LOCUS       NM_001077199            6699 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens splicing regulatory glutamic acid and lysine rich
            protein 1 (SREK1), transcript variant 1, mRNA.
ACCESSION   NM_001077199
VERSION     NM_001077199.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6699)
  AUTHORS   Chang,C., Rajasekaran,M., Qiao,Y., Dong,H., Wang,Y., Xia,H.,
            Deivasigamani,A., Wu,M., Sekar,K., Gao,H., Sun,M., Niu,Y., Li,Q.,
            Tao,L., Yan,Z., Wang,M., Chen,S., Zhao,S., Chen,D., Li,L., Yang,F.,
            Gao,H., Chen,B., Su,L., Xu,L., Chen,Y., Seshachalam,V.P., Chen,G.,
            Gunaratne,J., Hong,W., Shi,J., Chen,G., Grierson,D.S., Chabot,B.,
            Xie,T., Hui,K.M. and Chen,J.
  TITLE     The aberrant upregulation of exon 10-inclusive SREK1 through SRSF10
            acts as an oncogenic driver in human hepatocellular carcinoma
  JOURNAL   Nat Commun 13 (1), 1363 (2022)
   PUBMED   35296659
  REMARK    GeneRIF: The aberrant upregulation of exon 10-inclusive SREK1
            through SRSF10 acts as an oncogenic driver in human hepatocellular
            carcinoma.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6699)
  AUTHORS   Abudureheman,Z., Li,L., Zhong,X., Xu,J., Gong,H., Yilamujiang,S.,
            Ren,J., Xie,C., Zheng,A., Tuerxun,D., Abudukadeer,A., Aini,P.,
            Xu,A. and Zou,X.
  TITLE     The rs74794265 SNP of the SREK1 Gene is Associated with COPD in
            Kashi, China
  JOURNAL   Int J Chron Obstruct Pulmon Dis 16, 2631-2636 (2021)
   PUBMED   34556983
  REMARK    GeneRIF: The rs74794265 SNP of the SREK1 Gene is Associated with
            COPD in Kashi, China.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 6699)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 6699)
  AUTHORS   Buljan,M., Ciuffa,R., van Drogen,A., Vichalkovski,A., Mehnert,M.,
            Rosenberger,G., Lee,S., Varjosalo,M., Pernas,L.E., Spegg,V.,
            Snijder,B., Aebersold,R. and Gstaiger,M.
  TITLE     Kinase Interaction Network Expands Functional and Disease Roles of
            Human Kinases
  JOURNAL   Mol Cell 79 (3), 504-520 (2020)
   PUBMED   32707033
REFERENCE   5  (bases 1 to 6699)
  AUTHORS   Hernandez,I.H., Cabrera,J.R., Santos-Galindo,M., Sanchez-Martin,M.,
            Dominguez,V., Garcia-Escudero,R., Perez-Alvarez,M.J., Pintado,B.
            and Lucas,J.J.
  TITLE     Pathogenic SREK1 decrease in Huntington's disease lowers TAF1
            mimicking X-linked dystonia parkinsonism
  JOURNAL   Brain 143 (7), 2207-2219 (2020)
   PUBMED   32533168
  REMARK    GeneRIF: Pathogenic SREK1 decrease in Huntington's disease lowers
            TAF1 mimicking X-linked dystonia parkinsonism.
REFERENCE   6  (bases 1 to 6699)
  AUTHORS   Heese,K., Fujita,M., Akatsu,H., Yamamoto,T., Kosaka,K., Nagai,Y.
            and Sawada,T.
  TITLE     The splicing regulatory protein p18SRP is down-regulated in
            Alzheimer's disease brain
  JOURNAL   J Mol Neurosci 24 (2), 269-276 (2004)
   PUBMED   15456940
  REMARK    GeneRIF: p18SRP is a lysine-rich zinc finger domain-containing
            protein that interacts with the serine-arginine-rich splicing
            regulatory protein SRrp86; it is downregulated in brain of
            Alzheimer disease patients.
REFERENCE   7  (bases 1 to 6699)
  AUTHORS   Li,J., Hawkins,I.C., Harvey,C.D., Jennings,J.L., Link,A.J. and
            Patton,J.G.
