LOCUS       NM_004176               4901 bp    mRNA    linear   PRI 12-NOV-2024
DEFINITION  Homo sapiens sterol regulatory element binding transcription factor
            1 (SREBF1), transcript variant 2, mRNA.
ACCESSION   NM_004176
VERSION     NM_004176.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4901)
  AUTHORS   Dong,C., Zhang,Y., Zeng,J., Chong,S., Liu,Y., Bian,Z., Fan,S. and
            Chen,X.
  TITLE     FUT2 promotes colorectal cancer metastasis by reprogramming fatty
            acid metabolism via YAP/TAZ signaling and SREBP-1
  JOURNAL   Commun Biol 7 (1), 1297 (2024)
   PUBMED   39390072
  REMARK    GeneRIF: FUT2 promotes colorectal cancer metastasis by
            reprogramming fatty acid metabolism via YAP/TAZ signaling and
            SREBP-1.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4901)
  AUTHORS   Shi,Y.H., Liu,Z.D., Ma,M.J., Zhao,G.Y., Zhu,Y.Q., Wang,J.Q.,
            Yu,Y.Y., Huang,X.T., Ye,J.Y., Li,F.X., Wang,X.Y., Xu,Q.C. and
            Yin,X.Y.
  TITLE     Platelet-Derived Growth Factor C Facilitates Malignant Behavior of
            Pancreatic Ductal Adenocarcinoma by Regulating SREBP1 Mediated
            Lipid Metabolism
  JOURNAL   Adv Sci (Weinh) 11 (40), e2407069 (2024)
   PUBMED   39225567
  REMARK    GeneRIF: Platelet-Derived Growth Factor C Facilitates Malignant
            Behavior of Pancreatic Ductal Adenocarcinoma by Regulating SREBP1
            Mediated Lipid Metabolism.
REFERENCE   3  (bases 1 to 4901)
  AUTHORS   Kong,Y., Yang,G., Feng,X., Ji,Z., Wang,X., Shao,Y., Meng,J.,
            Yao,G., Ren,C. and Yang,G.
  TITLE     CTBP1 links metabolic syndrome to polycystic ovary syndrome through
            interruption of aromatase and SREBP1
  JOURNAL   Commun Biol 7 (1), 1174 (2024)
   PUBMED   39294274
  REMARK    GeneRIF: CTBP1 links metabolic syndrome to polycystic ovary
            syndrome through interruption of aromatase and SREBP1.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4901)
  AUTHORS   Jin,Q., Qi,D., Zhang,M., Qu,H., Dong,Y., Sun,M. and Quan,C.
  TITLE     CLDN6 inhibits breast cancer growth and metastasis through
            SREBP1-mediated RAS palmitoylation
  JOURNAL   Cell Mol Biol Lett 29 (1), 112 (2024)
   PUBMED   39169280
  REMARK    GeneRIF: CLDN6 inhibits breast cancer growth and metastasis through
            SREBP1-mediated RAS palmitoylation.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4901)
  AUTHORS   Hua,X., Wu,J., Goldstein,J.L., Brown,M.S. and Hobbs,H.H.
  TITLE     Structure of the human gene encoding sterol regulatory element
            binding protein-1 (SREBF1) and localization of SREBF1 and SREBF2 to
            chromosomes 17p11.2 and 22q13
  JOURNAL   Genomics 25 (3), 667-673 (1995)
   PUBMED   7759101
REFERENCE   6  (bases 1 to 4901)
  AUTHORS   Sato,R., Yang,J., Wang,X., Evans,M.J., Ho,Y.K., Goldstein,J.L. and
            Brown,M.S.
  TITLE     Assignment of the membrane attachment, DNA binding, and
            transcriptional activation domains of sterol regulatory
            element-binding protein-1 (SREBP-1)
  JOURNAL   J Biol Chem 269 (25), 17267-17273 (1994)
   PUBMED   8006035
REFERENCE   7  (bases 1 to 4901)
  AUTHORS   Wang,X., Sato,R., Brown,M.S., Hua,X. and Goldstein,J.L.
