LOCUS       NM_003130               1972 bp    mRNA    linear   PRI 02-MAR-2025
DEFINITION  Homo sapiens sorcin (SRI), transcript variant 1, mRNA.
ACCESSION   NM_003130
VERSION     NM_003130.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1972)
  AUTHORS   Zhang,H., Hu,S., Sanches,J.G.P., Li,Y., Wei,Y., Pu,C. and Zhang,J.
  TITLE     Sorcin promotes proliferation of hepatocellular carcinoma by
            regulating VEGFA/B via PI3K pathway
  JOURNAL   J Physiol Biochem 80 (2), 381-392 (2024)
   PUBMED   38536659
  REMARK    GeneRIF: Sorcin promotes proliferation of hepatocellular carcinoma
            by regulating VEGFA/B via PI3K pathway.
REFERENCE   2  (bases 1 to 1972)
  AUTHORS   Zhang,J., Guan,W., Xu,X., Wang,F., Li,X. and Xu,G.
  TITLE     A novel homeostatic loop of sorcin drives paclitaxel-resistance and
            malignant progression via Smad4/ZEB1/miR-142-5p in human ovarian
            cancer
  JOURNAL   Oncogene 40 (30), 4906-4918 (2021)
   PUBMED   34163033
  REMARK    GeneRIF: A novel homeostatic loop of sorcin drives
            paclitaxel-resistance and malignant progression via
            Smad4/ZEB1/miR-142-5p in human ovarian cancer.
REFERENCE   3  (bases 1 to 1972)
  AUTHORS   Parks,S.Z., Gao,T., Jimenez Awuapura,N., Ayathamattam,J.,
            Chabosseau,P.L., Kalvakolanu,D.V., Valdivia,H.H., Rutter,G.A. and
            Leclerc,I.
  TITLE     The Ca2+ -binding protein sorcin stimulates transcriptional
            activity of the unfolded protein response mediator ATF6
  JOURNAL   FEBS Lett 595 (13), 1782-1796 (2021)
   PUBMED   33960419
  REMARK    GeneRIF: The Ca(2+) -binding protein sorcin stimulates
            transcriptional activity of the unfolded protein response mediator
            ATF6.
REFERENCE   4  (bases 1 to 1972)
  AUTHORS   Berrocal,M., Saez,L. and Mata,A.M.
  TITLE     Sorcin Activates the Brain PMCA and Blocks the Inhibitory Effects
            of Molecular Markers of Alzheimer's Disease on the Pump Activity
  JOURNAL   Int J Mol Sci 22 (11), 6055 (2021)
   PUBMED   34205207
  REMARK    GeneRIF: Sorcin Activates the Brain PMCA and Blocks the Inhibitory
            Effects of Molecular Markers of Alzheimer's Disease on the Pump
            Activity.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1972)
  AUTHORS   Genovese,I., Giamogante,F., Barazzuol,L., Battista,T., Fiorillo,A.,
            Vicario,M., D'Alessandro,G., Cipriani,R., Limatola,C., Rossi,D.,
            Sorrentino,V., Poser,E., Mosca,L., Squitieri,F., Perluigi,M.,
            Arena,A., van Petegem,F., Tito,C., Fazi,F., Giorgi,C., Cali,T.,
            Ilari,A. and Colotti,G.
  TITLE     Sorcin is an early marker of neurodegeneration, Ca2+ dysregulation
            and endoplasmic reticulum stress associated to neurodegenerative
            diseases
  JOURNAL   Cell Death Dis 11 (10), 861 (2020)
   PUBMED   33060591
  REMARK    GeneRIF: Sorcin is an early marker of neurodegeneration, Ca(2+)
            dysregulation and endoplasmic reticulum stress associated to
            neurodegenerative diseases.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1972)
  AUTHORS   Meyers,M.B., Pickel,V.M., Sheu,S.S., Sharma,V.K., Scotto,K.W. and
            Fishman,G.I.
  TITLE     Association of sorcin with the cardiac ryanodine receptor
  JOURNAL   J Biol Chem 270 (44), 26411-26418 (1995)
   PUBMED   7592856
REFERENCE   7  (bases 1 to 1972)
  AUTHORS   Wang,S.L., Tam,M.F., Ho,Y.S., Pai,S.H. and Kao,M.C.
  TITLE     Isolation and molecular cloning of human sorcin a calcium-binding
            protein in vincristine-resistant HOB1 lymphoma cells
  JOURNAL   Biochim Biophys Acta 1260 (3), 285-293 (1995)
   PUBMED   7873602
REFERENCE   8  (bases 1 to 1972)
  AUTHORS   Meyers,M.B., Zamparelli,C., Verzili,D., Dicker,A.P., Blanck,T.J.
            and Chiancone,E.
