LOCUS       NM_004599               5237 bp    mRNA    linear   PRI 12-NOV-2024
DEFINITION  Homo sapiens sterol regulatory element binding transcription factor
            2 (SREBF2), transcript variant 1, mRNA.
ACCESSION   NM_004599
VERSION     NM_004599.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5237)
  AUTHORS   Moulton,M.J., Atala,K., Zheng,Y., Dutta,D., Grange,D.K., Lin,W.W.,
            Wegner,D.J., Wambach,J.A., Duker,A.L., Bober,M.B., Kratz,L.,
            Wise,C.A., Oxendine,I., Khanshour,A., Wangler,M.F., Yamamoto,S.,
            Cole,F.S., Rios,J. and Bellen,H.J.
  CONSRTM   Undiagnosed Diseases Network
  TITLE     Dominant missense variants in SREBF2 are associated with complex
            dermatological, neurological, and skeletal abnormalities
  JOURNAL   Genet Med 26 (9), 101174 (2024)
   PUBMED   38847193
  REMARK    GeneRIF: Dominant missense variants in SREBF2 are associated with
            complex dermatological, neurological, and skeletal abnormalities.
REFERENCE   2  (bases 1 to 5237)
  AUTHORS   Li,J., Sun,J., Xu,M., Yang,L., Yang,N., Deng,J., Ma,Y., Qi,Y.,
            Liu,Z., Ruan,Q., Liu,Y. and Huang,Y.
  TITLE     Human cytomegalovirus infection impairs neural differentiation via
            repressing sterol regulatory element binding protein 2-mediated
            cholesterol biosynthesis
  JOURNAL   Cell Mol Life Sci 81 (1), 289 (2024)
   PUBMED   38970696
  REMARK    GeneRIF: Human cytomegalovirus infection impairs neural
            differentiation via repressing sterol regulatory element binding
            protein 2-mediated cholesterol biosynthesis.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5237)
  AUTHORS   Xiong,Y., Luo,J., Hong,Z.Y., Zhu,W.Z., Hu,A. and Song,B.L.
  TITLE     Hyperactivation of SREBP induces pannexin-1-dependent lytic cell
            death
  JOURNAL   J Lipid Res 65 (7), 100579 (2024)
   PUBMED   38880128
  REMARK    GeneRIF: Hyperactivation of SREBP induces pannexin-1-dependent
            lytic cell death.
REFERENCE   4  (bases 1 to 5237)
  AUTHORS   Plebanek,M.P., Xue,Y., Nguyen,Y.V., DeVito,N.C., Wang,X.,
            Holtzhausen,A., Beasley,G.M., Theivanthiran,B. and Hanks,B.A.
  TITLE     A lactate-SREBP2 signaling axis drives tolerogenic dendritic cell
            maturation and promotes cancer progression
  JOURNAL   Sci Immunol 9 (95), eadi4191 (2024)
   PUBMED   38728412
  REMARK    GeneRIF: A lactate-SREBP2 signaling axis drives tolerogenic
            dendritic cell maturation and promotes cancer progression.
REFERENCE   5  (bases 1 to 5237)
  AUTHORS   Miserez,A.R., Cao,G., Probst,L.C. and Hobbs,H.H.
  TITLE     Structure of the human gene encoding sterol regulatory element
            binding protein 2 (SREBF2)
  JOURNAL   Genomics 40 (1), 31-40 (1997)
   PUBMED   9070916
REFERENCE   6  (bases 1 to 5237)
  AUTHORS   Hua,X., Sakai,J., Brown,M.S. and Goldstein,J.L.
  TITLE     Regulated cleavage of sterol regulatory element binding proteins
            requires sequences on both sides of the endoplasmic reticulum
            membrane
  JOURNAL   J Biol Chem 271 (17), 10379-10384 (1996)
   PUBMED   8626610
REFERENCE   7  (bases 1 to 5237)
  AUTHORS   Wang,X., Zelenski,N.G., Yang,J., Sakai,J., Brown,M.S. and
            Goldstein,J.L.
