LOCUS       NM_014850               8923 bp    mRNA    linear   PRI 03-MAY-2024
DEFINITION  Homo sapiens SLIT-ROBO Rho GTPase activating protein 3 (SRGAP3),
            transcript variant 1, mRNA.
ACCESSION   NM_014850
VERSION     NM_014850.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 8923)
  AUTHORS   Messelodi,D., Giuliani,C., Cipriani,F., Armuzzi,S., di Palmo,E.,
            Garagnani,P., Bertelli,L., Astolfi,A., Luiselli,D., Ricci,G. and
            Pession,A.
  TITLE     C5 and SRGAP3 Polymorphisms Are Linked to Paediatric Allergic
            Asthma in the Italian Population
  JOURNAL   Genes (Basel) 13 (2), 214 (2022)
   PUBMED   35205259
  REMARK    GeneRIF: C5 and SRGAP3 Polymorphisms Are Linked to Paediatric
            Allergic Asthma in the Italian Population.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 8923)
  AUTHORS   Hlushchenko,I., Khanal,P., Abouelezz,A., Paavilainen,V.O. and
            Hotulainen,P.
  TITLE     ASD-Associated De Novo Mutations in Five Actin Regulators Show Both
            Shared and Distinct Defects in Dendritic Spines and Inhibitory
            Synapses in Cultured Hippocampal Neurons
  JOURNAL   Front Cell Neurosci 12, 217 (2018)
   PUBMED   30123108
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 8923)
  AUTHORS   Wuertenberger,S. and Groemping,Y.
  TITLE     A single PXXP motif in the C-terminal region of srGAP3 mediates
            binding to multiple SH3 domains
  JOURNAL   FEBS Lett 589 (10), 1156-1163 (2015)
   PUBMED   25819436
  REMARK    GeneRIF: A single PXXP motif in the C-terminal region of srGAP3
            mediates binding to multiple SH3 domains.
REFERENCE   4  (bases 1 to 8923)
  AUTHORS   Dai,Y.K., Ma,Y., Chen,K., Mi,Y.J., Fu,H.L., Cui,D.X. and Jin,W.L.
  TITLE     A link between the nuclear-localized srGAP3 and the SWI/SNF
            chromatin remodeler Brg1
  JOURNAL   Mol Cell Neurosci 60, 10-25 (2014)
   PUBMED   24561795
  REMARK    GeneRIF: Nuclear-localized srGAP3 interacts with Brg1. This
            interaction is mediated by the C-terminal of srGAP3 and the ATPase
            motif of Brg1.
REFERENCE   5  (bases 1 to 8923)
  AUTHORS   Ellery,P.M., Ellis,R.J. and Holder,S.E.
  TITLE     Interstitial 3p25 deletion in a patient with features of 3p
            deletion syndrome: further evidence for the role of SRGAP3 in
            mental retardation
  JOURNAL   Clin Dysmorphol 23 (1), 29-31 (2014)
   PUBMED   24300292
  REMARK    GeneRIF: deletion of SRGAP3 provides the most convincing
            explanation for our patient's phenotype, and our observations lend
            further weight to a causative role of SRGAP3 haploinsufficiency in
            mental retardation.
REFERENCE   6  (bases 1 to 8923)
  AUTHORS   Yang,Y., Marcello,M., Endris,V., Saffrich,R., Fischer,R.,
            Trendelenburg,M.F., Sprengel,R. and Rappold,G.
  TITLE     MEGAP impedes cell migration via regulating actin and microtubule
            dynamics and focal complex formation
  JOURNAL   Exp Cell Res 312 (12), 2379-2393 (2006)
   PUBMED   16730001
  REMARK    GeneRIF: Data suggest that MEGAP negatively regulates cell
            migration by perturbing the actin and microtubule cytoskeleton and
            by hindering the formation of focal complexes.
REFERENCE   7  (bases 1 to 8923)
  AUTHORS   Soderling,S.H., Binns,K.L., Wayman,G.A., Davee,S.M., Ong,S.H.,
            Pawson,T. and Scott,J.D.
