LOCUS       NM_020762              22920 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens SLIT-ROBO Rho GTPase activating protein 1 (SRGAP1),
            transcript variant 1, mRNA.
ACCESSION   NM_020762 XM_051143
VERSION     NM_020762.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 22920)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   2  (bases 1 to 22920)
  AUTHORS   Li,Y., Qiao,L., Bai,Y., Xiao,C., Wu,J., Gao,X., Qiao,C., Shi,Y.,
            Hou,W., Wang,J., Xie,N. and Liu,N.
  TITLE     Identification of SRGAP2 as a potential oncogene and a prognostic
            biomarker in hepatocellular carcinoma
  JOURNAL   Life Sci 277, 119592 (2021)
   PUBMED   33984363
  REMARK    GeneRIF: Identification of SRGAP2 as a potential oncogene and a
            prognostic biomarker in hepatocellular carcinoma.
REFERENCE   3  (bases 1 to 22920)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 22920)
  AUTHORS   Huang,T., Zhou,Y., Zhang,J., Wong,C.C., Li,W., Kwan,J.S.H.,
            Yang,R., Chan,A.K.Y., Dong,Y., Wu,F., Zhang,B., Cheung,A.H.K.,
            Wu,W.K.K., Cheng,A.S.L., Yu,J., Wong,N., Kang,W. and To,K.F.
  TITLE     SRGAP1, a crucial target of miR-340 and miR-124, functions as a
            potential oncogene in gastric tumorigenesis
  JOURNAL   Oncogene 37 (9), 1159-1174 (2018)
   PUBMED   29234151
  REMARK    GeneRIF: High SRGAP1 expression is associated with gastric
            tumorigenesis.
REFERENCE   5  (bases 1 to 22920)
  AUTHORS   Liang,X., Kiru,S., Gomez,G.A. and Yap,A.S.
  TITLE     Regulated recruitment of SRGAP1 modulates RhoA signaling for
            contractility during epithelial junction maturation
  JOURNAL   Cytoskeleton (Hoboken) 75 (2), 61-69 (2018)
   PUBMED   29160905
  REMARK    GeneRIF: the RhoA antagonist, SRGAP1, is present at subconfluent
            junctions to a greater extent than in confluent cultures and SRGAP1
            RNAi restores RhoA signaling and contractility in subconfluent
            cultures to levels seen in confluent cells.
REFERENCE   6  (bases 1 to 22920)
  AUTHORS   He,H., Bronisz,A., Liyanarachchi,S., Nagy,R., Li,W., Huang,Y.,
            Akagi,K., Saji,M., Kula,D., Wojcicka,A., Sebastian,N., Wen,B.,
            Puch,Z., Kalemba,M., Stachlewska,E., Czetwertynska,M.,
            Dlugosinska,J., Dymecka,K., Ploski,R., Krawczyk,M., Morrison,P.J.,
            Ringel,M.D., Kloos,R.T., Jazdzewski,K., Symer,D.E., Vieland,V.J.,
            Ostrowski,M., Jarzab,B. and de la Chapelle,A.
  TITLE     SRGAP1 is a candidate gene for papillary thyroid carcinoma
            susceptibility
  JOURNAL   J Clin Endocrinol Metab 98 (5), E973-E980 (2013)
   PUBMED   23539728
  REMARK    GeneRIF: genome-wide linkage analysis in populations in Ohio and
            Poland: Data suggest that missense mutations in SRGAP1 are
            associated with genetic predisposition to papillary thyroid
            carcinoma.
REFERENCE   7  (bases 1 to 22920)
  AUTHORS   Ip,B.K., Bayatti,N., Howard,N.J., Lindsay,S. and Clowry,G.J.
  TITLE     The corticofugal neuron-associated genes ROBO1, SRGAP1, and CTIP2
            exhibit an anterior to posterior gradient of expression in early
            fetal human neocortex development
  JOURNAL   Cereb Cortex 21 (6), 1395-1407 (2011)
   PUBMED   21060114
  REMARK    GeneRIF: This study proposed that the expression of SRGAP1 in the
            anterior neocortex may mark the early location of the human motor
            cortex, including its corticospinal projection neurons, allowing
            further study of their early differentiation.
REFERENCE   8  (bases 1 to 22920)
  AUTHORS   Meek,S.E., Lane,W.S. and Piwnica-Worms,H.
  TITLE     Comprehensive proteomic analysis of interphase and mitotic
            14-3-3-binding proteins
  JOURNAL   J Biol Chem 279 (31), 32046-32054 (2004)
   PUBMED   15161933
REFERENCE   9  (bases 1 to 22920)
  AUTHORS   Katoh,M. and Katoh,M.
  TITLE     FNBP2 gene on human chromosome 1q32.1 encodes ARHGAP family protein
            with FCH, FBH, RhoGAP and SH3 domains
  JOURNAL   Int J Mol Med 11 (6), 791-797 (2003)
   PUBMED   12736724
  REMARK    GeneRIF: FNBP2, ARHGAP13, ARHGAP14 and ARHGAP4 constitute the FNBP2
            family characterized by FCH, RhoGAP and SH3 domains.
REFERENCE   10 (bases 1 to 22920)
  AUTHORS   Wong,K., Ren,X.R., Huang,Y.Z., Xie,Y., Liu,G., Saito,H., Tang,H.,
            Wen,L., Brady-Kalnay,S.M., Mei,L., Wu,J.Y., Xiong,W.C. and Rao,Y.
  TITLE     Signal transduction in neuronal migration: roles of GTPase
            activating proteins and the small GTPase Cdc42 in the Slit-Robo
            pathway
  JOURNAL   Cell 107 (2), 209-221 (2001)
   PUBMED   11672528
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC084357.23, DR000178.1,
            BC053903.1, AC020611.15, AC025576.26 and AI216583.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_020762.3.
