LOCUS       NM_015326               6884 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens SLIT-ROBO Rho GTPase activating protein 2 (SRGAP2),
            transcript variant 1, mRNA.
ACCESSION   NM_015326 XM_005277510 XM_059095
VERSION     NM_015326.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6884)
  AUTHORS   Segal,D., Maier,S., Mastromarco,G.J., Qian,W.W., Nabeel-Shah,S.,
            Lee,H., Moore,G., Lacoste,J., Larsen,B., Lin,Z.Y.,
            Selvabaskaran,A., Liu,K., Smibert,C., Zhang,Z., Greenblatt,J.,
            Peng,J., Lee,H.O., Gingras,A.C. and Taipale,M.
  TITLE     A central chaperone-like role for 14-3-3 proteins in human cells
  JOURNAL   Mol Cell 83 (6), 974-993 (2023)
   PUBMED   36931259
REFERENCE   2  (bases 1 to 6884)
  AUTHORS   Li,C., Zheng,Z., Wu,X., Xie,Q., Liu,P., Hu,Y., Chen,M., Liu,L.,
            Zhao,W., Chen,L., Guo,J. and Song,Y.
  TITLE     Stiff matrix induced srGAP2 tension gradients control migration
            direction in triple-negative breast cancer
  JOURNAL   Theranostics 13 (1), 59-76 (2023)
   PUBMED   36593959
  REMARK    GeneRIF: Stiff matrix induced srGAP2 tension gradients control
            migration direction in triple-negative breast cancer.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 6884)
  AUTHORS   Tang,Y., Liu,G., Jia,Y. and Sun,T.
  TITLE     SRGAP2 controls colorectal cancer chemosensitivity via regulation
            of mitochondrial complex I activity
  JOURNAL   Hum Cell 35 (6), 1928-1938 (2022)
   PUBMED   36059022
  REMARK    GeneRIF: SRGAP2 controls colorectal cancer chemosensitivity via
            regulation of mitochondrial complex I activity.
REFERENCE   4  (bases 1 to 6884)
  AUTHORS   Wang,L., Yang,L., Zhuang,T. and Shi,X.
  TITLE     Tumor-Derived Exosomal miR-29b Reduces Angiogenesis in Pancreatic
            Cancer by Silencing ROBO1 and SRGAP2
  JOURNAL   J Immunol Res 2022, 4769385 (2022)
   PUBMED   36277474
  REMARK    GeneRIF: Tumor-Derived Exosomal miR-29b Reduces Angiogenesis in
            Pancreatic Cancer by Silencing ROBO1 and SRGAP2.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 6884)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   6  (bases 1 to 6884)
  AUTHORS   Meek,S.E., Lane,W.S. and Piwnica-Worms,H.
  TITLE     Comprehensive proteomic analysis of interphase and mitotic
            14-3-3-binding proteins
  JOURNAL   J Biol Chem 279 (31), 32046-32054 (2004)
   PUBMED   15161933
REFERENCE   7  (bases 1 to 6884)
  AUTHORS   Madura,T., Yamashita,T., Kubo,T., Tsuji,L., Hosokawa,K. and
            Tohyama,M.
  TITLE     Changes in mRNA of Slit-Robo GTPase-activating protein 2 following
            facial nerve transection
  JOURNAL   Brain Res Mol Brain Res 123 (1-2), 76-80 (2004)
   PUBMED   15046868
REFERENCE   8  (bases 1 to 6884)
  AUTHORS   Katoh,M. and Katoh,M.
  TITLE     FNBP2 gene on human chromosome 1q32.1 encodes ARHGAP family protein
            with FCH, FBH, RhoGAP and SH3 domains
  JOURNAL   Int J Mol Med 11 (6), 791-797 (2003)
   PUBMED   12736724
  REMARK    GeneRIF: FNBP2 gene was linked to IKBKE and NORE1 genes on human
            chromosome 1q32.1. FNBP2 mRNA was expressed in melanoma, germ cell
            tumors, chondrosarcoma and retinoblastoma.