  TITLE     The WRP component of the WAVE-1 complex attenuates Rac-mediated
            signalling
  JOURNAL   Nat Cell Biol 4 (12), 970-975 (2002)
   PUBMED   12447388
REFERENCE   8  (bases 1 to 8923)
  AUTHORS   Olave,I., Wang,W., Xue,Y., Kuo,A. and Crabtree,G.R.
  TITLE     Identification of a polymorphic, neuron-specific chromatin
            remodeling complex
  JOURNAL   Genes Dev 16 (19), 2509-2517 (2002)
   PUBMED   12368262
REFERENCE   9  (bases 1 to 8923)
  AUTHORS   Endris,V., Wogatzky,B., Leimer,U., Bartsch,D., Zatyka,M., Latif,F.,
            Maher,E.R., Tariverdian,G., Kirsch,S., Karch,D. and Rappold,G.A.
  TITLE     The novel Rho-GTPase activating gene MEGAP/ srGAP3 has a putative
            role in severe mental retardation
  JOURNAL   Proc Natl Acad Sci U S A 99 (18), 11754-11759 (2002)
   PUBMED   12195014
  REMARK    GeneRIF: putative role in severe mental retardation
REFERENCE   10 (bases 1 to 8923)
  AUTHORS   Wong,K., Ren,X.R., Huang,Y.Z., Xie,Y., Liu,G., Saito,H., Tang,H.,
            Wen,L., Brady-Kalnay,S.M., Mei,L., Wu,J.Y., Xiong,W.C. and Rao,Y.
  TITLE     Signal transduction in neuronal migration: roles of GTPase
            activating proteins and the small GTPase Cdc42 in the Slit-Robo
            pathway
  JOURNAL   Cell 107 (2), 209-221 (2001)
   PUBMED   11672528
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK054831.1, AF427144.1, DA532895.1 and BM976179.1.
            
            On Nov 23, 2018 this sequence version replaced NM_014850.3.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF427144.1, SRR7346977.1492536.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000383836.8/ ENSP00000373347.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-593               AK054831.1         40-632
            594-7051            AF427144.1         1-6458
            7052-7181           DA532895.1         20-149
            7182-8920           AF427144.1         6589-8327
            8921-8923           BM976179.1         16-18               c
FEATURES             Location/Qualifiers
     source          1..8923
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3p25.3"
     gene            1..8923
                     /gene="SRGAP3"
                     /gene_synonym="ARHGAP14; MEGAP; SRGAP2; WRP"
                     /note="SLIT-ROBO Rho GTPase activating protein 3"
                     /db_xref="GeneID:9901"
                     /db_xref="HGNC:HGNC:19744"
                     /db_xref="MIM:606525"
     exon            1..762
                     /gene="SRGAP3"
                     /gene_synonym="ARHGAP14; MEGAP; SRGAP2; WRP"
                     /inference="alignment:Splign:2.1.0"
     CDS             696..3995
                     /gene="SRGAP3"
                     /gene_synonym="ARHGAP14; MEGAP; SRGAP2; WRP"
                     /note="isoform a is encoded by transcript variant 1;
                     SLIT-ROBO Rho GTPase activating protein 2; WAVE-associated
                     Rac GTPase activating protein; mental disorder-associated
