LOCUS       NM_001329984            7091 bp    mRNA    linear   PRI 11-FEB-2025
DEFINITION  Homo sapiens SLIT-ROBO Rho GTPase activating protein 2C (SRGAP2C),
            transcript variant 1, mRNA.
ACCESSION   NM_001329984 XM_005277497
VERSION     NM_001329984.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7091)
  AUTHORS   Schmidt,E.R.E., Zhao,H.T., Park,J.M., Dipoppa,M.,
            Monsalve-Mercado,M.M., Dahan,J.B., Rodgers,C.C., Lejeune,A.,
            Hillman,E.M.C., Miller,K.D., Bruno,R.M. and Polleux,F.
  TITLE     A human-specific modifier of cortical connectivity and circuit
            function
  JOURNAL   Nature 599 (7886), 640-644 (2021)
   PUBMED   34707291
  REMARK    GeneRIF: A human-specific modifier of cortical connectivity and
            circuit function.
            Erratum:[Nature. 2022 Jan;601(7893):E10. doi:
            10.1038/s41586-021-04302-8.. PMID: 34997244]
REFERENCE   2  (bases 1 to 7091)
  AUTHORS   Schmidt,E.R.E., Kupferman,J.V., Stackmann,M. and Polleux,F.
  TITLE     The human-specific paralogs SRGAP2B and SRGAP2C differentially
            modulate SRGAP2A-dependent synaptic development
  JOURNAL   Sci Rep 9 (1), 18692 (2019)
   PUBMED   31822692
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 7091)
  AUTHORS   Fossati,M., Pizzarelli,R., Schmidt,E.R., Kupferman,J.V.,
            Stroebel,D., Polleux,F. and Charrier,C.
  TITLE     SRGAP2 and Its Human-Specific Paralog Co-Regulate the Development
            of Excitatory and Inhibitory Synapses
  JOURNAL   Neuron 91 (2), 356-369 (2016)
   PUBMED   27373832
REFERENCE   4  (bases 1 to 7091)
  AUTHORS   Kutzner,A., Pramanik,S., Kim,P.S. and Heese,K.
  TITLE     All-or-(N)One - an epistemological characterization of the human
            tumorigenic neuronal paralogous FAM72 gene loci
  JOURNAL   Genomics 106 (5), 278-285 (2015)
   PUBMED   26206078
REFERENCE   5  (bases 1 to 7091)
  AUTHORS   Charrier,C., Joshi,K., Coutinho-Budd,J., Kim,J.E., Lambert,N., de
            Marchena,J., Jin,W.L., Vanderhaeghen,P., Ghosh,A., Sassa,T. and
            Polleux,F.
  TITLE     Inhibition of SRGAP2 function by its human-specific paralogs
            induces neoteny during spine maturation
  JOURNAL   Cell 149 (4), 923-935 (2012)
   PUBMED   22559944
REFERENCE   6  (bases 1 to 7091)
  AUTHORS   Dennis,M.Y., Nuttle,X., Sudmant,P.H., Antonacci,F., Graves,T.A.,
            Nefedov,M., Rosenfeld,J.A., Sajjadian,S., Malig,M., Kotkiewicz,H.,
            Curry,C.J., Shafer,S., Shaffer,L.G., de Jong,P.J., Wilson,R.K. and
            Eichler,E.E.
  TITLE     Evolution of human-specific neural SRGAP2 genes by incomplete
            segmental duplication
  JOURNAL   Cell 149 (4), 912-922 (2012)
   PUBMED   22559943
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC244453.2, AC243994.3 and
            AC244021.3.
            
            On May 17, 2019 this sequence version replaced NM_001329984.1.
