LOCUS       NM_001271870            6900 bp    mRNA    linear   PRI 03-OCT-2024
DEFINITION  Homo sapiens SLIT-ROBO Rho GTPase activating protein 2B (SRGAP2B),
            transcript variant 1, mRNA.
ACCESSION   NM_001271870 XM_024449122
VERSION     NM_001271870.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6900)
  AUTHORS   Schmidt,E.R.E., Kupferman,J.V., Stackmann,M. and Polleux,F.
  TITLE     The human-specific paralogs SRGAP2B and SRGAP2C differentially
            modulate SRGAP2A-dependent synaptic development
  JOURNAL   Sci Rep 9 (1), 18692 (2019)
   PUBMED   31822692
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6900)
  AUTHORS   Dougherty,M.L., Underwood,J.G., Nelson,B.J., Tseng,E., Munson,K.M.,
            Penn,O., Nowakowski,T.J., Pollen,A.A. and Eichler,E.E.
  TITLE     Transcriptional fates of human-specific segmental duplications in
            brain
  JOURNAL   Genome Res 28 (10), 1566-1576 (2018)
   PUBMED   30228200
REFERENCE   3  (bases 1 to 6900)
  AUTHORS   Charrier,C., Joshi,K., Coutinho-Budd,J., Kim,J.E., Lambert,N., de
            Marchena,J., Jin,W.L., Vanderhaeghen,P., Ghosh,A., Sassa,T. and
            Polleux,F.
  TITLE     Inhibition of SRGAP2 function by its human-specific paralogs
            induces neoteny during spine maturation
  JOURNAL   Cell 149 (4), 923-935 (2012)
   PUBMED   22559944
REFERENCE   4  (bases 1 to 6900)
  AUTHORS   Dennis,M.Y., Nuttle,X., Sudmant,P.H., Antonacci,F., Graves,T.A.,
            Nefedov,M., Rosenfeld,J.A., Sajjadian,S., Malig,M., Kotkiewicz,H.,
            Curry,C.J., Shafer,S., Shaffer,L.G., de Jong,P.J., Wilson,R.K. and
            Eichler,E.E.
  TITLE     Evolution of human-specific neural SRGAP2 genes by incomplete
            segmental duplication
  JOURNAL   Cell 149 (4), 912-922 (2012)
   PUBMED   22559943
REFERENCE   5  (bases 1 to 6900)
  AUTHORS   Choy,K.W., Wang,C.C., Ogura,A., Lau,T.K., Rogers,M.S., Ikeo,K.,
            Gojobori,T., Lam,D.S. and Pang,C.P.
  TITLE     Genomic annotation of 15,809 ESTs identified from pooled early
            gestation human eyes
  JOURNAL   Physiol Genomics 25 (1), 9-15 (2006)
   PUBMED   16368877
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC242498.3 and FP700111.23.
            
            On Jun 10, 2021 this sequence version replaced NM_001271870.4.
            
            Summary: This locus encodes a member of the SLIT-ROBO Rho GTPase
            activating protein family. This human-specific locus resulted from
            incomplete segmental duplication of the SLIT-ROBO Rho GTPase
            activating protein 2 locus. The encoded protein lacks the GTPase
            activating protein domain compared to proteins encoded by SLIT-ROBO
            Rho GTPase activating protein 2. The functionality of the protein
            encoded by this locus has been questioned, as several normal
            individuals with homozygous deletions for this locus have been
            identified, and the expression of this locus appears to be much
            lower than the similar SLIT-ROBO Rho GTPase activating protein 2C
            (SRGAP2C) locus. The SRGAP2C locus has been shown to encode a
            protein that functions antagonistically to SLIT-ROBO Rho GTPase
            activating protein 2 in cortical neuron development. [provided by
            RefSeq, Dec 2012].
