LOCUS       NM_003131               4231 bp    mRNA    linear   PRI 01-OCT-2024
DEFINITION  Homo sapiens serum response factor (SRF), transcript variant 1,
            mRNA.
ACCESSION   NM_003131
VERSION     NM_003131.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4231)
  AUTHORS   Gong,Y., Liu,M., Zhang,Q., Li,J., Cai,H., Ran,J., Ma,L., Ma,Y. and
            Quan,S.
  TITLE     Lysine acetyltransferase 14 mediates TGF-beta-induced fibrosis in
            ovarian endometrioma via co-operation with serum response factor
  JOURNAL   J Transl Med 22 (1), 561 (2024)
   PUBMED   38867256
  REMARK    GeneRIF: Lysine acetyltransferase 14 mediates TGF-beta-induced
            fibrosis in ovarian endometrioma via co-operation with serum
            response factor.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4231)
  AUTHORS   Yang,D., Yang,D., He,Y., Liu,J., Song,Y., Zhou,Y., Jiang,L.,
            Zeng,X., Xu,X., Xu,H., Li,J. and Dan,H.
  TITLE     MRTF-A/SRF signaling suppresses invasion of oral squamous cell
            carcinoma
  JOURNAL   Oral Dis 30 (4), 1919-1934 (2024)
   PUBMED   37154247
  REMARK    GeneRIF: MRTF-A/SRF signaling suppresses invasion of oral squamous
            cell carcinoma.
REFERENCE   3  (bases 1 to 4231)
  AUTHORS   Park,J., Shim,J.K., Lee,M., Kim,D., Yoon,S.J., Moon,J.H., Kim,E.H.,
            Park,J.Y., Chang,J.H. and Kang,S.G.
  TITLE     Classification of IDH wild-type glioblastoma tumorspheres into low-
            and high-invasion groups based on their transcriptional program
  JOURNAL   Br J Cancer 129 (7), 1061-1070 (2023)
   PUBMED   37558923
  REMARK    GeneRIF: Classification of IDH wild-type glioblastoma tumorspheres
            into low- and high-invasion groups based on their transcriptional
            program.
REFERENCE   4  (bases 1 to 4231)
  AUTHORS   Papa,B., Nguyen,M.A., Kumar,A., Song,L., Dorwal,P. and Cheah,A.L.
  TITLE     Cellular myofibromas with SRF fusions: clinicopathological and
            molecular study of 3 cases of a rare entity and a potential mimic
            of sarcoma
  JOURNAL   Hum Pathol 138, 41-48 (2023)
   PUBMED   37245628
  REMARK    GeneRIF: Cellular myofibromas with SRF fusions: clinicopathological
            and molecular study of 3 cases of a rare entity and a potential
            mimic of sarcoma.
REFERENCE   5  (bases 1 to 4231)
  AUTHORS   Al-Hetty,H.R.A.K., Ismaeel,G.L., Mohammad,W.T., Toama,M.A.,
            Kandeel,M., Saleh,M.M. and Turki Jalil,A.
  TITLE     SRF/MRTF-A and liver cirrhosis: Pathologic associations
  JOURNAL   J Dig Dis 23 (11), 614-619 (2022)
   PUBMED   36601855
  REMARK    GeneRIF: SRF/MRTF-A and liver cirrhosis: Pathologic associations.
            Review article
REFERENCE   6  (bases 1 to 4231)
  AUTHORS   Reason,A.J., Morris,H.R., Panico,M., Marais,R., Treisman,R.H.,
            Haltiwanger,R.S., Hart,G.W., Kelly,W.G. and Dell,A.
  TITLE     Localization of O-GlcNAc modification on the serum response
            transcription factor
  JOURNAL   J Biol Chem 267 (24), 16911-16921 (1992)
   PUBMED   1512232
REFERENCE   7  (bases 1 to 4231)
  AUTHORS   Grueneberg,D.A., Natesan,S., Alexandre,C. and Gilman,M.Z.
  TITLE     Human and Drosophila homeodomain proteins that enhance the
            DNA-binding activity of serum response factor
  JOURNAL   Science 257 (5073), 1089-1095 (1992)
   PUBMED   1509260
REFERENCE   8  (bases 1 to 4231)
  AUTHORS   Janknecht,R., Hipskind,R.A., Houthaeve,T., Nordheim,A. and
            Stunnenberg,H.G.
