LOCUS       NM_152546               2855 bp    mRNA    linear   PRI 08-JUN-2024
DEFINITION  Homo sapiens serum response factor binding protein 1 (SRFBP1),
            mRNA.
ACCESSION   NM_152546
VERSION     NM_152546.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2855)
  AUTHORS   Zhang,X., Williams,E.D., Azhar,G., Rogers,S.C. and Wei,J.Y.
  TITLE     Does p49/STRAP, a SRF-binding protein (SRFBP1), modulate cardiac
            mitochondrial function in aging?
  JOURNAL   Exp Gerontol 82, 150-159 (2016)
   PUBMED   27337995
  REMARK    GeneRIF: P49/STRAP expression was increased in the old versus young
            adult mouse hearts and also increased with advancing population
            doubling levels in cultured human umbilical vein endothelial cells.
            The increased expression of p49/STRAP in late life may alter the
            status of histone acetylation and impact mitochondrial dynamics and
            thereby reduce mitochondrial function and cardiac performance
            during mammalian senescence.
REFERENCE   2  (bases 1 to 2855)
  AUTHORS   Gerold,G., Meissner,F., Bruening,J., Welsch,K., Perin,P.M.,
            Baumert,T.F., Vondran,F.W., Kaderali,L., Marcotrigiano,J.,
            Khan,A.G., Mann,M., Rice,C.M. and Pietschmann,T.
  TITLE     Quantitative Proteomics Identifies Serum Response Factor Binding
            Protein 1 as a Host Factor for Hepatitis C Virus Entry
  JOURNAL   Cell Rep 12 (5), 864-878 (2015)
   PUBMED   26212323
  REMARK    GeneRIF: SRFBP1 is an HCV-specific, pan-genotypic host entry
            factor.
REFERENCE   3  (bases 1 to 2855)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   4  (bases 1 to 2855)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   5  (bases 1 to 2855)
  AUTHORS   Lin,J.L., Liu,F.H. and Wang,C.
  TITLE     Interaction of Hsp70 with p49/STRAP, a serum response factor
            binding protein
  JOURNAL   Biochem Biophys Res Commun 389 (4), 607-611 (2009)
   PUBMED   19751705
  REMARK    GeneRIF: p49/STRAP can be considered a bona fide co-chaperone of
            Hsp70.
REFERENCE   6  (bases 1 to 2855)
  AUTHORS   Zhang,X., Azhar,G., Helms,S., Zhong,Y. and Wei,J.Y.
  TITLE     Identification of a subunit of NADH-dehydrogenase as a
            p49/STRAP-binding protein
  JOURNAL   BMC Cell Biol 9, 8 (2008)
   PUBMED   18230186
  REMARK    GeneRIF: p49/STRAP plays a role in the regulation of intracellular
            processes such as cardiac cellular metabolism, gene expression, and
            possibly aging.
            Publication Status: Online-Only
REFERENCE   7  (bases 1 to 2855)
  AUTHORS   Lisinski,I., Matsumoto,H., Yver,D.R., Schurmann,A., Cushman,S.W.
            and Al-Hasani,H.
  TITLE     Identification and characterization of p49/STRAP as a novel
            GLUT4-binding protein
  JOURNAL   Biochem Biophys Res Commun 344 (4), 1179-1185 (2006)
   PUBMED   16647043
REFERENCE   8  (bases 1 to 2855)
  AUTHORS   Zhang,X., Azhar,G., Zhong,Y. and Wei,J.Y.
  TITLE     Identification of a novel serum response factor cofactor in cardiac
            gene regulation
  JOURNAL   J Biol Chem 279 (53), 55626-55632 (2004)
   PUBMED   15492011
  REMARK    GeneRIF: p49/STRAP may be an important SRF cofactor in the
            transcriptional regulation of mammalian cardiac muscle genes
            throughout the life span
REFERENCE   9  (bases 1 to 2855)
  AUTHORS   Harrington,J.J., Sherf,B., Rundlett,S., Jackson,P.D., Perry,R.,
            Cain,S., Leventhal,C., Thornton,M., Ramachandran,R.,
            Whittington,J., Lerner,L., Costanzo,D., McElligott,K., Boozer,S.,
            Mays,R., Smith,E., Veloso,N., Klika,A., Hess,J., Cothren,K., Lo,K.,
            Offenbacher,J., Danzig,J. and Ducar,M.
  TITLE     Creation of genome-wide protein expression libraries using random
            activation of gene expression
  JOURNAL   Nat Biotechnol 19 (5), 440-445 (2001)
   PUBMED   11329013
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK058015.1, BC017102.1, BG193119.1 and AC010255.9.