  TITLE     Cleavage of sterol regulatory element binding proteins (SREBPs) by
            CPP32 during apoptosis
  JOURNAL   EMBO J 15 (5), 1012-1020 (1996)
   PUBMED   8605870
REFERENCE   8  (bases 1 to 5237)
  AUTHORS   Hua,X., Wu,J., Goldstein,J.L., Brown,M.S. and Hobbs,H.H.
  TITLE     Structure of the human gene encoding sterol regulatory element
            binding protein-1 (SREBF1) and localization of SREBF1 and SREBF2 to
            chromosomes 17p11.2 and 22q13
  JOURNAL   Genomics 25 (3), 667-673 (1995)
   PUBMED   7759101
REFERENCE   9  (bases 1 to 5237)
  AUTHORS   Hua,X., Yokoyama,C., Wu,J., Briggs,M.R., Brown,M.S., Goldstein,J.L.
            and Wang,X.
  TITLE     SREBP-2, a second basic-helix-loop-helix-leucine zipper protein
            that stimulates transcription by binding to a sterol regulatory
            element
  JOURNAL   Proc Natl Acad Sci U S A 90 (24), 11603-11607 (1993)
   PUBMED   7903453
REFERENCE   10 (bases 1 to 5237)
  AUTHORS   Yokoyama,C., Wang,X., Briggs,M.R., Admon,A., Wu,J., Hua,X.,
            Goldstein,J.L. and Brown,M.S.
  TITLE     SREBP-1, a basic-helix-loop-helix-leucine zipper protein that
            controls transcription of the low density lipoprotein receptor gene
  JOURNAL   Cell 75 (1), 187-197 (1993)
   PUBMED   8402897
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL021453.1, BC051799.1,
            Z99716.4 and AA035591.1.
            
            On Nov 23, 2018 this sequence version replaced NM_004599.3.
            
            Summary: This gene encodes a member of the a ubiquitously expressed
            transcription factor that controls cholesterol homeostasis by
            regulating transcription of sterol-regulated genes. The encoded
            protein contains a basic helix-loop-helix-leucine zipper (bHLH-Zip)
            domain and binds the sterol regulatory element 1 motif. Alternate
            splicing results in multiple transcript variants. [provided by
            RefSeq, Jul 2013].
            
            Transcript Variant: This variant (1) encodes the functional
            protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC051799.1, BC056158.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000361204.9/ ENSP00000354476.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-8                 AL021453.1         52971-52978
            9-3675              BC051799.1         1-3667
            3676-5189           Z99716.4           48984-50497
            5190-5237           AA035591.1         36-83               c
FEATURES             Location/Qualifiers
     source          1..5237
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="22"
                     /map="22q13.2"
     gene            1..5237
                     /gene="SREBF2"
                     /gene_synonym="bHLHd2; SREBP-2; SREBP2"
                     /note="sterol regulatory element binding transcription
                     factor 2"
                     /db_xref="GeneID:6721"
                     /db_xref="HGNC:HGNC:11290"
                     /db_xref="MIM:600481"
     exon            1..254