            
            Summary: This locus encodes a member of the SLIT-ROBO Rho GTPase
            activating protein family. This human-specific locus resulted from
            segmental duplication of the SLIT-ROBO Rho GTPase activating
            protein 2B locus. The encoded protein lacks the GTPase activating
            protein domain compared to proteins encoded by SLIT-ROBO Rho GTPase
            activating protein 2, and acts antagonistically to these proteins
            in cortical neuron development. [provided by RefSeq, Dec 2012].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660803.222295.1,
                                           SRR7410570.30539.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000367123.8/ ENSP00000478290.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-150               AC244453.2         25506-25655         c
            151-759             AC244453.2         23117-23725         c
            760-952             AC243994.3         72696-72888         c
            953-1115            AC243994.3         33051-33213         c
            1116-1178           AC244021.3         89808-89870
            1179-1394           AC244021.3         98486-98701
            1395-1523           AC244021.3         99341-99469
            1524-1748           AC244021.3         107216-107440
            1749-1850           AC244021.3         111021-111122
            1851-7091           AC244021.3         112149-117389
FEATURES             Location/Qualifiers
     source          1..7091
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p11.2"
     gene            1..7091
                     /gene="SRGAP2C"
                     /gene_synonym="SRGAP2P1"
                     /note="SLIT-ROBO Rho GTPase activating protein 2C"
                     /db_xref="GeneID:653464"
                     /db_xref="HGNC:HGNC:30584"
                     /db_xref="MIM:614704"
     exon            1..150
                     /gene="SRGAP2C"
                     /gene_synonym="SRGAP2P1"
                     /inference="alignment:Splign:2.1.0"
     exon            151..759
                     /gene="SRGAP2C"
                     /gene_synonym="SRGAP2P1"
                     /inference="alignment:Splign:2.1.0"
     CDS             693..2072
                     /gene="SRGAP2C"
                     /gene_synonym="SRGAP2P1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     SLIT-ROBO Rho GTPase activating protein 2 pseudogene 1"
                     /codon_start=1
                     /product="SLIT-ROBO Rho GTPase-activating protein 2C
                     isoform 1"
                     /protein_id="NP_001316913.1"
                     /db_xref="CCDS:CCDS81364.1"
                     /db_xref="GeneID:653464"
                     /db_xref="HGNC:HGNC:30584"
                     /db_xref="MIM:614704"
                     /translation="MTSPAKFKKDKEIIAEYDTQVKEIRAQLTEQMKCLDQQCELRVQ
                     LLQDLQDFFRKKAEIEMDYSRNLEKLAEHFLAKTRSTKDQQFKKDQNVLSPVNCWNLL
                     LNQVKWESRDHTTLSDIYLNNIIPRFVQVSEDSGRLFKKSKEVGQQLQDDLMKVLNEL
