LOCUS       NM_002727               1217 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens serglycin (SRGN), transcript variant 1, mRNA.
ACCESSION   NM_002727
VERSION     NM_002727.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1217)
  AUTHORS   .
  TITLE     miR-26b-5p suppresses chemoresistance in breast cancer by targeting
            serglycin: Erratum
  JOURNAL   Anticancer Drugs 35 (3), 316 (2024)
   PUBMED   38411026
  REMARK    GeneRIF: miR-26b-5p suppresses chemoresistance in breast cancer by
            targeting serglycin: Erratum.
REFERENCE   2  (bases 1 to 1217)
  AUTHORS   Chen,F., Lei,L., Chen,S., Zhao,Z., Huang,Y., Jiang,G., Guo,X.,
            Li,Z., Zheng,Z. and Wang,J.
  TITLE     Serglycin secreted by late-stage nucleus pulposus cells is a
            biomarker of intervertebral disc degeneration
  JOURNAL   Nat Commun 15 (1), 47 (2024)
   PUBMED   38167807
  REMARK    GeneRIF: Serglycin secreted by late-stage nucleus pulposus cells is
            a biomarker of intervertebral disc degeneration.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1217)
  AUTHORS   Tanaka,I., Dayde,D., Tai,M.C., Mori,H., Solis,L.M., Tripathi,S.C.,
            Fahrmann,J.F., Unver,N., Parhy,G., Jain,R., Parra,E.R.,
            Murakami,Y., Aguilar-Bonavides,C., Mino,B., Celiktas,M.,
            Dhillon,D., Casabar,J.P., Nakatochi,M., Stingo,F.,
            Baladandayuthapani,V., Wang,H., Katayama,H., Dennison,J.B.,
            Lorenzi,P.L., Do,K.A., Fujimoto,J., Behrens,C., Ostrin,E.J.,
            Rodriguez-Canales,J., Hase,T., Fukui,T., Kajino,T., Kato,S.,
            Yatabe,Y., Hosoda,W., Kawaguchi,K., Yokoi,K., Chen-Yoshikawa,T.F.,
            Hasegawa,Y., Gazdar,A.F., Wistuba,I.I., Hanash,S. and Taguchi,A.
  TITLE     SRGN-Triggered Aggressive and Immunosuppressive Phenotype in a
            Subset of TTF-1-Negative Lung Adenocarcinomas
  JOURNAL   J Natl Cancer Inst 114 (2), 290-301 (2022)
   PUBMED   34524427
  REMARK    GeneRIF: SRGN-Triggered Aggressive and Immunosuppressive Phenotype
            in a Subset of TTF-1-Negative Lung Adenocarcinomas.
REFERENCE   4  (bases 1 to 1217)
  AUTHORS   Hosoya,K., Nosaka,K., Sakabe,T., Wakahara,M., Oshima,Y., Suzuki,Y.,
            Nakamura,H. and Umekita,Y.
  TITLE     Clinical Significance of Serglycin Expression in Human Breast
            Cancer Patients
  JOURNAL   Anticancer Res 42 (1), 279-285 (2022)
   PUBMED   34969735
  REMARK    GeneRIF: Clinical Significance of Serglycin Expression in Human
            Breast Cancer Patients.
REFERENCE   5  (bases 1 to 1217)
  AUTHORS   He,Y., Cheng,D., Lian,C., Liu,Y., Luo,W., Wang,Y., Ma,C., Wu,Q.,
            Tian,P., He,D., Jia,Z., Lv,X., Zhang,X., Pan,Z., Lu,J., Xiao,Y.,
            Zhang,P., Liang,Y., Yang,Q. and Hu,G.
  TITLE     Serglycin induces osteoclastogenesis and promotes tumor growth in
            giant cell tumor of bone
  JOURNAL   Cell Death Dis 12 (10), 868 (2021)
   PUBMED   34556636
  REMARK    GeneRIF: Serglycin induces osteoclastogenesis and promotes tumor
            growth in giant cell tumor of bone.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1217)
  AUTHORS   Humphries,D.E., Nicodemus,C.F., Schiller,V. and Stevens,R.L.
