LOCUS       NM_001005291            4991 bp    mRNA    linear   PRI 12-NOV-2024
DEFINITION  Homo sapiens sterol regulatory element binding transcription factor
            1 (SREBF1), transcript variant 1, mRNA.
ACCESSION   NM_001005291
VERSION     NM_001005291.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4991)
  AUTHORS   Dong,C., Zhang,Y., Zeng,J., Chong,S., Liu,Y., Bian,Z., Fan,S. and
            Chen,X.
  TITLE     FUT2 promotes colorectal cancer metastasis by reprogramming fatty
            acid metabolism via YAP/TAZ signaling and SREBP-1
  JOURNAL   Commun Biol 7 (1), 1297 (2024)
   PUBMED   39390072
  REMARK    GeneRIF: FUT2 promotes colorectal cancer metastasis by
            reprogramming fatty acid metabolism via YAP/TAZ signaling and
            SREBP-1.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4991)
  AUTHORS   Shi,Y.H., Liu,Z.D., Ma,M.J., Zhao,G.Y., Zhu,Y.Q., Wang,J.Q.,
            Yu,Y.Y., Huang,X.T., Ye,J.Y., Li,F.X., Wang,X.Y., Xu,Q.C. and
            Yin,X.Y.
  TITLE     Platelet-Derived Growth Factor C Facilitates Malignant Behavior of
            Pancreatic Ductal Adenocarcinoma by Regulating SREBP1 Mediated
            Lipid Metabolism
  JOURNAL   Adv Sci (Weinh) 11 (40), e2407069 (2024)
   PUBMED   39225567
  REMARK    GeneRIF: Platelet-Derived Growth Factor C Facilitates Malignant
            Behavior of Pancreatic Ductal Adenocarcinoma by Regulating SREBP1
            Mediated Lipid Metabolism.
REFERENCE   3  (bases 1 to 4991)
  AUTHORS   Kong,Y., Yang,G., Feng,X., Ji,Z., Wang,X., Shao,Y., Meng,J.,
            Yao,G., Ren,C. and Yang,G.
  TITLE     CTBP1 links metabolic syndrome to polycystic ovary syndrome through
            interruption of aromatase and SREBP1
  JOURNAL   Commun Biol 7 (1), 1174 (2024)
   PUBMED   39294274
  REMARK    GeneRIF: CTBP1 links metabolic syndrome to polycystic ovary
            syndrome through interruption of aromatase and SREBP1.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4991)
  AUTHORS   Jin,Q., Qi,D., Zhang,M., Qu,H., Dong,Y., Sun,M. and Quan,C.
  TITLE     CLDN6 inhibits breast cancer growth and metastasis through
            SREBP1-mediated RAS palmitoylation
  JOURNAL   Cell Mol Biol Lett 29 (1), 112 (2024)
   PUBMED   39169280
  REMARK    GeneRIF: CLDN6 inhibits breast cancer growth and metastasis through
            SREBP1-mediated RAS palmitoylation.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4991)
  AUTHORS   Hua,X., Wu,J., Goldstein,J.L., Brown,M.S. and Hobbs,H.H.
  TITLE     Structure of the human gene encoding sterol regulatory element
            binding protein-1 (SREBF1) and localization of SREBF1 and SREBF2 to
            chromosomes 17p11.2 and 22q13
  JOURNAL   Genomics 25 (3), 667-673 (1995)
   PUBMED   7759101
REFERENCE   6  (bases 1 to 4991)
  AUTHORS   Sato,R., Yang,J., Wang,X., Evans,M.J., Ho,Y.K., Goldstein,J.L. and
            Brown,M.S.
  TITLE     Assignment of the membrane attachment, DNA binding, and
            transcriptional activation domains of sterol regulatory
            element-binding protein-1 (SREBP-1)
  JOURNAL   J Biol Chem 269 (25), 17267-17273 (1994)
   PUBMED   8006035
REFERENCE   7  (bases 1 to 4991)
  AUTHORS   Wang,X., Sato,R., Brown,M.S., Hua,X. and Goldstein,J.L.
