"
                     /codon_start=1
                     /product="signal recognition particle 14 kDa protein
                     isoform 1"
                     /protein_id="NP_003125.3"
                     /db_xref="CCDS:CCDS42017.1"
                     /db_xref="GeneID:6727"
                     /db_xref="HGNC:HGNC:11299"
                     /db_xref="MIM:600708"
                     /translation="MVLLESEQFLTELTRLFQKCRTSGSVYITLKKYDGRTKPIPKKG
                     TVEGFEPADNKCLLRATDGKKKISTVVSSKEVNKFQMAYSNLLRANMDGLKKRDKKNK
                     TKKTKAAAAAAAAAPAAAATAPTTAATTAATAAQ"
     exon            90..162
                     /gene="SRP14"
                     /gene_synonym="ALURBP"
                     /inference="alignment:Splign:2.1.0"
     exon            163..275
                     /gene="SRP14"
                     /gene_synonym="ALURBP"
                     /inference="alignment:Splign:2.1.0"
     exon            276..308
                     /gene="SRP14"
                     /gene_synonym="ALURBP"
                     /inference="alignment:Splign:2.1.0"
     exon            309..1119
                     /gene="SRP14"
                     /gene_synonym="ALURBP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      748..753
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SRP14"
                     /gene_synonym="ALURBP"
                     /note="hexamer: ATTAAA"
     polyA_site      768
                     /gene="SRP14"
                     /gene_synonym="ALURBP"
                     /note="major polyA site"
     regulatory      1051..1056
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SRP14"
                     /gene_synonym="ALURBP"
                     /note="hexamer: AATAAA"
     polyA_site      1069
                     /gene="SRP14"
                     /gene_synonym="ALURBP"
                     /note="major polyA site"
ORIGIN      
        1 aggccgaact tccggctctc actgctaggg gcttaagcgg agggagtcga gccagcgtcg
       61 ccgcgatggt gttgttggag agcgagcagt tcctgacgga gctgaccaga cttttccaga
      121 agtgccggac gtcgggcagc gtctatatca ccttgaagaa gtatgacggt cgaaccaaac
      181 ccattccaaa gaagggtact gtggagggct ttgagcccgc agacaacaag tgtctgttaa
      241 gagctaccga tgggaagaag aagatcagca ctgtggtgag ctccaaggaa gtgaataagt
      301 ttcagatggc ttattcaaac ctccttagag ctaacatgga tgggctgaag aagagagaca
      361 aaaagaacaa aactaagaag accaaagcag cagcagcagc agcagcagca gcacctgccg
      421 cagcagcaac agcaccaaca acagcagcaa caacagcagc aacagcagca cagtaaaggg
      481 catacatttc ctgctttcac caattaacca ctgaattgct attttttcct tttggccaga
      541 tagctaggtt tctggttccc ccacagtagg tgttttcaca taagattagg gtccttttgg
      601 aaagaatagt tgcagtgttt ataggatagt tgtggtaaga atctagttta ttttgcattt
      661 ggctaattgg tctgtgctgc atggttatat actcctggat tatagattaa aagtctctgt
      721 agacatctct gtgaagagca agctatcatt aaacatgtct gtttatcagc actgtctctt
      781 tattcctttc ccaacccatt ttaatagttc tggcaataac tactaaatct agaatgatgt
      841 gattaatgaa taggctttag ctctataata tcttctaggt tattagaatt gaaacctgac
      901 agttttataa aaagtcatgt tatctcatga gctgcttccc acctggctgt ataattttat
      961 catcatggtt ccccagtttc gatgagttct cacagtcaaa tgagagtttg tttaaccacc
     1021 ttaggagaaa catactacaa agtcatcaag aataaaggtt ccaaagtaat tatgattttt
     1081 ggtttcttta tgccctttgg tttggatatt ttcatgtgc
//