                     YSVMKTYHMYNADSISAQSKLKEAEKQEEKQIGKSVKQEDRQTPCSPDSTANVRIEEK
                     HVRRSSVKKIEKMKEKHQAKYTENKLKAIKAQNEYLLALEATNASVFKYYIHDLSDLI
                     DQCCDLGYHASLNRALRTFLSAELNLEQSKHEGLDAIENAVENLDATSDKQRLMEMYN
                     NVFCPPMKFEFQPHMGDMASQLCAQQPVQSELVQRCQQLQSRLSTLKIENEEVKKTME
                     ATLQTIQDIVTVEDFDVSDCFQYSNSMESVKSTVSETFMSKPSIAKRRANQQETEQFY
                     FTVRECYGF"
     exon            760..952
                     /gene="SRGAP2C"
                     /gene_synonym="SRGAP2P1"
                     /inference="alignment:Splign:2.1.0"
     exon            953..1115
                     /gene="SRGAP2C"
                     /gene_synonym="SRGAP2P1"
                     /inference="alignment:Splign:2.1.0"
     exon            1116..1178
                     /gene="SRGAP2C"
                     /gene_synonym="SRGAP2P1"
                     /inference="alignment:Splign:2.1.0"
     exon            1179..1394
                     /gene="SRGAP2C"
                     /gene_synonym="SRGAP2P1"
                     /inference="alignment:Splign:2.1.0"
     exon            1395..1523
                     /gene="SRGAP2C"
                     /gene_synonym="SRGAP2P1"
                     /inference="alignment:Splign:2.1.0"
     exon            1524..1748
                     /gene="SRGAP2C"
                     /gene_synonym="SRGAP2P1"
                     /inference="alignment:Splign:2.1.0"
     exon            1749..1850
                     /gene="SRGAP2C"
                     /gene_synonym="SRGAP2P1"
                     /inference="alignment:Splign:2.1.0"
     exon            1851..7091
                     /gene="SRGAP2C"
                     /gene_synonym="SRGAP2P1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3152..3157
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SRGAP2C"
                     /gene_synonym="SRGAP2P1"
                     /note="hexamer: TATAAA"
     polyA_site      3172
                     /gene="SRGAP2C"
                     /gene_synonym="SRGAP2P1"
                     /note="major polyA site"
     regulatory      3179..3184
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SRGAP2C"
                     /gene_synonym="SRGAP2P1"
                     /note="hexamer: AATAAA"
     polyA_site      3210
                     /gene="SRGAP2C"
                     /gene_synonym="SRGAP2P1"
     regulatory      3384..3389
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SRGAP2C"
                     /gene_synonym="SRGAP2P1"
                     /note="hexamer: ATTAAA"
     polyA_site      3409
                     /gene="SRGAP2C"
                     /gene_synonym="SRGAP2P1"
     regulatory      3440..3445
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SRGAP2C"
                     /gene_synonym="SRGAP2P1"
                     /note="hexamer: TATAAA"
     regulatory      3482..3487
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SRGAP2C"
                     /gene_synonym="SRGAP2P1"
                     /note="hexamer: AATAAA"
     polyA_site      3483
                     /gene="SRGAP2C"
                     /gene_synonym="SRGAP2P1"