  TITLE     SREBP-1, a membrane-bound transcription factor released by
            sterol-regulated proteolysis
  JOURNAL   Cell 77 (1), 53-62 (1994)
   PUBMED   8156598
REFERENCE   8  (bases 1 to 4991)
  AUTHORS   Hua,X., Yokoyama,C., Wu,J., Briggs,M.R., Brown,M.S., Goldstein,J.L.
            and Wang,X.
  TITLE     SREBP-2, a second basic-helix-loop-helix-leucine zipper protein
            that stimulates transcription by binding to a sterol regulatory
            element
  JOURNAL   Proc Natl Acad Sci U S A 90 (24), 11603-11607 (1993)
   PUBMED   7903453
REFERENCE   9  (bases 1 to 4991)
  AUTHORS   Yokoyama,C., Wang,X., Briggs,M.R., Admon,A., Wu,J., Hua,X.,
            Goldstein,J.L. and Brown,M.S.
  TITLE     SREBP-1, a basic-helix-loop-helix-leucine zipper protein that
            controls transcription of the low density lipoprotein receptor gene
  JOURNAL   Cell 75 (1), 187-197 (1993)
   PUBMED   8402897
REFERENCE   10 (bases 1 to 4991)
  AUTHORS   Wang,X., Briggs,M.R., Hua,X., Yokoyama,C., Goldstein,J.L. and
            Brown,M.S.
  TITLE     Nuclear protein that binds sterol regulatory element of low density
            lipoprotein receptor promoter. II. Purification and
            characterization
  JOURNAL   J Biol Chem 268 (19), 14497-14504 (1993)
   PUBMED   8314806
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC057388.1, BC063281.1,
            BC026962.1, AC122129.9 and BQ025047.1.
            
            On Jun 2, 2019 this sequence version replaced NM_001005291.2.
            
            Summary: This gene encodes a basic helix-loop-helix-leucine zipper
            (bHLH-Zip) transcription factor that binds to the sterol regulatory
            element-1 (SRE1), which is a motif that is found in the promoter of
            the low density lipoprotein receptor gene and other genes involved
            in sterol biosynthesis. The encoded protein is synthesized as a
            precursor that is initially attached to the nuclear membrane and
            endoplasmic reticulum. Following cleavage, the mature protein
            translocates to the nucleus and activates transcription. This
            cleaveage is inhibited by sterols. This gene is located within the
            Smith-Magenis syndrome region on chromosome 17. Alternative
            promoter usage and splicing result in multiple transcript variants,
            including SREBP-1a and SREBP-1c, which correspond to RefSeq
            transcript variants 2 and 3, respectively. [provided by RefSeq, Nov
            2017].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC063281.1, SRR14038196.444036.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-112               BC057388.1         17-128
            113-1175            BC063281.1         113-1175
            1176-2154           BC057388.1         1102-2080
            2155-2759           BC063281.1         2155-2759
            2760-4246           BC026962.1         1311-2797
            4247-4925           AC122129.9         69138-69816         c
            4926-4976           BQ025047.1         12-62               c
            4977-4991           AC122129.9         69072-69086         c
FEATURES             Location/Qualifiers
     source          1..4991
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17p11.2"