                     GAP; rho GTPase-activating protein 14"
                     /codon_start=1
                     /product="SLIT-ROBO Rho GTPase-activating protein 3
                     isoform a"
                     /protein_id="NP_055665.1"
                     /db_xref="CCDS:CCDS2572.1"
                     /db_xref="GeneID:9901"
                     /db_xref="HGNC:HGNC:19744"
                     /db_xref="MIM:606525"
                     /translation="MSSQTKFKKDKEIIAEYEAQIKEIRTQLVEQFKCLEQQSESRLQ
                     LLQDLQEFFRRKAEIELEYSRSLEKLAERFSSKIRSSREHQFKKDQYLLSPVNCWYLV
                     LHQTRRESRDHATLNDIFMNNVIVRLSQISEDVIRLFKKSKEIGLQMHEELLKVTNEL
                     YTVMKTYHMYHAESISAESKLKEAEKQEEKQFNKSGDLSMNLLRHEDRPQRRSSVKKI
                     EKMKEKRQAKYSENKLKCTKARNDYLLNLAATNAAISKYYIHDVSDLIDCCDLGFHAS
                     LARTFRTYLSAEYNLETSRHEGLDVIENAVDNLDSRSDKHTVMDMCNQVFCPPLKFEF
                     QPHMGDEVCQVSAQQPVQTELLMRYHQLQSRLATLKIENEEVRKTLDATMQTLQDMLT
                     VEDFDVSDAFQHSRSTESVKSAASETYMSKINIAKRRANQQETEMFYFTKFKEYVNGS
                     NLITKLQAKHDLLKQTLGEGERAECGTTRPPCLPPKPQKMRRPRPLSVYSHKLFNGSM
                     EAFIKDSGQAIPLVVESCIRYINLYGLQQQGIFRVPGSQVEVNDIKNSFERGEDPLVD
                     DQNERDINSVAGVLKLYFRGLENPLFPKERFQDLISTIKLENPAERVHQIQQILVTLP
                     RVVIVVMRYLFAFLNHLSQYSDENMMDPYNLAICFGPTLMHIPDGQDPVSCQAHINEV
                     IKTIIIHHEAIFPSPRELEGPVYEKCMAGGEEYCDSPHSEPGAIDEVDHDNGTEPHTS
                     DEEVEQIEAIAKFDYMGRSPRELSFKKGASLLLYHRASEDWWEGRHNGVDGLIPHQYI
                     VVQDMDDAFSDSLSQKADSEASSGPLLDDKASSKNDLQSPTEHISDYGFGGVMGRVRL
                     RSDGAAIPRRRSGGDTHSPPRGLGPSIDTPPRAAACPSSPHKIPLTRGRIESPEKRRM
                     ATFGSAGSINYPDKKALSEGHSMRSTCGSTRHSSLGDHKSLEAEALAEDIEKTMSTAL
                     HELRELERQNTVKQAPDVVLDTLEPLKNPPGPVSSEPASPLHTIVIRDPDAAMRRSSS
                     SSTEMMTTFKPALSARLAGAQLRPPPMRPVRPVVQHRSSSSSSSGVGSPAVTPTEKMF
                     PNSSADKSGTM"
     exon            763..955
                     /gene="SRGAP3"
                     /gene_synonym="ARHGAP14; MEGAP; SRGAP2; WRP"
                     /inference="alignment:Splign:2.1.0"
     exon            956..1118
                     /gene="SRGAP3"
                     /gene_synonym="ARHGAP14; MEGAP; SRGAP2; WRP"
                     /inference="alignment:Splign:2.1.0"
     exon            1119..1181
                     /gene="SRGAP3"
                     /gene_synonym="ARHGAP14; MEGAP; SRGAP2; WRP"
                     /inference="alignment:Splign:2.1.0"
     exon            1182..1367
                     /gene="SRGAP3"
                     /gene_synonym="ARHGAP14; MEGAP; SRGAP2; WRP"
                     /inference="alignment:Splign:2.1.0"
     exon            1368..1496
                     /gene="SRGAP3"
                     /gene_synonym="ARHGAP14; MEGAP; SRGAP2; WRP"
                     /inference="alignment:Splign:2.1.0"
     exon            1497..1718