  TITLE     Calcium-dependent translocation of sorcin to membranes: functional
            relevance in contractile tissue
  JOURNAL   FEBS Lett 357 (3), 230-234 (1995)
   PUBMED   7835417
REFERENCE   9  (bases 1 to 1972)
  AUTHORS   Rasmussen,H.H., van Damme,J., Puype,M., Gesser,B., Celis,J.E. and
            Vandekerckhove,J.
  TITLE     Microsequences of 145 proteins recorded in the two-dimensional gel
            protein database of normal human epidermal keratinocytes
  JOURNAL   Electrophoresis 13 (12), 960-969 (1992)
   PUBMED   1286667
REFERENCE   10 (bases 1 to 1972)
  AUTHORS   Van der Bliek,A.M., Baas,F., Van der Velde-Koerts,T., Biedler,J.L.,
            Meyers,M.B., Ozols,R.F., Hamilton,T.C., Joenje,H. and Borst,P.
  TITLE     Genes amplified and overexpressed in human multidrug-resistant cell
            lines
  JOURNAL   Cancer Res 48 (21), 5927-5932 (1988)
   PUBMED   2901906
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA268050.1, AK129770.1,
            AK295225.1, AL117616.1, DB540255.1 and AC005075.2.
            
            On Dec 4, 2019 this sequence version replaced NM_003130.3.
            
            Summary: This gene encodes a calcium-binding protein with multiple
            E-F hand domains that relocates from the cytoplasm to the
            sarcoplasmic reticulum in response to elevated calcium levels. In
            addition to regulating intracellular calcium homeostasis it also
            modulates excitation-contraction coupling in the heart. Alternative
            splicing results in multiple transcript variants encoding distinct
            proteins. Multiple pseudogenes exist for this gene. [provided by
            RefSeq, Mar 2012].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (A).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: M32886.1, SRR5189661.90355.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000265729.7/ ENSP00000265729.3
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-519               DA268050.1         47-565
            520-796             AK129770.1         535-811
            797-932             AK295225.1         676-811
            933-1910            AL117616.1         124-1101
            1911-1911           DB540255.1         424-424
            1912-1970           AL117616.1         1103-1161
            1971-1972           AC005075.2         111177-111178       c
FEATURES             Location/Qualifiers
     source          1..1972
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q21.12"
     gene            1..1972
                     /gene="SRI"
                     /gene_synonym="CP-22; CP22; SCN; V19"
                     /note="sorcin"
                     /db_xref="GeneID:6717"
                     /db_xref="HGNC:HGNC:11292"
                     /db_xref="MIM:182520"
     exon            1..63
                     /gene="SRI"
                     /gene_synonym="CP-22; CP22; SCN; V19"
                     /inference="alignment:Splign:2.1.0"
     CDS             13..609
                     /gene="SRI"
                     /gene_synonym="CP-22; CP22; SCN; V19"
                     /note="isoform A is encoded by transcript variant 1;
                     H_RG167B05.1; calcium binding protein amplified in
                     mutlidrug-resistant cells; 22 kDa protein"
                     /codon_start=1
                     /product="sorcin isoform A"
                     /protein_id="NP_003121.1"
                     /db_xref="CCDS:CCDS5612.1"
                     /db_xref="GeneID:6717"
                     /db_xref="HGNC:HGNC:11292"
                     /db_xref="MIM:182520"
                     /translation="MAYPGHPGAGGGYYPGGYGGAPGGPAFPGQTQDPLYGYFAAVAG
                     QDGQIDADELQRCLTQSGIAGGYKPFNLETCRLMVSMLDRDMSGTMGFNEFKELWAVL
                     NGWRQHFISFDTDRSGTVDPQELQKALTTMGFRLSPQAVNSIAKRYSTNGKITFDDYI
                     ACCVKLRALTDSFRRRDTAQQGVVNFPYDDFIQCVMSV"
     exon            64..147
                     /gene="SRI"
                     /gene_synonym="CP-22; CP22; SCN; V19"
                     /inference="alignment:Splign:2.1.0"
     exon            148..217
                     /gene="SRI"