     gene            1..4991
                     /gene="SREBF1"
                     /gene_synonym="bHLHd1; HMD; IFAP2; SREBP1"
                     /note="sterol regulatory element binding transcription
                     factor 1"
                     /db_xref="GeneID:6720"
                     /db_xref="HGNC:HGNC:11289"
                     /db_xref="MIM:184756"
     exon            1..260
                     /gene="SREBF1"
                     /gene_synonym="bHLHd1; HMD; IFAP2; SREBP1"
                     /inference="alignment:Splign:2.1.0"
     CDS             170..3703
                     /gene="SREBF1"
                     /gene_synonym="bHLHd1; HMD; IFAP2; SREBP1"
                     /note="isoform 1 is encoded by transcript variant 1; class
                     D basic helix-loop-helix protein 1"
                     /codon_start=1
                     /product="sterol regulatory element-binding protein 1
                     isoform 1"
                     /protein_id="NP_001005291.1"
                     /db_xref="CCDS:CCDS32583.1"
                     /db_xref="GeneID:6720"
                     /db_xref="HGNC:HGNC:11289"
                     /db_xref="MIM:184756"
                     /translation="MDEPPFSEAALEQALGEPCDLDAALLTDIEGEVGAGRGRANGLD
                     APRAGADRGAMDCTFEDMLQLINNQDSDFPGLFDPPYAGSGAGGTDPASPDTSSPGSL
                     SPPPATLSSSLEAFLSGPQAAPSPLSPPQPAPTPLKMYPSMPAFSPGPGIKEESVPLS
                     ILQTPTPQPLPGALLPQSFPAPAPPQFSSTPVLGYPSPPGGFSTGSPPGNTQQPLPGL
                     PLASPPGVPPVSLHTQVQSVVPQQLLTVTAAPTAAPVTTTVTSQIQQVPVLLQPHFIK
                     ADSLLLTAMKTDGATVKAAGLSPLVSGTTVQTGPLPTLVSGGTILATVPLVVDAEKLP
                     INRLAAGSKAPASAQSRGEKRTAHNAIEKRYRSSINDKIIELKDLVVGTEAKLNKSAV
                     LRKAIDYIRFLQHSNQKLKQENLSLRTAVHKSKSLKDLVSACGSGGNTDVLMEGVKTE
                     VEDTLTPPPSDAGSPFQSSPLSLGSRGSGSGGSGSDSEPDSPVFEDSKAKPEQRPSLH
                     SRGMLDRSRLALCTLVFLCLSCNPLASLLGARGLPSPSDTTSVYHSPGRNVLGTESRD
                     GPGWAQWLLPPVVWLLNGLLVLVSLVLLFVYGEPVTRPHSGPAVYFWRHRKQADLDLA
                     RGDFAQAAQQLWLALRALGRPLPTSHLDLACSLLWNLIRHLLQRLWVGRWLAGRAGGL
                     QQDCALRVDASASARDAALVYHKLHQLHTMGKHTGGHLTATNLALSALNLAECAGDAV
                     SVATLAEIYVAAALRVKTSLPRALHFLTRFFLSSARQACLAQSGSVPPAMQWLCHPVG
                     HRFFVDGDWSVLSTPWESLYSLAGNPVDPLAQVTQLFREHLLERALNCVTQPNPSPGS
                     ADGDKEFSDALGYLQLLNSCSDAAGAPAYSFSISSSMATTTGVDPVAKWWASLTAVVI
                     HWLRRDEEAAERLCPLVEHLPRVLQESERPLPRAALHSFKAARALLGCAKAESGPASL
                     TICEKASGYLQDSLATTPASSSIDKAVQLFLCDLLLVVRTSLWRQQQPPAPAPAAQGT
                     SSRPQASALELRGFQRDLSSLRRLAQSFRPAMRRVFLHEATARLMAGASPTRTHQLLD
                     RSLRRRAGPGGKGGAVAELEPRPTRREHAEALLLASCYLPPGFLSAPGQRVGMLAEAA
                     RTLEKLGDRRLLHDCQQMLMRLGGGTTVTSS"
     exon            261..350
                     /gene="SREBF1"
                     /gene_synonym="bHLHd1; HMD; IFAP2; SREBP1"
                     /inference="alignment:Splign:2.1.0"
     exon            351..782
                     /gene="SREBF1"
                     /gene_synonym="bHLHd1; HMD; IFAP2; SREBP1"
                     /inference="alignment:Splign:2.1.0"
     exon            783..970
                     /gene="SREBF1"
                     /gene_synonym="bHLHd1; HMD; IFAP2; SREBP1"