                     /note="major polyA site"
     polyA_site      3506
                     /gene="SRGAP2C"
                     /gene_synonym="SRGAP2P1"
     regulatory      6063..6068
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SRGAP2C"
                     /gene_synonym="SRGAP2P1"
                     /note="hexamer: AATAAA"
     polyA_site      6088
                     /gene="SRGAP2C"
                     /gene_synonym="SRGAP2P1"
ORIGIN      
        1 ggggtcctgc ggagttggcg gaggcggcgg aggctcctcc agggactggg gcaccgatct
       61 gcgtagaaac gggtggcggg gaagagaggg gaggagagct ctgagtggga agcggaaccg
      121 ggggcctggg acccgtcgcg tcagagccag gcaagtgaac cggagcaaac gacttccgat
      181 ccagtctgcg ctgttgcggc tcccgtttgg gatttgattt gcagcatctt tgagcctcta
      241 cgacaaaaaa ccgcgaagca cgcccagccc tcccccggca ccccgaaaag cacccactcc
      301 ctcccgggga cacagctggg cgcgtccaca cccccgcagc cccacaccat gttgtgcgga
      361 aggacttcca ctccccgcct gtgtcgttga tgtcagaccc caggccagcc tccgggcgct
      421 gcagttctcc cggctaatgc tgaggctgcg gctccggctc tagcacaggc accagccgcc
      481 gccgcacccg gcctcagcgc ccaccgtctg catgtgcccg ccgtagccgt ctgcccagcc
      541 cgcagcccgc gctccacgga gcgctggaga ccaccgtggg gggccccttc tgccctcgag
      601 agaagcggtc ttggaggtat tgatttaggt ggttggattt tttccgtgga tctatcaatt
      661 cacaattcga atttggaaga aagaaggaaa acatgacgtc tccagccaaa ttcaaaaagg
      721 ataaggagat catagcagag tacgatactc aggtcaaaga gatccgtgct cagctcacag
      781 agcagatgaa atgcctggac cagcagtgtg agcttcgggt gcaactgttg caggacctcc
      841 aggacttctt ccgaaagaag gcagagattg agatggacta ctcccgcaac ctggagaagc
      901 tggcagaaca cttcctggcc aagacacgca gcaccaagga ccagcaattc aagaaggatc
      961 agaatgttct ctctccagtc aactgctgga atctcctctt aaaccaggtg aagtgggaaa
     1021 gcagggacca taccaccctg agtgacatct acctgaataa tatcattcct cgatttgtac
     1081 aagtcagcga ggactcagga agactcttta aaaagagtaa agaagtcggc cagcagctcc
     1141 aagatgattt gatgaaggtc ctgaacgagc tctactcggt catgaagaca tatcacatgt
     1201 acaatgccga cagcatcagt gctcagagca aactaaagga ggcggagaag caggaggaga
     1261 agcaaattgg taaatcggta aagcaggagg accggcagac cccatgctcc cctgactcca
     1321 cggccaacgt tcgcattgag gagaaacatg tccggaggag ctcagtgaag aagattgaga
     1381 agatgaagga gaagcaccaa gccaagtaca cggagaataa gctgaaggcc atcaaagccc
     1441 agaatgagta cttgctggct ttggaggcaa ccaatgcatc tgtcttcaag tactacatcc
     1501 atgacctatc tgaccttatt gatcagtgtt gtgacttagg ctaccatgca agtctgaacc
     1561 gggctctacg caccttcctc tctgctgagt taaacctgga acagtcgaag catgagggtc
     1621 tggatgccat cgagaatgca gtagaaaacc tggatgccac cagtgacaag cagcgcctca
     1681 tggagatgta caacaacgtc ttctgccccc ctatgaagtt tgagtttcag ccccacatgg
     1741 gggatatggc ttcccagctc tgtgcccagc agcctgtcca gagtgagctg gtacagagat
     1801 gccaacaact gcagtctcgc ttatccactc taaagattga aaacgaagag gtaaagaaga
     1861 caatggaggc caccctgcaa accatccagg acattgtgac tgtcgaggac tttgatgtgt
     1921 ctgactgctt ccagtacagc aactccatgg agtccgtcaa gtccacggtc tctgaaacct
     1981 tcatgagcaa gcccagcatt gctaagagga gagccaacca gcaagagaca gagcagtttt
     2041 atttcacagt aagggagtgc tatggctttt aaagagcgtc agcatgcact gcagcactca
