LOCUS       NM_001047               7035 bp    mRNA    linear   PRI 24-SEP-2024
DEFINITION  Homo sapiens steroid 5 alpha-reductase 1 (SRD5A1), transcript
            variant 1, mRNA.
ACCESSION   NM_001047
VERSION     NM_001047.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7035)
  AUTHORS   Schiffer,L., Arlt,W. and Storbeck,K.H.
  TITLE     5alpha-reduction of epitestosterone is catalysed by human SRD5A1
            and SRD5A2 and increases androgen receptor transactivation
  JOURNAL   J Steroid Biochem Mol Biol 241, 106516 (2024)
   PUBMED   38582131
  REMARK    GeneRIF: 5alpha-reduction of epitestosterone is catalysed by human
            SRD5A1 and SRD5A2 and increases androgen receptor transactivation.
REFERENCE   2  (bases 1 to 7035)
  AUTHORS   Bar-Sadeh,B., Amichai,O.E., Pnueli,L., Begum,K., Leeman,G.,
            Emes,R.D., Stoger,R., Bentley,G.R. and Melamed,P.
  TITLE     Epigenetic regulation of 5alpha reductase-1 underlies adaptive
            plasticity of reproductive function and pubertal timing
  JOURNAL   BMC Biol 20 (1), 11 (2022)
   PUBMED   34996447
  REMARK    GeneRIF: Epigenetic regulation of 5alpha reductase-1 underlies
            adaptive plasticity of reproductive function and pubertal timing.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 7035)
  AUTHORS   Csikos,E., Horvath,A., Acs,K., Papp,N., Balazs,V.L., Dolenc,M.S.,
            Kenda,M., Kocevar Glavac,N., Nagy,M., Protti,M., Mercolini,L.,
            Horvath,G., Farkas,A. and On Behalf Of The,Oemonom.
  TITLE     Treatment of Benign Prostatic Hyperplasia by Natural Drugs
  JOURNAL   Molecules 26 (23), 7141 (2021)
   PUBMED   34885733
  REMARK    GeneRIF: Treatment of Benign Prostatic Hyperplasia by Natural
            Drugs.
            Review article
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 7035)
  AUTHORS   Suminska,M., Podgorski,R., Fichna,P. and Fichna,M.
  TITLE     Steroid Metabolism in Children and Adolescents With Obesity and
            Insulin Resistance: Altered SRD5A and 20alpha/20betaHSD Activity
  JOURNAL   Front Endocrinol (Lausanne) 12, 759971 (2021)
   PUBMED   34764940
  REMARK    GeneRIF: Steroid Metabolism in Children and Adolescents With
            Obesity and Insulin Resistance: Altered SRD5A and 20alpha/20betaHSD
            Activity.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 7035)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   6  (bases 1 to 7035)
  AUTHORS   Jenkins,E.P., Andersson,S., Imperato-McGinley,J., Wilson,J.D. and
            Russell,D.W.
  TITLE     Genetic and pharmacological evidence for more than one human
            steroid 5 alpha-reductase
  JOURNAL   J Clin Invest 89 (1), 293-300 (1992)
   PUBMED   1345916
REFERENCE   7  (bases 1 to 7035)
  AUTHORS   Jenkins,E.P., Hsieh,C.L., Milatovich,A., Normington,K.,
            Berman,D.M., Francke,U. and Russell,D.W.
  TITLE     Characterization and chromosomal mapping of a human steroid 5
            alpha-reductase gene and pseudogene and mapping of the mouse
            homologue
  JOURNAL   Genomics 11 (4), 1102-1112 (1991)
   PUBMED   1686016
REFERENCE   8  (bases 1 to 7035)
  AUTHORS   Andersson,S. and Russell,D.W.
  TITLE     Structural and biochemical properties of cloned and expressed human
            and rat steroid 5 alpha-reductases
  JOURNAL   Proc Natl Acad Sci U S A 87 (10), 3640-3644 (1990)
   PUBMED   2339109
REFERENCE   9  (bases 1 to 7035)
  AUTHORS   Milewich,L., Kaimal,V. and Toews,G.B.
  TITLE     Androstenedione metabolism in human alveolar macrophages
  JOURNAL   J Clin Endocrinol Metab 56 (5), 920-924 (1983)
   PUBMED   6833469
REFERENCE   10 (bases 1 to 7035)
  AUTHORS   Moore,R.J. and Wilson,J.D.