            
            Summary: The protein encoded by this gene is a GTPase activator,
            working with the GTPase CDC42 to negatively regulate neuronal
            migration. The encoded protein interacts with the transmembrane
            receptor ROBO1 to inactivate CDC42. [provided by RefSeq, Sep 2016].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript was available
            for the full length of the gene. The extent of this transcript is
            supported by transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC053903.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA1968968
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000355086.8/ ENSP00000347198.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-53                AC084357.23        13654-13706         c
            54-61               DR000178.1         1-8
            62-1346             BC053903.1         1-1285
            1347-1347           AC020611.15        183184-183184
            1348-2390           BC053903.1         1287-2329
            2391-2391           AC025576.26        43216-43216
            2392-4407           BC053903.1         2331-4346
            4408-8501           AC025576.26        60895-64988
            8502-8566           AI216583.1         17-81               c
            8567-22920          AC025576.26        65054-79407
FEATURES             Location/Qualifiers
     source          1..22920
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q14.2"
     gene            1..22920
                     /gene="SRGAP1"
                     /gene_synonym="ARHGAP13; NMTC2"
                     /note="SLIT-ROBO Rho GTPase activating protein 1"
                     /db_xref="GeneID:57522"
                     /db_xref="HGNC:HGNC:17382"
                     /db_xref="MIM:606523"
     exon            1..184
                     /gene="SRGAP1"
                     /gene_synonym="ARHGAP13; NMTC2"
                     /inference="alignment:Splign:2.1.0"
     CDS             118..3375
                     /gene="SRGAP1"
                     /gene_synonym="ARHGAP13; NMTC2"
                     /note="isoform 1 is encoded by transcript variant 1; rho
                     GTPase-activating protein 13"
                     /codon_start=1
                     /product="SLIT-ROBO Rho GTPase-activating protein 1
                     isoform 1"
                     /protein_id="NP_065813.1"
                     /db_xref="CCDS:CCDS8967.1"
                     /db_xref="GeneID:57522"
                     /db_xref="HGNC:HGNC:17382"
                     /db_xref="MIM:606523"
                     /translation="MSTPSRFKKDKEIIAEYESQVKEIRAQLVEQQKCLEQQTEMRVQ
                     LLQDLQDFFRKKAEIETEYSRNLEKLAERFMAKTRSTKDHQQYKKDQNLLSPVNCWYL
                     LLNQVRRESKDHATLSDIYLNNVIMRFMQISEDSTRMFKKSKEIAFQLHEDLMKVLNE
                     LYTVMKTYHMYHAESISAESKLKEAEKQEEKQIGRSGDPVFHIRLEERHQRRSSVKKI
                     EKMKEKRQAKYSENKLKSIKARNEYLLTLEATNASVFKYYIHDLSDLIDCCDLGYHAS
                     LNRALRTYLSAEYNLETSRHEGLDIIENAVDNLEPRSDKQRFMEMYPAAFCPPMKFEF
                     QSHMGDEVCQVSAQQPVQAELMLRYQQLQSRLATLKIENEEVKKTTEATLQTIQDMVT
                     IEDYDVSECFQHSRSTESVKSTVSETYLSKPSIAKRRANQQETEQFYFMKLREYLEGS
                     NLITKLQAKHDLLQRTLGEGHRAEYMTTRPPNVPPKPQKHRKSRPRSQYNTKLFNGDL
                     ETFVKDSGQVIPLIVESCIRFINLYGLQHQGIFRVSGSQVEVNDIKNSFERGENPLAD
                     DQSNHDINSVAGVLKLYFRGLENPLFPKERFNDLISCIRIDNLYERALHIRKLLLTLP
                     RSVLIVMRYLFAFLNHLSQYSDENMMDPYNLAICFGPTLMPVPEIQDQVSCQAHVNEI
                     IKTIIIHHETIFPDAKELDGPVYEKCMAGDDYCDSPYSEHGTLEEVDQDAGTEPHTSE
                     DECEPIEAIAKFDYVGRSARELSFKKGASLLLYHRASEDWWEGRHNGIDGLVPHQYIV
                     VQDMDDTFSDTLSQKADSEASSGPVTEDKSSSKDMNSPTDRHPDGYLARQRKRGEPPP
                     PVRRPGRTSDGHCPLHPPHALSNSSVDLGSPSLASHPRGLLQNRGLNNDSPERRRRPG
                     HGSLTNISRHDSLKKIDSPPIRRSTSSGQYTGFNDHKPLDPETIAQDIEETMNTALNE
                     LRELERQSTAKHAPDVVLDTLEQVKNSPTPATSTESLSPLHNVALRSSEPQIRRSTSS
                     SSDTMSTFKPMVAPRMGVQLKPPALRPKPAVLPKTNPTIGPAPPPQGPTDKSCTM"
     exon            185..380
                     /gene="SRGAP1"
                     /gene_synonym="ARHGAP13; NMTC2"
                     /inference="alignment:Splign:2.1.0"
     exon            381..543
                     /gene="SRGAP1"
                     /gene_synonym="ARHGAP13; NMTC2"
                     /inference="alignment:Splign:2.1.0"
     exon            544..606
                     /gene="SRGAP1"
                     /gene_synonym="ARHGAP13; NMTC2"
                     /inference="alignment:Splign:2.1.0"
     exon            607..789
                     /gene="SRGAP1"
                     /gene_synonym="ARHGAP13; NMTC2"
                     /inference="alignment:Splign:2.1.0"
     exon            790..918
                     /gene="SRGAP1"
                     /gene_synonym="ARHGAP13; NMTC2"
                     /inference="alignment:Splign:2.1.0"
     exon            919..1140
                     /gene="SRGAP1"
                     /gene_synonym="ARHGAP13; NMTC2"
                     /inference="alignment:Splign:2.1.0"
     exon            1141..1242
                     /gene="SRGAP1"
                     /gene_synonym="ARHGAP13; NMTC2"
                     /inference="alignment:Splign:2.1.0"
     exon            1243..1440
                     /gene="SRGAP1"
                     /gene_synonym="ARHGAP13; NMTC2"