REFERENCE   9  (bases 1 to 6884)
  AUTHORS   Wong,K., Ren,X.R., Huang,Y.Z., Xie,Y., Liu,G., Saito,H., Tang,H.,
            Wen,L., Brady-Kalnay,S.M., Mei,L., Wu,J.Y., Xiong,W.C. and Rao,Y.
  TITLE     Signal transduction in neuronal migration: roles of GTPase
            activating proteins and the small GTPase Cdc42 in the Slit-Robo
            pathway
  JOURNAL   Cell 107 (2), 209-221 (2001)
   PUBMED   11672528
REFERENCE   10 (bases 1 to 6884)
  AUTHORS   Bertling,W.M., Beier,F. and Reichenberger,E.
  TITLE     Determination of 5' ends of specific mRNAs by DNA ligase-dependent
            amplification
  JOURNAL   PCR Methods Appl 3 (2), 95-99 (1993)
   PUBMED   8268792
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC244035.3, DA110905.1,
            AB007925.1, AK294060.1, AC244034.4 and BC063527.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On or before Jan 13, 2020 this sequence version replaced
            XM_005277510.3, NM_015326.4.
            
            Summary: This locus encodes a member of the SLIT-ROBO Rho GTPase
            activating protein family. The encoded protein stimulates GTPase
            activity of Rac1, and plays a role in cortical neuron development.
            This locus has several paralogs on human chromosome 1 resulting
            from segmental duplication. While this locus itself is conserved
            among various species, the paralogs are found only in the genus
            Homo, and not in the genomes of non-human great apes. Alternatively
            spliced transcript variants have been described for this locus.
            [provided by RefSeq, Jul 2014].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (a).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660809.153293.1,
                                           SRR1803614.153968.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000573034.8/ ENSP00000459615.2
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-110               AC244035.3         152890-152999
            111-590             DA110905.1         89-568
            591-2776            AB007925.1         11-2196
            2777-4179           AK294060.1         237-1639
            4180-6225           AC244034.4         150150-152195       c
            6226-6884           BC063527.1         1-659
FEATURES             Location/Qualifiers
     source          1..6884
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q32.1"
     gene            1..6884
                     /gene="SRGAP2"
                     /gene_synonym="ARHGAP34; FNBP2; SRGAP2A; SRGAP3"
                     /note="SLIT-ROBO Rho GTPase activating protein 2"
                     /db_xref="GeneID:23380"
                     /db_xref="HGNC:HGNC:19751"
                     /db_xref="MIM:606524"
     exon            1..110
                     /gene="SRGAP2"
                     /gene_synonym="ARHGAP34; FNBP2; SRGAP2A; SRGAP3"
                     /inference="alignment:Splign:2.1.0"
     exon            111..719
                     /gene="SRGAP2"
                     /gene_synonym="ARHGAP34; FNBP2; SRGAP2A; SRGAP3"
