LOCUS       NM_001324323            7537 bp    mRNA    linear   PRI 24-SEP-2024
DEFINITION  Homo sapiens steroid 5 alpha-reductase 1 (SRD5A1), transcript
            variant 3, mRNA.
ACCESSION   NM_001324323
VERSION     NM_001324323.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7537)
  AUTHORS   Schiffer,L., Arlt,W. and Storbeck,K.H.
  TITLE     5alpha-reduction of epitestosterone is catalysed by human SRD5A1
            and SRD5A2 and increases androgen receptor transactivation
  JOURNAL   J Steroid Biochem Mol Biol 241, 106516 (2024)
   PUBMED   38582131
  REMARK    GeneRIF: 5alpha-reduction of epitestosterone is catalysed by human
            SRD5A1 and SRD5A2 and increases androgen receptor transactivation.
REFERENCE   2  (bases 1 to 7537)
  AUTHORS   Bar-Sadeh,B., Amichai,O.E., Pnueli,L., Begum,K., Leeman,G.,
            Emes,R.D., Stoger,R., Bentley,G.R. and Melamed,P.
  TITLE     Epigenetic regulation of 5alpha reductase-1 underlies adaptive
            plasticity of reproductive function and pubertal timing
  JOURNAL   BMC Biol 20 (1), 11 (2022)
   PUBMED   34996447
  REMARK    GeneRIF: Epigenetic regulation of 5alpha reductase-1 underlies
            adaptive plasticity of reproductive function and pubertal timing.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 7537)
  AUTHORS   Csikos,E., Horvath,A., Acs,K., Papp,N., Balazs,V.L., Dolenc,M.S.,
            Kenda,M., Kocevar Glavac,N., Nagy,M., Protti,M., Mercolini,L.,
            Horvath,G., Farkas,A. and On Behalf Of The,Oemonom.
  TITLE     Treatment of Benign Prostatic Hyperplasia by Natural Drugs
  JOURNAL   Molecules 26 (23), 7141 (2021)
   PUBMED   34885733
  REMARK    GeneRIF: Treatment of Benign Prostatic Hyperplasia by Natural
            Drugs.
            Review article
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 7537)
  AUTHORS   Suminska,M., Podgorski,R., Fichna,P. and Fichna,M.
  TITLE     Steroid Metabolism in Children and Adolescents With Obesity and
            Insulin Resistance: Altered SRD5A and 20alpha/20betaHSD Activity
  JOURNAL   Front Endocrinol (Lausanne) 12, 759971 (2021)
   PUBMED   34764940
  REMARK    GeneRIF: Steroid Metabolism in Children and Adolescents With
            Obesity and Insulin Resistance: Altered SRD5A and 20alpha/20betaHSD
            Activity.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 7537)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   6  (bases 1 to 7537)
  AUTHORS   Jenkins,E.P., Andersson,S., Imperato-McGinley,J., Wilson,J.D. and
            Russell,D.W.
  TITLE     Genetic and pharmacological evidence for more than one human
            steroid 5 alpha-reductase
  JOURNAL   J Clin Invest 89 (1), 293-300 (1992)
   PUBMED   1345916
REFERENCE   7  (bases 1 to 7537)
  AUTHORS   Jenkins,E.P., Hsieh,C.L., Milatovich,A., Normington,K.,
            Berman,D.M., Francke,U. and Russell,D.W.
  TITLE     Characterization and chromosomal mapping of a human steroid 5
            alpha-reductase gene and pseudogene and mapping of the mouse
            homologue
  JOURNAL   Genomics 11 (4), 1102-1112 (1991)
   PUBMED   1686016
REFERENCE   8  (bases 1 to 7537)
  AUTHORS   Andersson,S. and Russell,D.W.
  TITLE     Structural and biochemical properties of cloned and expressed human
            and rat steroid 5 alpha-reductases
  JOURNAL   Proc Natl Acad Sci U S A 87 (10), 3640-3644 (1990)
   PUBMED   2339109
REFERENCE   9  (bases 1 to 7537)
  AUTHORS   Milewich,L., Kaimal,V. and Toews,G.B.
  TITLE     Androstenedione metabolism in human alveolar macrophages
  JOURNAL   J Clin Endocrinol Metab 56 (5), 920-924 (1983)
   PUBMED   6833469
REFERENCE   10 (bases 1 to 7537)
  AUTHORS   Moore,R.J. and Wilson,J.D.