                     /inference="alignment:Splign:2.1.0"
     exon            1441..1525
                     /gene="SRGAP1"
                     /gene_synonym="ARHGAP13; NMTC2"
                     /inference="alignment:Splign:2.1.0"
     exon            1526..1553
                     /gene="SRGAP1"
                     /gene_synonym="ARHGAP13; NMTC2"
                     /inference="alignment:Splign:2.1.0"
     exon            1554..1656
                     /gene="SRGAP1"
                     /gene_synonym="ARHGAP13; NMTC2"
                     /inference="alignment:Splign:2.1.0"
     exon            1657..1717
                     /gene="SRGAP1"
                     /gene_synonym="ARHGAP13; NMTC2"
                     /inference="alignment:Splign:2.1.0"
     exon            1718..1795
                     /gene="SRGAP1"
                     /gene_synonym="ARHGAP13; NMTC2"
                     /inference="alignment:Splign:2.1.0"
     exon            1796..1930
                     /gene="SRGAP1"
                     /gene_synonym="ARHGAP13; NMTC2"
                     /inference="alignment:Splign:2.1.0"
     exon            1931..2036
                     /gene="SRGAP1"
                     /gene_synonym="ARHGAP13; NMTC2"
                     /inference="alignment:Splign:2.1.0"
     exon            2037..2261
                     /gene="SRGAP1"
                     /gene_synonym="ARHGAP13; NMTC2"
                     /inference="alignment:Splign:2.1.0"
     exon            2262..2341
                     /gene="SRGAP1"
                     /gene_synonym="ARHGAP13; NMTC2"
                     /inference="alignment:Splign:2.1.0"
     exon            2342..2522
                     /gene="SRGAP1"
                     /gene_synonym="ARHGAP13; NMTC2"
                     /inference="alignment:Splign:2.1.0"
     exon            2523..2657
                     /gene="SRGAP1"
                     /gene_synonym="ARHGAP13; NMTC2"
                     /inference="alignment:Splign:2.1.0"
     exon            2658..2997
                     /gene="SRGAP1"
                     /gene_synonym="ARHGAP13; NMTC2"
                     /inference="alignment:Splign:2.1.0"
     exon            2998..22920
                     /gene="SRGAP1"
                     /gene_synonym="ARHGAP13; NMTC2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      8516..8521
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SRGAP1"
                     /gene_synonym="ARHGAP13; NMTC2"
                     /note="hexamer: AATAAA"
     polyA_site      8536
                     /gene="SRGAP1"
                     /gene_synonym="ARHGAP13; NMTC2"
                     /note="major polyA site"
     regulatory      9645..9650
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SRGAP1"
                     /gene_synonym="ARHGAP13; NMTC2"
                     /note="hexamer: TATAAA"
     polyA_site      9669
                     /gene="SRGAP1"
                     /gene_synonym="ARHGAP13; NMTC2"
     regulatory      14951..14956
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SRGAP1"
                     /gene_synonym="ARHGAP13; NMTC2"
                     /note="hexamer: ATTAAA"
     polyA_site      14974
                     /gene="SRGAP1"
                     /gene_synonym="ARHGAP13; NMTC2"
     regulatory      15228..15233
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SRGAP1"
                     /gene_synonym="ARHGAP13; NMTC2"
                     /note="hexamer: AAGAAA"
     polyA_site      15245
                     /gene="SRGAP1"
                     /gene_synonym="ARHGAP13; NMTC2"
     regulatory      22897..22902
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SRGAP1"
                     /gene_synonym="ARHGAP13; NMTC2"
                     /note="hexamer: AATAAA"
     polyA_site      22920
                     /gene="SRGAP1"
                     /gene_synonym="ARHGAP13; NMTC2"
ORIGIN      
        1 cggcgctgcc tctggattgc ctgcgtgtgg gagtacaact ctgcctctcc aaggagaacg
       61 ggttgtgacc actgaacaaa acttgcccat tgaaagcaaa cccggaacag ctggataatg
      121 tccaccccga gccgattcaa gaaggacaaa gagatcatag ccgagtatga aagtcaagtc
      181 aaagaaattc gagctcaact ggtagaacaa caaaaatgcc tggagcagca aacggagatg
      241 cgagttcagc ttctccagga tctgcaagat ttcttccgaa aaaaagctga aattgagacg
      301 gaatattccc ggaatctaga gaagttagca gaaaggttca tggcaaaaac aagaagcact
      361 aaggatcatc aacaatacaa gaaagaccag aacctgttgt ctccagtgaa ctgctggtat
      421 ttgctcctga accaagtaag gagagaaagc aaagaccatg caaccttgag tgacatctat
      481 ctgaacaatg tgattatgcg gttcatgcag ataagtgagg attctaccag gatgtttaaa
      541 aagagcaaag agattgcatt ccaacttcat gaggatttaa tgaaggttct taatgagctt
      601 tatacggtga tgaaaacata ccatatgtat catgcagaga gcatcagtgc agagagcaag
      661 ctgaaagagg ccgaaaaaca agaggaaaag caaattggga gatctggtga tccagtcttc
      721 catattcgac tagaggagag acatcaacgg cgaagctctg taaagaaaat tgaaaaaatg
      781 aaagaaaaaa gacaagcaaa atattcagaa aataagctaa aatcaattaa ggcacggaac
      841 gaatatctcc taacacttga agccaccaat gcctcagttt tcaagtacta tattcatgat
      901 ctttctgatt taattgattg ctgtgatctt ggctaccatg caagtctgaa cagagcccta
      961 agaacatatc tgtctgcgga gtacaacctt gaaacctcca gacatgaggg cttagacatt
     1021 attgagaatg cagttgataa tttagagccc aggagcgata agcagagatt catggagatg
     1081 taccctgctg cgttctgtcc accaatgaag tttgagtttc agtctcacat gggtgatgag
     1141 gtgtgccagg tcagtgccca gcagccagtc caggcagagc tcatgctcag gtaccaacag