                     /inference="alignment:Splign:2.1.0"
     exon            971..1105
                     /gene="SREBF1"
                     /gene_synonym="bHLHd1; HMD; IFAP2; SREBP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1106..1327
                     /gene="SREBF1"
                     /gene_synonym="bHLHd1; HMD; IFAP2; SREBP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1328..1442
                     /gene="SREBF1"
                     /gene_synonym="bHLHd1; HMD; IFAP2; SREBP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1443..1663
                     /gene="SREBF1"
                     /gene_synonym="bHLHd1; HMD; IFAP2; SREBP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1664..1865
                     /gene="SREBF1"
                     /gene_synonym="bHLHd1; HMD; IFAP2; SREBP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1866..2044
                     /gene="SREBF1"
                     /gene_synonym="bHLHd1; HMD; IFAP2; SREBP1"
                     /inference="alignment:Splign:2.1.0"
     exon            2045..2306
                     /gene="SREBF1"
                     /gene_synonym="bHLHd1; HMD; IFAP2; SREBP1"
                     /inference="alignment:Splign:2.1.0"
     exon            2307..2473
                     /gene="SREBF1"
                     /gene_synonym="bHLHd1; HMD; IFAP2; SREBP1"
                     /inference="alignment:Splign:2.1.0"
     exon            2474..2642
                     /gene="SREBF1"
                     /gene_synonym="bHLHd1; HMD; IFAP2; SREBP1"
                     /inference="alignment:Splign:2.1.0"
     exon            2643..2751
                     /gene="SREBF1"
                     /gene_synonym="bHLHd1; HMD; IFAP2; SREBP1"
                     /inference="alignment:Splign:2.1.0"
     exon            2752..2861
                     /gene="SREBF1"
                     /gene_synonym="bHLHd1; HMD; IFAP2; SREBP1"
                     /inference="alignment:Splign:2.1.0"
     exon            2862..2994
                     /gene="SREBF1"
                     /gene_synonym="bHLHd1; HMD; IFAP2; SREBP1"
                     /inference="alignment:Splign:2.1.0"
     exon            2995..3160
                     /gene="SREBF1"
                     /gene_synonym="bHLHd1; HMD; IFAP2; SREBP1"
                     /inference="alignment:Splign:2.1.0"
     exon            3161..3361
                     /gene="SREBF1"
                     /gene_synonym="bHLHd1; HMD; IFAP2; SREBP1"
                     /inference="alignment:Splign:2.1.0"
     exon            3362..3473
                     /gene="SREBF1"
                     /gene_synonym="bHLHd1; HMD; IFAP2; SREBP1"
                     /inference="alignment:Splign:2.1.0"
     exon            3474..4991
                     /gene="SREBF1"
                     /gene_synonym="bHLHd1; HMD; IFAP2; SREBP1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4232..4237
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SREBF1"
                     /gene_synonym="bHLHd1; HMD; IFAP2; SREBP1"
                     /note="hexamer: AATGAA"
     polyA_site      4248
                     /gene="SREBF1"
                     /gene_synonym="bHLHd1; HMD; IFAP2; SREBP1"
                     /note="major polyA site"
     regulatory      4956..4961
