LOCUS       NM_173829               6878 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens SREK1 interacting protein 1 (SREK1IP1), mRNA.
ACCESSION   NM_173829
VERSION     NM_173829.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6878)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 6878)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 6878)
  AUTHORS   Heese,K., Fujita,M., Akatsu,H., Yamamoto,T., Kosaka,K., Nagai,Y.
            and Sawada,T.
  TITLE     The splicing regulatory protein p18SRP is down-regulated in
            Alzheimer's disease brain
  JOURNAL   J Mol Neurosci 24 (2), 269-276 (2004)
   PUBMED   15456940
  REMARK    GeneRIF: p18SRP is a lysine-rich zinc finger domain-containing
            protein that interacts with the serine-arginine-rich splicing
            regulatory protein SRrp86; it is downregulated in brain of
            Alzheimer disease patients.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC008898.6 and AK094073.1.
            
            On Nov 22, 2018 this sequence version replaced NM_173829.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660805.185916.1,
                                           SRR1660809.28030.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2142853, SAMEA2145893
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000513458.9/ ENSP00000427401.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-22                AC008898.6         85253-85274         c
            23-2340             AK094073.1         1-2318
            2341-6878           AC008898.6         34731-39268         c
FEATURES             Location/Qualifiers
     source          1..6878
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q12.3"
     gene            1..6878
                     /gene="SREK1IP1"
                     /gene_synonym="P18SRP; SFRS12IP1"
                     /note="SREK1 interacting protein 1"
                     /db_xref="GeneID:285672"
                     /db_xref="HGNC:HGNC:26716"
     exon            1..187
                     /gene="SREK1IP1"
                     /gene_synonym="P18SRP; SFRS12IP1"
                     /inference="alignment:Splign:2.1.0"
     CDS             175..642
                     /gene="SREK1IP1"
                     /gene_synonym="P18SRP; SFRS12IP1"
                     /note="SFRS12-interacting protein 1; p18 splicing
                     regulatory protein; protein SFRS12IP1; splicing regulatory
                     protein of 18 kDa"
                     /codon_start=1
                     /product="protein SREK1IP1"
                     /protein_id="NP_776190.1"
                     /db_xref="CCDS:CCDS34171.1"
                     /db_xref="GeneID:285672"
                     /db_xref="HGNC:HGNC:26716"
                     /translation="MAVPGCNKDSVRAGCKKCGYPGHLTFECRNFLRVDPKRDIVLDV
                     SSTSSEDSDEENEELNKLQALQEKRINEEEEKKKEKSKEKIKLKKKRKRSYSSSSTEE
                     DTSKQKKQKYQKKEKKKEKKSKSKKGKHHKKEKKKRKKEKHSSTPNSSEFSRK"
     exon            188..235
                     /gene="SREK1IP1"
                     /gene_synonym="P18SRP; SFRS12IP1"
                     /inference="alignment:Splign:2.1.0"
     exon            236..379
                     /gene="SREK1IP1"