            
            Sequence Note:.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660809.104238.1,
                                           SRR1803614.110437.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000641863.3/ ENSP00000493121.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-106               AC242498.3         23503-23608
            107-715             AC242498.3         25388-25996
            716-908             AC242498.3         123631-123823
            909-1071            AC242498.3         163230-163392
            1072-1134           FP700111.23        180492-180554       c
            1135-1350           FP700111.23        171659-171874       c
            1351-1479           FP700111.23        170891-171019       c
            1480-1704           FP700111.23        162916-163140       c
            1705-1806           FP700111.23        159208-159309       c
            1807-6900           FP700111.23        153088-158181       c
FEATURES             Location/Qualifiers
     source          1..6900
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q21.1"
     gene            1..6900
                     /gene="SRGAP2B"
                     /gene_synonym="SRGAP2L; SRGAP2P2"
                     /note="SLIT-ROBO Rho GTPase activating protein 2B"
                     /db_xref="GeneID:647135"
                     /db_xref="HGNC:HGNC:35237"
                     /db_xref="MIM:614703"
     exon            1..106
                     /gene="SRGAP2B"
                     /gene_synonym="SRGAP2L; SRGAP2P2"
                     /inference="alignment:Splign:2.1.0"
     exon            107..715
                     /gene="SRGAP2B"
                     /gene_synonym="SRGAP2L; SRGAP2P2"
                     /inference="alignment:Splign:2.1.0"
     CDS             649..2028
                     /gene="SRGAP2B"
                     /gene_synonym="SRGAP2L; SRGAP2P2"
                     /note="isoform 1 is encoded by transcript variant 1;
                     SLIT-ROBO Rho GTPase activating protein 2 pseudogene 2;
                     SLIT-ROBO Rho GTPase activating protein 2B (pseudogene)"
                     /codon_start=1
                     /product="SLIT-ROBO Rho GTPase-activating protein 2B
                     isoform 1"
                     /protein_id="NP_001258799.2"
                     /db_xref="CCDS:CCDS72854.2"
                     /db_xref="GeneID:647135"
                     /db_xref="HGNC:HGNC:35237"
                     /db_xref="MIM:614703"
                     /translation="MTSPAKFKKDKEIIAEYDTQVKEIRAQLTEQMKCLDQQCELRVQ
                     LLQDLQDFFRKKAEIEMDYSRNLEKLAERFLAKTCSTKDQQFKKDQNVLSPVNCWNLL
                     LNQVKRESRDHTTLSDIYLNNIIPRFVQVSEDSGRLFKKSKEVGQQLQDDLMKVLNEL
                     YSVMKTYHMYNADSISAQSKLKEAEKQEEKQIGKSVKQEDRQTPRSPDSTANVRIEEK
                     HVRRSSVKKIEKMKEKRQAKYTENKLKAIKARNEYLLALEATNASVFKYYIHDLSDLI
                     DQCCDLGYHASLNRALRTFLSAELNLEQSKHEGLDAIENAVENLDATSDKQRLMEMYN
                     NVFCPPMKFEFQPHMGDMASQLCAQQPVQSELLQRCQQLQSRLSTLKIENEEVKKTME
                     ATLQTIQDIVTVEDFDVSDCFQYSNSMESVKSTVSETFMSKPSIAKRRANQQETEQFY
                     FTVRECYGF"
     exon            716..908
                     /gene="SRGAP2B"
                     /gene_synonym="SRGAP2L; SRGAP2P2"
                     /inference="alignment:Splign:2.1.0"
     exon            909..1071
                     /gene="SRGAP2B"
                     /gene_synonym="SRGAP2L; SRGAP2P2"