                     /inference="alignment:Splign:2.1.0"
     CDS             653..3868
                     /gene="SRGAP2"
                     /gene_synonym="ARHGAP34; FNBP2; SRGAP2A; SRGAP3"
                     /note="isoform a is encoded by transcript variant 1; rho
                     GTPase-activating protein 34; formin-binding protein 2;
                     SLIT-ROBO GAP2"
                     /codon_start=1
                     /product="SLIT-ROBO Rho GTPase-activating protein 2
                     isoform a"
                     /protein_id="NP_056141.2"
                     /db_xref="CCDS:CCDS73017.1"
                     /db_xref="GeneID:23380"
                     /db_xref="HGNC:HGNC:19751"
                     /db_xref="MIM:606524"
                     /translation="MTSPAKFKKDKEIIAEYDTQVKEIRAQLTEQMKCLDQQCELRVQ
                     LLQDLQDFFRKKAEIEMDYSRNLEKLAERFLAKTRSTKDQQFKKDQNVLSPVNCWNLL
                     LNQVKRESRDHTTLSDIYLNNIIPRFVQVSEDSGRLFKKSKEVGQQLQDDLMKVLNEL
                     YSVMKTYHMYNADSISAQSKLKEAEKQEEKQIGKSVKQEDRQTPRSPDSTANVRIEEK
                     HVRRSSVKKIEKMKEKRQAKYTENKLKAIKARNEYLLALEATNASVFKYYIHDLSDLI
                     DQCCDLGYHASLNRALRTFLSAELNLEQSKHEGLDAIENAVENLDATSDKQRLMEMYN
                     NVFCPPMKFEFQPHMGDMASQLCAQQPVQSELVQRCQQLQSRLSTLKIENEEVKKTME
                     ATLQTIQDIVTVEDFDVSDCFQYSNSMESVKSTVSETFMSKPSIAKRRANQQETEQFY
                     FTKMKEYLEGRNLITKLQAKHDLLQKTLGESQRTDCSLARRSSTVRKQDSSQAIPLVV
                     ESCIRFISRHGLQHEGIFRVSGSQVEVNDIKNAFERGEDPLAGDQNDHDMDSIAGVLK
                     LYFRGLEHPLFPKDIFHDLMACVTMDNLQERALHIRKVLLVLPKTTLIIMRYLFAFLN
                     HLSQFSEENMMDPYNLAICFGPSLMSVPEGHDQVSCQAHVNELIKTIIIQHENIFPSP
                     RELEGPVYSRGGSMEDYCDSPHGETTSVEDSTQDVTAEHHTSDDECEPIEAIAKFDYV
                     GRTARELSFKKGASLLLYQRASDDWWEGRHNGIDGLIPHQYIVVQDTEDGVVERSSPK
                     SEIEVISEPPEEKVTARAGASCPSGGHVADIYLANINKQRKRPESGSIRKTFRSDSHG
                     LSSSLTDSSSPGVGASCRPSSQPIMSQSLPKEGPDKCSISGHGSLNSISRHSSLKNRL
                     DSPQIRKTATAGRSKSFNNHRPMDPEVIAQDIEATMNSALNELRELERQSSVKHTPDV
                     VLDTLEPLKTSPVVAPTSEPSSPLHTQLLKDPEPAFQRSASTAGDIACAFRPVKSVKM
                     AAPVKPPATRPKPTVFPKTNATSPGVNSSTSPQSTDKSCTV"
     exon            720..912
                     /gene="SRGAP2"
                     /gene_synonym="ARHGAP34; FNBP2; SRGAP2A; SRGAP3"
                     /inference="alignment:Splign:2.1.0"
     exon            913..1075
                     /gene="SRGAP2"
                     /gene_synonym="ARHGAP34; FNBP2; SRGAP2A; SRGAP3"
                     /inference="alignment:Splign:2.1.0"
     exon            1076..1138
                     /gene="SRGAP2"
                     /gene_synonym="ARHGAP34; FNBP2; SRGAP2A; SRGAP3"
                     /inference="alignment:Splign:2.1.0"
     exon            1139..1354
                     /gene="SRGAP2"
                     /gene_synonym="ARHGAP34; FNBP2; SRGAP2A; SRGAP3"
                     /inference="alignment:Splign:2.1.0"
     exon            1355..1483