  TITLE     The human serglycin gene. Nucleotide sequence and methylation
            pattern in human promyelocytic leukemia HL-60 cells and
            T-lymphoblast Molt-4 cells
  JOURNAL   J Biol Chem 267 (19), 13558-13563 (1992)
   PUBMED   1377686
REFERENCE   7  (bases 1 to 1217)
  AUTHORS   Nicodemus,C.F., Avraham,S., Austen,K.F., Purdy,S., Jablonski,J. and
            Stevens,R.L.
  TITLE     Characterization of the human gene that encodes the peptide core of
            secretory granule proteoglycans in promyelocytic leukemia HL-60
            cells and analysis of the translated product
  JOURNAL   J Biol Chem 265 (10), 5889-5896 (1990)
   PUBMED   2180935
REFERENCE   8  (bases 1 to 1217)
  AUTHORS   Stellrecht,C.M. and Saunders,G.F.
  TITLE     Nucleotide sequence of a cDNA encoding a hemopoietic proteoglycan
            core protein
  JOURNAL   Nucleic Acids Res 17 (18), 7523 (1989)
   PUBMED   2798108
REFERENCE   9  (bases 1 to 1217)
  AUTHORS   Avraham,S., Stevens,R.L., Nicodemus,C.F., Gartner,M.C., Austen,K.F.
            and Weis,J.H.
  TITLE     Molecular cloning of a cDNA that encodes the peptide core of a
            mouse mast cell secretory granule proteoglycan and comparison with
            the analogous rat and human cDNA
  JOURNAL   Proc Natl Acad Sci U S A 86 (10), 3763-3767 (1989)
   PUBMED   2726751
REFERENCE   10 (bases 1 to 1217)
  AUTHORS   Mattei,M.G., Perin,J.P., Alliel,P.M., Bonnet,F., Maillet,P.,
            Passage,E., Mattei,J.F. and Jolles,P.
  TITLE     Localization of human platelet proteoglycan gene to chromosome 10,
            band q22.1, by in situ hybridization
  JOURNAL   Hum Genet 82 (1), 87-88 (1989)
   PUBMED   2714783
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from CB110512.1, BG548665.1,
            BG057351.1, CA308463.1 and BC015516.1.
            
            On Nov 23, 2018 this sequence version replaced NM_002727.3.
            
            Summary: This gene encodes a protein best known as a hematopoietic
            cell granule proteoglycan. Proteoglycans stored in the secretory
            granules of many hematopoietic cells also contain a
            protease-resistant peptide core, which may be important for
            neutralizing hydrolytic enzymes. This encoded protein was found to
            be associated with the macromolecular complex of granzymes and
            perforin, which may serve as a mediator of granule-mediated
            apoptosis. Two transcript variants, only one of them
            protein-coding, have been found for this gene. [provided by RefSeq,
            Jul 2010].