  TITLE     SREBP-1, a membrane-bound transcription factor released by
            sterol-regulated proteolysis
  JOURNAL   Cell 77 (1), 53-62 (1994)
   PUBMED   8156598
REFERENCE   8  (bases 1 to 4901)
  AUTHORS   Hua,X., Yokoyama,C., Wu,J., Briggs,M.R., Brown,M.S., Goldstein,J.L.
            and Wang,X.
  TITLE     SREBP-2, a second basic-helix-loop-helix-leucine zipper protein
            that stimulates transcription by binding to a sterol regulatory
            element
  JOURNAL   Proc Natl Acad Sci U S A 90 (24), 11603-11607 (1993)
   PUBMED   7903453
REFERENCE   9  (bases 1 to 4901)
  AUTHORS   Yokoyama,C., Wang,X., Briggs,M.R., Admon,A., Wu,J., Hua,X.,
            Goldstein,J.L. and Brown,M.S.
  TITLE     SREBP-1, a basic-helix-loop-helix-leucine zipper protein that
            controls transcription of the low density lipoprotein receptor gene
  JOURNAL   Cell 75 (1), 187-197 (1993)
   PUBMED   8402897
REFERENCE   10 (bases 1 to 4901)
  AUTHORS   Wang,X., Briggs,M.R., Hua,X., Yokoyama,C., Goldstein,J.L. and
            Brown,M.S.
  TITLE     Nuclear protein that binds sterol regulatory element of low density
            lipoprotein receptor promoter. II. Purification and
            characterization
  JOURNAL   J Biol Chem 268 (19), 14497-14504 (1993)
   PUBMED   8314806
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC057388.1, BC063281.1,
            BC026962.1, AC122129.9 and BQ025047.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Aug 13, 2020 this sequence version replaced NM_004176.4.
            
            Summary: This gene encodes a basic helix-loop-helix-leucine zipper
            (bHLH-Zip) transcription factor that binds to the sterol regulatory
            element-1 (SRE1), which is a motif that is found in the promoter of
            the low density lipoprotein receptor gene and other genes involved
            in sterol biosynthesis. The encoded protein is synthesized as a
            precursor that is initially attached to the nuclear membrane and
            endoplasmic reticulum. Following cleavage, the mature protein
            translocates to the nucleus and activates transcription. This
            cleaveage is inhibited by sterols. This gene is located within the
            Smith-Magenis syndrome region on chromosome 17. Alternative
            promoter usage and splicing result in multiple transcript variants,
            including SREBP-1a and SREBP-1c, which correspond to RefSeq
            transcript variants 2 and 3, respectively. [provided by RefSeq, Nov
            2017].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC057388.1, U00968.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000261646.11/ ENSP00000261646.5
            RefSeq Select criteria :: based on manual assertion, conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-112               BC057388.1         17-128
            113-260             BC063281.1         113-260
            261-1085            BC063281.1         351-1175
            1086-2064           BC057388.1         1102-2080
            2065-2669           BC063281.1         2155-2759
            2670-4156           BC026962.1         1311-2797
            4157-4835           AC122129.9         69138-69816         c