     1201 ttgcagtccc gccttgccac gctcaaaatc gagaatgaag aggttaagaa aacgactgaa
     1261 gccaccttgc agacgataca agatatggtc accatcgagg actatgatgt ttctgaatgc
     1321 ttccagcaca gtcgttccac agaatcagtg aagtccactg tctctgaaac ctacctgagt
     1381 aaacccagca tcgccaagag aagagccaac cagcaggaaa ctgaacagtt ctacttcatg
     1441 aaactcagag aatatttgga aggcagtaat ctcatcacaa aacttcaagc caaacatgac
     1501 ttgctgcaga ggaccctggg agaaggtcat agagctgaat atatgactac aaggcctcca
     1561 aatgttcccc ctaagcccca gaaacacagg aagtccaggc cccgctcaca gtataatact
     1621 aagttgttta atggggattt ggaaacattc gtcaaggact caggacaggt tattcccctc
     1681 attgtggaaa gctgtattcg gttcatcaat ctctatggtc ttcagcatca ggggattttc
     1741 agagtgtctg gttcccaggt ggaagtcaat gatattaaaa attcatttga gagaggtgaa
     1801 aatcctttgg ctgatgacca gagtaaccat gatattaact cagttgctgg cgttctgaag
     1861 ctctatttcc gtgggctgga aaaccccctc tttcctaagg aaagatttaa cgatctgatt
     1921 tcttgtatca gaatagataa tctctatgag agggcgcttc acatccgcaa actcctcctg
     1981 actttgccca ggtcggtcct tatagtgatg aggtacctct ttgccttcct caatcatcta
     2041 tcacagtaca gcgatgagaa tatgatggac ccttataacc tggccatttg ctttggccca
     2101 acattgatgc ctgtcccaga aatacaggat caagtgtctt gccaggcaca tgtgaatgaa
     2161 attatcaaaa ccatcatcat ccaccatgag actattttcc cagatgctaa agagctggat
     2221 ggccctgttt atgagaaatg tatggctgga gatgactatt gcgacagccc atacagtgag
     2281 cacggtacat tggaggaagt ggaccaagat gctggtacag agccccacac aagtgaagat
     2341 gaatgtgagc caatagaagc aatagccaag tttgactatg ttgggcggtc tgccagagaa
     2401 ctatccttca agaagggtgc ctccctgctg ctgtatcacc gtgcatctga ggactggtgg
     2461 gaaggcaggc acaacgggat tgacgggctg gtgcctcacc agtatatagt ggtgcaggat
     2521 atggatgata cgttttcaga cactctgagc caaaaagccg acagtgaggc cagcagtggg
     2581 ccagtcacgg aagacaagtc ctcatccaag gacatgaact ccccgacaga ccgtcatcct
     2641 gacggctatt tagccaggca acgaaaaaga ggagagccac cccctccagt aaggcgtcct
     2701 ggcaggacca gtgatggcca ttgcccgctc caccctccac atgccctttc taactcctca
     2761 gttgacctag ggtccccaag ccttgccagt cacccccggg gcctgctgca gaaccgtggc
     2821 ctcaacaatg acagtcctga gcggaggcgc aggcctggcc atggcagcct gaccaacatc
     2881 agccggcacg actccctcaa gaagatcgac agccctccca ttagaaggtc cacgtcatca
     2941 gggcaataca cgggcttcaa tgaccacaag ccactggacc cagagacaat tgctcaggat
     3001 attgaagaaa cgatgaacac agctttgaat gaactccgag aactggagag acagagcaca
     3061 gcaaagcatg cccctgatgt ggtgctggat accctggagc aagtgaaaaa ctctcccacc
     3121 cctgccactt ccacggaatc tctcagccct ttgcacaacg ttgccctcag gagctccgag
     3181 cctcagattc gacgtagcac gagctcctcc agtgacacaa tgagtacttt caagcctatg
     3241 gtggcaccca gaatgggcgt gcagctgaag cctccagccc ttaggccaaa acctgctgtt
     3301 cttccaaaaa caaatcctac cataggacct gccccacctc cccagggtcc aacagacaag
     3361 tcatgcacaa tgtaaaaacc agccaagcaa ggccataaag ggaggtgact taaaaaagaa
     3421 aatggattag tgacaaaagt cactgatcca taactttcct tagttttgtg cttataactg
     3481 gagatctttt ggcttttcta tgttgtcgaa tgtaatgtct gagactagct aaattaacac
     3541 gggcatttgt attttgtaat ttttttaaat aactggacat atgtcatttt aaggacaata
     3601 gaaacactta gacttacttg aaaatccaat gctgcaccac ttgtaatgaa ggcaacaccg
     3661 ctctccacat tgtacagagc ttcaggttta atgtagccca gctgagtcag aaaggttgtg
     3721 acctgaaggc agaagaaccc gaatgccaca cctcattgga gtatagccag tgttggtctg
     3781 tggcacttgg gctgaaaggt gataatggca ttgcgtggta gctgacaatg agcaccttcg
     3841 gttccatgtg gagcggggtt tagctcatgc aaaagacttg caattgtctc catgggacga
     3901 tcccagtggg actgtcagcc cacagctcga gtgggttgga tgcttgcctc tttcctaaca
     3961 gttatttccc cgggtccagc ttaaagactc gatggaagga ggtagaacct ctgctgttac
     4021 tgcttgaact taacctggga aaggagagga agacaccatc tccaaagcta ttaatgtcac
     4081 tccttttgcg agcatgatta ggccccggag atttccaagt ccccccatct acacttacaa
     4141 acgattagaa gggtttaatt ttaaagactt tctggttaca ctactccacg aactcctcca
     4201 aagatccgtt attcaataac tgcctagaaa atgtttccat ctcctctaaa tccctgtgtt
     4261 ctcctctgtg gaaatgaagg cagcaagaag cacctgaggc cttggttcat gcagtgttct
     4321 cttttgacta aatcacctag gttcctttaa acatgctaca aagcccaggc atggtggtgc
     4381 acacctgtac tcccagctac tcgggtggtt tacacaggag gatggctttg ggcctagtag
     4441 ttcgagtcca gcctgggcag catagtgtga gaccctgtct cttaaaaaaa aaaaaaatgc
     4501 tacaaagtcc tgatgatcct aaatttgaaa tcccaactgt cctctccatt tgtctttgag
     4561 ccaaccctga actggccctg gtacctgagt aagagccatg cagggccatc agcagaacat
     4621 ggccttgtgg ttctcaccca gttgtgtacc tcacaaccac aacttctttt tctttgtccc
     4681 ttttcccctt tttggttttg gttttgtatg tgggctctat gtaactccca tagtcagctg
     4741 aactctcaat tggagaccct ctttctctgg catcctagca cacaggcaat tttttaagcc
     4801 tatatttatg ctacattttc ccccatctta agaaaatttg ctttgatttc cattctccta
     4861 ctagcagcag ctgatatcac ctgtagacct atgagcattt tatctattct atcattgaag
     4921 ttactgataa agatttttgt tgttgttgtt gttgttggga gaaatggatt tcccacaact
     4981 aatccctctg gcccaccatt aatttccttc ttggtttcat ttcaaactgg cagccaattg
     5041 cacgcccatc taagagctac acagtgtaga ttttacttca tcagcccatt ggtgaatgca
     5101 tcgtgcagaa aagaactggg atctgtacta aaatcaagat cattactttg atctctacct
     5161 cagtttgcca gtgtagtcat tctattgcag gaagagatta aattgatgag atattgttac
     5221 tttcagagtc acactgctga ttgcttgcct ggggcctaat ttcacaaatg aatagtgact
     5281 tttttcccat gtatttctag gtatggtaaa cttttaaacc tccaaatttt cagagccata
     5341 ctttttgccc attttgaaaa agaagcccag gacagcacct tgtctagccc ctccccattt
     5401 ctcctgagct tttggggtcc ttcagcaccc ttggacaccg tggagatcca gccaagactg
     5461 agctttgaat agcactagcc cttttaaaca atcctcacaa attccttagg aatttaaact
     5521 ttccaaaata atcccccact tttttttttt tttttttttt tttttgagtt ggagtcttgc