                     /gene_synonym="P18SRP; SFRS12IP1"
                     /inference="alignment:Splign:2.1.0"
     exon            380..452
                     /gene="SREK1IP1"
                     /gene_synonym="P18SRP; SFRS12IP1"
                     /inference="alignment:Splign:2.1.0"
     exon            453..6878
                     /gene="SREK1IP1"
                     /gene_synonym="P18SRP; SFRS12IP1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1712..1717
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SREK1IP1"
                     /gene_synonym="P18SRP; SFRS12IP1"
                     /note="hexamer: AGTAAA"
     polyA_site      1734
                     /gene="SREK1IP1"
                     /gene_synonym="P18SRP; SFRS12IP1"
     regulatory      6854..6859
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SREK1IP1"
                     /gene_synonym="P18SRP; SFRS12IP1"
                     /note="hexamer: AATAAA"
     polyA_site      6878
                     /gene="SREK1IP1"
                     /gene_synonym="P18SRP; SFRS12IP1"
                     /note="major polyA site"
ORIGIN      
        1 atctactggt tctgccgtcg ctagaggcgt acaggccctt cccgaccgta gcgagggtgc
       61 tgctgcgctg ggggaaggaa aacgccgctt tgactgtgcc ttgttctcac agctggcggg
      121 aagcaagcgc cttttcgaaa gccagaggct cgagttaccc ctcttaccac cgtcatggca
      181 gtcccaggtt gcaacaagga cagtgtcaga gcaggctgta aaaaatgtgg ctaccctggt
      241 cacctgactt ttgaatgccg caattttctc cgagtagacc ctaaaaggga catagttttg
      301 gatgtcagca gtacaagtag tgaagatagc gatgaagaga atgaagaact gaataaattg
      361 caggcattac aggaaaaaag aataaatgaa gaagaggaaa agaagaaaga aaaaagcaaa
      421 gaaaaaatca aattgaaaaa aaaaaggaaa aggtcttact catccagttc cactgaagag
      481 gacacttcaa aacaaaagaa acaaaaatat cagaagaaag aaaagaaaaa agaaaaaaag
      541 agtaaatcaa aaaaagggaa acatcacaaa aaggaaaaaa agaagagaaa aaaggaaaag
      601 cattcttcta cacctaatag ttctgaattc tccagaaagt aactgagact ttggcttaag
      661 ccgttaaatt taaaaatttg tttttaaaac gtgtttgccc ttccttggaa tttgctatat
      721 attatgcttt gcaataaatc acagcctttt ccatatagac atttttcgta tttgggacca
      781 ttatccctct ggcaatatat ttttaatgtg ctgtaactgt aaagtattaa atcagtcttg
      841 ttacttgata gccatgcccc aagtatagct atttgtgtat actaaacaca tcatttttgg
      901 tatttgtgtc tctgtgtgtt tggctagtgt tactacttca taagttcatt gtaaaatggc
      961 tttactgcca tcaacatggg tcatctacct agcagttaat gagtattgct ggatcaggtg
     1021 tccaccttcc aatgatgaag caaggtaagg ggtaatgttt tgctcttgac acagagaaat
     1081 ttaatagctt tatgtactaa aatataatat cttttaaaga tagtgaaatt cttcagtttt
     1141 ttaaatctct agggattttt tttcaatgtt gtagaagatg cagctgctta atggtcttga
     1201 ctaggacttt ttaaatgaat ggtgtctgca ggtagatgat catgaaaata tctctaacaa
     1261 agttttactc ttctatgaaa tgcagaattt ctagtacctg cctcctttgt ttttgtaata
     1321 attaaaatac ttcttgtata aagagattag ttcagcctgt tagtaagtct gcagagatga
     1381 tgctgagttg gttgtgattt ttagaataga ctcctgggtt gttttacaaa tgtgccatat
     1441 tggcatgtct tacagtgata cctcaaacac agaaattttt atttaggaag atagctaaat
     1501 ctttattaga actgattttt attgtattca gtataaattt tatgaagctt gtttctatga
     1561 gtactgtgga aaattttata aatgtgagca tatatattta ttttgtctga cataatttgt
     1621 agttttaaag caagtttcac actgaactta acgttttcat aaatgaccag tttgggatgt