                     /gene="SRGAP3"
                     /gene_synonym="ARHGAP14; MEGAP; SRGAP2; WRP"
                     /inference="alignment:Splign:2.1.0"
     exon            1719..1820
                     /gene="SRGAP3"
                     /gene_synonym="ARHGAP14; MEGAP; SRGAP2; WRP"
                     /inference="alignment:Splign:2.1.0"
     exon            1821..2018
                     /gene="SRGAP3"
                     /gene_synonym="ARHGAP14; MEGAP; SRGAP2; WRP"
                     /inference="alignment:Splign:2.1.0"
     exon            2019..2103
                     /gene="SRGAP3"
                     /gene_synonym="ARHGAP14; MEGAP; SRGAP2; WRP"
                     /inference="alignment:Splign:2.1.0"
     exon            2104..2131
                     /gene="SRGAP3"
                     /gene_synonym="ARHGAP14; MEGAP; SRGAP2; WRP"
                     /inference="alignment:Splign:2.1.0"
     exon            2132..2234
                     /gene="SRGAP3"
                     /gene_synonym="ARHGAP14; MEGAP; SRGAP2; WRP"
                     /inference="alignment:Splign:2.1.0"
     exon            2235..2295
                     /gene="SRGAP3"
                     /gene_synonym="ARHGAP14; MEGAP; SRGAP2; WRP"
                     /inference="alignment:Splign:2.1.0"
     exon            2296..2373
                     /gene="SRGAP3"
                     /gene_synonym="ARHGAP14; MEGAP; SRGAP2; WRP"
                     /inference="alignment:Splign:2.1.0"
     exon            2374..2508
                     /gene="SRGAP3"
                     /gene_synonym="ARHGAP14; MEGAP; SRGAP2; WRP"
                     /inference="alignment:Splign:2.1.0"
     exon            2509..2614
                     /gene="SRGAP3"
                     /gene_synonym="ARHGAP14; MEGAP; SRGAP2; WRP"
                     /inference="alignment:Splign:2.1.0"
     exon            2615..2842
                     /gene="SRGAP3"
                     /gene_synonym="ARHGAP14; MEGAP; SRGAP2; WRP"
                     /inference="alignment:Splign:2.1.0"
     exon            2843..2922
                     /gene="SRGAP3"
                     /gene_synonym="ARHGAP14; MEGAP; SRGAP2; WRP"
                     /inference="alignment:Splign:2.1.0"
     exon            2923..3103
                     /gene="SRGAP3"
                     /gene_synonym="ARHGAP14; MEGAP; SRGAP2; WRP"
                     /inference="alignment:Splign:2.1.0"
     exon            3104..3253
                     /gene="SRGAP3"
                     /gene_synonym="ARHGAP14; MEGAP; SRGAP2; WRP"
                     /inference="alignment:Splign:2.1.0"
     exon            3254..3581
                     /gene="SRGAP3"
                     /gene_synonym="ARHGAP14; MEGAP; SRGAP2; WRP"
                     /inference="alignment:Splign:2.1.0"
     exon            3582..8923
                     /gene="SRGAP3"
                     /gene_synonym="ARHGAP14; MEGAP; SRGAP2; WRP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      7003..7008