            4836-4886           BQ025047.1         12-62               c
            4887-4901           AC122129.9         69072-69086         c
FEATURES             Location/Qualifiers
     source          1..4901
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17p11.2"
     gene            1..4901
                     /gene="SREBF1"
                     /gene_synonym="bHLHd1; HMD; IFAP2; SREBP1"
                     /note="sterol regulatory element binding transcription
                     factor 1"
                     /db_xref="GeneID:6720"
                     /db_xref="HGNC:HGNC:11289"
                     /db_xref="MIM:184756"
     exon            1..260
                     /gene="SREBF1"
                     /gene_synonym="bHLHd1; HMD; IFAP2; SREBP1"
                     /inference="alignment:Splign:2.1.0"
     CDS             170..3613
                     /gene="SREBF1"
                     /gene_synonym="bHLHd1; HMD; IFAP2; SREBP1"
                     /note="isoform 2 is encoded by transcript variant 2; class
                     D basic helix-loop-helix protein 1"
                     /codon_start=1
                     /product="sterol regulatory element-binding protein 1
                     isoform 2"
                     /protein_id="NP_004167.3"
                     /db_xref="CCDS:CCDS11189.1"
                     /db_xref="GeneID:6720"
                     /db_xref="HGNC:HGNC:11289"
                     /db_xref="MIM:184756"
                     /translation="MDEPPFSEAALEQALGEPCDLDAALLTDIEDMLQLINNQDSDFP
                     GLFDPPYAGSGAGGTDPASPDTSSPGSLSPPPATLSSSLEAFLSGPQAAPSPLSPPQP
                     APTPLKMYPSMPAFSPGPGIKEESVPLSILQTPTPQPLPGALLPQSFPAPAPPQFSST
                     PVLGYPSPPGGFSTGSPPGNTQQPLPGLPLASPPGVPPVSLHTQVQSVVPQQLLTVTA
                     APTAAPVTTTVTSQIQQVPVLLQPHFIKADSLLLTAMKTDGATVKAAGLSPLVSGTTV
                     QTGPLPTLVSGGTILATVPLVVDAEKLPINRLAAGSKAPASAQSRGEKRTAHNAIEKR
                     YRSSINDKIIELKDLVVGTEAKLNKSAVLRKAIDYIRFLQHSNQKLKQENLSLRTAVH
                     KSKSLKDLVSACGSGGNTDVLMEGVKTEVEDTLTPPPSDAGSPFQSSPLSLGSRGSGS
                     GGSGSDSEPDSPVFEDSKAKPEQRPSLHSRGMLDRSRLALCTLVFLCLSCNPLASLLG
                     ARGLPSPSDTTSVYHSPGRNVLGTESRDGPGWAQWLLPPVVWLLNGLLVLVSLVLLFV
                     YGEPVTRPHSGPAVYFWRHRKQADLDLARGDFAQAAQQLWLALRALGRPLPTSHLDLA
                     CSLLWNLIRHLLQRLWVGRWLAGRAGGLQQDCALRVDASASARDAALVYHKLHQLHTM
                     GKHTGGHLTATNLALSALNLAECAGDAVSVATLAEIYVAAALRVKTSLPRALHFLTRF
                     FLSSARQACLAQSGSVPPAMQWLCHPVGHRFFVDGDWSVLSTPWESLYSLAGNPVDPL
                     AQVTQLFREHLLERALNCVTQPNPSPGSADGDKEFSDALGYLQLLNSCSDAAGAPAYS
                     FSISSSMATTTGVDPVAKWWASLTAVVIHWLRRDEEAAERLCPLVEHLPRVLQESERP
                     LPRAALHSFKAARALLGCAKAESGPASLTICEKASGYLQDSLATTPASSSIDKAVQLF
                     LCDLLLVVRTSLWRQQQPPAPAPAAQGTSSRPQASALELRGFQRDLSSLRRLAQSFRP
                     AMRRVFLHEATARLMAGASPTRTHQLLDRSLRRRAGPGGKGGAVAELEPRPTRREHAE
                     ALLLASCYLPPGFLSAPGQRVGMLAEAARTLEKLGDRRLLHDCQQMLMRLGGGTTVTS
                     S"
     exon            261..692
                     /gene="SREBF1"
                     /gene_synonym="bHLHd1; HMD; IFAP2; SREBP1"
                     /inference="alignment:Splign:2.1.0"
     exon            693..880
