LOCUS       NM_080823               4082 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens src-related kinase lacking C-terminal regulatory
            tyrosine and N-terminal myristylation sites (SRMS), mRNA.
ACCESSION   NM_080823
VERSION     NM_080823.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4082)
  AUTHORS   Seo,S.U., Woo,S.M., Kim,M.W., Lee,E.W., Min,K.J. and Kwon,T.K.
  TITLE     Phosphorylation of OTUB1 at Tyr 26 stabilizes the mTORC1 component,
            Raptor
  JOURNAL   Cell Death Differ 30 (1), 82-93 (2023)
   PUBMED   35927303
REFERENCE   2  (bases 1 to 4082)
  AUTHORS   Park,J.M., Yang,S.W., Zhuang,W., Bera,A.K., Liu,Y., Gurbani,D., von
            Hoyningen-Huene,S.J., Sakurada,S.M., Gan,H., Pruett-Miller,S.M.,
            Westover,K.D. and Potts,M.B.
  TITLE     The nonreceptor tyrosine kinase SRMS inhibits autophagy and
            promotes tumor growth by phosphorylating the scaffolding protein
            FKBP51
  JOURNAL   PLoS Biol 19 (6), e3001281 (2021)
   PUBMED   34077419
  REMARK    GeneRIF: The nonreceptor tyrosine kinase SRMS inhibits autophagy
            and promotes tumor growth by phosphorylating the scaffolding
            protein FKBP51.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4082)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 4082)
  AUTHORS   Goel,R.K., Paczkowska,M., Reimand,J., Napper,S. and Lukong,K.E.
  TITLE     Phosphoproteomics Analysis Identifies Novel Candidate Substrates of
            the Nonreceptor Tyrosine Kinase, Src-related Kinase Lacking
            C-terminal Regulatory Tyrosine and N-terminal Myristoylation Sites
            (SRMS)
  JOURNAL   Mol Cell Proteomics 17 (5), 925-947 (2018)
   PUBMED   29496907
  REMARK    GeneRIF: Vimentin and Sam68, are identified as bona fide SRMS
            substrates through in vitro and in vivo assays.
REFERENCE   5  (bases 1 to 4082)
  AUTHORS   Fan,G., Aleem,S., Yang,M., Miller,W.T. and Tonks,N.K.
  TITLE     Protein-tyrosine Phosphatase and Kinase Specificity in Regulation
            of SRC and Breast Tumor Kinase
  JOURNAL   J Biol Chem 290 (26), 15934-15947 (2015)
   PUBMED   25897081
  REMARK    GeneRIF: SRMS phosphorylated the C terminus of BRK, but not SRC.
REFERENCE   6  (bases 1 to 4082)
  AUTHORS   Goel,R.K., Miah,S., Black,K., Kalra,N., Dai,C. and Lukong,K.E.
  TITLE     The unique N-terminal region of SRMS regulates enzymatic activity
            and phosphorylation of its novel substrate docking protein 1
  JOURNAL   FEBS J 280 (18), 4539-4559 (2013)
   PUBMED   23822091
  REMARK    GeneRIF: The unique N-terminal region of SRMS regulates enzymatic
            activity and phosphorylation of its novel substrate docking protein
            1.