                     /gene_synonym="CP-22; CP22; SCN; V19"
                     /inference="alignment:Splign:2.1.0"
     exon            218..261
                     /gene="SRI"
                     /gene_synonym="CP-22; CP22; SCN; V19"
                     /inference="alignment:Splign:2.1.0"
     exon            262..409
                     /gene="SRI"
                     /gene_synonym="CP-22; CP22; SCN; V19"
                     /inference="alignment:Splign:2.1.0"
     exon            410..523
                     /gene="SRI"
                     /gene_synonym="CP-22; CP22; SCN; V19"
                     /inference="alignment:Splign:2.1.0"
     exon            524..582
                     /gene="SRI"
                     /gene_synonym="CP-22; CP22; SCN; V19"
                     /inference="alignment:Splign:2.1.0"
     exon            583..1972
                     /gene="SRI"
                     /gene_synonym="CP-22; CP22; SCN; V19"
                     /inference="alignment:Splign:2.1.0"
     regulatory      777..782
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SRI"
                     /gene_synonym="CP-22; CP22; SCN; V19"
                     /note="hexamer: AATAAA"
     polyA_site      798
                     /gene="SRI"
                     /gene_synonym="CP-22; CP22; SCN; V19"
                     /note="major polyA site"
     regulatory      1951..1956
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SRI"
                     /gene_synonym="CP-22; CP22; SCN; V19"
                     /note="hexamer: AATAAA"
     polyA_site      1972
                     /gene="SRI"
                     /gene_synonym="CP-22; CP22; SCN; V19"
ORIGIN      
        1 gcagtctgca gcatggcgta cccggggcat cctggcgccg gcggcgggta ctacccaggc
       61 gggtatggag gggctcccgg agggcctgcg tttcccggac aaactcagga tccgctgtat
      121 ggttactttg ctgctgtagc tggacaggat gggcagatag atgctgatga attgcagaga
      181 tgtctgacac agtctggcat tgctggagga tacaaacctt ttaacctgga gacttgccgg
      241 cttatggttt caatgctgga tagagatatg tctggcacaa tgggtttcaa tgaatttaaa
      301 gaactctggg ctgtactgaa tggctggaga caacacttta tcagttttga cactgacagg
      361 agtggaacag tagacccaca agaattgcag aaggccctga caacaatggg atttaggttg
      421 agtccccagg ctgtgaattc aattgcaaaa cgatacagca ccaatggaaa gatcaccttc
      481 gacgactaca tcgcctgctg cgtcaaactg agggctctta cagacagctt tcgaagacgg
      541 gatactgctc agcaaggtgt tgtgaatttc ccatatgatg atttcattca atgtgtcatg
      601 agtgtttaaa tcaagaggaa gctgcatgaa tgtaatcaac attccaactg gagctctcct
      661 ttgcttgtcc tctttgcctt cggtaatatg tataaactta catcacgact ttctcttaac
      721 agctgttgta aagtttatta ctttatgtac aactgaagtt ttgttttagt tttgataata
      781 aattctttgg aactttaata agatctagtc tgttacacca tttagaactt tcctgagcca
      841 ttatcagtca tgccttattt tcttgctaaa actctatgta aatttaagta tgcaaaatgt
      901 ttaagtcaca ttatttattt ttcattgtga gacactaaaa actgttaatc agactacagc
      961 tgttatcttt cctctcctac aaagaatact ccacacataa aaacttaggt aaatgacata
     1021 gacgcacttg ggtgaaataa aacaacaaaa aaggtaatcc agtaatccac gtcaggattc
     1081 accttagaag tttagcacac gcccttcaaa acctgttgaa taatttgatt ggcaaatact
     1141 atctgtcacc aagtcccttt ttgtcatcta tttaaacctt tgttaactct ccttaaaaat
     1201 cttgtacatt ataagcttaa ctatataaaa agaaaattga tagaaaaaga ctaagggaat
     1261 atatggaaat attaacaatg tttattttgg atgaatggaa ttctagatga ctttaatttt
     1321 ctttatatca gtatttttca gattttctat atgctttcct tttaaaatca gattttagtt
     1381 tttaaaatac tgatacatcc attttgatat accatgtatt cacactttaa aaaatacaca
     1441 tagcagagta tcggaaagta tgtaccaaaa cattgatctg gctaccactg ggagtcagga
     1501 tcatgagttc atcttcttcc ttcttactgc ttttccaaac attctccagt aagcaggtac
     1561 tacatttata atggaaggaa ttttttaaaa aattttaagc tgtacacttt caagtaagat
     1621 ctgaattcta atgctggctt gtgcctctta ctatgtggtt tggtcattat agataatgcc
     1681 cagtttcagt ttccccatct ttgaaaagga gataatatgt tatctcttgg gagtagttct
     1741 gaatatgaag tgtgttgata caagaagcac tgacaatgtt tctgtttctt aaatttaaaa
     1801 ctggcctggt ttgccttttt tatcaagaga gcttaacaga taaaaaatga aattagtcta
     1861 ttttctactt gccagcagag tatctgtctt attttaggat gcagtgtgaa acttaccatt
     1921 caactgaaca actagttgtc aactaatgaa aataaaacat tttctctaag ca
//