  TITLE     Identification of multiple SRF N-terminal phosphorylation sites
            affecting DNA binding properties
  JOURNAL   EMBO J 11 (3), 1045-1054 (1992)
   PUBMED   1547771
REFERENCE   9  (bases 1 to 4231)
  AUTHORS   Marais,R.M., Hsuan,J.J., McGuigan,C., Wynne,J. and Treisman,R.
  TITLE     Casein kinase II phosphorylation increases the rate of serum
            response factor-binding site exchange
  JOURNAL   EMBO J 11 (1), 97-105 (1992)
   PUBMED   1740119
REFERENCE   10 (bases 1 to 4231)
  AUTHORS   Manak,J.R. and Prywes,R.
  TITLE     Mutation of serum response factor phosphorylation sites and the
            mechanism by which its DNA-binding activity is increased by casein
            kinase II
  JOURNAL   Mol Cell Biol 11 (7), 3652-3659 (1991)
   PUBMED   2046671
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL355385.15 and BC052572.1.
            
            On Nov 23, 2018 this sequence version replaced NM_003131.3.
            
            Summary: This gene encodes a ubiquitous nuclear protein that
            stimulates both cell proliferation and differentiation. It is a
            member of the MADS (MCM1, Agamous, Deficiens, and SRF) box
            superfamily of transcription factors. This protein binds to the
            serum response element (SRE) in the promoter region of target
            genes. This protein regulates the activity of many immediate-early
            genes, for example c-fos, and thereby participates in cell cycle
            regulation, apoptosis, cell growth, and cell differentiation. This
            gene is the downstream target of many pathways; for example, the
            mitogen-activated protein kinase pathway (MAPK) that acts through
            the ternary complex factors (TCFs). Two transcript variants
            encoding different isoforms have been found for this gene.
            [provided by RefSeq, May 2014].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC052572.1, J03161.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000265354.6/ ENSP00000265354.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-26                AL355385.15        123340-123365
            27-4231             BC052572.1         1-4205
FEATURES             Location/Qualifiers
     source          1..4231
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6p21.1"
     gene            1..4231
                     /gene="SRF"
                     /gene_synonym="MCM1"
                     /note="serum response factor"
                     /db_xref="GeneID:6722"
                     /db_xref="HGNC:HGNC:11291"
                     /db_xref="MIM:600589"
     exon            1..901
                     /gene="SRF"
                     /gene_synonym="MCM1"
                     /inference="alignment:Splign:2.1.0"
     CDS             389..1915
                     /gene="SRF"
                     /gene_synonym="MCM1"
                     /note="isoform 1 is encoded by transcript variant 1; c-fos
                     serum response element-binding transcription factor;
                     minichromosome maintenance 1 homolog"
                     /codon_start=1
                     /product="serum response factor isoform 1"
                     /protein_id="NP_003122.1"
                     /db_xref="CCDS:CCDS4889.1"
                     /db_xref="GeneID:6722"
                     /db_xref="HGNC:HGNC:11291"
                     /db_xref="MIM:600589"
                     /translation="MLPTQAGAAAALGRGSALGGSLNRTPTGRPGGGGGTRGANGGRV
                     PGNGAGLGPGRLEREAAAAAATTPAPTAGALYSGSEGDSESGEEEELGAERRGLKRSL