            
            On May 17, 2019 this sequence version replaced NM_152546.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660803.34121.1,
                                           SRR1660803.219092.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000339397.5/ ENSP00000341324.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1091              AK058015.1         15-1105
            1092-1400           BC017102.1         689-997
            1401-1594           BG193119.1         241-434
            1595-2156           AK058015.1         1610-2171
            2157-2822           BC017102.1         1754-2419
            2823-2855           AC010255.9         167520-167552       c
FEATURES             Location/Qualifiers
     source          1..2855
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q23.1"
     gene            1..2855
                     /gene="SRFBP1"
                     /gene_synonym="BUD22; P49; p49/STRAP; Rlb1; STRAP"
                     /note="serum response factor binding protein 1"
                     /db_xref="GeneID:153443"
                     /db_xref="HGNC:HGNC:26333"
                     /db_xref="MIM:610479"
     exon            1..94
                     /gene="SRFBP1"
                     /gene_synonym="BUD22; P49; p49/STRAP; Rlb1; STRAP"
                     /inference="alignment:Splign:2.1.0"
     CDS             59..1348
                     /gene="SRFBP1"
                     /gene_synonym="BUD22; P49; p49/STRAP; Rlb1; STRAP"
                     /note="BUD22 homolog; SRF-dependent transcription
                     regulation-associated protein"
                     /codon_start=1
                     /product="serum response factor-binding protein 1"
                     /protein_id="NP_689759.2"
                     /db_xref="CCDS:CCDS43354.1"
                     /db_xref="GeneID:153443"
                     /db_xref="HGNC:HGNC:26333"
                     /db_xref="MIM:610479"
                     /translation="MAQPGTLNLNNEVVKMRKEVKRIRVLVIRKLVRSVGRLKSKKGT
                     EDALLKNQRRAQRLLEEIHAMKELKPDIVTKSALGDDINFEKIFKKPDSTATERAIAR
                     LAVHPLLKKKIDVLKAAVQAFKEARQNVAEVESSKNASEDNHSENTLYSNDNGSNLQR
                     EATVISEQKVKETKILAKKPIHNSKEKIAKMEHGPKAVTIANSPSKPSEKDSVVSLES
                     QKTPADPKLKTLSQTKKNKGSDSSLSGNSDGGEEFCEEEKEYFDDSTEERFYKQSSMS
                     EDSDSGDDFFIGKVRRTRKKESSCHSSVKEQKPLEKVFLKEDTGETHGDTRNDKIKPS
                     TETRKLESVFFHSLSGSKSSRRNFKEQAPKTRSLDFPQNEPQIKNQFNKKLSGRLENT
                     KQQLQLPLHPSWEASRRRKEQQSNIAVFQGKKITFDD"
     exon            95..183
                     /gene="SRFBP1"
                     /gene_synonym="BUD22; P49; p49/STRAP; Rlb1; STRAP"
                     /inference="alignment:Splign:2.1.0"
     exon            184..256
                     /gene="SRFBP1"
                     /gene_synonym="BUD22; P49; p49/STRAP; Rlb1; STRAP"
                     /inference="alignment:Splign:2.1.0"
     exon            257..328
                     /gene="SRFBP1"
                     /gene_synonym="BUD22; P49; p49/STRAP; Rlb1; STRAP"
                     /inference="alignment:Splign:2.1.0"
     exon            329..410
                     /gene="SRFBP1"
                     /gene_synonym="BUD22; P49; p49/STRAP; Rlb1; STRAP"
                     /inference="alignment:Splign:2.1.0"
     exon            411..1125
                     /gene="SRFBP1"
                     /gene_synonym="BUD22; P49; p49/STRAP; Rlb1; STRAP"
                     /inference="alignment:Splign:2.1.0"
     exon            1126..1163
                     /gene="SRFBP1"
                     /gene_synonym="BUD22; P49; p49/STRAP; Rlb1; STRAP"
                     /inference="alignment:Splign:2.1.0"
     exon            1164..2855
                     /gene="SRFBP1"
                     /gene_synonym="BUD22; P49; p49/STRAP; Rlb1; STRAP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2136..2141
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SRFBP1"