                     /inference="alignment:Splign:2.1.0"
     exon            1072..1134
                     /gene="SRGAP2B"
                     /gene_synonym="SRGAP2L; SRGAP2P2"
                     /inference="alignment:Splign:2.1.0"
     exon            1135..1350
                     /gene="SRGAP2B"
                     /gene_synonym="SRGAP2L; SRGAP2P2"
                     /inference="alignment:Splign:2.1.0"
     exon            1351..1479
                     /gene="SRGAP2B"
                     /gene_synonym="SRGAP2L; SRGAP2P2"
                     /inference="alignment:Splign:2.1.0"
     exon            1480..1704
                     /gene="SRGAP2B"
                     /gene_synonym="SRGAP2L; SRGAP2P2"
                     /inference="alignment:Splign:2.1.0"
     exon            1705..1806
                     /gene="SRGAP2B"
                     /gene_synonym="SRGAP2L; SRGAP2P2"
                     /inference="alignment:Splign:2.1.0"
     exon            1807..6900
                     /gene="SRGAP2B"
                     /gene_synonym="SRGAP2L; SRGAP2P2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6868..6873
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SRGAP2B"
                     /gene_synonym="SRGAP2L; SRGAP2P2"
                     /note="hexamer: CATAAA"
     regulatory      6877..6882
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SRGAP2B"
                     /gene_synonym="SRGAP2L; SRGAP2P2"
                     /note="hexamer: ATTAAA"
     polyA_site      6886
                     /gene="SRGAP2B"
                     /gene_synonym="SRGAP2L; SRGAP2P2"
     polyA_site      6900
                     /gene="SRGAP2B"
                     /gene_synonym="SRGAP2L; SRGAP2P2"
                     /note="major polyA site"
ORIGIN      
        1 actggggcac agatctgcgt agaaacgggt ggcggggaag agaggggagg agagctctga
       61 gtgggaagcg gagccggggg cctgggaccc gtcgcgtcag agccaggcaa gtgaaccgga
      121 gcaaacgact tccgatccag tctgcgctgt tgcggctccc gtttgggatt tgatttgcag
      181 catctttgag cctctacgac aaaaaaccgc gaagcacgcc cagccctccc ccggcacccc
      241 gaaaagcacc cactccctcc cggggacaca gctgggcgcg tccacacccc cgcagcccca
      301 caccatgttg tgcggaagga cttccactcc ccgcctgtgt cgttgatgtc agaccccagg
      361 ccagcctccg ggcgctgcag ttctcccggc taatgctgag gctgcggctc cggctctagc
      421 acaggcacca gccgccgccg cacccggcct cagcgcccac cgtctgcatg tgcccgccgt
      481 agccgtctgc ccagcccgca gcccgcgctc cacggagcgc tggagaccac cgtggggggc
      541 cccttctgcc ctcgagagaa gcggtcttgg aggtattgat ttaggtggtt ggattttttc
      601 cgtggatcta tcaattcaca attcgaattt ggaagaaaga aggaaaacat gacgtctcca
      661 gccaaattca aaaaggataa ggagatcata gcagagtacg atactcaggt caaagagatc
      721 cgtgctcagc tcacagagca gatgaaatgc ctggaccagc agtgtgagct tcgggtgcaa
      781 ctgttgcagg acctccagga cttcttccga aagaaggcag agattgagat ggactactcc
      841 cgcaacctgg agaagctggc agaacgcttc ctggccaaga catgcagcac caaggaccag
      901 caattcaaga aggatcagaa tgttctctct ccagtcaact gctggaatct cctcttaaac
      961 caggtgaagc gggaaagcag ggaccatacc accctgagtg acatctacct gaataatatc
     1021 attcctcgat ttgtacaagt cagcgaggac tcaggaagac tctttaaaaa gagtaaagaa
     1081 gtcggccagc agctccaaga tgatttgatg aaggtcctga acgagctcta ctcggtcatg
     1141 aagacatatc acatgtacaa tgccgacagc atcagtgctc agagcaaact aaaggaggcg
     1201 gagaagcagg aggagaagca aattggtaaa tcggtaaagc aggaggaccg gcagacccca
     1261 cgctcccctg actccacggc caacgttcgc attgaggaga aacatgtccg gaggagctca
     1321 gtgaagaaga ttgagaagat gaaggagaag cgccaagcca agtacacgga gaataagctg