                     SEMEIGMVVGGPEASAAATGGYGPVSGAVSGAKPGKKTRGRVKIKMEFIDNKLRRYTT
                     FSKRKTGIMKKAYELSTLTGTQVLLLVASETGHVYTFATRKLQPMITSETGKALIQTC
                     LNSPDSPPRSDPTTDQRMSATGFEETDLTYQVSESDSSGETKDTLKPAFTVTNLPGTT
                     STIQTAPSTSTTMQVSSGPSFPITNYLAPVSASVSPSAVSSANGTVLKSTGSGPVSSG
                     GLMQLPTSFTLMPGGAVAQQVPVQAIQVHQAPQQASPSRDSSTDLTQTSSSGTVTLPA
                     TIMTSSVPTTVGGHMMYPSPHAVMYAPTSGLGDGSLTVLNAFSQAPSTMQVSHSQVQE
                     PGGVPQVFLTASSGTVQIPVSAVQLHQMAVIGQQAGSSSNLTELQVVNLDTAHSTKSE
                     "
     exon            902..1168
                     /gene="SRF"
                     /gene_synonym="MCM1"
                     /inference="alignment:Splign:2.1.0"
     exon            1169..1430
                     /gene="SRF"
                     /gene_synonym="MCM1"
                     /inference="alignment:Splign:2.1.0"
     exon            1431..1550
                     /gene="SRF"
                     /gene_synonym="MCM1"
                     /inference="alignment:Splign:2.1.0"
     exon            1551..1742
                     /gene="SRF"
                     /gene_synonym="MCM1"
                     /inference="alignment:Splign:2.1.0"
     exon            1743..1819
                     /gene="SRF"
                     /gene_synonym="MCM1"
                     /inference="alignment:Splign:2.1.0"
     exon            1820..4231
                     /gene="SRF"
                     /gene_synonym="MCM1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4205..4210
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SRF"
                     /gene_synonym="MCM1"
                     /note="hexamer: AATAAA"
     polyA_site      4231
                     /gene="SRF"
                     /gene_synonym="MCM1"
                     /note="major polyA site"
ORIGIN      
        1 aaacattgta tctctttata tggggggaag ggtcggggga tccctccgcc gccagcgcgt
       61 ggtcccggcc ccctccaccc gccgtctcgg ccgcggccag cagcccctgc cccccggggg
      121 acgctgacgg ccgcccggcg cgccgcccta gcagacggac agggggcgct gcgcgcggcc
      181 tggggcaacc cgggccacag gggcaggaaa gtgagggccc aggtcggccc gggcgtgcag
      241 gggccccggg ttcgcagcgg cggccgcggc agcgatagcg gcactagcag cagcgggagt
      301 gccgggttga gccgggaagc cgatggcggc ggctgcggcg gctccgattc ctcgctgact
      361 gcccgtccgc cctcctgcat cgagcgccat gttaccgacc caagctgggg ccgcggcggc
      421 tctgggccgg ggctcggccc tggggggcag cctgaaccgg accccgacgg ggcggccggg
      481 cggcggcggc gggacacgcg gggctaacgg gggccgggtc cccgggaatg gcgcggggct
      541 cgggcccggc cgcctggagc gggaggctgc ggcagcggcg gcaaccaccc cggcgcccac
      601 cgcgggggcc ctctacagcg gcagcgaggg cgactcggag tcgggcgagg aggaggagct
      661 gggcgccgag cggcgcggcc tgaagcggag cctgagcgag atggagatcg gtatggtggt
      721 cggtgggccc gaggcgtcgg cagcggccac cgggggctac gggccggtga gcggcgcggt
      781 gagcggggcc aagccgggta agaagacccg gggccgcgtg aagatcaaga tggagttcat
      841 cgacaacaag ctgcggcgct acacgacctt cagcaagagg aagacgggca tcatgaagaa
      901 ggcctatgag ctgtccacgc tgacagggac acaggtgctg ttgctggtgg ccagtgagac
      961 aggccatgtg tatacctttg ccacccgaaa actgcagccc atgatcacca gtgagaccgg
     1021 caaggcactg attcagacct gcctcaactc gccagactct ccaccccgtt cagaccccac
     1081 aacagaccag agaatgagtg ccactggctt tgaagagaca gatctcacct accaggtgtc
     1141 ggagtctgac agcagtgggg agaccaagga cacactgaag ccggcgttca cagtcaccaa
     1201 cctgccgggt acaacctcca ccatccaaac agcacctagc acctctacca ccatgcaagt
     1261 cagcagcggc ccctcctttc ccatcaccaa ctacctggca ccagtgtctg ctagtgtcag
     1321 ccccagtgct gtcagcagtg ccaatgggac tgtgctgaag agtacaggca gcggccctgt