     2101 agggagattt ggaactcaga gtccttgtta agtgtctgaa ggacaggcat tgaatatctt
     2161 agatacgaat gtgggcatac tcagagacca tccctacact taaaggtgca aacattaaaa
     2221 gttgtatatg tctaacaggg atccgcccaa gagaaaggat gctcccaagt atacaactaa
     2281 gaagattttc ttttttaaga aatttttaac tagctagtag gctttcactg gaaagtttcc
     2341 ttctcaggca caggggatcc tgaaagggga acttcatctt ttagttcttg gagagtacat
     2401 acaaatattc ataataacac atattttgtt tataaaaatc tataatctct tctaggtgat
     2461 atgatgacat tattttataa cttttattgt tgggaaacta ttttttctaa ttattgctaa
     2521 aacttaaagg atgggtaata tgcagcatta ctattttgca cataattcca aaacatcgta
     2581 ttttcttatt catgtatctc tagtcttctt ttagacagtt ggaccctttt ttctttttct
     2641 tttttttttt ttttttttaa gtattgttaa caatcctttg gaagtcacta ctggtctttg
     2701 tgtgctgctt tttaataatt gagttatttt gagcttgcca agtaggatct attgcctgga
     2761 ctaaaattta tttcctaatc ttctgatgac caagaaagga aaaattaagt ttgcagatgt
     2821 gagatgaaat atagccagtg aatatgcata ctgattctga atgaaaggaa ttaacttttc
     2881 agtcaagaaa cagtctgcat gcagtaaatt gaatttttcc tgcaactgga atgatttgtt
     2941 taattcttct ttgaacactg ccctttctcc agtaagaaca ctaatgattt gctaatattt
     3001 tttaaagaaa tctgtttttt taattagtta agctcagact tcctcttatt ttttatccta
     3061 gagaaaactg ctaaaaggga atgatatatc agtactattc ttctaaaaca actttttaaa
     3121 aatgattata caaagccaaa tatgctcatt atataaaatt tagaagcaaa aagaaggaaa
     3181 taaaaatttt ccataattct accagctaga gataatggtg ttagaatata ttcctttcta
     3241 atctgttttc tatgcatgca caaacacata tgtgagcaca tatttataat tttattctaa
     3301 aaaataggac actgctgtac atattgtttt acaatctaag tcatataatt ataatattct
     3361 ttaagcatat ttatgagtaa aatattaaaa cctatacaaa aaaataacag aatggcattt
     3421 tagctcattc attgattttt ataaaatatt taacacactc cctggtttgt agttagcgtt
     3481 caataaatgc taaaaattta tcttcaccat catcattaat ttatttatta atcattatta
     3541 aattattcat tgatcatttt ttgaggattt actattgcca gacactgtgc tacaagctgg
     3601 gaatgctgac agtataagat aaagagggaa atgatggggg atgggtcatg taaagggaga
     3661 actttcattt ttacttcata tatatctaag cagttataat aggttgattt ttgtaattta
     3721 aaaaatgtaa aaatgcatac atgcactagt gcatgaatgg cagccaggat gagtggaatt
     3781 ggagaagcat cacacacaca gtgacttttg tgtttgatct tgaagaatga gcgaaccagg
     3841 cagggagtcg gggaggagaa tcgcattcct tgaggaaaga gcagcatgtg ggaaaacata
     3901 aatgcacgca ataacctggc tcacatgtta agagaacttt ctgactataa tgagggatgt
     3961 gttgctgccc caagcttcat tatctaagga gtttgttgaa cactctctag aggcttttaa
     4021 taataggatt gtttagctgg tctgtctgga ctggttagat ataacactat ttaaatgacc
     4081 caatctcatt acattgtgaa gatttccatt ttttaggtta cgtaagaaat tttggaccta
     4141 aaaatcttgc attttaagac agtctttgtc agaattactt tttggctcta aatgaattct
     4201 gtaacatttg tattctaaat tgacctttag taaaagcagg aatggccata ttcaaactgg
     4261 taacctcgca aatcctgccc accctttcac tttctgtctc aatacattga tgtcctctaa
     4321 cccatttcct gtcttatgtg gctttagtgc cacttatcaa aattgtgtgc aaatttcctt
     4381 ggctaacagt aacagttttt gtctgggctt gtctagcagt ggaattctgc ctgagttcat
     4441 catttttgtg actggtactt gaagtgcatc agatgattaa tttcatgata agagggcttt
     4501 ttggggtggt gaaatagaca tttatggaaa atgggatacc cacattaagc agggtgacta
     4561 cctgtttacc atacaaccca cacaaagcca atacaactat agatgtgctt tctttagtct