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SREBF1"
                     /gene_synonym="bHLHd1; HMD; IFAP2; SREBP1"
                     /note="hexamer: AATAAA"
     polyA_site      4991
                     /gene="SREBF1"
                     /gene_synonym="bHLHd1; HMD; IFAP2; SREBP1"
ORIGIN      
        1 agtttccgag gaacttttcg ccggcgccgg gccgcctctg aggccagggc aggacacgaa
       61 cgcgcggagc ggcggcggcg actgagagcc ggggccgcgg cggcgctccc taggaagggc
      121 cgtacgaggc ggcgggcccg gcgggcctcc cggaggaggc ggctgcgcca tggacgagcc
      181 acccttcagc gaggcggctt tggagcaggc gctgggcgag ccgtgcgatc tggacgcggc
      241 gctgctgacc gacatcgaag gtgaagtcgg cgcggggagg ggtagggcca acggcctgga
      301 cgccccaagg gcgggcgcag atcgcggagc catggattgc actttcgaag acatgcttca
      361 gcttatcaac aaccaagaca gtgacttccc tggcctattt gacccaccct atgctgggag
      421 tggggcaggg ggcacagacc ctgccagccc cgataccagc tccccaggca gcttgtctcc
      481 acctcctgcc acattgagct cctctcttga agccttcctg agcgggccgc aggcagcgcc
      541 ctcacccctg tcccctcccc agcctgcacc cactccattg aagatgtacc cgtccatgcc
      601 cgctttctcc cctgggcctg gtatcaagga agagtcagtg ccactgagca tcctgcagac
      661 ccccacccca cagcccctgc caggggccct cctgccacag agcttcccag ccccagcccc
      721 accgcagttc agctccaccc ctgtgttagg ctaccccagc cctccgggag gcttctctac
      781 aggaagccct cccgggaaca cccagcagcc gctgcctggc ctgccactgg cttccccgcc
      841 aggggtcccg cccgtctcct tgcacaccca ggtccagagt gtggtccccc agcagctact
      901 gacagtcaca gctgccccca cggcagcccc tgtaacgacc actgtgacct cgcagatcca
      961 gcaggtcccg gtcctgctgc agccccactt catcaaggca gactcgctgc ttctgacagc
     1021 catgaagaca gacggagcca ctgtgaaggc ggcaggtctc agtcccctgg tctctggcac
     1081 cactgtgcag acagggcctt tgccgaccct ggtgagtggc ggaaccatct tggcaacagt
     1141 cccactggtc gtagatgcgg agaagctgcc tatcaaccgg ctcgcagctg gcagcaaggc
     1201 cccggcctct gcccagagcc gtggagagaa gcgcacagcc cacaacgcca ttgagaagcg
     1261 ctaccgctcc tccatcaatg acaaaatcat tgagctcaag gatctggtgg tgggcactga
     1321 ggcaaagctg aataaatctg ctgtcttgcg caaggccatc gactacattc gctttctgca
     1381 acacagcaac cagaaactca agcaggagaa cctaagtctg cgcactgctg tccacaaaag
     1441 caaatctctg aaggatctgg tgtcggcctg tggcagtgga gggaacacag acgtgctcat
     1501 ggagggcgtg aagactgagg tggaggacac actgacccca cccccctcgg atgctggctc
     1561 acctttccag agcagcccct tgtcccttgg cagcaggggc agtggcagcg gtggcagtgg
     1621 cagtgactcg gagcctgaca gcccagtctt tgaggacagc aaggcaaagc cagagcagcg
     1681 gccgtctctg cacagccggg gcatgctgga ccgctcccgc ctggccctgt gcacgctcgt
     1741 cttcctctgc ctgtcctgca accccttggc ctccttgctg ggggcccggg ggcttcccag
     1801 cccctcagat accaccagcg tctaccatag ccctgggcgc aacgtgctgg gcaccgagag
     1861 cagagatggc cctggctggg cccagtggct gctgccccca gtggtctggc tgctcaatgg
     1921 gctgttggtg ctcgtctcct tggtgcttct ctttgtctac ggtgagccag tcacacggcc
     1981 ccactcaggc cccgccgtgt acttctggag gcatcgcaag caggctgacc tggacctggc
     2041 ccggggagac tttgcccagg ctgcccagca gctgtggctg gccctgcggg cactgggccg
     2101 gcccctgccc acctcccacc tggacctggc ttgtagcctc ctctggaacc tcatccgtca
     2161 cctgctgcag cgtctctggg tgggccgctg gctggcaggc cgggcagggg gcctgcagca
     2221 ggactgtgct ctgcgagtgg atgctagcgc cagcgcccga gacgcagccc tggtctacca
     2281 taagctgcac cagctgcaca ccatggggaa gcacacaggc gggcacctca ctgccaccaa
     2341 cctggcgctg agtgccctga acctggcaga gtgtgcaggg gatgccgtgt ctgtggcgac