     1381 aaggccatca aagcccggaa tgagtacttg ctggctttgg aggcaaccaa tgcatctgtc
     1441 ttcaagtact acatccatga cctatctgac cttattgatc agtgttgtga cttaggctac
     1501 catgcaagtc tgaaccgggc tctacgcacc ttcctctctg ctgagttaaa cctggaacag
     1561 tcgaagcatg agggtctgga tgccatcgag aatgcagtag aaaacctgga tgccaccagt
     1621 gacaagcagc gcctcatgga gatgtacaac aacgtcttct gcccccctat gaagtttgag
     1681 tttcagcccc acatggggga tatggcttcc cagctctgtg cccagcagcc tgtccagagt
     1741 gagctgctac agagatgcca acaactgcag tctcgcttat ccactctaaa gattgaaaac
     1801 gaagaggtaa agaagacaat ggaggccacc ctgcaaacca tccaggacat tgtgactgtc
     1861 gaggacttcg atgtgtctga ctgcttccag tacagcaact ccatggagtc cgtcaagtcc
     1921 acggtctctg aaaccttcat gagcaagccc agcattgcta agaggagagc caaccagcaa
     1981 gagacagagc agttttattt cacagtgagg gagtgctatg gcttttaaag agcgtcagca
     2041 tgcactgcag cactcaaggg agatttggaa ctcagagtcc ttgttaagtg tctgaaggac
     2101 aggcgttgaa tatcttagat acgaatgtgg gcatactcag agaccatccc tacagttaaa
     2161 ggtgcaaaca ttaaaagttg tatatgtcta acagggatcc gcccaagaga aaggatgctc
     2221 ccaagtatac aactaagaag attttctttt ttaagaaatt tttaactagc tagtaggctt
     2281 tcactggaaa gtttccttct caggcacagg ggatcctgaa aggggaactt catcttttag
     2341 ttcttggaga gtacatacaa atattcataa taacacatat tttgtttata aaaatctata
     2401 atctcttcta ggtgatatga tgacattatt ttataacttt tattgttggg aaactatttt
     2461 ttctaattat tgctaaaact taaaggatgg gtaatatgca gcattactat tttgcacata
     2521 attccaaaac atcgtatttt cttattcatg tatctctagt cttcttttag acagttggac
     2581 ccttttttct cttttttttt tttttttttt ttttttaagt attgttaaca atcctttgga
     2641 agtcactact ggtctttgtg tgctgctttt taataattga gttattttga gcttgccaag
     2701 taggatctat tgcctggact aaaatttatt tcctaatctt ctgatgacca agaaaggaaa
     2761 aattaagttt gcagatgtga gatgaaatat agccagtgaa tatgcatact gattctgaat
     2821 gaaaggaatt aacttttcag tcaagaaaca gtctgcatgc agtaaattga atttttcctg
     2881 caactggaat gatttgttta attcttcttt gaacactgcc ctttctccag taagaacact
     2941 aatgatttgc taatattttt taaagaaatc tgttttttta attagttaag ctcagacttc
     3001 ctcttatttt ttatcctaga gaaaactgct aaaagggaat gatatatcag tactattctt
     3061 ctaaaacaac tttttaaaaa tgattataca aagccaaata tgctcattat ataaaattta
     3121 gaagcaaaaa gaaggaaata aaaattttcc ataattctac cagctagaga taatggtgtt
     3181 agaatatatt cctttctaat ctgttttcta tgcatgcaca aacacatatg tgagcacata
     3241 tttataattt tattctaaaa aataggatac tgctgtacat attgttttac aatctaagtc
     3301 atataattat aatattcttt aagcatattt atgagtaaaa tattaaaacc tatacaaaaa
     3361 aataatagaa tggcatttta gctcattcat tgatttttat aaaatattta acacactccc
     3421 tggtttgtag ttagcgttca ataaatgcta aaaatttatc ttcaccatca tcattaattt
     3481 atttattaat cattattaaa ttattcattg atcatttttt gaggatttac tattgccaga
     3541 cactgtgcta caagctggga atgctgacag tataagataa agagggaaat gatgggggat
     3601 gggtcatgta aagggagaac tttcattttt acttcatata tatctaagca gttataatag
     3661 gttgattttt gtaatttaaa aaatgtaaaa atgcatacat gcactagtgc atgaatggca
     3721 gccaggatga gtggaattgg agaagcatca cacacacagt gacttttgtg tttgatcttg
     3781 aagaatgagc gaaccaggca gggagtcggg gaggagaatc gcattccttg aggaaagagc
     3841 agcatgtggg aaaacataaa tgcacgcaat aacctggctc acatgttaag agaactttct
     3901 gactataatg agggatgtgt tgctgcccca agcttcatta tctaaggagt ttgttgaaca
     3961 ctctctagag gcttttaata ataggattgt ttagctggtc tgtctggact ggttagatat
     4021 aacactattt aaatgaccca atctcattac attgtgaaga tttccatttt ttaggttacg
     4081 taagaaattt tggacctaaa aatcttgcat tttaagacag tctttgtcag aattactttt