  TITLE     Localization of the reduced nicotinamide adenine dinucleotide
            phosphate: 4 -3-ketosteroid 5 -oxidoreductase in the nuclear
            membrane of the rat ventral prostate
  JOURNAL   J Biol Chem 247 (3), 958-967 (1972)
   PUBMED   4400474
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA170063.1, BC007033.1, M32313.1, AF052126.1 and AC010366.6.
            
            On Nov 22, 2018 this sequence version replaced NM_001047.3.
            
            Summary: Steroid 5-alpha-reductase (EC 1.3.99.5) catalyzes the
            conversion of testosterone into the more potent androgen,
            dihydrotestosterone (DHT). Also see SRD5A2 (MIM 607306).[supplied
            by OMIM, Mar 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC007033.1, SRR1660805.143522.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000274192.7/ ENSP00000274192.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-227               DA170063.1         74-300
            228-1281            BC007033.1         228-1281
            1282-2157           M32313.1           1175-2050
            2158-2211           AF052126.1         2148-2201
            2212-7035           AC010366.6         97441-102264
FEATURES             Location/Qualifiers
     source          1..7035
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5p15.31"
     gene            1..7035
                     /gene="SRD5A1"
                     /gene_synonym="S5AR 1"
                     /note="steroid 5 alpha-reductase 1"
                     /db_xref="GeneID:6715"
                     /db_xref="HGNC:HGNC:11284"
                     /db_xref="MIM:184753"
     exon            1..430
                     /gene="SRD5A1"
                     /gene_synonym="S5AR 1"
                     /inference="alignment:Splign:2.1.0"
     CDS             138..917
                     /gene="SRD5A1"
                     /gene_synonym="S5AR 1"
                     /EC_number="1.3.1.22"
                     /note="isoform 1 is encoded by transcript variant 1;
                     steroid 5-alpha-reductase type I; SR type 1;
                     steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5
                     alpha-steroid delta 4-dehydrogenase alpha 1)"
                     /codon_start=1
                     /product="3-oxo-5-alpha-steroid 4-dehydrogenase 1 isoform
                     1"
                     /protein_id="NP_001038.1"
                     /db_xref="CCDS:CCDS3870.1"
                     /db_xref="GeneID:6715"
                     /db_xref="HGNC:HGNC:11284"
                     /db_xref="MIM:184753"
                     /translation="MATATGVAEERLLAALAYLQCAVGCAVFARNRQTNSVYGRHALP
                     SHRLRVPARAAWVVQELPSLALPLYQYASESAPRLRSAPNCILLAMFLVHYGHRCLIY
                     PFLMRGGKPMPLLACTMAIMFCTCNGYLQSRYLSHCAVYADDWVTDPRFLIGFGLWLT
                     GMLINIHSDHILRNLRKPGDTGYKIPRGGLFEYVTAANYFGEIMEWCGYALASWSVQG
                     AAFAFFTFCFLSGRAKEHHEWYLRKFEEYPKFRKIIIPFLF"
     exon            431..597
                     /gene="SRD5A1"
                     /gene_synonym="S5AR 1"
                     /inference="alignment:Splign:2.1.0"
     exon            598..699
                     /gene="SRD5A1"
                     /gene_synonym="S5AR 1"
                     /inference="alignment:Splign:2.1.0"
     exon            700..850