     1381 ctcctctggg ggccttatgc agctgcctac cagcttcacc ctcatgcctg gtggggcagt
     1441 ggcccagcag gtcccagtgc aggccattca agtgcaccag gccccacagc aagcgtctcc
     1501 ctcccgtgac agcagcacag acctcacgca gacctcctcc agcgggacag tgacgctgcc
     1561 cgccaccatc atgacgtcat ccgtgcccac aactgtgggt ggccacatga tgtaccctag
     1621 cccgcatgcg gtgatgtatg cccccacctc gggcctgggt gatggcagcc tcaccgtgct
     1681 gaatgccttc tcccaggcac catccaccat gcaggtgtca cacagccagg tccaggagcc
     1741 aggtggcgtc ccccaggtgt tcctgacagc atcatctggg acagtgcaga tccctgtttc
     1801 agcagttcag ctccaccaga tggctgtgat agggcagcag gccgggagca gcagcaacct
     1861 caccgagcta caggtggtga acctggacac cgcccacagc accaagagtg aatgatccgc
     1921 ccgccgccct ggacagatgg cccaagggat ggcaccactt atttattgtt gccttttcac
     1981 gttttcttta cacacacgtt gacgggccgc aggagggagg cggggaggag gaacgggcag
     2041 ccacaggact gagccctctc actccagcca aagaaatggg cctgcctgcc tccacccgtc
     2101 ctccctcagc ctccccttct tcccgcccca cctcccattt ctgttgctgg aggggctgtc
     2161 ctccttcctg ggaccccctc gccagcttgg ctcgatgttt gccatgagta ttagcttacc
     2221 caatgggacc gtgccccacc tccccacaca caggccttct gtggggctgg gcaccgtgtc
     2281 ctcctctgag gaagcagttg gggccctctt gccagcctcc ttgctgaccc caggtcagcc
     2341 ctgtgtctgt cacaggctgg gtcaaaagag ccctggctct gcccctcagg gggccagctg
     2401 gggagatggg ggcttcttcc tcacactgct gtcctctccc ccttcagctc ctgagtagct
     2461 gggcctgtgc actgggcagg ttcctggggc cgcctgccct gccttgccgc tccccttgga
     2521 cctccagggg ctcctgggtt ggagggaacc accagcgttc ccttctcccc cttgtcttcc
     2581 cccctctcct cccagctgct ttacttaaag ttgattttga actttttatt tgaggagacg
     2641 aagtgaaaac aaatctataa atatatattt ttaaaatatt taactttttt ttatggcgtt
     2701 tttctcgtcc ccctccctgc ccaaactccc cttccctggg gagccctcag gctccccaga
     2761 actggctggg cccctgggga cagagccacc ccatgagctc ggggtccacc agtgtgtggg
     2821 ggagattctg ggtttgccca gtcctgggtt gtttccagga gaaagccggg ggaggggccc
     2881 tcaggccatt ccccaacggg gtggggaggg tgacccacag ctctgggcct ctttttgccc
     2941 tttagggctg ttgctaggga gagggaagag ggagaccaaa tgtcggggtt ggggtgggag
     3001 ggcgtcaggc agaggcaact gacttcattt gtgccacacg catgggcatt gcagccttgc
     3061 gctgtcccag gcatgcagct gcctggggcc caagttgcag tgagcagggt ggggtctggg
     3121 agggggtgag aggcaggaat gggggtcaga agaagtggga gcagcttctt gggctgagtg
     3181 cagccaaagg ggagccagaa atgggcagtt ctcccaggga gtgagcagct actgtaactt
     3241 ttttaaatta agacaaaaag ccttgaagaa aatgacttta tttttctaag tgtaacctca
     3301 gtatttatgt aatttgtaca ggggccatgc cccacccccc tcctccccct ttggggtaga
     3361 ccttgagggt gggccagcat aggggggagg gtcttttacc ctgtgtcaga gcctaccttc
     3421 accacctata tccagaaggg gagctttttc agaaacaggg cagcagtggg gtgaaatttt
     3481 cttaacccct aagactgcct tcagtaggaa caagctggct tctgtgatta ggtgaaggga
     3541 tgggggaaga ttttatgcac agcctagtta tcaaggggat gatttgccga catgtttgag
     3601 aaccccctaa cctctaaccc tcattgctgt cttgccccag tttggggtgc caagatggaa
     3661 gtcacctttc tgggctttct cctggagata gctggggctt atgggtggct ttcaaggctg
     3721 gggcatggca aatcaggggc cagagagcag gggagcttgg gactcaggtc tgtaactgcc
     3781 cagccccttt tctctgctct tgtttcactc caccatcact cactcactcc ccactccccc
     3841 acccatgggg aggagacctt tgatgaattc ttcctctcct tcccacaaaa gacagaccca
     3901 gtgagtgaat caggcaaagt gcttataatg tgtgttgtgt gagcgtggcc ttgggaggac
     3961 atgcgtgtgt cagggatgag ttgaggtgat atttttatgt gcagcgaccc ttggtgtttc
     4021 ccttcctcgg tggctctggg gtatgtgtgt gtgggtgtgt gcgcctgagt gagtgtgtgt
     4081 gcttgaatgt gagtgtgtat gtcagtggtt tctacttccc ctgggatgct gacccaggaa
     4141 tagtggacat ggtcacagtc ctatgtacag agctttcttt tgtattaaaa aaaaatactc
     4201 tttcaataaa tgtatcattt ttgtgcacag a
//