  TITLE     Regulation of alternative splicing by SRrp86 and its interacting
            proteins
  JOURNAL   Mol Cell Biol 23 (21), 7437-7447 (2003)
   PUBMED   14559993
REFERENCE   8  (bases 1 to 6699)
  AUTHORS   Li,J., Barnard,D.C. and Patton,J.G.
  TITLE     A unique glutamic acid-lysine (EK) domain acts as a splicing
            inhibitor
  JOURNAL   J Biol Chem 277 (42), 39485-39492 (2002)
   PUBMED   12183448
  REMARK    GeneRIF: the unique glutamic acid-lysine domain of SRrp86 plays a
            modulatory role controlling serine-arginine domain function
REFERENCE   9  (bases 1 to 6699)
  AUTHORS   Barnard,D.C., Li,J., Peng,R. and Patton,J.G.
  TITLE     Regulation of alternative splicing by SRrp86 through coactivation
            and repression of specific SR proteins
  JOURNAL   RNA 8 (4), 526-533 (2002)
   PUBMED   11991645
  REMARK    GeneRIF: SRrp86 can activate SRp20 and repress SC35 in a
            dose-dependent manner both in vitro and in vivo
REFERENCE   10 (bases 1 to 6699)
  AUTHORS   Barnard,D.C. and Patton,J.G.
  TITLE     Identification and characterization of a novel serine-arginine-rich
            splicing regulatory protein
  JOURNAL   Mol Cell Biol 20 (9), 3049-3057 (2000)
   PUBMED   10757789
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from CD706234.1, BC047322.1,
            BC112343.1 and AC008772.6.
            
            On Nov 22, 2018 this sequence version replaced NM_001077199.2.
            
            Summary: This gene encodes a member of a family of
            serine/arginine-rich (SR) splicing proteins containing RNA
            recognition motif (RRM) domains. The encoded protein interacts with
            other SR proteins to modulate splice site selection. Alternatively
            spliced transcript variants encoding multiple isoforms have been
            observed for this gene. [provided by RefSeq, Jul 2012].
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (a).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660803.256286.1,
                                           SRR1803614.241324.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000334121.11/ ENSP00000334538.6
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-49                CD706234.1         121-169
            50-1225             BC047322.1         1-1176
            1226-3611           BC112343.1         830-3215
            3612-6699           AC008772.6         73238-76325
FEATURES             Location/Qualifiers
     source          1..6699
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q12.3"
     gene            1..6699
                     /gene="SREK1"
                     /gene_synonym="SFRS12; SRrp508; SRrp86"
                     /note="splicing regulatory glutamic acid and lysine rich
                     protein 1"
                     /db_xref="GeneID:140890"
                     /db_xref="HGNC:HGNC:17882"
                     /db_xref="MIM:609268"
     exon            1..238
                     /gene="SREK1"
                     /gene_synonym="SFRS12; SRrp508; SRrp86"
                     /inference="alignment:Splign:2.1.0"
     CDS             78..1952
                     /gene="SREK1"
                     /gene_synonym="SFRS12; SRrp508; SRrp86"