     5581 tctgtcgccc aggccagagt acagtggtgc aatctcggct ccctgcaacc tccatctccc
     5641 gggttcaagc aattctcctg agtagctggg attacaggcg ccaccaccac gcccagctaa
     5701 tttttgtatt tttagtagag atggggtgtc accatgttgg ccaggctggt ctcaaactcc
     5761 tgacctcagg tgacccacca gcctcagcct cccaaagtgc tgggattaca gatgtgagcc
     5821 accatgcccg gccattccac cacttcttta aaatagtaag aattcttaaa aaccatattc
     5881 cttgtttgat ggaagagtaa gatgttaaca gagggcatca aagggccaga ggtgtctttg
     5941 aatttatttt ttttcaatgt cttttctgag cttcagcctt agcttttcag atcttcctcc
     6001 tacctgttca tttattcagc cttctatctg gtcatcctcc ccagcggctc ctctctctga
     6061 tgtgtccacc tacggtggaa cgaggattgc ctttctgtgc tccccatcag gactttgctg
     6121 tcttggccgg caggagtcgt gctgctgcag agcctcacag gctgtgcctt gtttcaggaa
     6181 acagctccta atactctccc atcactcact ttacctgtct ccatcttatt tccctatact
     6241 cctattgtca gcttgagact tttttttttt ttcaattcca aatgaagggt atgacctcag
     6301 agtgagtgag gactcagtaa agactcacct ctccttactt ggtttattaa atgtcttcag
     6361 attccagaga taagacaagg tggccacttc acaaagaatc cagaatcatg ctcagtaaag
     6421 ctcattaaaa gccactgcag ctgagaaggt tcacagccct tctttatagc cacagaggca
     6481 gcacacaggg gaggtgggaa gacacaggga aacgagagaa gaaggataat gaggccttga
     6541 ggtgttctgc ccccaatttc aaggagctta tcaggcttca tgtgcaattt ggggagggga
     6601 gctttttgat ggtgggtaaa taatggctct acaaagatta cctgactcca ctgacacaag
     6661 aatatgtatt ctcagctgat ataactgtgt gttcacatcc catccataga actcactgaa
     6721 ggagattcat caagtcagcc ttttggactg ggttggggtt tggggagtgg atttggggat
     6781 agagagaaag gtgtacttag tacacatttt ctaatgggcg ttacgtgaac tgtttgaacc
     6841 tgctgagtgg cgctttgtag agctccatgt tcacgttcag tgtcaacacc attcaacagc
     6901 tttgcacatc ttcgtacaac ataatctggc tttggtgccc cttgagccac ctgtagaata
     6961 atttatagca gggtcccaca atctactgca atgatcgtga acagttatca gtggatatag
     7021 tgctccaaga gtcaaattgt atccgttaag ggttttctaa cttttgctat cccccccgcg
     7081 accaaaaaaa gggggggttt ataatttaaa gaaaaggaaa agaggcgtgg gttggtagtt
     7141 gtgtccttaa catttaggaa tgacatagcc tctggagtct acaaactgaa gaaactttca
     7201 tctgatcagc cttggaaatc caaagttaaa gagcctatgt gtctcttgag gcgggggtta
     7261 gaggattcaa atttgggatg atgctcattg attcctgacc atagcagtga gaggccattt
     7321 tttgtgcagg aaatgtgctt aggactcagt cttgttttcg attatccacc acagaaaccc
     7381 tgagacacag agcagcttag aagtctctac ccaggcgtaa atagagctcc ctactccaga
     7441 ccacctgcca cccacctccc aagttgagaa cacaagctcc agctgggctg gagagtcagg
     7501 cttggtgcag ggtgactttg gcgaagtttt gtcagatcca taaagcaaac tggaatttga
     7561 gctttcactt accctagtat acgttcttaa aaaaaaaaaa aagtctatgt ggtataatcg
     7621 agatggatac ctgtgtcttt aaattacgta gggaattttg tatgtttaaa taattgtact
     7681 gggttccata atgcttatct tagaaacttt agtaaaagaa aatatatgaa ccgtgcattt
     7741 gtgaatgccc cccttagagc attcatccaa gttcagtgtg tagtgtgatg gttattatag
     7801 atatttaaag tatagtaagt ggctgtgtaa caggagagac tgctgtttac ctacgtactg
     7861 aagggtaact gctgcccgcg taattaaatc agtattgtcc tttcctgtcg gtttgatcaa
     7921 ttgcggtacc ggtagcttcc tgcttgtgac tgttacctaa ttgtgtcaat gtacatctgt
     7981 agtatgtaca tgtgaaagtg cctttctatt ttagaggagt tttagccttg ctcttgtacc
     8041 gttgccccgc tctgtgcccc acccccacct cctcctccca attcctgctg cccactcgag
     8101 tgtttcgaag cttcctccct gtcccccacc ttccccatcc ccgccttcct gtgcctcggt
     8161 gctcagtaat gtcccatctc acctccctgt cggtcctcag actgtctcgt tttccttgta
     8221 gacgtgattg tgcctttctc acccctgtgt cctcccatcc caccgcatca gtcccccgct
     8281 catgtgctgc tgacagcatc gcattcgccc gtgctctgta ctgcctctca ccatttcatt
     8341 ccctcctctc tgaggtgaaa ataaaggggg atgcttttac agtctggaaa gaaaaaaaat
     8401 gttttgttaa tctgttgtga caatgcactt ttatgtatag tactgtacat ttttggcatg
     8461 taccattaca ggcttcagta tacagtcagg tttgttcttc acggtgtatc tttataataa
     8521 ataagatagt tctggctgcc tttgtctgct tccagtttga tgtgcatctc tgtggtgtct
     8581 ttgttccttt cctttcattc atcactactt tctccttgac agctagcttg cattaaataa
     8641 tgtgaaactt ttacctttaa aatatttttt tatctcactt tcatttcttg ttcatttgga
     8701 aatagggtgt cctgcacagg gccctgccca tgaagctgtg gtttttcagt catggtttgg
     8761 aggctcaatg tgtagtcaga gaaaagagtc ttggcagaca cttaactgag aagctgagag
     8821 tgtacaagcc tcctaaacat acaccagatt gaaatctttc ttttgagaaa gactctagtt
     8881 aaccacggca agcccatctt tggtttcatt tgaataaatt gaaaaataat ccttaggtta
     8941 tttttctgtg cttagaactc cccgtgtatt ggtatttttc tttacttttt tttttttttt
     9001 tttgagacga atctctctgt gtcacccagg ctgtagtgca gtggtgcaat ctcagctcac
     9061 tgcaacctcc ccctcctgga ttcaagcgat tctcctgcct cagcctccta agtagctgta
     9121 attacaggca cccgccacca cacccagcta cttttcgtat ttttagtgga aacggggttt
     9181 caccatgttg gccaggctgg tctcaaactc ctgacctaaa gtgatctatc tacctgcctc
     9241 agcctcccaa gtgctgggat tacaggtgtg agccattgca tctggccagg tatttttctt
     9301 taaatataaa aaaaagataa cttgaggtct agcaatatgt agtagatagc tttgtaaaac
     9361 aatgtaagtt gtgcaagatt gaatattgat aagatataaa gtttaaaaaa tgacaggcaa
     9421 atcaaggaaa aacacttttt attaaagtgc agaatactaa caaaagtgtg caaatcatta
     9481 gtgtaacagt tctcacgagc tgacacactg atgtatccac cacccagttt aagcaatagc
     9541 acattatcag catcccagaa gctactgtgc tcatgcctct gtgaatgtat cagtatcctg
     9601 actaatcaca ccatggtgta gttttgcctg tcatcttagc tttctataaa tgggttcata
     9661 cagtatgtag attttgtgtc tggctccttt tgttgaaatg tatgtttgta agagtcgtca
     9721 ttgttagtaa aatagtggtt tttccatttt tactgctata tagaattcca ttacatgaat
     9781 atgctcaata ttatatttat tttagtattt cctgattaaa ctttgggtag tatatgcaga
     9841 tatctttaaa catggagaaa tgaatggggg gtgagggacc cacctgtcaa aggaattgtt