     4621 gttgcctctg caaacattgc ccgtgtgttt ctctatgccc ttcaaaaaca tcagagcagc
     4681 acatcctgga agatcctatc ttttgtaagt ttaagaagca gcctcttgtc acagcttgac
     4741 tcctaggtag tgtgcctagt gaccaagagg gctgctaaga aagctttctg accacttgtg
     4801 gctgtcattg gactgatttg cccagatgac atcaattggg aatttgaggc atgacctata
     4861 aagatcagtt gcttgcaaga gtctcaggaa aataattgtg gagttaagaa acttgaagcg
     4921 atttttaaaa attacctaac ccaaccttct catttgaaaa attaaaaaat aaataggcca
     4981 gatatggcgg ctcatgcctg taatcccagc gctgtgggag cctgaggcgg gtgggtctct
     5041 tgaggccagg agttcaagac cagcctggac aatgtggtga aaccctgtct ctactaaaaa
     5101 cacaaaaatt agctgggtgt ggtggcaggc gcctgtaatc ccagctactc aggaggctaa
     5161 ggtgggagga ttacttgaac tggggaggca taggttgtag tgagccaagg tcgtgtcact
     5221 gcactccagc ctgggtgaca gagtaagact ctgcctaaaa aaaaaaaaag aaagattaaa
     5281 aaataaataa atctgctggg cgtggtggct cacgcctgta atcccagcac tttgggaggc
     5341 cgaggcgggt ggatcacctg aggtcgggag tttgagacca gcctgatcaa catggagaaa
     5401 cctcgtctct actaaaaaca caaaaaaatt agctgggcgt ggtggcgcat gcctcattca
     5461 cgtacatggg agagtctaca aagtcacacg tattcatagg ttaagccaca tgctgacaaa
     5521 tgtcataaga agaccctaca cttttacctt ggccgatccc tcccctcagt gcaagctctg
     5581 tgcaagagtg aacttgaact tcactcagtg caagagtgaa cacacacttt gtgccggctt
     5641 taaagaaccc agcacaaagc cagtctgcat ggcctacaga catattttgc tggacaatga
     5701 ttacttgctt ttctttttgt ttttcttgta tatgcctgtt tgattggttc ctgacatacc
     5761 agaaaatcac tgtcaaaaca ttagcttaac atttgttaag gaaacaaaaa gacttcggtg
     5821 accacacctt ataaaccaaa cagttttgta aatcactttg gaaaatttca ctaaaaaaaa
     5881 aaatccttaa caatataata agtaaagaaa atttaaaacc acaaaacatt actgtgtttg
     5941 tagggggagg tctgatttac agagtaacca catagtaatt ataattatta gaatgtccag
     6001 ttttcaaaaa acgttacaag gcatacaaag aatgggaaag tgtggctcat tcaaaggaac
     6061 aaaataaagt gacagaaaat atccctaagg aaacccagac atcaaactta ccagacaaag
     6121 actttaaaac aactctcttc attatactca aatgtcaaaa ggaaaacata aacaaagaaa
     6181 taaaggaatc agaaaaaata ttaaaaagta ggaatatcag caaagagata acaaattctg
     6241 gagtggaaaa ctacaatgat aaaaatttaa aaatcaccag agggatttaa gagtatattt
     6301 gcacacacag aggaagccat gaacttgaag agaagaaaat ggaaaatact gtctctgaga
     6361 aacagaaaga ataaaaaata aacaatgagc agagactaat gaatttgtgg gacatcatca
     6421 aatagaccaa cattcatatt ctagaaggat aaattatgtt gttaaaaagt ttaccattct
     6481 ttcttttcac ctttcttcct tcttccttcc ccctcctcct ttttactttt cttcctcttc
     6541 ctttctcttc ttctttctcg ccttcattat ccctttcgct gtttctcttt ctccctttct
     6601 cttttttctt ttctttcaat tttctcaatt actaagagat gtttaagtac ccttagcatg
     6661 ttagtagata tggttatttc tccctttagt tctcttttga gatttatagt cactcaaata
     6721 aagagataac ccaaacataa gcgtcacaaa caggctttca taccattctt aatttggtcc
     6781 tgtaattctt cattgctgta ttaattttct gatgctttta aggatgtttt ataacaaatt
     6841 gtgtagcttt ttccaatgga atgtttattc tgaattatct aattcatatt gtaagtatag
     6901 agggagttta atataaaatt attaaactaa tatttgtgaa agaatgtatt tgagcattta
     6961 acaaatatgt taatcctcag actgttattg ggcagctgag catacaggaa taaaaataac
     7021 acaattttta tgtgtacaat atttatggaa tacgttactg gacccaataa ataatttagt
     7081 taataacatg a
//