                     /gene="SRGAP2"
                     /gene_synonym="ARHGAP34; FNBP2; SRGAP2A; SRGAP3"
                     /inference="alignment:Splign:2.1.0"
     exon            1484..1708
                     /gene="SRGAP2"
                     /gene_synonym="ARHGAP34; FNBP2; SRGAP2A; SRGAP3"
                     /inference="alignment:Splign:2.1.0"
     exon            1709..1810
                     /gene="SRGAP2"
                     /gene_synonym="ARHGAP34; FNBP2; SRGAP2A; SRGAP3"
                     /inference="alignment:Splign:2.1.0"
     exon            1811..2008
                     /gene="SRGAP2"
                     /gene_synonym="ARHGAP34; FNBP2; SRGAP2A; SRGAP3"
                     /inference="alignment:Splign:2.1.0"
     exon            2009..2093
                     /gene="SRGAP2"
                     /gene_synonym="ARHGAP34; FNBP2; SRGAP2A; SRGAP3"
                     /inference="alignment:Splign:2.1.0"
     exon            2094..2121
                     /gene="SRGAP2"
                     /gene_synonym="ARHGAP34; FNBP2; SRGAP2A; SRGAP3"
                     /inference="alignment:Splign:2.1.0"
     exon            2122..2146
                     /gene="SRGAP2"
                     /gene_synonym="ARHGAP34; FNBP2; SRGAP2A; SRGAP3"
                     /inference="alignment:Splign:2.1.0"
     exon            2147..2207
                     /gene="SRGAP2"
                     /gene_synonym="ARHGAP34; FNBP2; SRGAP2A; SRGAP3"
                     /inference="alignment:Splign:2.1.0"
     exon            2208..2285
                     /gene="SRGAP2"
                     /gene_synonym="ARHGAP34; FNBP2; SRGAP2A; SRGAP3"
                     /inference="alignment:Splign:2.1.0"
     exon            2286..2420
                     /gene="SRGAP2"
                     /gene_synonym="ARHGAP34; FNBP2; SRGAP2A; SRGAP3"
                     /inference="alignment:Splign:2.1.0"
     exon            2421..2526
                     /gene="SRGAP2"
                     /gene_synonym="ARHGAP34; FNBP2; SRGAP2A; SRGAP3"
                     /inference="alignment:Splign:2.1.0"
     exon            2527..2751
                     /gene="SRGAP2"
                     /gene_synonym="ARHGAP34; FNBP2; SRGAP2A; SRGAP3"
                     /inference="alignment:Splign:2.1.0"
     exon            2752..2831
                     /gene="SRGAP2"
                     /gene_synonym="ARHGAP34; FNBP2; SRGAP2A; SRGAP3"
                     /inference="alignment:Splign:2.1.0"
     exon            2832..3012
                     /gene="SRGAP2"
                     /gene_synonym="ARHGAP34; FNBP2; SRGAP2A; SRGAP3"
                     /inference="alignment:Splign:2.1.0"
     exon            3013..3159
                     /gene="SRGAP2"
                     /gene_synonym="ARHGAP34; FNBP2; SRGAP2A; SRGAP3"
                     /inference="alignment:Splign:2.1.0"
     exon            3160..3484
                     /gene="SRGAP2"
                     /gene_synonym="ARHGAP34; FNBP2; SRGAP2A; SRGAP3"
                     /inference="alignment:Splign:2.1.0"