     9901 ttcccaaact atgacggaat aatgttgaac taacctgttg accggaaggc ctactcaaag
     9961 gcaaggatac ttttctttct ttccaaaaaa gcactgtctg atatggagac tggaaatatt
    10021 catagatgac actgaaacta gttgaagctt tacttgatgc ttatcaagtc atgttctctt
    10081 acccgatgct ggatgctttt tcttcaatgc ctactttagg accacagagt tggatttaga
    10141 ggctagccca ccaggaacaa atgcccaaat cagtctgtag agttgttcca ggaaagactc
    10201 caccatcctg ctaccctcaa atcttaagct cctcagcctg ccacgaccat ctcctgttga
    10261 gaaaattgcg cctgcctccc catctctcac tcccgaacca gagtcccaac ggggtgtaac
    10321 tggtcgtcag ttcccacagt tcatatgcct gcaccctgta agaatcttag aaaggcagag
    10381 caagggtgtt tgctggcttc tgccttgagt agttgggact cctaaaaagg aaaattcccc
    10441 aagtttgacc tagaatgtca aaaaggtcct aaaagcacag aatgatggta aattctatcc
    10501 acaggccata tagccctgga aaatattggg aaactgaggc atgggttggt aatttattga
    10561 agtttagtaa acgaatttga attaattagg accagataat caatttttgg cttacttata
    10621 ctatagtata agcaaataag tatttaaact ttagtataaa tatttttgct cacttaataa
    10681 tcacggtgag gttcatcacc tcttcagtag ccttttatct gtttctacat agtaaataga
    10741 aaacttgcct tctataataa aaacaaaata gtttttctat caaggtcagt ctcagcaaga
    10801 gaaatgggac tgggctggat atcaacacat gtgcttgtgt gcatgtgcac gtgtgtgggt
    10861 gggagggtgc ggaggggttg ggaagagaga ttgctcctcc cgcagtgctg aaacaacatg
    10921 ccttgttcag tattaacatc ttgaaggcag ttatggcagc atgatccagg agatcgtcag
    10981 ctctaggata tttgcgatcc aattctggcg acttatggat ggatccttca cacccaacag
    11041 ctgtctatca ggggtgcttc cgagggtcac tgggtttctt ttagctgctt ggctgtgcag
    11101 ctgaagttag gacttttgat gaattaccct ctcaatgatg gtgtattgtt ctaatcttct
    11161 gtctctgaca tacccaagga accccttgtg taaaaatcat gtccctctaa atgcaagtgg
    11221 atgattgtgc caataagcca ggagagaagg aaacatcttc agtggtccag tggcacattc
    11281 aaaattgtac aatgacatga cattaactca aaaatgaagt ttgaggttct gggcctttga
    11341 tggactgcat ctattaaaaa caaaaagtgg tgtctcatgc ctgtaatccc agcactttga
    11401 gaggccaagg caggaggatc aaaaaatgcg aatttttata tttttttgtg agatcccatc
    11461 tctaccaaaa aaaaaaaaaa tacaaaaatt agccagacat agtagtacat gcctatagta
    11521 ctaggtactt gggaggctga ggcaggaaga ttgcttgagc ccagatgttt gaggctgcaa
    11581 taagctatga ttgcaccact gcactccaac ctgggtggaa gagtgagaag ctatctcaaa
    11641 aaaaaaaaaa aaaaaaaaaa aaacatggtc aagatttgta atagaaattg ccatttgaat
    11701 tttggtctgt aagcccaaag attgttactg tgttagtaac taaatattac gagatgcatt
    11761 aggaaaagaa ggaaaagaaa ttttaagtaa gccaaaaatc tattatatag tcataagtca
    11821 aactcagtta ctagacttca acaaatacca acccatgcct ccatttccca aacagaaata
    11881 ataatatgaa catcttagta tattgtcttc taatccttac attatgttat ttttaagcag
    11941 agtcaaactc atattctgta tataattgta tatacattgg gtttttctcc cttatagcaa
    12001 ttcacactag gagtctcagt caacatgatt ttttaatggc tgtataatat tctagcgtat
    12061 gaacacatca ttatttaacc attttcctgt cactgagtga gcctgtttga aggttttgtt
    12121 tttttttcaa ttgaatgtta tgttgtggtg agcagctctg tatataataa ttaattgtct
    12181 gtgtttggat cataaagtta gcattgactc caaaaagtga aatcactggg tcagaggatg
    12241 caattatctg taaggctcat gacaaatatt gccgacctgt tttccagcaa agttgtacaa
    12301 atttacatcc ctgccagtaa tgcataacag tacacgagta taaaacatgg tcatgtttct
    12361 ttaccagtgt actaggtgag tgataggctc aatgcaaatt cttagcagtt tgttaatgtg
    12421 cacacccaca tttccagagt acaaatctct atttcactca cctctgtgtc ctaaacttca
    12481 gatgactctt tattgtttca gctaaacatc agcaaacaga gattttcctc aggcacctta
    12541 agctcaacag acccaaaaat taaacccact ttgtttcatt ccaaaaaata ttctgcagcc
    12601 cctctacatc ctccaatctg ttccgctgcc tatctctgct ctaagctaat tctgtgcacc
    12661 attccccttg ccacaacgat tgccgtagct tccacggtgg tgtggctgtg cccactgtct
    12721 cctccttgaa atgattatct acactgctgc caataaatca tctttctcaa aaacaaaatg
    12781 agaaacctaa caaacaatca ttgaaaatgt accatgtact gacatcgttt tcctcaacac
    12841 gttgcatgtc aatagccaac atgtattgag taccagactc catgctacaa atgttaaccc
    12901 tcataagaaa gccaagagag ccacagttat tatcatcatc tttatccgta agaaaattaa
    12961 gccgcaggag ttaaacactt gccctggtca cacagctaga tagtgacaga gcaggatttg
    13021 attccacgcc atctggtgct ggaggctatg ctcataacca ctgctgcatt ctgacctctg
    13081 taacatgctc atgtcattac cctgctcaaa agccacacgt gggtccccac tgctgcagga
    13141 cggcatacta ctgtgtctta ttcatctttg tatcttcaag cctaatgcat cactaactaa
    13201 atagcaaatc ggcggaactg aaatgaattc aatgtctgcc gctttgacct cagcctgcca
    13261 tttcagcctt cctgctcacc acctcctctt cggaaccttt agtttcagcc atagcaagct
    13321 acctttcttt gaaaatgtga tgctgtgtgc tccctccgca tatacttcat gtcattcctc
    13381 agcctaaaat gtcccctact tcatcctgac aactgcctgt tgaaattata ttcatcattc
    13441 caaacccaac aaaatggtta catccttcat gaagggttcc ccaaacctcc cagctggcat
    13501 taattgttct gttacatttt gttttcatta aatcaggctc ccttccgggg atctagctgt
    13561 gaatgagaca cacagggctc ctggtctcat ggagtgtact tcctggtatg atttaaaaaa
    13621 aaaaaaaaaa aaaaaaaaac cactacataa gccaacagct aaaccggcaa aataatttca
    13681 ggtgttgata actgctacaa aaagcaaaag tgaaataaac agggtgatag aatttagagt
    13741 gtctaggaga agcattttag atgggacagc ttgaatgcca ccttggatgt ggtagcattt
    13801 gagctaagac ctgaataatg agaaggaacc agccatgtga aaaggaagag aaagacccaa
    13861 gcagaaggaa ctgcacatgg gaaaacagga ccatgctcac gtggttaaag agtcaaacac
    13921 attcactgtg actgtaccac cataagcaag aagccctgga gatgaaaata aaggccagaa
    13981 tgtggacaga gatcagattt tggaggccaa agtaaggtac ttaaaattag ccgggcttgg
    14041 tggtgcacaa ctgtaatccc acctactcgg gaggctgaag caggggaatt gcttgaaccc
    14101 atgagacgga ggttgcagtg acccgagatt gtgccactgc actacagcct gggcggcaca
    14161 gtgagactcc atctcaaaaa aaaaaaaaaa agtaaggtac ttagatgtca ttctaagttc