  TITLE     Localization of the reduced nicotinamide adenine dinucleotide
            phosphate: 4 -3-ketosteroid 5 -oxidoreductase in the nuclear
            membrane of the rat ventral prostate
  JOURNAL   J Biol Chem 247 (3), 958-967 (1972)
   PUBMED   4400474
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK297208.1, CV570670.1, BC008673.2, M32313.1, AF052126.1 and
            AC010366.6.
            
            On May 31, 2019 this sequence version replaced NM_001324323.1.
            
            Summary: Steroid 5-alpha-reductase (EC 1.3.99.5) catalyzes the
            conversion of testosterone into the more potent androgen,
            dihydrotestosterone (DHT). Also see SRD5A2 (MIM 607306).[supplied
            by OMIM, Mar 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK297208.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA2145122
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-515               AK297208.1         14-528
            516-525             CV570670.1         363-372
            526-1275            AK297208.1         539-1288
            1276-1785           BC008673.2         748-1257
            1786-2711           M32313.1           1177-2102
            2712-2713           AF052126.1         2200-2201
            2714-7537           AC010366.6         97441-102264
FEATURES             Location/Qualifiers
     source          1..7537
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5p15.31"
     gene            1..7537
                     /gene="SRD5A1"
                     /gene_synonym="S5AR 1"
                     /note="steroid 5 alpha-reductase 1"
                     /db_xref="GeneID:6715"
                     /db_xref="HGNC:HGNC:11284"
                     /db_xref="MIM:184753"
     exon            1..430
                     /gene="SRD5A1"
                     /gene_synonym="S5AR 1"
                     /inference="alignment:Splign:2.1.0"
     exon            431..932
                     /gene="SRD5A1"
                     /gene_synonym="S5AR 1"
                     /inference="alignment:Splign:2.1.0"
     CDS             859..1419
                     /gene="SRD5A1"
                     /gene_synonym="S5AR 1"
                     /EC_number="1.3.1.22"
                     /note="isoform 3 is encoded by transcript variant 3;
                     steroid 5-alpha-reductase type I; SR type 1;
                     steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5
                     alpha-steroid delta 4-dehydrogenase alpha 1)"
                     /codon_start=1
                     /product="3-oxo-5-alpha-steroid 4-dehydrogenase 1 isoform
                     3"
                     /protein_id="NP_001311252.1"
                     /db_xref="GeneID:6715"
                     /db_xref="HGNC:HGNC:11284"
                     /db_xref="MIM:184753"
                     /translation="MTLPWRTWSEWKQITSFTVFPALLRCLIYPFLMRGGKPMPLLAC
                     TMAIMFCTCNGYLQSRYLSHCAVYADDWVTDPRFLIGFGLWLTGMLINIHSDHILRNL
                     RKPGDTGYKIPRGGLFEYVTAANYFGEIMEWCGYALASWSVQGAAFAFFTFCFLSGRA
                     KEHHEWYLRKFEEYPKFRKIIIPFLF"
     exon            933..1099
                     /gene="SRD5A1"
                     /gene_synonym="S5AR 1"
                     /inference="alignment:Splign:2.1.0"
     exon            1100..1201
                     /gene="SRD5A1"
                     /gene_synonym="S5AR 1"
                     /inference="alignment:Splign:2.1.0"
     exon            1202..1352
                     /gene="SRD5A1"