                     /gene="SRD5A1"
                     /gene_synonym="S5AR 1"
                     /inference="alignment:Splign:2.1.0"
     exon            851..7035
                     /gene="SRD5A1"
                     /gene_synonym="S5AR 1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2030..2035
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SRD5A1"
                     /gene_synonym="S5AR 1"
                     /note="hexamer: AATAAT"
     polyA_site      2047
                     /gene="SRD5A1"
                     /gene_synonym="S5AR 1"
     regulatory      2193..2198
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SRD5A1"
                     /gene_synonym="S5AR 1"
                     /note="hexamer: AATAGA"
     polyA_site      2211
                     /gene="SRD5A1"
                     /gene_synonym="S5AR 1"
                     /note="major polyA site"
     regulatory      7010..7015
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SRD5A1"
                     /gene_synonym="S5AR 1"
                     /note="hexamer: ATTAAA"
     polyA_site      7035
                     /gene="SRD5A1"
                     /gene_synonym="S5AR 1"
ORIGIN      
        1 cctttctgca gagtcccggc agtgcgggac tccggtagcc gcccctccgg tagccgcccc
       61 tcctgccccc gcgccgccgc cctatatgtt gcccgccgcg gcctctgggg catggagcac
      121 gctgcccagc cctggcgatg gcaacggcga cgggggtggc ggaggagcgc ctgctggccg
      181 cgctcgccta cctgcagtgc gccgtgggct gcgcggtctt cgcgcgcaat cgtcagacga
      241 actcagtgta cggccgccac gcgctgccca gccacaggct ccgagtgccg gcgcgggccg
      301 cctgggtggt gcaggagctg ccctcgctgg ccctgccgct ctaccagtac gccagcgagt
      361 ccgccccgcg tctccgcagc gcgcccaact gcatcctcct ggccatgttc ctcgtccact
      421 acgggcatcg gtgcttaatt tacccatttc tgatgcgagg aggaaagcct atgccactgt
      481 tggcgtgtac aatggcgatt atgttctgta cctgtaacgg ctatttgcaa agcagatact
      541 tgagccattg tgcagtgtat gctgatgact gggtaacaga tccccgtttt ctaataggtt
      601 ttggcttgtg gttaacgggc atgttgataa acatccattc agatcatatc ctaaggaatc
      661 tcagaaaacc aggagatact ggatacaaaa taccaagggg aggcttattt gaatacgtaa
      721 ctgcagccaa ctattttgga gaaatcatgg agtggtgtgg ctatgccctg gccagctggt
      781 ctgtccaagg cgcggctttt gctttcttca cgttttgttt tttatctggt agagcaaaag
      841 agcatcatga gtggtacctc cggaaatttg aagagtatcc aaagttcaga aaaattataa
      901 ttccattttt gttttaagtg cgtttttcat gaaattatct tcaacttgaa gctttccaat
      961 ggcgcttctc tatggacttt gtaaataagt tatatctttg taattttcct gctactttat
     1021 cattttcaag atgtcctcta ggaatttttt ttctagtaat tttgcaatct acctaataag
     1081 tacctaaata cgctgaaatg gaggttgaat atcctactgt gtaacaggtc agaatttcaa
     1141 gctctgggta ataactgctg atattttttc taatttcaaa tttacctctt ttggctatgt
     1201 cttgccaagt gtgtatgaga ctagacttta caactgtctt tgatggcatt ttcagaacaa
     1261 taaatgtcac aatcccttct atagccccct acagtgatct cttcaaggtc aactgcagtg
     1321 ttgcttccct ccccctatag ggctggaatc tgtctaggag ccctctctcg gaggccacag
     1381 aggctggggg tagccattgt gcagtcatgg cccgggggaa acttgccaac cttcgtgtca
     1441 ggtgctgtgt gtaagtggag aacttgggga tagaggagga agctcctcgt ggcccttcca
     1501 aggtgaggca aaggcatctg gacttgttcc agcccagccc accgggtgac atcaccgggc
     1561 agggaggggt gctggtggtg gttcatacgg agtaagctgc tctgcctgtg tgagtggctc
     1621 ctgggcccta aacaggcacc tttaggccat gggtcactca ccgtgagcca tcaatgtgct
     1681 ctggtctgac atggtttctc tctgtcttct agtctagacc tagttttttt gttctgttcc