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SRGAP3"
                     /gene_synonym="ARHGAP14; MEGAP; SRGAP2; WRP"
                     /note="hexamer: ATTAAA"
     polyA_site      7032
                     /gene="SRGAP3"
                     /gene_synonym="ARHGAP14; MEGAP; SRGAP2; WRP"
     regulatory      8898..8903
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SRGAP3"
                     /gene_synonym="ARHGAP14; MEGAP; SRGAP2; WRP"
                     /note="hexamer: AATAAA"
     polyA_site      8923
                     /gene="SRGAP3"
                     /gene_synonym="ARHGAP14; MEGAP; SRGAP2; WRP"
                     /note="major polyA site"
ORIGIN      
        1 agtccagcct tgtgttcacc ggagcttaag cgttgcagca ggaaaacttc catctcgctc
       61 tcctggcttt gatcctcact ggacatcaga ccagaggcac cgaagggagg gaggatgcga
      121 gatgaccggc cctttggcaa cctgaccatc gacttagcag agccttcaaa agcaagccag
      181 gggctggctg cacgaccaaa gaggcgccgc gcctctcgtg gatgtgtgtg tgtgagtgat
      241 ccagcgagtg tgtgtgcgtg tgagggtgtg tgtgtgtatg cctgtgtgca cagcacaact
      301 gtgtgcgtgt cccggtgagt gtgcctgtgc atgcgtgagt gtgtgtacgt gtgcatgtgt
      361 gtgtgagtgc gcttggttat tactattatt attatttttg gaagaaaaat ctttgaaaat
      421 ctggggcagg ttactgtgct cctagggtga ttcttctttt gcaagaggag ctgaccaggg
      481 caagctacta gagccatttc tcggcaagta aagagatttt tccttccaga aggagaagga
      541 tttttctccc tgctctgcag ccaagtgaaa gagattagtc cctaaacctg tgaaatcgac
      601 cagagctgtg tgattaccag ggcttgagag aggactcgaa aagaaaagga gaaataaatc
      661 aaacagcctg tcagttcctt tggccacgtc agaagatgtc atctcaaact aagttcaaga
      721 aagacaaaga gatcattgct gaatatgaag cccaaataaa agagatccgc acgcagctgg
      781 tggagcagtt caaatgtctg gagcagcaat cagagtcgcg actgcagctg cttcaagacc
      841 tccaggagtt tttccgccgg aaagctgaga ttgagctcga gtactcccgc agcctggaga
      901 agctggctga gcgcttctcc tccaaaatcc gcagctcccg ggagcaccag ttcaagaagg
      961 accagtacct cctctcgcct gtgaactgtt ggtatctggt tctgcatcag acccggcggg
     1021 agagccgaga ccatgccacc ctcaatgaca tcttcatgaa caatgtcatc gtccgcctct
     1081 cccagatcag tgaggatgtc atcagactct tcaaaaagag caaggagatt ggcctgcaga
     1141 tgcacgagga gctcctgaag gtgaccaatg agctctacac agtcatgaaa acctaccaca
     1201 tgtaccatgc agagagcatc agtgcggaaa gcaagctgaa ggaggctgag aagcaggagg
     1261 agaagcagtt caataagtca ggagacctca gcatgaacct gctccggcac gaggaccggc
     1321 cccagcgccg cagctctgtg aagaagattg agaagatgaa ggagaagagg caggccaagt
     1381 actctgagaa caagctgaaa tgcacaaagg cccggaatga ctacttgctc aatctggcag
     1441 ccaccaacgc agctataagc aaatactaca tccatgatgt ctctgatctg atcgattgct
     1501 gtgatttggg cttccatgcc agcctggccc gcaccttccg gacctatctc tcagctgaat
     1561 acaacctgga gacctctcgc cacgaagggc tggatgtcat tgagaatgca gtggacaacc
     1621 tggattcccg aagtgacaag cacacagtca tggacatgtg caatcaagtc ttctgccctc
     1681 cactcaagtt cgagttccag ccccacatgg gggatgaggt ctgccaggtc agcgctcagc
     1741 agcccgtcca gacagaactg ctcatgcgtt atcaccagct gcagtccaga ctggccaccc