     1681 ttctctcttt tactttagtg gcaaactcaa gagtaaaaag tgtcaaaaaa agaattgaga
     1741 attttattct gtacttttta aaatttaaga gccagggagt tgcatcatga aagcctttgt
     1801 ataataatgg aaattttata tgggtaagca ttttcaaaca catattagta gatacgtttt
     1861 ttaaatttct attttcacat tgatcagtgt tactttgctt aatacttagg tagcccttat
     1921 gtccactaaa gtaaatgctt atgttgtaga agcatcgaac atcaaccaat gtcatggcac
     1981 agcaccaaag attgcaaata cctcactatg gtgcgcttag aaattttcaa attgataacc
     2041 tatagatacg gctgcaggtg aattcatgat agtgaaatca gctaagtata cttaacctca
     2101 caggctagaa aggtttactg attcttgttt cacctggcac ccaatgtgga taccctcagt
     2161 aagactcagg gagccttata actcctctta acatatgctt acccatgctt aaattctagg
     2221 gaagctgtat ccacagccct ctgcattgca gccatgagag ctctcacgct ttcaaccctt
     2281 ccataaccta atttagtcat ttgggcctct caaaaggaaa tgcttttgtt taaataggtc
     2341 agtcagttac tgggagaaaa aatacagagc cagtaggttt ttagggattt gttttgcctt
     2401 tgctgctagt tttttgaaaa tattcttcga ttatcaagat tttaaaaatc ggtttttaat
     2461 ataaagcttt tttaaaaacg aggctggcac aagtgcagtg gtgtttcttt actcccactg
     2521 cttgacttga ctagccttga aaaaataaca gtaaaataaa atattaaaaa ataattagaa
     2581 aatgctacaa aggcaatgac cttattccat tgagtaagat agttaaaaat gatagtaatt
     2641 gtagtgaaat agttaattac ttgtaagttt tattactgtt aattgtagag attataaatt
     2701 ggctcattag gtttctgaat ggtgacacaa taatgactga gaagagcaaa agtcagtcct
     2761 cgttaactaa tgtagtatgc aaattaaaat attttaatga tcagtaattt tccccccaga
     2821 aatgatgttg gcatttctaa gtaaatttcc cataatttta gcatagttta tgaaattgaa
     2881 taaaaattta ttttcactga agtaattttc ttctaatatg atattattat tgagattgga
     2941 tgcaaatctc atgaatatgt tttagaagaa aattaatgaa attccctccc aggcagtatg
     3001 taccagaagg aaaactgaat ttagcagtaa aacagtcctg gtcattctaa ctacctgtat
     3061 gatcttgaac aaagtcactt agtttccctg ggccttggtg tctttcgtct ataaaatatt
     3121 gtaccagatt atctctgaaa tcacttcaag gtttaatata tataattatc aatattttaa
     3181 aattcaagca atattcactt tagaaattat tataacattc tataatagta aaggttgaat
     3241 ttattaatat aataaacacg ttcaacttct tcaagcagat aattgatatt tggttcatat
     3301 tcttacaacc taatgcatgt cattttcacc aaatgcaggc agaatttata tttaggtttg
     3361 catctggaac tagattatct ggcactttat ggccattatt tttgggttga tggaccttct
     3421 caccacacaa tttccccctt tttttttttt gcatatcata tgttggttga tatttctcag
     3481 aggtatccct atttcttcat acttaatata catctccatt tacatctttg actctctgag
     3541 gtcaaaacaa caataaatga gaagtaaaac aactatatgt gtttgtattt acaactgtat
     3601 ctaaaattat ataaccctag tttaccttca gagtaaacta ggctgaagag ttgttaataa
     3661 tgttgataaa aatgccattg aatcctttct tcaacaaata tttattgagt acctaacgtg
     3721 gcaaacgctg tgctaagtac tggggataca gagataagta agacacattt gcctccctga
     3781 aggacttcac agtgtagttg gtaggagaaa caccagagca tacaccgtta tataattagt
     3841 gcagtaattg acatgaacat gagtttatag aaactcgggg ttacctaaag tagtctggat
     3901 aaattagaag aggctaccta gagaaagtag tgactgaatt gcaatttgat taaggataag
     3961 aatgagggtt atggcagttc ctgacagagt gggtactgtg aacaaacacc agaggtagaa
     4021 caagctgtgt tatgtgtttg tcaagaatta caagcaatct ggtgttgctg gtgtatcata
     4081 ggcgaggcag gaagtggtaa gaattgagac taccatttta agttcttagg aacaggagga
     4141 aggagtcgtg tgttccgtgt ttgggagctt gaactgtaat gtgtaagcaa tgagacacca
     4201 ttaaagagtt tcaagggggg ccgggcacag tggctcacgc ctgtaatccc agcactttgg
     4261 gaggctgagg cgggcggatc acctgaggtc aggagttcaa gaccagcctg gccaacttgg