                     /gene="SREBF1"
                     /gene_synonym="bHLHd1; HMD; IFAP2; SREBP1"
                     /inference="alignment:Splign:2.1.0"
     exon            881..1015
                     /gene="SREBF1"
                     /gene_synonym="bHLHd1; HMD; IFAP2; SREBP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1016..1237
                     /gene="SREBF1"
                     /gene_synonym="bHLHd1; HMD; IFAP2; SREBP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1238..1352
                     /gene="SREBF1"
                     /gene_synonym="bHLHd1; HMD; IFAP2; SREBP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1353..1573
                     /gene="SREBF1"
                     /gene_synonym="bHLHd1; HMD; IFAP2; SREBP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1574..1775
                     /gene="SREBF1"
                     /gene_synonym="bHLHd1; HMD; IFAP2; SREBP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1776..1954
                     /gene="SREBF1"
                     /gene_synonym="bHLHd1; HMD; IFAP2; SREBP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1955..2216
                     /gene="SREBF1"
                     /gene_synonym="bHLHd1; HMD; IFAP2; SREBP1"
                     /inference="alignment:Splign:2.1.0"
     exon            2217..2383
                     /gene="SREBF1"
                     /gene_synonym="bHLHd1; HMD; IFAP2; SREBP1"
                     /inference="alignment:Splign:2.1.0"
     exon            2384..2552
                     /gene="SREBF1"
                     /gene_synonym="bHLHd1; HMD; IFAP2; SREBP1"
                     /inference="alignment:Splign:2.1.0"
     exon            2553..2661
                     /gene="SREBF1"
                     /gene_synonym="bHLHd1; HMD; IFAP2; SREBP1"
                     /inference="alignment:Splign:2.1.0"
     exon            2662..2771
                     /gene="SREBF1"
                     /gene_synonym="bHLHd1; HMD; IFAP2; SREBP1"
                     /inference="alignment:Splign:2.1.0"
     exon            2772..2904
                     /gene="SREBF1"
                     /gene_synonym="bHLHd1; HMD; IFAP2; SREBP1"
                     /inference="alignment:Splign:2.1.0"
     exon            2905..3070
                     /gene="SREBF1"
                     /gene_synonym="bHLHd1; HMD; IFAP2; SREBP1"
                     /inference="alignment:Splign:2.1.0"
     exon            3071..3271
                     /gene="SREBF1"
                     /gene_synonym="bHLHd1; HMD; IFAP2; SREBP1"
                     /inference="alignment:Splign:2.1.0"
     exon            3272..3383
                     /gene="SREBF1"
                     /gene_synonym="bHLHd1; HMD; IFAP2; SREBP1"
                     /inference="alignment:Splign:2.1.0"
     exon            3384..4901
                     /gene="SREBF1"
                     /gene_synonym="bHLHd1; HMD; IFAP2; SREBP1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4142..4147
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SREBF1"
                     /gene_synonym="bHLHd1; HMD; IFAP2; SREBP1"
                     /note="hexamer: AATGAA"
     polyA_site      4158
                     /gene="SREBF1"
                     /gene_synonym="bHLHd1; HMD; IFAP2; SREBP1"