     1801 tcaagataga gaatgaggag gttaggaaaa ccctggatgc caccatgcag acattacagg
     1861 acatgctgac tgtggaggac tttgatgtct ccgatgcctt ccaacacagt cgatcgacag
     1921 agtccgtcaa gtcggctgcc tctgagacct acatgagcaa gatcaacatt gccaagagga
     1981 gagccaacca gcaggaaaca gaaatgtttt attttacaaa atttaaagag tatgtgaatg
     2041 gcagtaacct catcaccaag ctgcaggcca agcacgattt actcaagcag accctgggcg
     2101 aaggggaaag agcagaatgc ggcaccacca ggcccccctg tcttccccct aaaccacaga
     2161 aaatgaggag acctaggcct ctctcagtgt atagccataa actctttaac ggcagtatgg
     2221 aagcattcat taaggattca ggacaagcta taccgcttgt agtcgagagc tgcatccgtt
     2281 acatcaattt atatggactc cagcagcagg ggatcttcag agtgccagga tctcaggtgg
     2341 aagtcaatga catcaaaaat tcctttgaga gaggtgaaga cccccttgtg gacgatcaaa
     2401 atgaacgaga tatcaattca gtcgctggtg ttttaaaact gtatttccga ggactggaaa
     2461 acccactctt tcctaaggaa aggtttcaag atttgatatc tactattaaa ctggagaacc
     2521 cagccgagag ggtgcaccag atccaacaaa tcctcgtcac ccttccccgc gtggtcattg
     2581 tggtcatgag atacctcttc gctttcctca accacctctc ccagtatagc gacgagaaca
     2641 tgatggatcc ctacaacctg gccatctgct tcgggcctac cctcatgcac atccctgatg
     2701 ggcaggaccc tgtgtcctgc caggcacaca tcaatgaagt catcaaaacc atcatcatcc
     2761 atcatgaagc catcttcccc agcccccggg agctagaggg acctgtgtat gaaaaatgca
     2821 tggctggagg ggaagaatat tgtgacagcc cacacagcga gccaggggcc atcgatgaag
     2881 ttgaccatga caatggcact gagcctcata ccagcgatga agaagtggag cagatcgagg
     2941 ctattgccaa gtttgactac atggggcggt ccccgcgtga gctatccttc aagaaggggg
     3001 cctcgctgct cctgtaccac cgcgcctcgg aggactggtg ggagggccgg cacaacggcg
     3061 tggatggact catcccccat cagtacatag ttgtacagga catggatgat gccttctccg
     3121 acagcctgag ccagaaggct gacagcgagg ccagcagtgg gccattgctg gatgacaagg
     3181 cctcttccaa aaacgacctc cagtccccca cggagcacat ctcggattac ggctttgggg
     3241 gggtgatggg ccgagtgcgg ttacgatctg atggagcagc catccccaga cgccgaagcg
     3301 ggggcgacac acacagcccg ccccggggcc tgggccccag catagacaca ccaccccggg
     3361 ctgctgcctg ccccagcagc ccccacaaaa tccccctcac ccgggggagg atcgagagcc
     3421 ctgagaagcg gaggatggcg acgttcggga gcgctggcag catcaactac cctgacaaga
     3481 aggcgctctc cgaagggcac tcgatgaggt cgacctgcgg ttccaccagg cacagcagcc
     3541 taggggacca caagtccctg gaggccgagg ccctggcaga agacatcgag aagaccatga
     3601 gcacggctct gcacgagttg cgggaactcg agaggcagaa cacggtcaag caggcgccag
     3661 atgtggtgct ggacaccctg gagcccctga agaacccgcc aggccccgtc agctcggagc
     3721 ccgccagtcc ccttcacacc atcgtcatcc gcgaccccga tgccgccatg cgccgcagca
     3781 gcagctcctc caccgagatg atgaccacct tcaagccagc cctgtccgcc cgcctggctg
     3841 gcgcccagct ccgcccgccc cccatgcggc ccgtgcggcc ggtggtccag caccggtcca
     3901 gcagcagcag cagctcgggc gtgggcagcc cggccgtgac gcccaccgag aagatgttcc
     3961 ccaacagctc agcggacaag tcgggcacca tgtgacctgc aggatgggcc gcgccgccgt
     4021 ggcccgctgt ggctcaccac ggcccagggt ggccttggtg gcttccacgt gcttcccagt
     4081 gaccctggcc ttggagggca gaggtccgtc tgggagggtg tgtctgtgca gagctgaggc
     4141 ccgggcgctg gctgcagctc acgtccagcc atgggaatcc cacggacctc tcgcgtgtca