     1741 ccacgtatgg atatagtaga gattgttgtc tgtgaaattt ctcttttgta gattttgagt
     1801 tttcccttgt agtgtaaaga atgatcactt tctgtaacaa taacaagacc actttttaag
     1861 atttatcctg tttgttcttt gttgattgaa acataataat tgttaaaatt ctctacagcc
     1921 ttctttttct tccatagcta atcttccttc taatagtttt tgctttctgt tttgctgttg
     1981 ttgctttgca aagctttccc ctcatagcct gtacctgtta tcaatataaa ataatcttcc
     2041 tgttgaatgc ttcatgactt gaattctact ttgataaaaa cattgccata ctgcttttta
     2101 tcttgatgaa ttcatctggc attgctttgc cttatcatct catctggagt ttttaaatgc
     2161 catttgtttc agttgtcttt aacaacataa taaatagact ttgccattta acaaggtagc
     2221 tcaaattctt ttactaattg ttacatcgaa acattctttc atcatatttc ctgtttttat
     2281 ttggtttttt caacttcttc tgtttactat ctacagtgat ttggaaagga gatttccttt
     2341 aaaacaaaca agcttattgg gaatggcttt tatgattttt aaagtagcct tgagagcttc
     2401 cagttaaatc tgatgagctg aacatacacc tttccttctc ccctctctat tctgacccca
     2461 gttgaaatca cctcaaagga atttaggtgg gggagtggcc ccataaagag agtgagagag
     2521 agtcaccact gcagatggac cacagcacgg gtggagatgg gcctgatgtg gcagagcaga
     2581 gaggccatga cagtgcacac cctgcggaga ccctgggtcc tcacatctgg gctgacagaa
     2641 ggcagaggga aatgagcatc tcaaagtgag accaactaaa catggcgcct gcagcagaaa
     2701 gcagtgtcct ctgcaccccc actctccagg gagagcacag agagcccaga aatgagccat
     2761 gtgcccattg ccggggaaga gaaggtaggc tgaggaggtg gcctttccta acacaaaaat
     2821 taactaagtg gggaaaacca gagaactagg tgttggcatc ccaggaaaaa aataaagtct
     2881 ccacattttg gcctataggg atcctgcccc ataatggctg gttacctcct gcctcaagct
     2941 gcagggaagc cagggggtgg catggccatg gcttctccct cagagaggcc tctgtgcacg
     3001 acttcagtca cccaacactg acagaacttg gaacccaaaa gcccatttct ctccttccgt
     3061 ccagaccctg tctgctgtta tctgtaggaa gaccacagcc aactgctatc atgaccaaag
     3121 ctaaaatcca atgaggcaga gaacaatagt tgtacccatc tcctccttag tctccaaggc
     3181 cagcggtgca tgcatttgtg cattcaacaa catttgccaa gcacttactg tatatcaagc
     3241 acagcagtgg gtgctgagga cggatgggta gaaaaaacag tcctggccca ggtggagtga
     3301 caggtaagaa acaagtaagt agctaaaata atgttaggta gaaaaaaata acaagaataa
     3361 aagcaaggaa aagggaaggg accctcactt gtgtctgata cagccataat cttctctatc
     3421 ggccattgct gtaaccaaag cttaaccacc tttcttaaga tattgatcaa ccagatcatt
     3481 gcaaatactg ctaattgatt cctttttatg gctgagtagt attccattgt atatatatat
     3541 ataccacttg ttgactgatg ggcatttggg ttggttccac gattttgcag ttgtgaattg
     3601 tgctgctata aacatgtgcg tgcaagtatc tttttttgaa taatgacttc ttttcctctg
     3661 ggtagatacc cagtaatggg attgctggat caaatggtag ttctactttt agttctaagg
     3721 aatttccaca ctgttttcca tggtggctct aatagtttac attcccacca gcagtgtgga
     3781 agtgttccat gattgccgca tgcatgccaa catctactgt tttttgattt ttttggttat
     3841 ggccgttctt gcaggagtaa gggggtatcg cactgtagtt tttatttgca tttccctgat
     3901 cattagtgat gttgagcatt ttttcatact ttgttggcca tttgtatatc ttcttttgag
     3961 aattgtctat tcatgtcctt aacccacttt ttgatgggat tgtttgtttt tttcttactg
     4021 atttgtttga gtttgttgta gattctggat attagtcctt tgtctgatgt atagattgtg
     4081 aagattttct cccactctgt gcgttgtctg tttactctgc tgactgttgc ttttaccatg
     4141 caaaagctct ttagtttaat taagtcccat ctatttatct ttgtttttat tgttggaaac
     4201 tattattcta agttaagtaa ctcaggaatg gaaaaccaaa caacctatgt tctcattgat
     4261 atgtgggagc taagctatga ggacacaaag gcataagaat ggtacaatgg actttgggga
     4321 cttgggggga agggtaaggg ggggtgagga ataaaagaca acatatatgg tatagtatat