     4321 cgaaaccctg tctctactaa aaatagaaaa attagccgga cgtggtgaca ggcacctgta
     4381 ttcccagcta ctctggagtc tggggcagga gaatcgctca aacccaggag gtggaagttg
     4441 cagtaagctg agatcacacc actgtactcc agcctgggcg acagagcgag actctatctc
     4501 aaaaaaaaaa aaagatttta aggaaggaaa tgacttttat tagggtttgg ttttatcaat
     4561 ttcataatcc gattaatccc accattttta aaagatgaaa ttgctttcat tagaaggcta
     4621 cataaaatat aatttgatta ttttaggctc tattattaga ctcacatttc tttctacagt
     4681 ctcattatta tttccaaaaa ttacacagta acctaaatca tctaaaaaca cataaagcta
     4741 ctgtattctt tattagatcc atccccagag ttatatgtac atgtacatac tttgagatgt
     4801 gttttgttct taattgtatt ttaggttatt tttgactgac ttaaattcta tcactatttt
     4861 aatatttgtt aggtccgaat aaaccattta gaatattttt cagtgtacaa aatgtgctgt
     4921 aatttaataa ggccccttgc ttttaaaatt tggcttaacc tgtgaagcac aactgcttca
     4981 gagttacaga gaaacatacc agttggtcca ctggatgagc cctgtggttc tacctcaggt
     5041 aacctagtga taagctagct cagcagggag tgcttcaagg actccagctg atcctagtgc
     5101 tgagaccaaa acttcctgga cattgggtgc ccaagaacag taggtttctt ataccagtgt
     5161 gacaataatc ccagttgcga aggccagtct tctgatctca gtatctcctc ccaactcctc
     5221 taaaaatagg tagagtggca gagaattggg gtgcctcttc tatagcacaa cccatgatgc
     5281 atccagtcat gcctgacccc actatgcctt tcccacaaat tgggaggagt tggggcagtg
     5341 agcattttgc tagctctgtc tgtttcttgc ttcttgtgcc atttatagtc cttggccatg
     5401 agcaacaaaa gtagaatggt gccagtgcct taactaaatt tttctcaacc tagattttca
     5461 cctgagacaa tatggtaata ttattaaatt actgtaaaga tagcaaattt tctgggatac
     5521 tttaaaatca aagttgtatc aaagatcaag aagcacccat aaaagcttta taaactttca
     5581 caaaaaataa gtgaaaattc tttgttttta tggccgtgta aaatgtcatt tttataatgg
     5641 aaatgtctta attttcaaac ttaacatata ctttaagcaa ttttagtatt taaacctttg
     5701 caaaattgta tttttgaatg tgaagttcaa ctttggcagt aggttgttgc aatagtgatc
     5761 tggcactatg gtgccagtat agccacatag ggttatttaa attaattaaa taaatgaaaa
     5821 attttatttt ttcagttgca ttagccacat cttaagtgtt cagtagccac atgtgactgg
     5881 tggctaccat attagtgcag atatagaaag aacatttcca tcatcacaga aacttctctt
     5941 aattctggtc tagaagataa ccttagtact tggtagaaat tttgacaggc taatgacgaa
     6001 aagtttgtaa ccctgagctt tgcatgccca agaaaaataa ggtattcttt tttatatatc
     6061 agaccagaga agctgtattc agcacatttt gaaatgctag tttttggcta tggccatacc
     6121 accctaaatg tgccagatct tgtctgaaat gctagtttct gactacaaaa actacaggac
     6181 atagtagata tgctcagtag agctgcttaa aataattccc tttttttttc tgttgaattc
     6241 tgttacaaaa ccaggtctgt gttataatag aaaacacact tatgaataaa aatctttaaa
     6301 aattataatt tgcagaaatt agttttattt ctagatttct aggtggtatt aatgtgatag
     6361 cattaggtgg gaccagagaa ctcatttgtt ttgtagcttt cattatacag attatttagg
     6421 aaatatatca gcaaaggatt ttttgttatg cttatctctt gaaacaaaat atttattgta
     6481 cagattatac attgtgattt ttttgttact gagtatattg tttgtgccca gaaaaatcta
     6541 aaaagatgtg ggttgacttc taagagattt aagaacaagt cacctctagt ttttaagaca
     6601 gttcccttga tatttaccta tccagtacca tctcataaga ataactgcct gtaagtatca
     6661 gaaagttgag aaatgctggt aatgtgacat aaacttctca ctgttcttca ctgagatagg
     6721 actgcttatc ttgttattga taaattattt aatttctcct gaataattag cataatctca
     6781 tgtgatacag aaacatctta attagcaaat aaatttatac aaaggaaaac caataaaacc
     6841 ttaatgtgcg tttaataaag taactgaatg atcaaaaa
//