                     /gene="SREBF2"
                     /gene_synonym="bHLHd2; SREBP-2; SREBP2"
                     /inference="alignment:Splign:2.1.0"
     CDS             167..3592
                     /gene="SREBF2"
                     /gene_synonym="bHLHd2; SREBP-2; SREBP2"
                     /note="class D basic helix-loop-helix protein 2"
                     /codon_start=1
                     /product="sterol regulatory element-binding protein 2"
                     /protein_id="NP_004590.2"
                     /db_xref="CCDS:CCDS14023.1"
                     /db_xref="GeneID:6721"
                     /db_xref="HGNC:HGNC:11290"
                     /db_xref="MIM:600481"
                     /translation="MDDSGELGGLETMETLTELGDELTLGDIDEMLQFVSNQVGEFPD
                     LFSEQLCSSFPGSGGSGSSSGSSGSSSSSSNGRGSSSGAVDPSVQRSFTQVTLPSFSP
                     SAASPQAPTLQVKVSPTSVPTTPRATPILQPRPQPQPQPQTQLQQQTVMITPTFSTTP
                     QTRIIQQPLIYQNAATSFQVLQPQVQSLVTSSQVQPVTIQQQVQTVQAQRVLTQTANG
                     TLQTLAPATVQTVAAPQVQQVPVLVQPQIIKTDSLVLTTLKTDGSPVMAAVQNPALTA
                     LTTPIQTAALQVPTLVGSSGTILTTMPVMMGQEKVPIKQVPGGVKQLEPPKEGERRTT
                     HNIIEKRYRSSINDKIIELKDLVMGTDAKMHKSGVLRKAIDYIKYLQQVNHKLRQENM
                     VLKLANQKNKLLKGIDLGSLVDNEVDLKIEDFNQNVLLMSPPASDSGSQAGFSPYSID
                     SEPGSPLLDDAKVKDEPDSPPVALGMVDRSRILLCVLTFLCLSFNPLTSLLQWGGAHD
                     SDQHPHSGSGRSVLSFESGSGGWFDWMMPTLLLWLVNGVIVLSVFVKLLVHGEPVIRP
                     HSRSSVTFWRHRKQADLDLARGDFAAAAGNLQTCLAVLGRALPTSRLDLACSLSWNVI
                     RYSLQKLRLVRWLLKKVFQCRRATPATEAGFEDEAKTSARDAALAYHRLHQLHITGKL
                     PAGSACSDVHMALCAVNLAECAEEKIPPSTLVEIHLTAAMGLKTRCGGKLGFLASYFL
                     SRAQSLCGPEHSAVPDSLRWLCHPLGQKFFMERSWSVKSAAKESLYCAQRNPADPIAQ
                     VHQAFCKNLLERAIESLVKPQAKKKAGDQEEESCEFSSALEYLKLLHSFVDSVGVMSP
                     PLSRSSVLKSALGPDIICRWWTSAITVAISWLQGDDAAVRSHFTKVERIPKALEVTES
                     PLVKAIFHACRAMHASLPGKADGQQSSFCHCERASGHLWSSLNVSGATSDPALNHVVQ
                     LLTCDLLLSLRTALWQKQASASQAVGETYHASGAELAGFQRDLGSLRRLAHSFRPAYR
                     KVFLHEATVRLMAGASPTRTHQLLEHSLRRRTTQSTKHGEVDAWPGQRERATAILLAC
                     RHLPLSFLSSPGQRAVLLAEAARTLEKVGDRRSCNDCQQMIVKLGGGTAIAAS"
     exon            255..704
                     /gene="SREBF2"
                     /gene_synonym="bHLHd2; SREBP-2; SREBP2"
                     /inference="alignment:Splign:2.1.0"
     exon            705..886
                     /gene="SREBF2"
                     /gene_synonym="bHLHd2; SREBP-2; SREBP2"
                     /inference="alignment:Splign:2.1.0"
     exon            887..1033
                     /gene="SREBF2"
                     /gene_synonym="bHLHd2; SREBP-2; SREBP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1034..1255
                     /gene="SREBF2"
                     /gene_synonym="bHLHd2; SREBP-2; SREBP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1256..1370
                     /gene="SREBF2"
                     /gene_synonym="bHLHd2; SREBP-2; SREBP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1371..1552