    14221 aaggaaagcc attggaagtt tccaaaaagg aacatgacag catctatatt tttagaagat
    14281 gaccctcaaa accacaatga gatatcacct catacccatt aggatggcca ctctcaaatg
    14341 atcaaactcc agaaaataac aagtattggc cagggtgtag agaaactgac acccttgtgc
    14401 actgttggtg ggaatgtaaa atggtagagc cactaaggaa aacagtgtgg aagttcctca
    14461 aaaaattaaa aataaaaccc tcatatgatc caccaagccc acttctgggt acatatccaa
    14521 aagaattgaa aacagaagag atatttgcac actcatgttc acgcagctta attcacaata
    14581 gccacaagag agaagcaacc catgaatgga tgaatgggta aagaaaatgt gccatacaca
    14641 taaaatagaa tattatgcag ccttaaaaaa gaaggaattc ctgtcatatg ccacaatatg
    14701 gatgaaactt aaggatacta agctaagtga aatgagccaa tcaataaagg acaaacattg
    14761 catgatttta cttctatgag atatctaaag tagtcaaact cttataaaca gaaagcagaa
    14821 tggtgattgc cagggatcgg gatgaggaag aaaatggaaa ttgttgttca gtgtttacag
    14881 ggtttcagtt ttgcaagata aaaagttcta aagatctgtt gtccaacaat atgcatgcag
    14941 ataacatcat attaaacatg gttaagatag taaattttat actatgtaat tttttaacca
    15001 caattttaaa catcactgta gatgttgtag ttgtgtttgg ggtccacggg tggggaggag
    15061 cttgggaagg aatggcatga gggaagtgag agaccacaat taaggagcaa cacaggagat
    15121 gagggtggct tggactagat agccaggtag aaggagagga agggatgaac cgggggttcg
    15181 tttcagagtc aaaatcaaga tttgctaata aattaaatat gggaataaag aaagaaaaga
    15241 atcaagagtg gctcctagta tttgtttgag caaatgggtg gaatatattg atatatactt
    15301 aaaaagaatg actggggaaa ggaagaagtt ggccaggatg tacaaccaag tattcacgtt
    15361 tgaatttatt taatttaaga taggtattag acttccaagt ggagaagtct aggaggcaga
    15421 tggacttgaa gctcagggga ggatttctgg ccagaaggtg taaatttgat atttaaagct
    15481 atgggactcc cggaaagaga aagagaaagg aaggtacaga gcacataacc aagccctggg
    15541 aagcccagct tgggagagct tgggtggagt gaggagctgg cagaggagac agaaggagca
    15601 gccagggcgg aggaggaaaa ccaggaggag catgtaatgt gatcagtacc cagggaagaa
    15661 atgattgcca tttctagtgt gcatttgtta acataaatat gataataaaa atagttaaca
    15721 tttgttaaat atatatattt ttttcttttt ctttttcttt tttttgagac agagtctcac
    15781 tctgtcaccc aggctggagt gcagtggcat gatcttggct caccgcaacc tctgcctccc
    15841 aggctcaagt gatcctccca cctcagcctc ccaagtacga gggattacag gtgcatgcaa
    15901 ccatgcccag ctagtttttg tatttttttg tagagacggg gtttcaccat gttgcttgtt
    15961 aaggccgggc acggtggctc acgcctgtaa tgccagcact ttgggaggcc gagacaggcg
    16021 gatcacctga ggtcaggagt ttgagaccag cctggccaac atggcgaaac cccatctcta
    16081 ctaaaaatac aaaaaaatta gccgggtgtg gtggcgcccg cctatagtcc cagctgttcg
    16141 ggaggctgag gcaggagaat tgcttgaacc agggaggtgg aggttgcagt gagccaaggt
    16201 cacgccacgg cactccagct tgggtgatag agtgggactc cgtctcaaaa taaataaata
    16261 aataaatata ttaaaaaata aacaagttca ggcttgttaa atatttttta tgtttgtttg
    16321 tttgctttgt tttttttgag acgtagtccc gctccgtctc ccaggctgga gtgcagtggc
    16381 gcgacctcgg ctcaccacga cctcggctca ccgcaacctc tgcctcccgg tttcaagcga
    16441 ttctcctgcc tcagcctcca gagcagctgg gactacaagt gcgcacaacc acacccagct
    16501 aatttttttg tatttttagt acagccgggg tttcgccatg ttggccaggc tggtcttgaa
    16561 ctcctgacct caggtgatcc acccgcctcg gtctcccaaa ctgttggcat tacaggcatg
    16621 agccaccacg cctggctgag ttaaatattt tctatgtgcc aagcactgtg ctaactgctt
    16681 tcatattatc ggatttagtc ctgtaagacc ggaatcatta ttatccccat ttttcagatt
    16741 aaaacaaaca aacaaaagct gaggtttaaa gaaattatct cttgtaaaat cacacagcta
    16801 acaattgagc cagtatctgg acctagatct attgcctaca gagccgcacg tttaactact
    16861 gttatcttgc ctccttattg ctccacacac ttgaaatata aatttttaaa gacattttat
    16921 tcttttttgt cttcatcaga atttattgaa tcctgattat tttttcctta atgttgattt
    16981 tgtagactca tttgcaggaa gaacaatgtc aggtggagag aaggaattga atgaatattt
    17041 ttaataaatt tgtagatgtt aatatgattt acttatttgc aattttcata gctatatgat
    17101 attctatccc atttccagtg tttttgctct tttagtagca aatactctga atctctgcat
    17161 atgttactca ttttctatca tcctattcct tgtgatggat acccaagggt actcatctac
    17221 aggatgaaag ggtatgagca cgtttctagg tgccctgacc ccaagattag gggttttgtt
    17281 agaggcaaag ctaaaaggaa atgataaaat aaatgaatat ttatagaagt taaatctatt
    17341 aatctagcct tattacaccg agtacaacag ggaataataa gccatctatc tgaacgtgca
    17401 cggttagggc ctcaaggaaa gtgggctcag caatgagtgt tggtacacat ggaaaatcac
    17461 atttgccatg ttttctatgg ctttgggctg ctgctgcatc actgcagttt aataggagga
    17521 ggctggtgaa aatgttacca actgccaggg gtcaatggcg aaagaacaca tttctctagg
    17581 aaagattacc ttctctgaag aagtgatagg gggaataagg cataaaatta tctgacctga
    17641 gagaccttaa cagctaggcc tgcactgctc atgctttggg accagaaagc ggatggtttg
    17701 atatggtagc tgcacttcta aaaaaaaaag ggggcattct tggcaggaga aagggtgtta
    17761 catggaaaga tcagcgatag tacacacgcc ttcccataga gtgaggtggc tttcccaccc
    17821 ctcaacactc cttcagaccc ccactgtaac aaagggatgt gtctacctct aaattcatca
    17881 tttactgaac aaataactca tgagggttac catatgtctg acactgtagg aagagctgaa
    17941 gcagggccta aaacactata gtgcaagtat ctgtttacac atctgtatga gagtaattga
    18001 tgctagctgc tgtaacaaac aaccccccaa actcagtaac acaatcaagc tgtatttctc
    18061 cttcacatca tagcctggtg tgggtcaggt aggtgactca gggttctagg ctccttccat
    18121 ttttttgtcg ctgccacact ggaaatggga tagaatatcg tatagctatg agaattgcaa
    18181 ataagtaaat tatattaaca tgtacaaatt tattaaaaat actctttcaa ttccttctct
    18241 ctgcctgaca ttgttcttcc tggaaatgag tctacaaaat caacattaag gaaaaaatga
    18301 tcaggattca ataaattctg gatagaaaaa agaataaaat gtctttaaaa atttatattt
    18361 caagtgtgtg ggggcaataa agaggccaga taatagtagt taaatgtggg gctctgtagg
    18421 caatagatct aggtcagata ctggctcaat tgttagctgt gtgatttcac aagagataac
    18481 tgatgctagc tgctgtaaca aacaaccccc caaactcagt aacacaatca agctgaattt
    18541 ctccttcaca tcacaacttg gtgtggatcg ggcaggtgac tcagggttct gggctccttc