     4381 actactcagg agatgggtgc accaggatct cacaaatcac cactaaagaa tttactcatg
     4441 taaccaaata ccacctgtac ccccaataac ttatgggaaa aaaagatatt catcgaccta
     4501 ttccaggtcc tctctccacc actgagcctc gtggggacat aaagagctgc ctgccctccc
     4561 ctgttcccct tgcctttttg cagcaggatt cctgaaaatg ttgacttaca gatacgtttt
     4621 tgagatatga acgtttgtta tttcctggtg cttagggaag aaaataattg atgttgtgag
     4681 ttgggcggga ctttagggac tatgctgaac aatccactga ccactgcagg ctcccattta
     4741 tgatcttggg ccaacagcca ccagcctctg ttcatgcagt ctcactgagg gcagttactt
     4801 ctttggagtg gcatgcctct gagcagataa ttccaataat caatgtcaaa ctagatattg
     4861 aaacagccca agtgtcctgg taaagctagc tgttgatact cctgactgtt gcattatttt
     4921 gttttttgtt ttgttttgtt ttgagacgga gtcttgctct gtcacccagg ctggagtgca
     4981 atggtgcgat cttggctcac tgcaagctgt gcctcccggg ttcaaacaat tcttctgcct
     5041 cagcctcccg agtagctggg attacaggtg catgccacca tgcccagcta attttgtatt
     5101 tttagtagag acagggtttc accatgttgt ccaggctggt cttgaactcc tgacctcaag
     5161 tgatccaccc accttggcct cccaaggtgc tgggattaca ggcacaagcc acagctcccg
     5221 gcccaactgt tgcattatta tttgcaaatg ttggctatcc ctgctgttgt ctatatatca
     5281 attttgtcta cccaacacag ctgtaaactt ctcaaggtga ggagtgagcc atcactcttt
     5341 gcacctcttg ctgtgattga catggtatac cttaagatat atgttaattc ctatgtctta
     5401 ataaatattg gcttatggag aatttgttgg agcaagtaca gaccctatgt ttaacttctt
     5461 ttattcaaca gaattaaaaa actagctagt tctctcaata aaataatact ttcttttctt
     5521 tcttaaaatc tagctgatct ggtctaaaat acacatgtgg gaggcgggat tgtagaaata
     5581 tctcaaatta attagcgtct agctctttgt aaggtaattg acagtctgag ttagttgctt
     5641 cccccactgc aaagcagcaa aatctgctct caaaggcttc acgtagccgg gaaaactccg
     5701 ttcccaattc agatcctctg gggagggcat caattatttc ctattgtttt tagcaccgat
     5761 tgttctgtct aatttgaaag gatccaaaaa aggaaatgat acttggcatt agtatcattc
     5821 tccatcactc ttgaaagata tatgaaggga atgttggcgc aatcagtcta gaaacatatt
     5881 tctcccataa caataagcca gttctttttg ctttgaatca gaaatagctc catcaggccc
     5941 atgaaggaaa gggaaacaaa actgagtgcc aagcatatga taacatgctc agcatcatat
     6001 gacattaggg gattgcaaat tgaaacaaca gtaccaccac acacctatca gaatggccaa
     6061 aatccagaag actgacatca ccaatgctag tgagaatgtg gagcaacagg aactctcatt
     6121 cacggctggt ggggatgcaa agtggtggag ccacttggga agacagtctg gcagattcct
     6181 aaaaaggtaa acatactctt actaaacaat ctagtagatt tgctcctagg tgtttaccca
     6241 aaggagttga aaacatgtcc acacagaaaa cctgcacatg aatgtttata gcagctttac
     6301 tcaaaattgc caaaaattgg aagcaaccaa gatgtccttc aataggtggg cggataaaga
     6361 aattgtatcc aattctattt ctatgaggaa aatctattca tacaatagaa tactagtgtc
     6421 agagattttt ttttaacaaa gagctatcaa gccatgaaaa gataaggaag aactttaatg
     6481 catattggta agtgaaaaaa gccagtttgc aaaggctaga tactatatga tcccaactgt
     6541 ataacattct gaaaaaggca caactatgga gacaataaaa agaacagagt tttggatgaa
     6601 gggagggatg aacaggcaga atacaaacaa attttagggc agtgaaacta ttattatgat
     6661 actttatgga tatagaatat tatgcatttt tcaaaacaca tagaatatac aacatgaaga
     6721 atgaatgcta atgtaaactc tggattttta ttaataatat tatttaatta aaatgattta
     6781 ttttacttat tttcattatt atctaaaatg ttatttaatt attaaattta gatgctactt
     6841 aatttttgct ttattattat tatgttaata tcatcaactg taactagtgt acaacactaa
     6901 tgcaagatgt taatagggga aatcgtgttg gagagagaga tatgtgagaa ctctgtactt
     6961 tcttttcaat gtttctgtaa acataaagct gctctaaaaa attaaatcta ttaaaaaaaa
     7021 aactgagtgg aaaaa
//