                     /gene_synonym="S5AR 1"
                     /inference="alignment:Splign:2.1.0"
     exon            1353..7537
                     /gene="SRD5A1"
                     /gene_synonym="S5AR 1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2532..2537
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SRD5A1"
                     /gene_synonym="S5AR 1"
                     /note="hexamer: AATAAT"
     polyA_site      2549
                     /gene="SRD5A1"
                     /gene_synonym="S5AR 1"
     regulatory      2695..2700
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SRD5A1"
                     /gene_synonym="S5AR 1"
                     /note="hexamer: AATAGA"
     polyA_site      2713
                     /gene="SRD5A1"
                     /gene_synonym="S5AR 1"
                     /note="major polyA site"
     regulatory      7512..7517
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SRD5A1"
                     /gene_synonym="S5AR 1"
                     /note="hexamer: ATTAAA"
     polyA_site      7537
                     /gene="SRD5A1"
                     /gene_synonym="S5AR 1"
ORIGIN      
        1 cctttctgca gagtcccggc agtgcgggac tccggtagcc gcccctccgg tagccgcccc
       61 tcctgccccc gcgccgccgc cctatatgtt gcccgccgcg gcctctgggg catggagcac
      121 gctgcccagc cctggcgatg gcaacggcga cgggggtggc ggaggagcgc ctgctggccg
      181 cgctcgccta cctgcagtgc gccgtgggct gcgcggtctt cgcgcgcaat cgtcagacga
      241 actcagtgta cggccgccac gcgctgccca gccacaggct ccgagtgccg gcgcgggccg
      301 cctgggtggt gcaggagctg ccctcgctgg ccctgccgct ctaccagtac gccagcgagt
      361 ccgccccgcg tctccgcagc gcgcccaact gcatcctcct ggccatgttc ctcgtccact
      421 acgggcatcg gaaatgttgg tatgcaagca cttgcagtgt gcctacatcc caaatgccag
      481 cccatggtac ccattgtctg cccggatctg aatcatgatt ccaagacgca gagagaaatt
      541 gctgggattc gttgttctta ttcattgctt ggcaacactg cagcttccag gagaataccc
      601 acctcactga tgacacaaca tctgaatgca cacttactgg ccaacacgtg ctttgctgta
      661 aatcagtatg aagtcttcct aggggtcctg gcctgaatga gatgagaacc ttggaggctg
      721 cttttgactc atgtgaatgt cttccccagg agttaagtgg gagtgctggg gagagagtgg
      781 cttgaggatg cacagccagc atgacactac tattatgtga ttactgtcga cgttcataac
      841 cataactaat gactaattat gactttaccc tggcgcacat ggtcagaatg gaaacaaata
      901 acaagcttta cagtttttcc tgctctatta aggtgcttaa tttacccatt tctgatgcga
      961 ggaggaaagc ctatgccact gttggcgtgt acaatggcga ttatgttctg tacctgtaac
     1021 ggctatttgc aaagcagata cttgagccat tgtgcagtgt atgctgatga ctgggtaaca
     1081 gatccccgtt ttctaatagg ttttggcttg tggttaacgg gcatgttgat aaacatccat
     1141 tcagatcata tcctaaggaa tctcagaaaa ccaggagata ctggatacaa aataccaagg
     1201 ggaggcttat ttgaatacgt aactgcagcc aactattttg gagaaatcat ggagtggtgt
     1261 ggctatgccc tggccagctg gtctgtccaa ggcgcggctt ttgctttctt cacgttttgt
     1321 tttttatctg gtagagcaaa agagcatcat gagtggtacc tccggaaatt tgaagagtat
     1381 ccaaagttca gaaaaattat aattccattt ttgttttaag tgcgtttttc atgaaattat
     1441 cttcaacttg aagctttcca atggcgcttc tctatggact ttgtaaataa gttatatctt
     1501 tgtaattttc ctgctacttt atcattttca agatgtcctc taggaatttt ttttctagta
     1561 attttgcaat ctacctaata agtacctaaa tacgctgaaa tggaggttga atatcctact
     1621 gtgtaacagg tcagaatttc aagctctggg taataactgc tgatattttt tctaatttca
     1681 aatttacctc ttttggctat gtcttgccaa gtgtgtatga gactagactt tacaactgtc
     1741 tttgatggca ttttcagaac aataaatgtc acaatccctt ctatagcccc ctacagtgat
     1801 ctcttcaagg tcaactgcag tgttgcttcc ctccccctat agggctggaa tctgtctagg
     1861 agccctctct cggaggccac agaggctggg ggtagccatt gtgcagtcat ggcccggggg