    18601 catttttttt gttgctgcca ccttagtacg tggccaccat gaagaggaag agaaagcact
    18661 tgcaatgatg tgaggttttc tgtcttggta tggaggagac atgaatcact actgtacatg
    18721 tccaagtcac atggcaaggg aggccaggaa atgtcatctt cctataatgc aagaaaaaga
    18781 acccagggcc gggcacagtg gctcacgcct ataatcccca caatttggga ggctgaggca
    18841 agaggattgc ttgagcccag agcaattaaa cactgcctgg tgcatagtta gtgctcaaga
    18901 attgtgctat aatcaatgtt actaaattat ctaggattag atgtttctaa attaaaacta
    18961 tttcctgctt tgtatttgtc ctttattcca aaaacttaaa aatttctcat ttctggtttg
    19021 tcagggatga aatactaaag caacttcatg gattgtgatt tcaagtatat gaaaagttta
    19081 agacccaatt gcttttgaag gagattcatc tagaaaaacc agggattcaa acccaacaca
    19141 tcgggtgcta aagtctaccc tcttagttga catagaatta aattaaaatc agtattgatt
    19201 ggattatgct ttgataaaaa tgtaacttca tttaagtcta gtaaataatt aggattatga
    19261 ggtcaggagt ttgagaccag cctggccaat atggtgaaac cccgtctcta ctaatgatac
    19321 gaaaattagc cgggcatggt ggcgtgcacc tgtagtccca gctactcggg aggctgaggc
    19381 agaagtatca cttgaacccg ggaggtggac gttgcagtga gccaagatcg caccactgca
    19441 ctccagcctg ggtgacaggg tgagactcca tcttaagaag aaaaaaaaag caattacttt
    19501 tgcaccaacc taataaaaat gaaaaatccc aatgaaaatg catgaatatc atgtgccttg
    19561 acaacttacg gagcatttgg aacatgtcaa acagtaatca gaggtcaggt tgaggaaaaa
    19621 atgataagaa ccctctctgc cccaccattc acatcattca gtggatctat gtactaaatc
    19681 tagccagtgg gttgtgagca aaaatgatct gtgtcacttg tgggttaaaa tataaaagag
    19741 tgctaggcac actggctcgc acctgtaatc ccagcacttt gggaggctaa gtgggaggat
    19801 cgcttgagcc taggagttca agaccagcct gggcaacata gcaagacccc atccctacaa
    19861 aacagttttt taaaaaacta gctgtagggc aggcacggtg gttcacacct gtaatcccag
    19921 aactttagaa ggccgaggtg ggtggatcac ttgaggtcag gagttcagga ccaacctgac
    19981 caacatggtg aaaccccatc tctactaaaa atacaaaatt agccaggcgt ggtggcgcat
    20041 gcctgtaatc ccagctactc aggaggctga ggcaggagac ttgctttaac ccaggaagcg
    20101 gaggttgcag tgagccaaga ttgcaccatt gcactccaac ctgggcaaca aaagtgaaac
    20161 tccatctcaa caaacaaaca aacaaacaaa cagtagctgg ttgtggtggt gtgtgactgt
    20221 gatcccagct acttgggagg ctgaagtgaa aggatcgctt gagcctggga ggtagacgct
    20281 gcagtgagct gagatcatac ctctgcactt cagcctgggt gacagagtga gatcctgtct
    20341 caaaaaataa taacaataac gtatgagaga ggattcaagc tttccaagca gtctcttccc
    20401 ctgccatggc actcatagaa gcctcccgtt aagatggcag agctgtaatg ctagaaaagc
    20461 acagactgtt aagtcactgc atggaggatg gtcatcctgg agaattgttt ggactcgagt
    20521 ggactctaca acagcaggaa ataaactact gttatatcaa gctactgaca ttgagaatta
    20581 ggttgcatag ttatgccaca gcataatgta gcctttcctg atgcatacaa ttacttttcc
    20641 tttctttttt cttttccctg gagttcataa ttacctttgt ttcatttgct tagctttcta
    20701 tttacataaa taggtaaaaa ttccttctca aaaatctttt acagaagtgt tctcaaactc
    20761 aatgcattga aacatgctat agtttataaa tcttggatcc atcacttaaa gaggcatttg
    20821 acctgtttca gtatggataa gttgttctct aagtctactg catagctgag agcctaagat
    20881 ctctggggac tcactccact tttctcttga gttggttcca ctatttcctg gaacctcata
    20941 cagccatctc agctagtcat gactgaccta gatttaacac agtatatcct taatcagctt
    21001 cctgattgag agtgtatttt gagacattcc atgtctagaa agtgtcttta tctcacatgt
    21061 aattgtgata gtctggctga gtataaaatc ttacttagga tgttaactta aaatcaatgt
    21121 ggtcaaggaa aggaggaaaa atatgtcctc ctagtaattc ccagtgtaag tggaaatgac
    21181 ccagccctag atttacttgg ctttagtttc catcaccata gatttctcaa tcaaaaggca
    21241 aatatatctc atatgtcgga agattaatgt atgaataatc agtaccactg gcatatggct
    21301 actctcctat tttccttacc cctttgtctt cacaaggaag cccagactct gtttgccagt
    21361 ggctgggtcc tggggccgat aacttcaagc taaacattca atatcagtat ggtaggtgag
    21421 gaagattttc tcagagtggc tcattatctg gaaagtgtaa gaatgaggtg gcagaaagag
    21481 gtagaaacag catgaaaagg cagagccaag gagagatcga caaacaagaa ggattgtgcc
    21541 catatttctc tattctctct agcattatga atcatttccc ctcaggattt tggagatgtt
    21601 gcatcagtgt tgctaccgaa cattccaaag ccattctaat tctgttactt tgtatgttct
    21661 tttttttccc tatacataat ttactattgc atgtttttct cagggtttct gaaatttcag
    21721 aatatcctga tgtggatcta ttttgattca ttgtactgaa gaccatttca gcccatctta
    21781 cactttgatt ctggaaagtc ttcttttccc tggagcttat aattactttt atttcatttg
    21841 cttagctttc tatgtacata agtagataaa aattaattca ttctcaaaat cttccacaga
    21901 aatgctttca aactcaatgc attaaaaaca tgctatagtt tataaacctt cttggatcta
    21961 tcaaggaaga tttatttgat tattttatct cctccattcc atctgttttc ttataattcc
    22021 taatatttgg aggttggacc tcatgaactg atcctataat tttactaatt ttcctccagt
    22081 ttttcatcta tttgactttt tgctctattt tcagggaaat atcctcaact ttatctgcta
    22141 actcttctgt taagtacttt atttctgctc tcatgctttt aatttccaaa agctcttttt
    22201 gtgagctggc tgttcatttt tttatagaat cctgtcctta tttgacaggt cctatatatt
    22261 tttttatttt gagattatta gtgatagttc ttctaagttt tcttctctct gcacactgta
    22321 tttcctctaa gttgcttttt taaatttttg acctgtgttt gctttgcttt cgtttatgtt
    22381 acaggctttc ctaaaattcc tggtgatcct tggctatctg ctcgaattta aaaacaagca
    22441 ctaaagaagg gcactaaaaa acagattgtc atagcagtat tatccataat agccaaatga
    22501 tagaagcaat gcaaatgtcc atcaacagag ggacaaatga ataagcaaat gtggtatatt
    22561 gatacaatgg aatactattc tgtaatgaag atgggaaaga acggagtact gatacacgct
    22621 acaacatggg taaactgaaa acattattac gtgaaataag ccagtcataa accacatatt
    22681 gtgtatattt tatccataag aaatgttcag aataggcaaa tctataaaaa tacaaagtag
    22741 atttgtagtt gctgagggct gggaaaaggg tttggggaga gaaatgactg ctaatgggag
    22801 tatgggatgt tcttttgggg ctgataaaat gttccaaaat tcattgtgtg ataactacac
    22861 atctgtaaat atactaaaaa ccactgaatt gtatccaata aagtactaaa ttgtatgata
//