                     /note="isoform a is encoded by transcript variant 1;
                     splicing factor, arginine/serine-rich 12;
                     serine-arginine-rich splicing regulatory protein 508;
                     serine/arginine-rich-splicing regulatory protein 86;
                     splicing regulatory glutamine/lysine-rich protein 1;
                     splicing regulatory glutamic acid/lysine-rich protein 1"
                     /codon_start=1
                     /product="splicing regulatory glutamine/lysine-rich
                     protein 1 isoform a"
                     /protein_id="NP_001070667.1"
                     /db_xref="CCDS:CCDS43323.1"
                     /db_xref="GeneID:140890"
                     /db_xref="HGNC:HGNC:17882"
                     /db_xref="MIM:609268"
                     /translation="MNSGGGFGLGLGFGLTPTSVIQVTNLSSAVTSEQMRTLFSFLGE
                     IEELRLYPPDNAPLAFSSKVCYVKFRDPSSVGVAQHLTNTVFIDRALIVVPCAEGKIP
                     EESKALSLLAPAPTMTSLMPGAGLLPIPTPNPLTTLGVSLSSLGAIPAAALDPNIATL
                     GEIPQPPLMGNVDPSKIDEIRRTVYVGNLNSQTTTADQLLEFFKQVGEVKFVRMAGDE
                     TQPTRFAFVEFADQNSVPRALAFNGVMFGDRPLKINHSNNAIVKPPEMTPQAAAKELE
                     EVMKRVREAQSFISAAIEPESGKSNERKGGRSRSHTRSKSRSSSKSHSRRKRSQSKHR
                     SRSHNRSRSRQKDRRRSKSPHKKRSKSRERRKSRSRSHSRDKRKDTREKIKEKERVKE
                     KDREKEREREKEREKEKERGKNKDRDKEREKDREKDKEKDREREREKEHEKDRDKEKE
                     KEQDKEKEREKDRSKEIDEKRKKDKKSRTPPRSYNASRRSRSSSRERRRRRSRSSSRS
                     PRTSKTIKRKSSRSPSPRSRNKKDKKREKERDHISERRERERSTSMRKSSNDRDGKEK
                     LEKNSTSLKEKEHNKEPDSSVSKEVDDKDAPRTEENKIQHNGNCQLNEENLSTKTEAV
                     "
     exon            239..372
                     /gene="SREK1"
                     /gene_synonym="SFRS12; SRrp508; SRrp86"
                     /inference="alignment:Splign:2.1.0"
     exon            373..488
                     /gene="SREK1"
                     /gene_synonym="SFRS12; SRrp508; SRrp86"
                     /inference="alignment:Splign:2.1.0"
     exon            489..653
                     /gene="SREK1"
                     /gene_synonym="SFRS12; SRrp508; SRrp86"
                     /inference="alignment:Splign:2.1.0"
     exon            654..832
                     /gene="SREK1"
                     /gene_synonym="SFRS12; SRrp508; SRrp86"
                     /inference="alignment:Splign:2.1.0"
     exon            833..963
                     /gene="SREK1"
                     /gene_synonym="SFRS12; SRrp508; SRrp86"
                     /inference="alignment:Splign:2.1.0"
     exon            964..1078
                     /gene="SREK1"
                     /gene_synonym="SFRS12; SRrp508; SRrp86"
                     /inference="alignment:Splign:2.1.0"
     exon            1079..1198
                     /gene="SREK1"
                     /gene_synonym="SFRS12; SRrp508; SRrp86"
                     /inference="alignment:Splign:2.1.0"
     exon            1199..1561
                     /gene="SREK1"
                     /gene_synonym="SFRS12; SRrp508; SRrp86"
                     /inference="alignment:Splign:2.1.0"
     exon            1562..1657
                     /gene="SREK1"
                     /gene_synonym="SFRS12; SRrp508; SRrp86"