     1921 aaacttgcca accttcgtgt caggtgctgt gtgtaagtgg agaacttggg gatagaggag
     1981 gaagctcctc gtggcccttc caaggtgagg caaaggcatc tggacttgtt ccagcccagc
     2041 ccaccgggtg acatcaccgg gcagggaggg gtgctggtgg tggttcatac ggagtaagct
     2101 gctctgcctg tgtgagtggc tcctgggccc taaacaggca cctttaggcc atgggtcact
     2161 caccgtgagc catcaatgtg ctctggtctg acatggtttc tctctgtctt ctagtctaga
     2221 cctagttttt ttgttctgtt ccccacgtat ggatatagta gagattgttg tctgtgaaat
     2281 ttctcttttg tagattttga gttttccctt gtagtgtaaa gaatgatcac tttctgtaac
     2341 aataacaaga ccacttttta agatttatcc tgtttgttct ttgttgattg aaacataata
     2401 attgttaaaa ttctctacag ccttcttttt cttccatagc taatcttcct tctaatagtt
     2461 tttgctttct gttttgctgt tgttgctttg caaagctttc ccctcatagc ctgtacctgt
     2521 tatcaatata aaataatctt cctgttgaat gcttcatgac ttgaattcta ctttgataaa
     2581 aacattgcca tactgctttt tatcttgatg aattcatctg gcattgcttt gccttatcat
     2641 ctcatctgga gtttttaaat gccatttgtt tcagttgtct ttaacaacat aataaataga
     2701 ctttgccatt taacaaggta gctcaaattc ttttactaat tgttacatcg aaacattctt
     2761 tcatcatatt tcctgttttt atttggtttt ttcaacttct tctgtttact atctacagtg
     2821 atttggaaag gagatttcct ttaaaacaaa caagcttatt gggaatggct tttatgattt
     2881 ttaaagtagc cttgagagct tccagttaaa tctgatgagc tgaacataca cctttccttc
     2941 tcccctctct attctgaccc cagttgaaat cacctcaaag gaatttaggt gggggagtgg
     3001 ccccataaag agagtgagag agagtcacca ctgcagatgg accacagcac gggtggagat
     3061 gggcctgatg tggcagagca gagaggccat gacagtgcac accctgcgga gaccctgggt
     3121 cctcacatct gggctgacag aaggcagagg gaaatgagca tctcaaagtg agaccaacta
     3181 aacatggcgc ctgcagcaga aagcagtgtc ctctgcaccc ccactctcca gggagagcac
     3241 agagagccca gaaatgagcc atgtgcccat tgccggggaa gagaaggtag gctgaggagg
     3301 tggcctttcc taacacaaaa attaactaag tggggaaaac cagagaacta ggtgttggca
     3361 tcccaggaaa aaaataaagt ctccacattt tggcctatag ggatcctgcc ccataatggc
     3421 tggttacctc ctgcctcaag ctgcagggaa gccagggggt ggcatggcca tggcttctcc
     3481 ctcagagagg cctctgtgca cgacttcagt cacccaacac tgacagaact tggaacccaa
     3541 aagcccattt ctctccttcc gtccagaccc tgtctgctgt tatctgtagg aagaccacag
     3601 ccaactgcta tcatgaccaa agctaaaatc caatgaggca gagaacaata gttgtaccca
     3661 tctcctcctt agtctccaag gccagcggtg catgcatttg tgcattcaac aacatttgcc
     3721 aagcacttac tgtatatcaa gcacagcagt gggtgctgag gacggatggg tagaaaaaac
     3781 agtcctggcc caggtggagt gacaggtaag aaacaagtaa gtagctaaaa taatgttagg
     3841 tagaaaaaaa taacaagaat aaaagcaagg aaaagggaag ggaccctcac ttgtgtctga
     3901 tacagccata atcttctcta tcggccattg ctgtaaccaa agcttaacca cctttcttaa
     3961 gatattgatc aaccagatca ttgcaaatac tgctaattga ttccttttta tggctgagta
     4021 gtattccatt gtatatatat atataccact tgttgactga tgggcatttg ggttggttcc
     4081 acgattttgc agttgtgaat tgtgctgcta taaacatgtg cgtgcaagta tctttttttg
     4141 aataatgact tcttttcctc tgggtagata cccagtaatg ggattgctgg atcaaatggt
     4201 agttctactt ttagttctaa ggaatttcca cactgttttc catggtggct ctaatagttt
     4261 acattcccac cagcagtgtg gaagtgttcc atgattgccg catgcatgcc aacatctact
     4321 gttttttgat ttttttggtt atggccgttc ttgcaggagt aagggggtat cgcactgtag
     4381 tttttatttg catttccctg atcattagtg atgttgagca ttttttcata ctttgttggc
     4441 catttgtata tcttcttttg agaattgtct attcatgtcc ttaacccact ttttgatggg
     4501 attgtttgtt tttttcttac tgatttgttt gagtttgttg tagattctgg atattagtcc
     4561 tttgtctgat gtatagattg tgaagatttt ctcccactct gtgcgttgtc tgtttactct
     4621 gctgactgtt gcttttacca tgcaaaagct ctttagttta attaagtccc atctatttat
     4681 ctttgttttt attgttggaa actattattc taagttaagt aactcaggaa tggaaaacca