REFERENCE   7  (bases 1 to 4082)
  AUTHORS   Eeles,R.A., Olama,A.A., Benlloch,S., Saunders,E.J.,
            Leongamornlert,D.A., Tymrakiewicz,M., Ghoussaini,M., Luccarini,C.,
            Dennis,J., Jugurnauth-Little,S., Dadaev,T., Neal,D.E., Hamdy,F.C.,
            Donovan,J.L., Muir,K., Giles,G.G., Severi,G., Wiklund,F.,
            Gronberg,H., Haiman,C.A., Schumacher,F., Henderson,B.E., Le
            Marchand,L., Lindstrom,S., Kraft,P., Hunter,D.J., Gapstur,S.,
            Chanock,S.J., Berndt,S.I., Albanes,D., Andriole,G., Schleutker,J.,
            Weischer,M., Canzian,F., Riboli,E., Key,T.J., Travis,R.C.,
            Campa,D., Ingles,S.A., John,E.M., Hayes,R.B., Pharoah,P.D.,
            Pashayan,N., Khaw,K.T., Stanford,J.L., Ostrander,E.A.,
            Signorello,L.B., Thibodeau,S.N., Schaid,D., Maier,C., Vogel,W.,
            Kibel,A.S., Cybulski,C., Lubinski,J., Cannon-Albright,L.,
            Brenner,H., Park,J.Y., Kaneva,R., Batra,J., Spurdle,A.B.,
            Clements,J.A., Teixeira,M.R., Dicks,E., Lee,A., Dunning,A.M.,
            Baynes,C., Conroy,D., Maranian,M.J., Ahmed,S., Govindasami,K.,
            Guy,M., Wilkinson,R.A., Sawyer,E.J., Morgan,A., Dearnaley,D.P.,
            Horwich,A., Huddart,R.A., Khoo,V.S., Parker,C.C., Van As,N.J.,
            Woodhouse,C.J., Thompson,A., Dudderidge,T., Ogden,C., Cooper,C.S.,
            Lophatananon,A., Cox,A., Southey,M.C., Hopper,J.L., English,D.R.,
            Aly,M., Adolfsson,J., Xu,J., Zheng,S.L., Yeager,M., Kaaks,R.,
            Diver,W.R., Gaudet,M.M., Stern,M.C., Corral,R., Joshi,A.D.,
            Shahabi,A., Wahlfors,T., Tammela,T.L., Auvinen,A., Virtamo,J.,
            Klarskov,P., Nordestgaard,B.G., Roder,M.A., Nielsen,S.F.,
            Bojesen,S.E., Siddiq,A., Fitzgerald,L.M., Kolb,S., Kwon,E.M.,
            Karyadi,D.M., Blot,W.J., Zheng,W., Cai,Q., McDonnell,S.K.,
            Rinckleb,A.E., Drake,B., Colditz,G., Wokolorczyk,D.,
            Stephenson,R.A., Teerlink,C., Muller,H., Rothenbacher,D.,
            Sellers,T.A., Lin,H.Y., Slavov,C., Mitev,V., Lose,F.,
            Srinivasan,S., Maia,S., Paulo,P., Lange,E., Cooney,K.A.,
            Antoniou,A.C., Vincent,D., Bacot,F., Tessier,D.C., Kote-Jarai,Z.
            and Easton,D.F.
  CONSRTM   COGS-Cancer Research UK GWAS-ELLIPSE (part of GAME-ON) Initiative;
            Australian Prostate Cancer Bioresource; UK Genetic Prostate Cancer
            Study Collaborators/British Association of Urological Surgeons'
            Section of Oncology; UK ProtecT (Prostate testing for cancer and
            Treatment) Study Collaborators; PRACTICAL (Prostate Cancer
            Association Group to Investigate Cancer-Associated Alterations in