     2401 gctggccgag atctatgtgg cggctgcatt gagagtgaag accagtctcc cacgggcctt
     2461 gcattttctg acacgcttct tcctgagcag tgcccgccag gcctgcctgg cacagagtgg
     2521 ctcagtgcct cctgccatgc agtggctctg ccaccccgtg ggccaccgtt tcttcgtgga
     2581 tggggactgg tccgtgctca gtaccccatg ggagagcctg tacagcttgg ccgggaaccc
     2641 agtggacccc ctggcccagg tgactcagct attccgggaa catctcttag agcgagcact
     2701 gaactgtgtg acccagccca accccagccc tgggtcagct gatggggaca aggaattctc
     2761 ggatgccctc gggtacctgc agctgctgaa cagctgttct gatgctgcgg gggctcctgc
     2821 ctacagcttc tccatcagtt ccagcatggc caccaccacc ggcgtagacc cggtggccaa
     2881 gtggtgggcc tctctgacag ctgtggtgat ccactggctg cggcgggatg aggaggcggc
     2941 tgagcggctg tgcccgctgg tggagcacct gccccgggtg ctgcaggagt ctgagagacc
     3001 cctgcccagg gcagctctgc actccttcaa ggctgcccgg gccctgctgg gctgtgccaa
     3061 ggcagagtct ggtccagcca gcctgaccat ctgtgagaag gccagtgggt acctgcagga
     3121 cagcctggct accacaccag ccagcagctc cattgacaag gccgtgcagc tgttcctgtg
     3181 tgacctgctt cttgtggtgc gcaccagcct gtggcggcag cagcagcccc cggccccggc
     3241 cccagcagcc cagggcacca gcagcaggcc ccaggcttcc gcccttgagc tgcgtggctt
     3301 ccaacgggac ctgagcagcc tgaggcggct ggcacagagc ttccggcccg ccatgcggag
     3361 ggtgttccta catgaggcca cggcccggct gatggcgggg gccagcccca cacggacaca
     3421 ccagctcctc gaccgcagtc tgaggcggcg ggcaggcccc ggtggcaaag gaggcgcggt
     3481 ggcggagctg gagccgcggc ccacgcggcg ggagcacgcg gaggccttgc tgctggcctc
     3541 ctgctacctg ccccccggct tcctgtcggc gcccgggcag cgcgtgggca tgctggctga
     3601 ggcggcgcgc acactcgaga agcttggcga tcgccggctg ctgcacgact gtcagcagat
     3661 gctcatgcgc ctgggcggtg ggaccactgt cacttccagc tagaccccgt gtccccggcc
     3721 tcagcacccc tgtctctagc cactttggtc ccgtgcagct tctgtcctgc gtcgaagctt
     3781 tgaaggccga aggcagtgca agagactctg gcctccacag ttcgacctgc ggctgctgtg
     3841 tgccttcgcg gtggaaggcc cgaggggcgc gatcttgacc ctaagaccgg cggccatgat
     3901 ggtgctgacc tctggtggcc gatcggggca ctgcaggggc cgagccattt tggggggccc
     3961 ccctccttgc tctgcaggca ccttagtggc ttttttcctc ctgtgtacag ggaagagagg
     4021 ggtacatttc cctgtgctga cggaagccaa cttggctttc ccggactgca agcagggctc
     4081 tgccccagag gcctctctct ccgtcgtggg agagagacgt gtacatagtg taggtcagcg
     4141 tgcttagcct cctgacctga ggctcctgtg ctactttgcc ttttgcaaac tttattttca
     4201 tagattgaga agttttgtac agagaattaa aaatgaaatt atttataatc tgggttttgt
     4261 gtcttcagct gatggatgtg ctgactagtg agagtgcttg ggccctcccc cagcacctag
     4321 ggaaaggctt cccctccccc tccggccaca aggtacacaa cttttaactt agctcttccc
     4381 gatgtttgtt tgttagtggg aggagtgggg agggctggct gtatggcctc cagcctacct
     4441 gttccccctg ctcccagggc acatggttgg gctgtgtcaa cccttagggc ctccatgggg
     4501 tcagttgtcc cttctcacct cccagctctg tccccatcag gtccctgggt ggcacgggag
     4561 gatggactga cttccaggac ctgttgtgtg acaggagcta cagcttgggt ctccctgcaa
     4621 gaagtctggc acgtctcacc tcccccatcc cggcccctgg tcatctcaca gcaaagaagc
     4681 ctcctccctc ccgacctgcc gccacactgg agagggggca caggggcggg ggaggtttcc
     4741 tgttctgtga aaggccgact ccctgactcc attcatgccc ccccccccag cccctccctt
     4801 cattcccatt ccccaaccta aagcctggcc cggctcccag ctgaatctgg tcggaatcca
     4861 cgggctgcag attttccaaa acaatcgttg tatctttatt gacttttttt tttttttttt
     4921 tctgaatgca atgactgttt tttactctta aggaaaataa acatctttta gaaacagctc
     4981 gatacacaca a
//