     4201 acagacgacc agaggagtgc tggagctcca gcagccccaa ccacagcatt ccctaacatg
     4261 gaggcaaaat accacatggc ttctcccgca tatcgtcact ggaaacttcc tctctcgaca
     4321 ttctctctac atacgtatat gtgtgtgtat atcgatgtgt gcatatatac acatgtatac
     4381 gtatgtacgt gtctgtaggt gtgtgtatat atatatatat ttatgcatct atatacatat
     4441 actagatctg gacacacgca tactaagtgt atatagtatc tcctttttct ttttatgaaa
     4501 cttagattta cctcagatcc atgccaccaa acatctccca ccgagttatt tggtgggatt
     4561 tgcagggact tttctgggag aacttaaagg cccatagtaa ctgcgaatga agcaatatac
     4621 cactaacctg cagaaaaaca caaacaaaaa cagactccca ctgtctccag aagtcgtggc
     4681 cttccagaac agtctgcccc tcaaggaagg gtggggcagg cagtaccccc aagcaggctg
     4741 ctcccagagg tggggaaccc ttcataggaa atccccaccc ccgtccaccc cagagaccct
     4801 gcccttccac ccggaggcca aaggccaact gtactcccaa aggcatggga gaaggttggc
     4861 gagaagaccc ctgactacca catccttgtg tttgtgtgta gagacggggg atagtgagaa
     4921 cctaagcccc atcgtagcac agtattacat gtggttggga aaaataaaaa tacagtggtg
     4981 tggaatactc caaaacctag aaatgctgta ggaataaatc tgtggtaact atagaggttt
     5041 aacttatatc attttcaaac tatttaattt tttcttttcc tggttctact aattatactg
     5101 tgtcagattt ggaactaaac aggcaaggag gctttgagtc acatcgtttt cattttaaat
     5161 caggctgtga tgcactgtgg ctggtgccgt cttgcatgaa acgcatgagc cgtgagcgcc
     5221 cagttcagac tggggccagg gaggggcagt ccttggcact ttctgtccta gaggacactg
     5281 tcagttgagt taatacaagt gacatagctt cccttccctc ccccttcacc cactccctcc
     5341 agaacattta gtgtagatga aaatgtggtg atagaaatgg gtgcatgatc ttcacgtgtg
     5401 acagccaggc ctttgcctct tggccaagta aagcccttcc gggtcgctct ccttcgattc
     5461 cattttacct cctcttctga tcacttccag agatgagctg tttctggata atggcacacg
     5521 ggcaaatctg tgtgccctgt gggccgctgt tacttaccct ctcctgcgag acccaggggc
     5581 ttttccctac tgttcccacg cttcctctct ctcgaggcca ctgaagtttg gagtcaaaag
     5641 gcccagagtc tgagtcccag ccctgagcac ttaggagcct tctgacttag ggtttgtcac
     5701 tccacctcat tgagcctgac tgttctgctc cataaaatag ggtaataaag gtcaaacatc
     5761 agtgagcaag ctgtgtacac tggaaaacac tgaatcaata caatgcgttt gtgattatca
     5821 ttagtaaggt aagtcttaga tcagagccct ccagcccttc tttttgaaac ctcccaatgg
     5881 catttcagaa gtgagcagtg gaattttcct gccatcctaa taagagccct ggattccatc
     5941 attaacattt cagcccattg gatgaagtgg tgccctctcc tctggtcccc cgcgaaaagg
     6001 taaatacacc caaagggagg gacctagtta agtcactggc acctagataa gttaggaggg
     6061 taaagccact acctcgtctg aaggactgga cttgacaccc cacagtggaa gggagcatca
     6121 ggagaggaac aaaaaaaggg atctcaggga gaggccagtg tcaaacttga cctcccttgt
     6181 ttggcctaga atgaaccctt ctctttagct cctggatatg aaaggccatc tgcttggagc
     6241 acagaaagat attgccattt tacagcttaa gagagtaagg ccttgggctg tgctgtgacc
     6301 tgcccaagat ttgacactgg ctaggagcag aggctgcgtc aggctcttaa agtcatgtgt
     6361 ttgcatgctg gatgctatac tgtccagcca ggacacaaga cttctgattt ctaccctcaa
     6421 gatactccca gatcctaaat ccagtagcct cccaggcaaa atatagcaat ctgccacaac
     6481 tgccagatga aaagcaacaa tcagagtaga aaaatctgtt gcctgatata cataacacca