     exon            3485..6884
                     /gene="SRGAP2"
                     /gene_synonym="ARHGAP34; FNBP2; SRGAP2A; SRGAP3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6860..6865
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SRGAP2"
                     /gene_synonym="ARHGAP34; FNBP2; SRGAP2A; SRGAP3"
                     /note="hexamer: AATAAA"
     polyA_site      6884
                     /gene="SRGAP2"
                     /gene_synonym="ARHGAP34; FNBP2; SRGAP2A; SRGAP3"
                     /note="major polyA site"
ORIGIN      
        1 agggactggg gcaccgatct gcgtagaaac gggtggcggg gaagagaggg gaggagagct
       61 ctgagtggga agcggagccg ggggcctggg acccgtcgcg tcagagccag gcaagtgaac
      121 cggagcaaac gacttccgat ccagtctgcg ctgttgcggc tcccgtttgg gatttgattt
      181 gcagcatctt tgagcctcta cgacaaaaaa ccgcgaagca cgcccagccc tcccccggca
      241 ccccgaaaag cacccactcc ctcccgggga cacagctggg cgcgtccaca cccccgcagc
      301 cccacaccat gttgtgcgga aggacttcca ctccccgcct gtgtcgttga tgtcagaccc
      361 caggccagcc tccgggcgct gcagttctcc cggctaatgc tgaggctgcg gctccggctc
      421 tagcacaggc accagccgcc gccgcacccg gccccagcgc ccaccgtctg catgtgcccg
      481 ccgtagccgt ctgcccagcc cgcagcccgc gctccacgga gcgctggaga ccaccgtggg
      541 gggccccttc tgccctcgag agaagcggtc ttggaggtat tgatttaggt ggttggattt
      601 tttccgtgga tctatcaatt cacaattcga atttggaaga aagaaggaaa acatgacgtc
      661 tccagccaaa ttcaaaaagg ataaggagat catagcagag tacgatactc aggtcaaaga
      721 gatccgtgct cagctcacag agcagatgaa atgcctggac cagcagtgtg agcttcgggt
      781 gcaactgttg caggacctcc aggacttctt ccgaaagaag gcagagattg agatggacta
      841 ctcccgcaac ctggagaagc tggcagaacg cttcctggcc aagacacgca gcaccaagga
      901 ccagcaattc aagaaggatc agaatgttct ctctccagtc aactgctgga atctcctctt
      961 aaaccaggtg aagcgggaaa gcagggacca taccaccctg agtgacatct acctgaataa
     1021 tatcattcct cgatttgtac aagtcagcga ggactcagga agactcttta aaaagagtaa
     1081 agaagtcggc cagcagctcc aagatgattt gatgaaggtc ctgaacgagc tctactcggt
     1141 gatgaagaca tatcacatgt acaatgccga cagcatcagt gctcagagca aactaaagga
     1201 ggcggagaag caggaggaga agcaaattgg taaatcggta aagcaggagg accggcagac
     1261 cccacgctcc cctgactcca cggccaacgt tcgcattgag gagaaacatg tccggaggag
     1321 ctcagtgaag aagattgaga agatgaagga gaagcgtcaa gccaagtaca cggagaataa
     1381 gctgaaggcc atcaaagccc ggaatgagta cttgctggct ttggaggcaa ccaatgcatc
     1441 tgtcttcaag tactacatcc atgacctatc tgaccttatt gatcagtgtt gtgacttagg
     1501 ctaccatgca agtctgaacc gggctctacg caccttcctc tctgctgagt taaacctgga
     1561 acagtcgaag catgagggtc tggatgccat cgagaatgca gtagaaaacc tggatgccac
     1621 cagtgacaag cagcgcctca tggagatgta caacaacgtc ttctgccccc ctatgaagtt
     1681 tgagtttcag ccccacatgg gggatatggc ttcccagctc tgtgcccagc agcctgtcca
     1741 gagtgagctg gtacagagat gccaacaact gcagtctcgc ttatccactc taaagattga
     1801 aaacgaagag gtaaagaaga caatggaggc caccctgcaa accatccagg acattgtgac
     1861 tgtcgaggac tttgatgtgt ctgactgctt ccagtacagc aactccatgg agtccgtcaa
     1921 gtccacggtc tctgaaacct tcatgagcaa gcccagcatt gctaagagga gagccaacca