            the Genome) Consortium
  TITLE     Identification of 23 new prostate cancer susceptibility loci using
            the iCOGS custom genotyping array
  JOURNAL   Nat Genet 45 (4), 385-391 (2013)
   PUBMED   23535732
REFERENCE   8  (bases 1 to 4082)
  AUTHORS   Deloukas,P., Matthews,L.H., Ashurst,J., Burton,J., Gilbert,J.G.,
            Jones,M., Stavrides,G., Almeida,J.P., Babbage,A.K., Bagguley,C.L.,
            Bailey,J., Barlow,K.F., Bates,K.N., Beard,L.M., Beare,D.M.,
            Beasley,O.P., Bird,C.P., Blakey,S.E., Bridgeman,A.M., Brown,A.J.,
            Buck,D., Burrill,W., Butler,A.P., Carder,C., Carter,N.P.,
            Chapman,J.C., Clamp,M., Clark,G., Clark,L.N., Clark,S.Y.,
            Clee,C.M., Clegg,S., Cobley,V.E., Collier,R.E., Connor,R.,
            Corby,N.R., Coulson,A., Coville,G.J., Deadman,R., Dhami,P.,
            Dunn,M., Ellington,A.G., Frankland,J.A., Fraser,A., French,L.,
            Garner,P., Grafham,D.V., Griffiths,C., Griffiths,M.N., Gwilliam,R.,
            Hall,R.E., Hammond,S., Harley,J.L., Heath,P.D., Ho,S., Holden,J.L.,
            Howden,P.J., Huckle,E., Hunt,A.R., Hunt,S.E., Jekosch,K.,
            Johnson,C.M., Johnson,D., Kay,M.P., Kimberley,A.M., King,A.,
            Knights,A., Laird,G.K., Lawlor,S., Lehvaslaiho,M.H., Leversha,M.,
            Lloyd,C., Lloyd,D.M., Lovell,J.D., Marsh,V.L., Martin,S.L.,
            McConnachie,L.J., McLay,K., McMurray,A.A., Milne,S., Mistry,D.,
            Moore,M.J., Mullikin,J.C., Nickerson,T., Oliver,K., Parker,A.,
            Patel,R., Pearce,T.A., Peck,A.I., Phillimore,B.J.,
            Prathalingam,S.R., Plumb,R.W., Ramsay,H., Rice,C.M., Ross,M.T.,
            Scott,C.E., Sehra,H.K., Shownkeen,R., Sims,S., Skuce,C.D.,
            Smith,M.L., Soderlund,C., Steward,C.A., Sulston,J.E., Swann,M.,
            Sycamore,N., Taylor,R., Tee,L., Thomas,D.W., Thorpe,A., Tracey,A.,
            Tromans,A.C., Vaudin,M., Wall,M., Wallis,J.M., Whitehead,S.L.,
            Whittaker,P., Willey,D.L., Williams,L., Williams,S.A., Wilming,L.,
            Wray,P.W., Hubbard,T., Durbin,R.M., Bentley,D.R., Beck,S. and
            Rogers,J.
  TITLE     The DNA sequence and comparative analysis of human chromosome 20
  JOURNAL   Nature 414 (6866), 865-871 (2001)
   PUBMED   11780052
REFERENCE   9  (bases 1 to 4082)
  AUTHORS   Kohmura,N., Yagi,T., Tomooka,Y., Oyanagi,M., Kominami,R.,
            Takeda,N., Chiba,J., Ikawa,Y. and Aizawa,S.
  TITLE     A novel nonreceptor tyrosine kinase, Srm: cloning and targeted
            disruption
  JOURNAL   Mol Cell Biol 14 (10), 6915-6925 (1994)
   PUBMED   7935409
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL121829.30.