                     /gene="SREBF2"
                     /gene_synonym="bHLHd2; SREBP-2; SREBP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1553..1745
                     /gene="SREBF2"
                     /gene_synonym="bHLHd2; SREBP-2; SREBP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1746..1927
                     /gene="SREBF2"
                     /gene_synonym="bHLHd2; SREBP-2; SREBP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1928..2204
                     /gene="SREBF2"
                     /gene_synonym="bHLHd2; SREBP-2; SREBP2"
                     /inference="alignment:Splign:2.1.0"
     exon            2205..2374
                     /gene="SREBF2"
                     /gene_synonym="bHLHd2; SREBP-2; SREBP2"
                     /inference="alignment:Splign:2.1.0"
     exon            2375..2543
                     /gene="SREBF2"
                     /gene_synonym="bHLHd2; SREBP-2; SREBP2"
                     /inference="alignment:Splign:2.1.0"
     exon            2544..2661
                     /gene="SREBF2"
                     /gene_synonym="bHLHd2; SREBP-2; SREBP2"
                     /inference="alignment:Splign:2.1.0"
     exon            2662..2771
                     /gene="SREBF2"
                     /gene_synonym="bHLHd2; SREBP-2; SREBP2"
                     /inference="alignment:Splign:2.1.0"
     exon            2772..2904
                     /gene="SREBF2"
                     /gene_synonym="bHLHd2; SREBP-2; SREBP2"
                     /inference="alignment:Splign:2.1.0"
     exon            2905..3073
                     /gene="SREBF2"
                     /gene_synonym="bHLHd2; SREBP-2; SREBP2"
                     /inference="alignment:Splign:2.1.0"
     exon            3074..3259
                     /gene="SREBF2"
                     /gene_synonym="bHLHd2; SREBP-2; SREBP2"
                     /inference="alignment:Splign:2.1.0"
     exon            3260..3371
                     /gene="SREBF2"
                     /gene_synonym="bHLHd2; SREBP-2; SREBP2"
                     /inference="alignment:Splign:2.1.0"
     exon            3372..5237
                     /gene="SREBF2"
                     /gene_synonym="bHLHd2; SREBP-2; SREBP2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5213..5218
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SREBF2"
                     /gene_synonym="bHLHd2; SREBP-2; SREBP2"
                     /note="hexamer: AATAAA"
     polyA_site      5237
                     /gene="SREBF2"
                     /gene_synonym="bHLHd2; SREBP-2; SREBP2"
                     /note="major polyA site"
ORIGIN      
        1 ctttctgtgc ggcgcccggg cgcaacgcaa acatggcggc gggtggcacc cgtcggtgag
       61 gcggtgccgg gcgggggttg tcgggtgtca tgggcggtgg cgacggcacc gcccccgcgt
      121 ctccctgagc gggacggcag ggggggcttc tgcgctgagc cgggcgatgg acgacagcgg
      181 cgagctgggt ggtctggaga ccatggagac cctcacggag ctgggcgacg agctgaccct
      241 gggagacatc gacgagatgc tgcaatttgt cagtaatcaa gtgggagagt tccctgactt