     1981 gcaagagaca gagcagtttt atttcacaaa aatgaaagag tacctggagg gcaggaacct
     2041 catcaccaag ttacaagcca agcatgacct tctgcagaaa accctgggag aaagtcagcg
     2101 gacagattgc agtctagcca ggcgcagctc aactgtgagg aaacaggact ccagccaggc
     2161 aattcctctg gtggtggaaa gctgtatccg gtttatcagc agacacggac tacagcatga
     2221 aggaattttc cgggtgtcag gatcccaggt ggaagtgaat gacatcaaaa atgcctttga
     2281 gagaggagag gaccccctgg ctggggacca gaacgaccat gacatggatt ccatagctgg
     2341 tgtcctgaag ctttacttcc gggggctgga acaccctctc ttccccaagg acatctttca
     2401 tgacctgatg gcctgcgtca caatggacaa cctgcaggag agagctctgc acatccggaa
     2461 agtcctccta gtcctgccca aaaccactct gattatcatg agatacctct ttgccttcct
     2521 caatcattta tcacagttca gtgaagagaa catgatggac ccctacaacc tcgccatctg
     2581 cttcgggccc tcgctaatgt cagtgccaga gggccacgac caggtgtcct gccaagccca
     2641 cgtgaatgag ctgatcaaaa ccatcatcat ccagcatgag aacatcttcc caagccccag
     2701 ggagctggag ggccctgtct acagcagagg aggaagcatg gaggattact gtgatagccc
     2761 tcatggagag actacctcgg ttgaagactc aacccaggat gtgaccgcag agcaccacac
     2821 gagcgatgac gaatgtgagc ccatcgaggc cattgccaag tttgactacg tgggccggac
     2881 agcccgagag ctatccttta agaagggagc atccctgctg ctttaccagc gggcttccga
     2941 cgactggtgg gaaggccggc acaatggcat cgacggactc atcccccatc agtacatcgt
     3001 ggtccaagac accgaggacg gtgtcgtgga gaggtccagc cccaagtctg agattgaggt
     3061 catttctgag ccacctgaag aaaaggtgac agccagagcg ggggccagct gtcccagtgg
     3121 gggtcatgta gccgatattt atcttgcaaa catcaacaag caaaggaagc gtccagaatc
     3181 tgggagcatc cggaaaactt ttcggagtga cagccatggg ctgagcagtt ccctgactga
     3241 ctcctcctcc ccaggggtgg gggctagctg ccgcccatcc tcccagccca tcatgagcca
     3301 gagcctcccc aaagaagggc cagataagtg ttccatcagt gggcacggga gcctcaactc
     3361 catcagccgc cactcatccc tgaagaatcg gctggatagt ccacagatcc ggaagactgc
     3421 cacagcggga aggtcaaaaa gcttcaataa ccatcggccc atggaccctg aggtcattgc
     3481 tcaggatatt gaggcaacaa tgaactcggc cctgaatgag ctacgggaac tagaacggca
     3541 gagcagtgtc aaacacaccc ctgacgtggt tctggacacc ttggagcccc tcaaaacctc
     3601 cccagtggtg gcccccacgt cagagccctc cagccctctg cacacccagc tcctcaagga
     3661 ccccgagccc gccttccagc gcagcgccag tactgctggg gacatcgcct gcgccttccg
     3721 gcctgtcaag tctgtcaaga tggctgcccc ggtcaaacca ccagccacac ggcccaagcc
     3781 cactgtcttc cccaaaacaa atgccactag ccctggtgtc aactcatcaa cttccccaca
     3841 gtctactgac aagtcttgta ctgtctgagg gataataatt taattgttct agacaagggg
     3901 actataggga ctgactgtta ttaaaatctt cctatttaac tagcttgggg acttcagttg
     3961 aaaattaggt tctaagttgt tcttgcagga attagcctcc ccgtctccca aaaccttgag
     4021 aatgaagccc ttggtatcgc ctctcccttc ccactgccct ctgcttcccc cagtcgtcgt
     4081 aattcagcca gctgcagtcc gtaccgttct taggttagcc agagacaggt tttcattatc
     4141 aggtcactgt gaaatctggt aaggcagtcc tgaggacatg ggctcaagtc tcagtcccct
     4201 cagaccacgg tgatgccttg accagatggt tggctactgc catccagctt tcagtggcat
     4261 cttgttttgg gaactgatta tagagaatca tatatagtcc agtcttcatt ttacatacac
     4321 acacatattt tacacacaca cacattttac acacacacac acacacacac acacacatat
     4381 gtttttctag tctctggcat gtgtagcctc tcctggtcat agaccagtct ctttgtaagt