            
            Transcript Variant: This variant (1) lacks an exon in the 5' UTR
            compared to variant 2. Both variants 1 and 3 encode isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189664.52881.1,
                                           SRR5189655.129251.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000242465.4/ ENSP00000242465.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-146               CB110512.1         32-177
            147-658             BG548665.1         102-613
            659-721             BG057351.1         9-71                c
            722-950             CA308463.1         2-230               c
            951-1217            BC015516.1         935-1201
FEATURES             Location/Qualifiers
     source          1..1217
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q22.1"
     gene            1..1217
                     /gene="SRGN"
                     /gene_synonym="PPG; PRG; PRG1"
                     /note="serglycin"
                     /db_xref="GeneID:5552"
                     /db_xref="HGNC:HGNC:9361"
                     /db_xref="MIM:177040"
     exon            1..134
                     /gene="SRGN"
                     /gene_synonym="PPG; PRG; PRG1"
                     /inference="alignment:Splign:2.1.0"
     CDS             56..532
                     /gene="SRGN"
                     /gene_synonym="PPG; PRG; PRG1"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; serglycin proteoglycan; proteoglycan 1,
                     secretory granule; secretory granule proteoglycan core
                     peptide; proteoglycan protein core for mast cell secretory
                     granule; hematopoetic proteoglycan core peptide; p.PG;
                     platelet proteoglycan core protein; hematopoetic
                     proteoglycan core protein; secretory granule proteoglycan
                     core protein; hematopoietic proteoglycan core protein"
                     /codon_start=1
                     /product="serglycin isoform 1 precursor"
                     /protein_id="NP_002718.2"
                     /db_xref="CCDS:CCDS7285.1"
                     /db_xref="GeneID:5552"
                     /db_xref="HGNC:HGNC:9361"
                     /db_xref="MIM:177040"
                     /translation="MMQKLLKCSRLVLALALILVLESSVQGYPTRRARYQWVRCNPDS
                     NSANCLEEKGPMFELLPGESNKIPRLRTDLFPKTRIQDLNRIFPLSEDYSGSGFGSGS
                     GSGSGSGSGFLTEMEQDYQLVDESDAFHDNLRSLDRNLPSDSQDLGQHGLEEDFML"
     exon            135..282
                     /gene="SRGN"
                     /gene_synonym="PPG; PRG; PRG1"
                     /inference="alignment:Splign:2.1.0"
     exon            283..1217
                     /gene="SRGN"
                     /gene_synonym="PPG; PRG; PRG1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1195..1200
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SRGN"
                     /gene_synonym="PPG; PRG; PRG1"
                     /note="hexamer: ATTAAA"
     polyA_site      1217
                     /gene="SRGN"
                     /gene_synonym="PPG; PRG; PRG1"
                     /note="major polyA site"
ORIGIN      
        1 acatttccta atcaagaagt tggcgtgcag ctgggagagc tagactaagt tggtcatgat
       61 gcagaagcta ctcaaatgca gtcggcttgt cctggctctt gccctcatcc tggttctgga
      121 atcctcagtt caaggttatc ctacgcggag agccaggtac caatgggtgc gctgcaatcc
      181 agacagtaat tctgcaaact gccttgaaga aaaaggacca atgttcgaac tacttccagg
      241 tgaatccaac aagatccccc gtctgaggac tgaccttttt ccaaagacga gaatccagga
      301 cttgaatcgt atcttcccac tttctgagga ctactctgga tcaggcttcg gctccggctc
      361 cggctctgga tcaggatctg ggagtggctt cctaacggaa atggaacagg attaccaact
      421 agtagacgaa agtgatgctt tccatgacaa ccttaggtct cttgacagga atctgccctc
      481 agacagccag gacttgggtc aacatggatt agaagaggat tttatgttat aaaagaggat
      541 tttcccacct tgacaccagg caatgtagtt agcatatttt atgtaccatg gttatatgat
      601 taatcttggg acaaagaatt ttatagaaat ttttaaacat ctgaaaaaga agcttaagtt
      661 ttatcatcct tttttttctc atgaattctt aaaggattat gctttaatgc tgttatctat
      721 tttattgttc ttgaaaatac ctgcattttt tggtatcatg ttcaaccaac atcattatga
      781 aattaattag attcccatgg ccataaaatg gctttaaaga atatatatat atttttaaag
      841 tagcttgaga agcaaattgg caggtaatat ttcataccta aattaagact ctgacttgga
      901 ttgtgaatta taatgatatg ccccttttct tataaaaaca aaaaaaaaaa taatgaaaca
      961 cagtgaattt gtagagtggg ggtatttgac atattttaca gggtggagtg tactatatac
     1021 tattaccttt gaatgtgttt gcagagctag tggatgtgtt tgtctacaag tatgattgct
     1081 gttacataac accccaaatt aactcccaaa ttaaaacaca gttgtgctgt caatacctca
     1141 tactgcttta cctttttttc ctggatatct gtgtattttc aaatgttact atatattaaa
     1201 gcagaaatat aaccaaa
//