            
            On Sep 25, 2020 this sequence version replaced NM_080823.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR18074969.3523403.1,
                                           SRR18074967.1489375.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1968540,
                                           SAMEA1968968 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000217188.2/ ENSP00000217188.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-642               AL121829.30        76113-76754         c
            643-764             AL121829.30        73232-73353         c
            765-931             AL121829.30        72319-72485         c
            932-1073            AL121829.30        71445-71586         c
            1074-1232           AL121829.30        71168-71326         c
            1233-1414           AL121829.30        70444-70625         c
            1415-1571           AL121829.30        70196-70352         c
            1572-4082           AL121829.30        67494-70004         c
FEATURES             Location/Qualifiers
     source          1..4082
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="20"
                     /map="20q13.33"
     gene            1..4082
                     /gene="SRMS"
                     /gene_synonym="C20orf148; dJ697K14.1; PTK70; SRM"
                     /note="src-related kinase lacking C-terminal regulatory
                     tyrosine and N-terminal myristylation sites"
                     /db_xref="GeneID:6725"
                     /db_xref="HGNC:HGNC:11298"
                     /db_xref="MIM:617797"
     exon            1..642
                     /gene="SRMS"
                     /gene_synonym="C20orf148; dJ697K14.1; PTK70; SRM"
                     /inference="alignment:Splign:2.1.0"
     CDS             287..1753
                     /gene="SRMS"
                     /gene_synonym="C20orf148; dJ697K14.1; PTK70; SRM"
                     /EC_number="2.7.10.2"
                     /codon_start=1
                     /product="tyrosine-protein kinase Srms"
                     /protein_id="NP_543013.1"
                     /db_xref="CCDS:CCDS13525.1"
                     /db_xref="GeneID:6725"
                     /db_xref="HGNC:HGNC:11298"
                     /db_xref="MIM:617797"
                     /translation="MEPFLRRRLAFLSFFWDKIWPAGGEPDHGTPGSLDPNTDPVPTL
                     PAEPCSPFPQLFLALYDFTARCGGELSVRRGDRLCALEEGGGYIFARRLSGQPSAGLV
                     PITHVAKASPETLSDQPWYFSGVSRTQAQQLLLSPPNEPGAFLIRPSESSLGGYSLSV
                     RAQAKVCHYRVSMAADGSLYLQKGRLFPGLEELLTYYKANWKLIQNPLLQPCMPQKAP
                     RQDVWERPHSEFALGRKLGEGYFGEVWEGLWLGSLPVAIKVIKSANMKLTDLAKEIQT
                     LKGLRHERLIRLHAVCSGGEPVYIVTELMRKGNLQAFLGTPEGRALRLPPLLGFACQV
                     AEGMSYLEEQRVVHRDLAARNVLVDDGLACKVADFGLARLLKDDIYSPSSSSKIPVKW
                     TAPEAANYRVFSQKSDVWSFGVLLHEVFTYGQCPYEGMTNHETLQQIMRGYRLPRPAA
                     CPAEVYVLMLECWRSSPEERPSFATLREKLHAIHRCHP"
     exon            643..764
                     /gene="SRMS"
                     /gene_synonym="C20orf148; dJ697K14.1; PTK70; SRM"
                     /inference="alignment:Splign:2.1.0"
     exon            765..931
                     /gene="SRMS"