                     /inference="alignment:Splign:2.1.0"
     exon            1658..1802
                     /gene="SREK1"
                     /gene_synonym="SFRS12; SRrp508; SRrp86"
                     /inference="alignment:Splign:2.1.0"
     exon            1803..6699
                     /gene="SREK1"
                     /gene_synonym="SFRS12; SRrp508; SRrp86"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3946..3951
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SREK1"
                     /gene_synonym="SFRS12; SRrp508; SRrp86"
                     /note="hexamer: AATAAA"
     polyA_site      3972
                     /gene="SREK1"
                     /gene_synonym="SFRS12; SRrp508; SRrp86"
                     /note="major polyA site"
     regulatory      5552..5557
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SREK1"
                     /gene_synonym="SFRS12; SRrp508; SRrp86"
                     /note="hexamer: AATAAA"
     polyA_site      5575
                     /gene="SREK1"
                     /gene_synonym="SFRS12; SRrp508; SRrp86"
     regulatory      6675..6680
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SREK1"
                     /gene_synonym="SFRS12; SRrp508; SRrp86"
                     /note="hexamer: AATAAA"
     polyA_site      6699
                     /gene="SREK1"
                     /gene_synonym="SFRS12; SRrp508; SRrp86"
ORIGIN      
        1 gttctccgct ttcccggctc cgtcgctgac gcgtcgtaga cgttggggag cgggaaggca
       61 acggcagcgg gatcgggatg aacagcggcg gcggcttcgg tttgggctta ggcttcggcc
      121 tcacccccac gtcggtgatt caggtgacga atctgtcgtc ggcggtgacc agcgagcaga
      181 tgcggacgct tttttccttc ctaggagaaa tcgaggagct gcggctctac cccccggaca
      241 acgcacctct tgctttttcc tccaaagtat gttatgttaa gtttcgtgat ccatcaagtg
      301 ttggcgtggc ccagcatcta actaacacgg tttttattga cagagctctg atagttgttc
      361 cttgtgcaga aggtaaaatc ccagaggaat ccaaagccct ctctttattg gctcctgctc
      421 caaccatgac aagtctgatg cctggtgcag gattgcttcc aataccgacc ccaaatcctt
      481 tgactactct tggtgtttca cttagcagtt tgggagctat accagcagca gcactagacc
      541 ccaacattgc aacacttgga gagataccac agccaccact tatgggaaac gtggatcctt
      601 ccaaaataga tgaaattagg agaacggttt atgttggaaa tctgaattcc cagacaacga
      661 cagctgatca actacttgaa ttttttaaac aagttggaga agtgaagttt gtgcggatgg
      721 caggtgatga gactcagcca actcggtttg cttttgtgga atttgcagac caaaattctg
      781 taccaagggc ccttgctttt aatggagtta tgtttggaga caggccactg aaaataaatc
      841 actccaacaa tgcaatagta aaaccccctg agatgacacc tcaggctgca gctaaggagt
      901 tagaagaagt aatgaagcga gtacgagaag ctcagtcatt tatctcagca gctattgaac
      961 cagagtctgg aaagagcaat gaaagaaaag gcggtcgatc tcgttcccat actcgctcaa
     1021 aatccaggtc tagctcaaaa tcccattcta gaaggaaaag atcacaatca aaacacagga
     1081 gtagatccca taatagatca cgttcaagac agaaagacag acgtagatct aagagcccac
     1141 ataaaaaacg ctctaaatca agggagagac ggaagtcaag gagtcgttcg cattcacggg
     1201 acaagagaaa agacactcga gaaaagatca aggaaaagga aagagtgaaa gagaaagaca
     1261 gggaaaagga gagagagagg gaaaaggaac gtgaaaaaga aaaggaacgg ggtaaaaaca
     1321 aagaccggga caaggaacgg gaaaaggacc gggaaaaaga caaggaaaag gacagagaga
     1381 gagaacggga aaaagagcat gagaaggatc gagacaaaga gaaggaaaag gaacaggaca
     1441 aagaaaagga acgagaaaaa gacagatcca aagagataga tgaaaaaaga aagaaggata