     6541 atcagaccgt gtggattttt ctctgaattg actgattttg tttttttctt actgaaaatg
     6601 gacctgcctt tcactgaatt ttctgagggc agagtcttag ctgttttctt taagcacctt
     6661 tttttttttt ttccattggg aaatggctga tgagttcaca tttagggatg tacacacaca
     6721 gatggcagac gtctccccac tcatccagcc ccagatctga gccttgacgc aggccaagtg
     6781 gaaaaatact ttcccgcccc cctcccctgt tcccacttcc tcatctggca ctatgcatgt
     6841 ctcactcacc ctccacagca ctcagtccca tcgacgttca ctgaacattg gctttctctt
     6901 tctgactcct gcctgtttta gtccactata tattgctgta tttgcttaaa tgctggaaag
     6961 taactgttaa aatgtgaaat tgtaattttt aaaaaggcta caattaaatt ttagccaatg
     7021 ccactcacca aatctttgca cctagtagat agatcaatgt aaaaacaaat acctaactgt
     7081 acagtgagtg tgggggaaat gtagtaacct agttagtagt cttcaatata accaattgta
     7141 caaggggaag tggtgtttac ctacttgttc atcaccatta ttgaaagccg tactgatcag
     7201 ttagttgaca acgggcattt ttttttcttt gcttcatgga atgatttctt ttcttaacct
     7261 tcgacttatc ctgaggtcaa gccttttgtc tttatgtgta accgacgttc agtctattct
     7321 aggaatgaac cagcaagttg ttcatttaaa actgaccaaa gacaattaat tcctggtcta
     7381 gtttcctggg ccttgtggct cagctgccac taaagagctt tttggataaa attgagaaca
     7441 agctgtgctt cctaccccac tctccccgtc cccttttatt cccttttcct cttaaagagc
     7501 tgctctgagc tgtgggattc tatgaaaaat tcttgccttt ccttgtttca gtgctaacga
     7561 tttctcacct cgaagcgcct tttgaacccc ggacagagtg cacaatcgga gggaattgcg
     7621 agcttgggaa ttagactttg gagtcttttc tctgaagtca ccaggccagg ggtcaggaga
     7681 gagatggatt cccaagggat gaaaggtttc tattcaatga agaaatcgga gtgggaagag
     7741 acacagggaa attgagccat attttggcta tcggctggaa ccagcagttc agagatctgc
     7801 cttataaaca tttaaaaccg gtttgtggta cacaaagagg aaccagtgtg ggaaggggcc
     7861 tttatgtggg gctttcttct ctgttggagt cccttggagt gccttgttgg gtatatttct
     7921 ctgtcattca ggaggcacga atgtggagga cttctcgtga cctggtcgtg atgtggcatt
     7981 cagtgcatgt ccacagctaa tggaaaaaca cgaggactcg ggtaatggtt cttcctctca
     8041 gtctttctat tcctaacttt tcacacatcc agatggttcc acactagtgc aaatgcctca
     8101 ctctcctgag aaacccagaa agaagagtgg ctggctcaca accatggggt tagcccctgc
     8161 tgggctggga gtcggggtgg cggccaggag gaaaggcaga aaggggtgag ccgaggtgtt
     8221 gcctagctga ttttctgctg tgcagagcta atgctgacat ttcatgtcaa cttccccggt
     8281 tctctggggt ctcctctcct ctgagcagcc acatagaaca ttccccacat atccaaagct
     8341 gcccagggga gccgagagaa gggactttgc tgtcaggtcc aagccctcct gacctccctg
     8401 agattgatct gccagtgtcc tgctgtccct ctgggactgg ccacatggcc atcgctgccc
     8461 cttgttgaca cctcctttct gtgtgagttg tccccggcca ataacaaagc tgttccttga
     8521 accagaacaa ccagagtgca cttttccttc cttagacgga agtagatcct ggctagggtt
     8581 tctgcccagg cccttgttcc cggcagtgtg actgtttaca tggtttggca ataggtttga
     8641 ttctgattgc ttcagagtgg ctggtctatt ttgtttcctt tggtttcctt cctccccaaa
     8701 ttgtgacagg aaaaacagac caaaaccacc ctaggaaatt gctggttgcc tgtccccacg
     8761 tgatgataaa tgttgccctc ttctggatat cgtttctcta ccttacgacc aaacgcccgt
     8821 cctatagagt gtctgattgg atcctctgtc gcgtattctg atggtgcctg ctggtttgac
     8881 gtggagctat cctgtgaaat aaaacagctt aacttttctc aaa
//