                     /gene_synonym="BUD22; P49; p49/STRAP; Rlb1; STRAP"
                     /note="hexamer: ATTAAA"
     polyA_site      2157
                     /gene="SRFBP1"
                     /gene_synonym="BUD22; P49; p49/STRAP; Rlb1; STRAP"
                     /note="major polyA site"
     polyA_site      2855
                     /gene="SRFBP1"
                     /gene_synonym="BUD22; P49; p49/STRAP; Rlb1; STRAP"
ORIGIN      
        1 gcggtctgag agaccggttc acgtgcaggc agcggcggat catattcctt catctaccat
       61 ggctcagccg ggaactctga acctcaataa cgaggttgtg aagatgagaa aagaagtgaa
      121 gagaattcga gttttagtta tccgaaaact tgtcaggagt gttggccgac tgaagtcaaa
      181 aaagggtact gaagatgcac tgttaaaaaa ccaaagacgg gcgcaaagat tgcttgaaga
      241 aatccatgcc atgaaggaat tgaaacctga catagtaact aaatctgctc ttggtgatga
      301 tatcaacttt gaaaaaatct tcaaaaagcc agattctact gcaactgaaa gagcaattgc
      361 cagactagca gtacatcctc ttctgaagaa aaagatagat gtgctaaaag ctgctgtaca
      421 agcctttaaa gaagcaagac aaaatgttgc tgaagttgag tcatcaaaga atgcttcaga
      481 ggacaatcat tctgagaata ctttgtattc aaatgataat ggaagtaatt tacagcgtga
      541 agcaactgtc atcagtgagc aaaaagtcaa agaaaccaaa atattggcga agaaaccaat
      601 acataattca aaggaaaaaa tagcaaagat ggaacatgga cctaaagcag tgactattgc
      661 aaattctcca tcaaagcctt cagaaaagga ttctgtagtt tcccttgagt cccagaagac
      721 acctgctgac ccaaaactga aaactctaag tcaaaccaaa aaaaacaaag gatctgatag
      781 ctcactctct ggtaacagtg atggcggaga agaattttgt gaagaggaga aggaatattt
      841 tgatgatagc acagaagaaa ggttttacaa gcagtcttcc atgtctgaag atagtgatag
      901 cggtgacgac ttcttcattg ggaaagtcag acggacacga aagaaggaaa gtagttgtca
      961 ttcttcagtt aaggaacaaa aaccactaga aaaagtgttt cttaaagaag atacaggtga
     1021 aactcatggg gatacaagaa atgacaaaat caagccaagt acagaaacca gaaagttaga
     1081 atcagtgttt ttccactctt tatctggatc taaaagctct agaagaaatt tcaaagaaca
     1141 ggctccaaaa acaagatccc tagattttcc acagaatgag cctcagatca agaatcagtt
     1201 taataagaag ctatcaggaa gacttgaaaa tacaaaacag caattgcagc tgcctcttca
     1261 tccttcatgg gaagcaagca gaaggcgaaa agaacagcaa tctaatattg ctgtgtttca
     1321 ggggaaaaaa attacgtttg atgattgatt agtgcctctt tctgcaaact tttccatcta
     1381 aaaaaaaaaa tgtttttttt aagacaggat ctcattctgt tgcccagact agagtacaat
     1441 attgcaatca cagctcactg cagcctcaaa ctcctgggct caagtgatcc tcccacctct
     1501 gcctcccaaa gggctgggac tgcaggtgca tgcactacca tgcccagctt tctcacccca
     1561 ggctctgcag ctattactta aactcgtatt tgaataagtc tcttggggag aattatagaa
     1621 tgtttgtttt tgtatttttt tttaaagtaa attcaactta cgcttatata agcctttcac
     1681 aaatccaata tgtacttaaa ttgattttta ataatatccc tcagactgtt tcccttatga
     1741 agtaatttgg ggattttagt gatctcatat tttctcttta gtgcttatca tgaaatgtgc
     1801 ttcactggtt cagctctgtt gtttccttaa acataaatgt caatatatat ttaaaataat
     1861 aatggaaaca taggaaatca gctatttaaa ccagatcacc cttgttaaaa atcattcttg
     1921 ttagcaaact aaaatagtaa cttttattat ggatgtacag ataaatatta attttattat
     1981 agttttaagt acttgtgatc atgtactttt tgattctaaa atagttgtct aggacaattt
     2041 tgggattctt aattatattt tagttaagaa aattgtttaa atatagcaat acaaccaata
     2101 atttgtttta tgtttcactg catataaata tttccattaa atcaagaatg tatattatct
     2161 agtttttact atacttattt taaaattttt gaggaatcat agattctaat ttttaagaac
     2221 aaattctgaa ggtggtagga ttaaaagaat atttccactg atggctaagc aaagaagttg
     2281 taagatgact cactgaggaa gggactgctt tatacatcac agtactgcta tttaaaagga
     2341 aaacagaaat ttttaaatcc cttcaaatgt ttcacttttg ctatgctggg aaaaattttg
     2401 aagttcttgg taaactgaat aatgctaatc catgtttcct gcacattagt tcctttaatg
     2461 gcagggaagg ccatctggtt aacctgtatt cacaaactct caagagtttc tacttatttc
     2521 aggagcttaa gaatttagat aactcagccg ggcgtggtga ctcatgccta taatcccagc
     2581 actttgggag gctgaggcgg gtagatcgct agaggcaagg agttcaaaac cagcctgggc
     2641 aacatggtga aaccctgtct ctactaaaaa tacagaaaat tatccaggcg tggtggccgg
     2701 catctgtaat tccagctact cagaaggctg aggcataaga attgcttgaa cctgggaggt
     2761 ggaggttgca gtgagccaag attgcaccac tgcactccag cctgggtgac agagtatgac
     2821 tgtctcaaaa aaaaaaaaaa atttgataaa tagaa
//