      301 gttttcagaa cagctgtgta gctcctttcc tggcagtggt ggtagtggta gcagcagcgg
      361 cagcagtggc agcagcagca gcagcagcaa tggcaggggc agcagcagcg gagctgtgga
      421 cccttcagtg caacggtcat tcacccaggt cacattacct tccttctctc cctcggcggc
      481 ctccccacag gctccaactc tgcaagtcaa ggtttctccc acctcagttc ccaccacacc
      541 cagggcaact cctattcttc agccccgccc ccagccccag cctcaacctc aaactcagct
      601 gcaacaacag acggtaatga tcacgccaac attcagcacc actccgcaga cgaggatcat
      661 ccagcagcct ttgatatacc agaatgcagc tactagcttt caagtccttc agcctcaagt
      721 ccaaagcctg gtgacatcct cccaggtaca gccggtcacc attcagcagc aggtgcagac
      781 agtacaggcc cagcgggtgc tgacacaaac ggccaatggc acgctgcaga cccttgcccc
      841 ggctacggtg cagacagttg ctgcgccaca ggtgcagcag gtcccggtcc tggtccagcc
      901 tcagatcatc aagacagatt cccttgtttt gaccacactg aagacagatg gcagccctgt
      961 tatggctgcg gtccagaacc cggccctcac cgccctcacc acccctatcc agacggctgc
     1021 ccttcaagta ccaaccctgg tgggcagcag tgggaccatt ctgaccacaa tgcctgtaat
     1081 gatggggcaa gagaaagtgc ccattaagca ggtacctggg ggagtcaagc agcttgagcc
     1141 ccccaaagaa ggagaaaggc ggacaaccca taatatcatt gagaaacgat atcgctcctc
     1201 catcaatgac aaaatcatcg aattgaaaga cctggtcatg gggacagacg ccaagatgca
     1261 caagtctggc gttctgagga aggccattga ttacatcaaa tacttgcagc aggtcaatca
     1321 taaactgcgc caggagaaca tggtgctgaa gctggcaaat caaaagaaca agcttctaaa
     1381 gggcatcgac ctaggcagtc tggtggacaa tgaggtggac ctgaagatcg aggactttaa
     1441 tcagaatgtc cttctgatgt cccccccagc ctctgactca gggtcccagg ctggcttctc
     1501 tccctactcc attgactctg agccaggaag ccctctattg gatgatgcaa aggtcaaaga
     1561 tgagccagac tctcctcctg tggcgctggg catggtagac cgctcacgga ttcttctgtg
     1621 tgtcctcacc ttcctgtgcc tctcctttaa ccccctgact tccctgctgc agtggggagg
     1681 ggcccacgac tctgaccagc acccacactc aggctctggc cgcagtgtcc tgtcattcga
     1741 gtcaggttct gggggctggt ttgactggat gatgcctact cttctcttat ggctggtaaa
     1801 tggtgtgatt gtcctgagcg tctttgtgaa gctgctggtt catggggagc cagtgatccg
     1861 gccacactcg cgctcctcgg tcaccttctg gaggcaccgg aaacaggcag atctggatct
     1921 cgccagagga gattttgcag ctgctgccgg caacctacaa acctgcctgg cagttttggg
     1981 ccgggcactg cccacctccc gcctggacct ggcctgcagc ctctcctgga acgtgatccg
     2041 ctacagcctg cagaagctac gcctggtgcg ctggctgctc aagaaagtct tccagtgccg
     2101 gcgggccacg ccagccactg aggcaggctt tgaagacgaa gctaagacca gcgcccggga
     2161 tgcggctctg gcctatcacc ggctgcacca gctgcacatc acagggaagc ttcctgcagg
     2221 atccgcctgt tccgatgtac acatggcgtt gtgtgccgtg aacctggctg aatgtgcaga
     2281 ggagaagatc ccaccgagca cactggttga gatccatctg actgctgcca tggggctcaa
     2341 gacccggtgt ggaggcaagc tgggcttcct ggccagctac ttcctcagcc gagcccagag
     2401 cctgtgtggc cccgagcaca gtgctgttcc tgactccctg cgctggctct gccaccccct
     2461 gggccagaag tttttcatgg agcggagctg gtctgtgaag tcagctgcca aggagagtct
     2521 atactgtgcc cagaggaacc cagctgaccc cattgcgcag gtccaccagg ccttctgcaa
     2581 gaacctgctg gagcgagcta tagagtcctt ggtgaaacct caggccaaga agaaggctgg
     2641 agaccaggaa gaagagagct gtgaattctc cagtgctctg gagtacttga aattacttca
     2701 ttcttttgtg gactctgtgg gggttatgag ccccccactc tccaggagct ccgtgctcaa