                     /note="major polyA site"
     regulatory      4866..4871
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SREBF1"
                     /gene_synonym="bHLHd1; HMD; IFAP2; SREBP1"
                     /note="hexamer: AATAAA"
     polyA_site      4901
                     /gene="SREBF1"
                     /gene_synonym="bHLHd1; HMD; IFAP2; SREBP1"
ORIGIN      
        1 agtttccgag gaacttttcg ccggcgccgg gccgcctctg aggccagggc aggacacgaa
       61 cgcgcggagc ggcggcggcg actgagagcc ggggccgcgg cggcgctccc taggaagggc
      121 cgtacgaggc ggcgggcccg gcgggcctcc cggaggaggc ggctgcgcca tggacgagcc
      181 acccttcagc gaggcggctt tggagcaggc gctgggcgag ccgtgcgatc tggacgcggc
      241 gctgctgacc gacatcgaag acatgcttca gcttatcaac aaccaagaca gtgacttccc
      301 tggcctattt gacccaccct atgctgggag tggggcaggg ggcacagacc ctgccagccc
      361 cgataccagc tccccaggca gcttgtctcc acctcctgcc acattgagct cctctcttga
      421 agccttcctg agcgggccgc aggcagcgcc ctcacccctg tcccctcccc agcctgcacc
      481 cactccattg aagatgtacc cgtccatgcc cgctttctcc cctgggcctg gtatcaagga
      541 agagtcagtg ccactgagca tcctgcagac ccccacccca cagcccctgc caggggccct
      601 cctgccacag agcttcccag ccccagcccc accgcagttc agctccaccc ctgtgttagg
      661 ctaccccagc cctccgggag gcttctctac aggaagccct cccgggaaca cccagcagcc
      721 gctgcctggc ctgccactgg cttccccgcc aggggtcccg cccgtctcct tgcacaccca
      781 ggtccagagt gtggtccccc agcagctact gacagtcaca gctgccccca cggcagcccc
      841 tgtaacgacc actgtgacct cgcagatcca gcaggtcccg gtcctgctgc agccccactt
      901 catcaaggca gactcgctgc ttctgacagc catgaagaca gacggagcca ctgtgaaggc
      961 ggcaggtctc agtcccctgg tctctggcac cactgtgcag acagggcctt tgccgaccct
     1021 ggtgagtggc ggaaccatct tggcaacagt cccactggtc gtagatgcgg agaagctgcc
     1081 tatcaaccgg ctcgcagctg gcagcaaggc cccggcctct gcccagagcc gtggagagaa
     1141 gcgcacagcc cacaacgcca ttgagaagcg ctaccgctcc tccatcaatg acaaaatcat
     1201 tgagctcaag gatctggtgg tgggcactga ggcaaagctg aataaatctg ctgtcttgcg
     1261 caaggccatc gactacattc gctttctgca acacagcaac cagaaactca agcaggagaa
     1321 cctaagtctg cgcactgctg tccacaaaag caaatctctg aaggatctgg tgtcggcctg
     1381 tggcagtgga gggaacacag acgtgctcat ggagggcgtg aagactgagg tggaggacac
     1441 actgacccca cccccctcgg atgctggctc acctttccag agcagcccct tgtcccttgg
     1501 cagcaggggc agtggcagcg gtggcagtgg cagtgactcg gagcctgaca gcccagtctt
     1561 tgaggacagc aaggcaaagc cagagcagcg gccgtctctg cacagccggg gcatgctgga
     1621 ccgctcccgc ctggccctgt gcacgctcgt cttcctctgc ctgtcctgca accccttggc
     1681 ctccttgctg ggggcccggg ggcttcccag cccctcagat accaccagcg tctaccatag
     1741 ccctgggcgc aacgtgctgg gcaccgagag cagagatggc cctggctggg cccagtggct
     1801 gctgccccca gtggtctggc tgctcaatgg gctgttggtg ctcgtctcct tggtgcttct
     1861 ctttgtctac ggtgagccag tcacacggcc ccactcaggc cccgccgtgt acttctggag
     1921 gcatcgcaag caggctgacc tggacctggc ccggggagac tttgcccagg ctgcccagca
     1981 gctgtggctg gccctgcggg cactgggccg gcccctgccc acctcccacc tggacctggc
     2041 ttgtagcctc ctctggaacc tcatccgtca cctgctgcag cgtctctggg tgggccgctg
     2101 gctggcaggc cgggcagggg gcctgcagca ggactgtgct ctgcgagtgg atgctagcgc
     2161 cagcgcccga gacgcagccc tggtctacca taagctgcac cagctgcaca ccatggggaa
     2221 gcacacaggc gggcacctca ctgccaccaa cctggcgctg agtgccctga acctggcaga