     1501 aaaaatccag aacaccaccc aggagttaca atgcatcgcg aagatctcgt agttccagca
     1561 gggaaaggcg taggaggagg agcaggagtt cttccagatc gccaagaaca tcaaaaacca
     1621 taaaaaggaa atcttctaga tctccgtccc ccaggagcag aaataagaag gataaaaaga
     1681 gagaaaaaga aagggaccac atcagtgaaa gaagagagag agaacgttca acgtctatga
     1741 gaaagagttc taatgataga gatgggaagg agaagttgga gaagaacagt acttcactta
     1801 aagagaaaga gcacaataaa gaaccagatt caagtgtgag caaagaagta gatgacaagg
     1861 atgcaccaag gactgaggaa aacaaaatac agcacaatgg gaattgtcag ctgaatgaag
     1921 aaaacctctc taccaaaaca gaagcagtat aggaccgaca agtgtacctc tgcactcaat
     1981 gctggaatca aatccaaagc ttttaattct ctcaacaaga tgtaaacagg aaagaaatct
     2041 agttgagcat gaagatagga tctaacagct tttccagttg ttagatgact ttgtggccat
     2101 cttgttattg agtaagaaaa taaagcatgg acatcatgaa aataacagat gttacccaaa
     2161 ctcatcttct aaaatctgtg catttccatg gtggctgaca cacttgtcat gtggtctgtt
     2221 agtgtttgcc aagaaccatt gcaaataaat tgaacatcaa agatccaagt ttgtactatc
     2281 cctaaagact ggagataagc attggaggct cttttaaaaa atgctagtta ctgaattttg
     2341 tattgtttta cttttttttt tatttcaata tatacagttt gatgatgtgc ttgaaattgg
     2401 tgcaaatata tacacaccct tgtaagtgca aagtatgtaa gaagttttaa catttacttc
     2461 acaggacttg tgattgtgtt aaattctcac tattgtgttt tcttttgctc actgtttagg
     2521 acaatttttc tttaaaatag ttttgcagat taaaattgct taaataagtg gattaaaaaa
     2581 ctgacaatgc atgctactgt tctctttcaa aaggaagagc aaccgtgttg aatactaata
     2641 atgatgaatt agtattcagt gtttagaatc attgggacta cccacaaagt gagcatttct
     2701 ttttaaattt tcttgacatt tccaagctta ttatgaataa tattgcagtg tgtcttgtca
     2761 gctgtaggtg gcaaaggtgc ccttataaaa aaggaaactg gcttttcaaa atgggctatg
     2821 ggagcacaag ctgaagcttt agtgccttct acaatgtggt atactgtttt ctagaatttt
     2881 atatgtgcta gtcattctca attcatatgg aatctagatg gatatttcat gcatacccat
     2941 agagaagtgt gtaagtgata tgtcagaaga gcttcttact gatttcacct aaaatgagaa
     3001 ggaagtcctg ttttcaagaa tgacattaga gtcatgcagc tttgggacca tcagttttat
     3061 actgtgataa ttgaaaatga aacatgttct tattttcctt aaattgaaga aaacccttta
     3121 gttgtctaca ttggatggcc ttattacctc tcaatcatct tttcataaat gatgtgcaga
     3181 aattgtactt aaggacttag gagtatatgg gaggttattg gttttatgtt taaggatacg
     3241 tttacttgag tttaagatac aggtcatcca tcattcttag gctcactttt tacagaaagt
     3301 atgcaaatag taaagtgaca gcactgctaa tgtttttccc cagtactata acttgtggtt
     3361 tctgaactca ttattgttgt atttccaaaa aagtaatacc ttttaattag tgtattaaaa
     3421 gttaagtata attattttaa tgcaatctaa tacaatcaga ttactcagtt gccttacctc
     3481 atgggaagag ttactttttt agatctaaaa agctgaatag catgttagtt acttggtttc
     3541 aacttgagtt ttcttttaat gttaataaga ttgaaacttt agtatttagt ggggaatgga
     3601 aagagttgcc cttgttgcaa gtaatgaagc ctgatttgat tatgaagctg cttaatcact
     3661 cttcatgtgt tcagaattac tgtttttttt gtttgttttt cctttttgtc actgtgtaca
     3721 ttaaaatttt ggaagatgct ttactatgta aagtatagat ggtcatttta atcattcagc
     3781 cacatacggt tggctggtaa acagcttatt ctgatacaag aatgcttggg tgcatatgga
     3841 aagattgtga aagagtgtgt cttgcatcaa cagctgtctt atttatgata tataagtaga
     3901 aatagagcaa atgttggaat ctgttatttt tagtaccatg tctttaataa agctaagtat
     3961 tttagaggaa aatgtttgtt tatgcatttc aaaaaagcat tttagtttta tcctgctcat
     4021 tttagttgtc atagagattg ttgtgacgtg gagagtgcat gtttgtgtgg tgtctataaa