     2761 gtccgccctg ggtccagaca tcatctgtcg gtggtggacg tctgcaatca ctgtggccat
     2821 cagctggctc cagggagacg atgcagctgt gcgctctcat tttaccaaag tggaacgcat
     2881 ccccaaggcc ctggaagtga cagagagccc cctggtgaag gccatcttcc atgcctgcag
     2941 agccatgcat gcctcactcc ctgggaaagc agatgggcag cagagttcct tctgccattg
     3001 cgagagggcc agtggccacc tatggagcag cctcaacgtc agtggggcca cctctgaccc
     3061 tgccctcaac cacgtggtcc agctgctcac ctgtgacctg ctactgtcgc tacggacagc
     3121 gctctggcaa aaacaggcca gtgccagcca ggctgtgggg gagacctacc acgcgtcagg
     3181 cgctgaactg gcgggcttcc aacgggacct gggcagcctg cgcaggctgg cacacagctt
     3241 ccgcccagca taccgcaagg tgttcctgca tgaagccacc gtgcgcctga tggcaggagc
     3301 cagccccacc cgcacccacc agctgctgga acacagcctg cggcggcgca ccacgcagag
     3361 caccaagcac ggagaggtgg atgcctggcc cggccagcga gagcgggcca ccgccatcct
     3421 gctggcctgc cgccacctgc ccctctcctt cctctcctcc ccgggccagc gggcagtgct
     3481 gctggccgaa gctgcccgca ccctggagaa ggtgggcgac cggcgctcct gcaacgactg
     3541 ccagcagatg attgttaagc tgggtggtgg cactgccatt gccgcctcct gaccaccagg
     3601 ctcagcccac ccctccacct ctctctcgat ttctctctct ccccctcagc atcttcccgc
     3661 tgagagtggt ggggaagagc cttgtcttct tagctgtcac ctgccgaggc ttctgggcca
     3721 ctcaggccag tgcacccctg ggcagagccc cttaaagctg ctgtcactag atgcccatgg
     3781 tccagggcct ggtgggcgtg agaggatagg tggcagggca gaaactgggc agccctgact
     3841 tgatagcagc agggggagct cccaagctgc caagcccctg cctccagcct tcctgagttt
     3901 ctctctcctg aaccctactc tctccttttt gcttcctcag tttttatcag gctttctctg
     3961 ggggacagca gtctctgagc accagggagc agttgccctc aggcctgtgc ccagcatgcc
     4021 ctcccctttt tatacgaatg ttttctacca gtgtgcttgg gtttgccatg atgcgaggct
     4081 gagttgctgt agcgtcttga ttctctccct gggtctgcgt tccctcccct gggcctgact
     4141 gagcctgctc attgtttttc cctttattac acaggacagc caggggagga ggggggccca
     4201 gccctgggag gctggtggga ggcagggggc aggcctgcgg atgcatgaaa taatgttggc
     4261 attatttttt aattttttaa aaaataaatg gtatcttatt taattgtcct gttccttccc
     4321 actccccgcc tcctaggatg ttagcccaag ctcagggtag gcccaggggg ctgggagaaa
     4381 tgaagccacc catggggact ggggaccagg ggccttcagc atggcttcta ggttccctcc
     4441 tccccctacc ccatctccta cctccacagt acagactgtc cccaacttaa cagtggttca
     4501 acttaaacca tgtttcaact ttacaattgg tctgttgggg tattaaatga atttgtgact
     4561 taggatattt tcatttatga tgggtttatc aggaagtaac cccatggtaa gttgaggcat
     4621 atctgtatat atttaaacct aattaattct tgagctgaaa ataaataaac caggatggca
     4681 gggaccaacc cctaatccct ccccagcggc aagcccctct tttcagagtg ggcagagggt
     4741 tgcctatggt gggcactagg aatgaggtcc cctgcctcga tgcgggtcct aggagaaaaa
     4801 gtcctacttt tctgggtccc caggtgcagc acctcccgga gactgtttct cccatggcct
     4861 cctgagtgat gggccctgcc tccctgtgcc tcatcctcag gctggttgga gcagagggtg
     4921 ggcaggagcc ccagcacaga ctggggggtg ctcacagcag ggccaccttg atgcaggctg
     4981 gaatgttatc cctggggtgt gcttggaccc cacctgcttt ctttctctcc tgcccctccc
     5041 ctactctcac tgtaatttat ggaccctgcc cgcctgcgtg ttgtgtgtat gtcctgtgcc
     5101 ttttctcact attgtttggg tgtgggaggg ggtggttttt cactgaaaag gggggtacac
     5161 ctatagcttt cttgatgttc aatcaatcag tcactgtgtc ccagacatat tcaataaaca
     5221 cagattggta ccaccca
//