     4441 tattgtggca gttcacacag tagccaccag gggtctctgt ttccatcaca aactttgttc
     4501 tgtctgggcc agagaaccta gcctttgaaa tctctccatc atatgaaaca taacgggatg
     4561 ggacaatccc gtaacctgtt tggggttggg ggctttctct ctgtgttctt tccattgatg
     4621 tgaattggtc attggtgttt gctcttgcct ctcctccatc ccctagaagt acacccccgt
     4681 cttattaagg agcttttaaa gtttttctga atgtatagac atttctcggg ttcctacctt
     4741 tgtctctgat ggaccatttt ccatttaaga cattttcctg tataagacag ttttatagct
     4801 ggttcctttt agggtaaaga gtcttaagag agttttattg tgtctatggc aggtttggga
     4861 aaggtaagaa atgggtcctt tttcctccta atgtttttgg cacttaaaac ataaaattca
     4921 ttatcctatt aaaaaattaa attcagcttt gctaatccag aaattgttcc caaatgaaaa
     4981 cttgttttaa gtccacccct tagtttcctt attttacaag gtctctcttc agggaccaac
     5041 aggggcttag agagccttag ttagattaaa gggagaccct acctcttaaa accagttttc
     5101 atttatgcaa acaaggacaa ttaagggaac cctgacccca caggctctca agtcttccca
     5161 aggccagaat cgaaagaaaa ttaaaatttg aatgctgaat attctggctc tactctggcc
     5221 ttttttctgg ttcccttcca aaatgcacaa atcataccct tgtctgctcc aattcagtct
     5281 ccaaacctgg tgcctgtgct cctggccccc ctagcatcat gctatcccag gagtatcagg
     5341 accagacaca tccacagcca ggctcatggg tctcagacag caacttgagt taaagctgaa
     5401 actcatcctt cttctctgtg ttttctggtt taaaagctgc acttatattt tagccttatt
     5461 attttctgta gttccggaga gatggtgggt tgccattctg gtaggaaaat ctgagttttc
     5521 ttatctttga cctagaagag attctttttg gaccaacctg cgaaattggt agttaggtct
     5581 atggaaagtg gtaggatttt ttttttttta atcctgtgca aaggaaaaga ggtgctttgt
     5641 gggaaatcac taatgagaag gctaacctgc agcaccagag aaacctttcc aagtgctagg
     5701 caggagaact gaagaactct ttcagtgaag tgagtcagcc tagaagaggc aacccacagt
     5761 cttgattttt gttgctgttt cctgacctgt tcttgcctgt cacctgggcc tacacaggtc
     5821 ccaagccaac ggggctttca tacccaagga tctgtttcct tgctgaaaat gaaaccctat
     5881 ctttcacttt acattccttt caatccaact gatcaaaact ggtacccaca cttgcccttt
     5941 ctccctctct ccagcacact cccctctaag aaagtaaaag caaagctttc ttaatggcaa
     6001 cactttgggc ctgttctgtt gctcctgcct tatttctctt tcaaccctgt acatgactcg
     6061 tgttcaccat ccccttgatc agtgtccatc cgcgctaatt tgcatcatga actgaacagt
     6121 gtgtgagtgg tcacctacta aacccagctc tgggggcaga gctgtcttcc ccatctctgg
     6181 tgctcctaac acctgtgaga tggtcctgtc gagaggacta ggaaccgata ggaggagagt
     6241 ccttctcggc agagctcact gcaaacaact ggaattgagg ttgcacactg tgatttttac
     6301 accgaaaagc caaaaggagc tggccatcca gggcctaggg agaccagcct tcctcagcta
     6361 tgcttgccga aaccagcatg atgcttcaaa gagccctgct ccacccctca tggcatggat
     6421 ccttttcctg gtgtggactc tgaagggtca gtcttcgggg aagagaggtg gggtggggct
     6481 actagcatcc caatttagaa aatagaggag tttgtagcca gcagcctgta aactggaaac
     6541 actggtctca gccaacctcc tcagggcgcc ctggcttctc cccaaggaga tgaggagcgg
     6601 tgatgccagc accgggatgc gcagagcact ggaagggctg gtgcagatct acttcccatg
     6661 cagaagagaa gtcacatctt ccagggaatc gcaatgttgt ggcgtctgac ttgtatgtca
     6721 catttgtgta aaatggtata ttctttaaaa tagtgttgat aactggaata ttgtatgtat
     6781 gcttggagat gctttgtgtg aacctaagac tgtcactcaa cagatgttgg attggggaaa
     6841 atccaaagca caacttcaaa ataaaataca tttttaggtt tcga
//