                     /gene_synonym="C20orf148; dJ697K14.1; PTK70; SRM"
                     /inference="alignment:Splign:2.1.0"
     exon            932..1073
                     /gene="SRMS"
                     /gene_synonym="C20orf148; dJ697K14.1; PTK70; SRM"
                     /inference="alignment:Splign:2.1.0"
     exon            1074..1232
                     /gene="SRMS"
                     /gene_synonym="C20orf148; dJ697K14.1; PTK70; SRM"
                     /inference="alignment:Splign:2.1.0"
     exon            1233..1414
                     /gene="SRMS"
                     /gene_synonym="C20orf148; dJ697K14.1; PTK70; SRM"
                     /inference="alignment:Splign:2.1.0"
     exon            1415..1571
                     /gene="SRMS"
                     /gene_synonym="C20orf148; dJ697K14.1; PTK70; SRM"
                     /inference="alignment:Splign:2.1.0"
     exon            1572..4082
                     /gene="SRMS"
                     /gene_synonym="C20orf148; dJ697K14.1; PTK70; SRM"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4057..4062
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SRMS"
                     /gene_synonym="C20orf148; dJ697K14.1; PTK70; SRM"
                     /note="hexamer: AATAAA"
     polyA_site      4082
                     /gene="SRMS"
                     /gene_synonym="C20orf148; dJ697K14.1; PTK70; SRM"
                     /note="major polyA site"
ORIGIN      
        1 gcactccaga cgccaaggag gtcgaggaca ggaggtgctg tcggtgtgcc tgaggcaggg
       61 ggtccgccct gcgccccacc cagccccaac gccagcccgg acgccggtgg gaaccgtgtg
      121 cctcctggat ccaggggacc tctgagtgac cgcagggccg gggtcccctg tcaccccacg
      181 gccagggcag ggagcgctgg acaccgggtc ccaccggccc tgccagttcc tcttccgggc
      241 tcgcgggctc ccatggccct cgggcccagc gtggtgaccc cgggggatgg agccgttcct
      301 caggaggcgg ctggccttcc tgtccttctt ctgggacaag atctggccgg cgggcggcga
      361 gccggaccat ggcacccccg ggtccctgga ccccaacact gacccagtgc ccacgctccc
      421 cgccgagcct tgcagcccct tccctcagct cttccttgcg ctctatgact tcacggcgcg
      481 gtgtggcggg gagctgagtg tccgccgcgg ggacaggctc tgtgccctcg aagagggggg
      541 cggctacatc ttcgcacgca ggctttcggg ccagcccagc gccgggctcg tgcccatcac
      601 ccacgtggcc aaggcttctc ctgagacgct ctcagaccaa ccctggtact ttagcggggt
      661 cagtcggacc caggcacagc agctgctcct ctccccaccc aacgaaccag gggccttcct
      721 catccggccc agcgagagca gcctcggggg ctactcactg tcagtccggg cccaggccaa
      781 ggtctgccac taccgggtct ccatggcagc tgatggcagc ctctacctgc agaagggacg
      841 gctctttccc ggcctggagg agctgctcac ctactacaag gccaactgga agctgatcca
      901 gaaccccctg ctgcagccct gcatgcccca gaaggccccg aggcaggacg tgtgggagcg
      961 gccacactcc gaattcgccc ttgggaggaa gctgggtgaa ggctactttg gggaggtgtg
     1021 ggaaggcctg tggctgggct ccctgcccgt ggcgatcaag gtcatcaagt cagccaacat
     1081 gaagctcact gacctcgcca aggagatcca gacactgaag ggcctgcggc acgagcggct
     1141 catccggctg cacgcagtgt gctcgggcgg ggagcctgtg tacatcgtca cggaactcat
     1201 gcgcaagggg aacctgcagg ccttcctggg cacccccgag ggccgggccc tgcgtctgcc
     1261 gccactcctg ggctttgcct gccaggtggc tgagggcatg agctacctgg aggagcagcg
     1321 cgttgtgcac cgggacttgg ccgcccggaa cgtgctcgtg gacgacggcc tggcctgcaa
     1381 ggtggctgac ttcggcctgg cccggctgct caaggacgac atctactccc cgagcagcag
     1441 ctccaagatc ccggtcaagt ggacagcgcc tgaggcggcc aattatcgtg tcttctccca