     4081 acaagtcatt taaagtatga gtgttttctt gtactctgga cctattacat gtttctttat
     4141 gttggtaatt aacatttaat ttggttcttg ctgctaatta ttttctctgc tgatatttat
     4201 taagctttaa aataatcgta ctataatctt gaaacactga tttgtaaaaa ctaagaatga
     4261 gtaggaatac aagagatctg gaggaacaaa tcagattgtt attagggttt gacttttttt
     4321 ttacatgggc ttatggaagc aaggcattct agggtctaga gggatgtgtg tgtgtgcttg
     4381 tgtgtccatg tgtgcgcatg cgcacgtgtg tatctgtttg agacatactt tctctgttca
     4441 cttaaaagag ctcatgtttt catttgttta ttcttttctt tcagggtatt ttgttttttt
     4501 ctttaagact tcttttttta aatcccaggt agatgttgtc agataaactt gaggtaaggc
     4561 caagaagaca gacattttat gcttcatact ttctgtaatt atcttttgta gcttgattac
     4621 atagagtacc ctctcttcct taagttgtag ttgctattta tcattgtaga caaattctgt
     4681 tgcctttcag caacgtatgc tgaactagta tcataagatg gtgcatcagt tcataagcta
     4741 gtgcataagt tttgtgtcaa aacttttaaa tcctgaagtt ctgcagttat catcttagtt
     4801 attttctatc taattagctt ataattgcaa acactagtca gcttgtgatc tctgtgtttc
     4861 aagttctttt cttcacgagg ttcagtacct gctatgttga tctttggcag tgccagaggc
     4921 ttaaattttg acctgctcaa ttaaaaataa acactggcgt ttataatgaa aaggtttttt
     4981 tgtcgggggg gggggggtca agagaattta ttttgtgata gtaataattt tcaagacctt
     5041 cagtcattcc tatgtctatg ttgctatctt tattttaaaa cttagaaccc tgatctaact
     5101 cccttctcaa gtgaagatac tgtgtagatt caagaattat aatgtagagt aataggcctt
     5161 taagtttttt tttaatctgt tagaaataaa gagcatgatt taattattgt tgaattaaca
     5221 attaaaatga atccctttgg agggatggca ttgaataact tataatttca gtgaatcatt
     5281 tacgttttca ttggaagaca gtatctgatt tcaactggtg cgttacgaag tagagccatt
     5341 cccacaaagt aaatgtgcag tgcccatgtt tcttgtgttt aaatattttt tattttcact
     5401 acatatatat tattttctca tgtttattta ctaatgtaat tttcacttaa aattagatgt
     5461 ttattttcaa attttaaaag ctagtgctct taaaagagct aaattatatt tctggaagca
     5521 ggagtttagt ataaatgtaa taaaatttta aaataaaatt gacttcccta cttaatcttg
     5581 ggtttgtggg tgagtttgtt tttagtacac tcttattggt ggttttgcct gaagagtaat
     5641 acattattat tattactttt ctttttgaga cagggtctca ctctgtcact caggctggag
     5701 tgcagtgaca cgatcatggc tcactgcaat cttgaccttt ctcggcatgg atgatcctct
     5761 cacctcagcc tcttgaatag ctgggaccac agacatgtgc caccaagccc agttaatttt
     5821 agaatttttt ttgtagagac aggatcttgc catgttgcct agactggtct caaactcctg
     5881 ggctcaaaca atctgtctgc ctcagccttc taaagtgctg agattacagg tgtgaggtac
     5941 tgcacctggc aatacgttat tttaaaagta aacgctaagc catttatgac tttggttata
     6001 ttcagtcagt tggatttagt aactaataac tagctttctt ccattctaag gtacttttat
     6061 agtttctagc aattagtttg ttacaattag cttatatcag atataacagt tcttaatata
     6121 atgtttataa aaggttttaa gtctgttgcc tgatttttaa atttatatct agttaacatt
     6181 ttaattttaa aattgccaac ttttgggaga tttcacatat tttacctcta tattttattt
     6241 ttccaggatt ggtatggagg agtagtacct tctattcttg gtttattttt atttgctaga
     6301 cataatttct taactacata tgtaagtata aattcataaa aatcacactg aaagaatagg
     6361 ttgatttcaa ccattttgag ggtactggta ggtaacacac tgttggggaa taaactaaag
     6421 aatttctgat ttctacaata gatttaagta tgaaatttga gtatactgtg tagctgtgta
     6481 gatcaactta atgcttaaaa aattacctcc ttaatgatta gattaataga acagtgttag
     6541 attatcaagg gaagagtttg gaatgtaaac ataaacatgc tgcataggtg gtggttattt
     6601 gtgagtagga ctacttttaa atggtactag taaagattta tcaaacaatg ctgctattat
     6661 gttgctatat ttttaataaa atgaaaatct taaaatctt
//