     2281 gtgtgcaggg gatgccgtgt ctgtggcgac gctggccgag atctatgtgg cggctgcatt
     2341 gagagtgaag accagtctcc cacgggcctt gcattttctg acacgcttct tcctgagcag
     2401 tgcccgccag gcctgcctgg cacagagtgg ctcagtgcct cctgccatgc agtggctctg
     2461 ccaccccgtg ggccaccgtt tcttcgtgga tggggactgg tccgtgctca gtaccccatg
     2521 ggagagcctg tacagcttgg ccgggaaccc agtggacccc ctggcccagg tgactcagct
     2581 attccgggaa catctcttag agcgagcact gaactgtgtg acccagccca accccagccc
     2641 tgggtcagct gatggggaca aggaattctc ggatgccctc gggtacctgc agctgctgaa
     2701 cagctgttct gatgctgcgg gggctcctgc ctacagcttc tccatcagtt ccagcatggc
     2761 caccaccacc ggcgtagacc cggtggccaa gtggtgggcc tctctgacag ctgtggtgat
     2821 ccactggctg cggcgggatg aggaggcggc tgagcggctg tgcccgctgg tggagcacct
     2881 gccccgggtg ctgcaggagt ctgagagacc cctgcccagg gcagctctgc actccttcaa
     2941 ggctgcccgg gccctgctgg gctgtgccaa ggcagagtct ggtccagcca gcctgaccat
     3001 ctgtgagaag gccagtgggt acctgcagga cagcctggct accacaccag ccagcagctc
     3061 cattgacaag gccgtgcagc tgttcctgtg tgacctgctt cttgtggtgc gcaccagcct
     3121 gtggcggcag cagcagcccc cggccccggc cccagcagcc cagggcacca gcagcaggcc
     3181 ccaggcttcc gcccttgagc tgcgtggctt ccaacgggac ctgagcagcc tgaggcggct
     3241 ggcacagagc ttccggcccg ccatgcggag ggtgttccta catgaggcca cggcccggct
     3301 gatggcgggg gccagcccca cacggacaca ccagctcctc gaccgcagtc tgaggcggcg
     3361 ggcaggcccc ggtggcaaag gaggcgcggt ggcggagctg gagccgcggc ccacgcggcg
     3421 ggagcacgcg gaggccttgc tgctggcctc ctgctacctg ccccccggct tcctgtcggc
     3481 gcccgggcag cgcgtgggca tgctggctga ggcggcgcgc acactcgaga agcttggcga
     3541 tcgccggctg ctgcacgact gtcagcagat gctcatgcgc ctgggcggtg ggaccactgt
     3601 cacttccagc tagaccccgt gtccccggcc tcagcacccc tgtctctagc cactttggtc
     3661 ccgtgcagct tctgtcctgc gtcgaagctt tgaaggccga aggcagtgca agagactctg
     3721 gcctccacag ttcgacctgc ggctgctgtg tgccttcgcg gtggaaggcc cgaggggcgc
     3781 gatcttgacc ctaagaccgg cggccatgat ggtgctgacc tctggtggcc gatcggggca
     3841 ctgcaggggc cgagccattt tggggggccc ccctccttgc tctgcaggca ccttagtggc
     3901 ttttttcctc ctgtgtacag ggaagagagg ggtacatttc cctgtgctga cggaagccaa
     3961 cttggctttc ccggactgca agcagggctc tgccccagag gcctctctct ccgtcgtggg
     4021 agagagacgt gtacatagtg taggtcagcg tgcttagcct cctgacctga ggctcctgtg
     4081 ctactttgcc ttttgcaaac tttattttca tagattgaga agttttgtac agagaattaa
     4141 aaatgaaatt atttataatc tgggttttgt gtcttcagct gatggatgtg ctgactagtg
     4201 agagtgcttg ggccctcccc cagcacctag ggaaaggctt cccctccccc tccggccaca
     4261 aggtacacaa cttttaactt agctcttccc gatgtttgtt tgttagtggg aggagtgggg
     4321 agggctggct gtatggcctc cagcctacct gttccccctg ctcccagggc acatggttgg
     4381 gctgtgtcaa cccttagggc ctccatgggg tcagttgtcc cttctcacct cccagctctg
     4441 tccccatcag gtccctgggt ggcacgggag gatggactga cttccaggac ctgttgtgtg
     4501 acaggagcta cagcttgggt ctccctgcaa gaagtctggc acgtctcacc tcccccatcc
     4561 cggcccctgg tcatctcaca gcaaagaagc ctcctccctc ccgacctgcc gccacactgg
     4621 agagggggca caggggcggg ggaggtttcc tgttctgtga aaggccgact ccctgactcc
     4681 attcatgccc ccccccccag cccctccctt cattcccatt ccccaaccta aagcctggcc
     4741 cggctcccag ctgaatctgg tcggaatcca cgggctgcag attttccaaa acaatcgttg
     4801 tatctttatt gacttttttt tttttttttt tctgaatgca atgactgttt tttactctta
     4861 aggaaaataa acatctttta gaaacagctc gatacacaca a
//