     4141 tggctctaaa tgaattctgt aacatttgta ttctaaattg acctttagta aaagcaggaa
     4201 tggccatatt caaactggta acctcgcaaa tcctgcccac cctttcactt tctgtctcaa
     4261 tacattgatg tcctctaacc catttcctgt cttatgtggc tttagtgcca cttatcaaaa
     4321 ttgtgtgcaa atttccttgg ctaacagtaa cagtttttgt ctgggcttgt ctagcagtgg
     4381 aattctgcct gagttcatca tttttgtgac tggtacttga agtgcatcag atgattaatt
     4441 tcatgataag agggcttttt ggggtggtga aatagacatt tatggaaaat gggataccca
     4501 cattaagcag ggtgactacc tgtttaccat acaacccaca caaagccaat acaactatag
     4561 atgtgcttta tttagtctgt tgcctctgca aacattgccc gtgtgtttct ctatgccctt
     4621 caaaaacatc agagcagcac atcctggaag atcctatctt ttgtaagttt aagaagcagc
     4681 ctcttgtcac aggttgactc ctaggtagtg tgcctagtga ccaagagggc tgctaagaaa
     4741 gctttctgac cacttgtggc tgtcattgga ctgatttgcc cagatgacat caattgggaa
     4801 tttgaggcat gacctataaa gatcagttgc ttgcaagagt ctcaggaaaa taattgtgga
     4861 gttaagaaac ttgaagcgat ttttaaaaat tacctaaccc aaccttctca tttgaaaaat
     4921 taaaaaataa ataggccaga tatggcagct catgcctgta atcccagcgc tgtgggagcc
     4981 tgaggcgggt gggtctcttg aggccaggag ttcaagacca gcctggacaa catggtgaaa
     5041 ccctgtctct actaaaaaca caaaaattag ctgagtgtgg tggcaggcgc ctgtaatccc
     5101 agctactcag gaggctaagg tgggaggatt acttgaaccg gggaggcata ggttgtagtg
     5161 agccaagatc gtgtcactgc actccagcct gggtgacaga gtaagactct gcctaaaaaa
     5221 aaaaaagaaa gattaaaaaa taaataaatc tgctgggcgt ggtggctcac gcctgtaatc
     5281 ccagcacttt gggaggccga ggcgggcgga tcacctgagg tcgggagttt gagaccagcc
     5341 tgatcaacat ggagaaacct cgtctctact aaaaacacga aaaaattagc tgggcgtggt
     5401 ggcgcatgcc tcattcacgt acatgggaga gtctacaaag tcacacgtat tcataggtta
     5461 agccacatgc tgacaaatgt cataagaaga ccctacactt ttaccttggc cgatccctcc
     5521 cctcagtgca agctctgtgc aagagtgaac ttgaacttca ctcagtgcaa gagtgaacac
     5581 acactttgtg ccggctttaa agaacccagc acaaagccag tctgcatggc ctacagacat
     5641 attttgctgg acaatgatta cttgcttttc tttttgtttt tcttgtattt gcctgtttga
     5701 ttggctcctg acataccaga aaatcactgt caaaacatta gcttaacatt tgttaaggaa
     5761 acaaaaagac ttcggtgacc acaccttata aaccaaacag ttttgtaaat cactttggaa
     5821 aatttcacta aaaaaaaaaa tccttaacaa tataataagt aaagaaaatt taaaaccaca
     5881 aaacatcact gtgtttgtag ggggaggtct gatttacaga gtaaccacat agtaattata
     5941 attattagaa tgtccagttt tcaaaaaacg ttacaaggca tacaaagaat gggaaagtgt
     6001 ggctcattca aaggaacaaa ataaagtgac agaaaatatc cctaaagaaa cccagacatc
     6061 aaacttacca gacaaagact ttaaaacaac tgtcttcatt atactcaaat gtcaaaagga
     6121 aaacataaac aaagaaataa aggaatcaga aaaaatatta aaaagtagga atatcagcaa
     6181 agagataaca aattctggag tggaaaacta caatgataaa aatttaaaaa tcaccagagg
     6241 gatttaagag tatatttgca cacacagagg aagccatgaa cttgaagaga agaaaatgga
     6301 aaatactctg agaaacagaa agaataaaaa ataaacaatg agcacagact aatgaatctg
     6361 tgggacatca tcaaatagac caacattcat attctagaag gataaattat gttgttaaaa
     6421 agtttaccat tctttctttt cacctttctt ccttcttcct tccccctcct cctccttttt
     6481 acttttcttc ctcttccttt ctcttcttct ttctctcctt cattatccct ttcgctgtct
     6541 ctctttctcc ctttctcttt tttcttttct ttcaattttc tcaattacta agagatgttt
     6601 aagtaccctt agcatgttag tagatacggt tatttctccc tttagttctc ttttgagatt
     6661 tatagtcact caaataaaga gataacccaa acataagcgt cacaaacagg ctttcatacc
     6721 attcttaatt tggtcctgta attcttcatt gctgtattaa ttttctgatg cttttaagga
     6781 tgttttataa caagttgtgt agctttttcc aatggaatgt ttattctgaa ttatctaatt
     6841 catattgtaa gtatagaggg agtttaacat aaaattatta aactaatatt tgtgaaagaa
//