     4741 aacaacctat gttctcattg atatgtggga gctaagctat gaggacacaa aggcataaga
     4801 atggtacaat ggactttggg gacttggggg gaagggtaag ggggggtgag gaataaaaga
     4861 caacatatat ggtatagtat atactactca ggagatgggt gcaccaggat ctcacaaatc
     4921 accactaaag aatttactca tgtaaccaaa taccacctgt acccccaata acttatggga
     4981 aaaaaagata ttcatcgacc tattccaggt cctctctcca ccactgagcc tcgtggggac
     5041 ataaagagct gcctgccctc ccctgttccc cttgcctttt tgcagcagga ttcctgaaaa
     5101 tgttgactta cagatacgtt tttgagatat gaacgtttgt tatttcctgg tgcttaggga
     5161 agaaaataat tgatgttgtg agttgggcgg gactttaggg actatgctga acaatccact
     5221 gaccactgca ggctcccatt tatgatcttg ggccaacagc caccagcctc tgttcatgca
     5281 gtctcactga gggcagttac ttctttggag tggcatgcct ctgagcagat aattccaata
     5341 atcaatgtca aactagatat tgaaacagcc caagtgtcct ggtaaagcta gctgttgata
     5401 ctcctgactg ttgcattatt ttgttttttg ttttgttttg ttttgagacg gagtcttgct
     5461 ctgtcaccca ggctggagtg caatggtgcg atcttggctc actgcaagct gtgcctcccg
     5521 ggttcaaaca attcttctgc ctcagcctcc cgagtagctg ggattacagg tgcatgccac
     5581 catgcccagc taattttgta tttttagtag agacagggtt tcaccatgtt gtccaggctg
     5641 gtcttgaact cctgacctca agtgatccac ccaccttggc ctcccaaggt gctgggatta
     5701 caggcacaag ccacagctcc cggcccaact gttgcattat tatttgcaaa tgttggctat
     5761 ccctgctgtt gtctatatat caattttgtc tacccaacac agctgtaaac ttctcaaggt
     5821 gaggagtgag ccatcactct ttgcacctct tgctgtgatt gacatggtat accttaagat
     5881 atatgttaat tcctatgtct taataaatat tggcttatgg agaatttgtt ggagcaagta
     5941 cagaccctat gtttaacttc ttttattcaa cagaattaaa aaactagcta gttctctcaa
     6001 taaaataata ctttcttttc tttcttaaaa tctagctgat ctggtctaaa atacacatgt
     6061 gggaggcggg attgtagaaa tatctcaaat taattagcgt ctagctcttt gtaaggtaat
     6121 tgacagtctg agttagttgc ttcccccact gcaaagcagc aaaatctgct ctcaaaggct
     6181 tcacgtagcc gggaaaactc cgttcccaat tcagatcctc tggggagggc atcaattatt
     6241 tcctattgtt tttagcaccg attgttctgt ctaatttgaa aggatccaaa aaaggaaatg
     6301 atacttggca ttagtatcat tctccatcac tcttgaaaga tatatgaagg gaatgttggc
     6361 gcaatcagtc tagaaacata tttctcccat aacaataagc cagttctttt tgctttgaat
     6421 cagaaatagc tccatcaggc ccatgaagga aagggaaaca aaactgagtg ccaagcatat
     6481 gataacatgc tcagcatcat atgacattag gggattgcaa attgaaacaa cagtaccacc
     6541 acacacctat cagaatggcc aaaatccaga agactgacat caccaatgct agtgagaatg
     6601 tggagcaaca ggaactctca ttcacggctg gtggggatgc aaagtggtgg agccacttgg
     6661 gaagacagtc tggcagattc ctaaaaaggt aaacatactc ttactaaaca atctagtaga
     6721 tttgctccta ggtgtttacc caaaggagtt gaaaacatgt ccacacagaa aacctgcaca
     6781 tgaatgttta tagcagcttt actcaaaatt gccaaaaatt ggaagcaacc aagatgtcct
     6841 tcaataggtg ggcggataaa gaaattgtat ccaattctat ttctatgagg aaaatctatt
     6901 catacaatag aatactagtg tcagagattt ttttttaaca aagagctatc aagccatgaa
     6961 aagataagga agaactttaa tgcatattgg taagtgaaaa aagccagttt gcaaaggcta
     7021 gatactatat gatcccaact gtataacatt ctgaaaaagg cacaactatg gagacaataa
     7081 aaagaacaga gttttggatg aagggaggga tgaacaggca gaatacaaac aaattttagg
     7141 gcagtgaaac tattattatg atactttatg gatatagaat attatgcatt tttcaaaaca
     7201 catagaatat acaacatgaa gaatgaatgc taatgtaaac tctggatttt tattaataat
     7261 attatttaat taaaatgatt tattttactt attttcatta ttatctaaaa tgttatttaa
     7321 ttattaaatt tagatgctac ttaatttttg ctttattatt attatgttaa tatcatcaac
     7381 tgtaactagt gtacaacact aatgcaagat gttaataggg gaaatcgtgt tggagagaga
     7441 gatatgtgag aactctgtac tttcttttca atgtttctgt aaacataaag ctgctctaaa
     7501 aaattaaatc tattaaaaaa aaaactgagt ggaaaaa
//