     1501 gaagtcagac gtctggtcct tcggcgtcct gctgcacgag gttttcacct atggccagtg
     1561 tccctatgaa gggatgacca accacgagac gctgcagcag atcatgcgag ggtaccggct
     1621 gccgcgcccg gctgcctgcc cggcggaggt ctacgtgctc atgctggagt gctggaggag
     1681 cagccccgag gaacggccct ccttcgccac gctgcgggag aagctgcacg ccatccacag
     1741 atgccacccc tgagtcctca cgtgacccaa cgctctgggc tccagccagg ccagcccctc
     1801 ctccctgcag agcgccaact cgaagggatg ccggtctgcc ggaccgagga gcctctggct
     1861 gtgggcctca ggccctggcg tgcacacatg ttcgtgcacc aggcagacgt gcagacggag
     1921 ggctggggct gacgtccccc gtgcagtgtg actcgtgcag acggagggct ggggctgacg
     1981 tcccccatgc agtgtgactc gtgcagacga agggctgggg ctgacgttcc ccgtgcagtg
     2041 tgactcgtgc agacggaggg ctggggctga cgttccccgt gcagtgtgac acgtgtccct
     2101 ggcctctcaa gagagacaac ggcacaggag ggtgggtaga agcctcggag gctctgggtg
     2161 aggaaccctg agccctgtgt gtctcctgcc tgggtcccct ggactccctc ccagggtgaa
     2221 gagccaaagg cccagttctc tccctagtcc cagcttgggt ttgtggaaat gaccagtgct
     2281 gactcccagg cagaccgtgg tgttgacccc actggatgtg tggtatgtag gcacggggtg
     2341 gcaccgtcac ctgcccctca cagacacact ggcggcctgt gcacaaaccc actcacgcac
     2401 acagcactca gtaagccggg actgacccac tcagacacgc acacaggcgc acatcacaca
     2461 caggctcagc cccccaaacc cagacccagg agctggagcg tacgggtcca cgtggctaga
     2521 aaatgcaggt tggagcggcc cccatgccgc ccggaccccc agcccaggac atcatggtgc
     2581 ccagagagcg tgagccccaa gggcattggc aggagctgcc gattccatct ccctgggtgg
     2641 gttccaggtg gcacaggaag ggtgggccgg gaggcttggt gacctgggag ctgcccttgg
     2701 aggctatttc caggggcctc agggtgggcc gtgggggatt tggagtcttc tgcctgtgca
     2761 gggtcaggca gggtcggttg ggggctcgga ggtagatgcc atggtatgct gggcagcaag
     2821 tggctcagga agcctctggg tgtgagtcct cgggggtcac caaggcagga gggggcaggg
     2881 atgtgcaggg tccgccctcg tctccccacg tctggctcag ggaagcttct gctcaggtct
     2941 tcgtgaaaca cgtcaagaag caagggggcc ggtggggtct gtttgtggcc cccggagacc
     3001 ctgcccccca ccctcctggg agcccaggtt ggcagctgtg cccagaaggc tttcggggac
     3061 agaaagtttg gagacaagtt caggcctgac tgagtccttg tcccctagag ttggggtcag
     3121 ctctgtacct gctgagccga agtgctgatg gctgccgtcc acaggccccg gccaaagcct
     3181 ggctcaggag ggagctaaga gatgagactc ccgtgtgcag agacaggtgg ccccggggaa
     3241 ggaagaggcc actcggaggc tccgagaacg gaggcagcgc gggggcttcc tggggcccgt
     3301 gcatcggagg aacaaggcca agcggaggga agcagcagga accaggaccc ctgcagatgg
     3361 tggaggcaag aggctttatc tgagcctttg ggaccctggc cacctgccca gctccatctg
     3421 catgggagaa cctaggggag gggctggttc tggtacctgg gcccactgag gccttgagct
     3481 gagcttccag ttctggcagg tccccagcac agcagcctgg gggctcctct ggcacagaag
     3541 gcctcgccct ctgtgctctc tgcagccgcc actgggatta aggggaccag gtgtgtctgt
     3601 ggcacctgtg ccctcctagg catctcgcca gccaccagct gaacaggttt ggtgctcctg
     3661 ggtatctggg aggggctggg gacgttcctg cctcctggtg tggcttagac tgaaagtcct
     3721 gcacgtccga actcagggat actcgaggct tcctggacat agactcacgg gcccagagtc
     3781 tggccgggct ctgagggacg ctgcccggcc aggtgccccg gcaccctcct tccgcattcc
     3841 ccacccccca cccctccccc tgcatcctcc ccaaccgacc ccagacagag ctgggagggc
     3901 ctgagggaca ctgcccaggc cggcaccccg ctgcccctcc ccaccttggt cagcgctgag
     3961 ctgggctgcc cagaaatcta tgagcctgtt aaataatcca gattattgtt cttaatctca
     4021 aaacaatgag tggaaggtgc cattatttct ctttgcaata aaaataaaag ttgaaatacg
     4081 ca
//
