LOCUS       NM_025248               7065 bp    mRNA    linear   PRI 17-SEP-2024
DEFINITION  Homo sapiens SRC kinase signaling inhibitor 1 (SRCIN1), mRNA.
ACCESSION   NM_025248 XM_290806
VERSION     NM_025248.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7065)
  AUTHORS   Shen,H.T., Hung,C.S., Davis,C., Su,C.M., Liao,L.M., Shih,H.M.,
            Lee,K.D., Ansar,M. and Lin,R.K.
  TITLE     Hypermethylation of the Gene Body in SRCIN1 Is Involved in Breast
            Cancer Cell Proliferation and Is a Potential Blood-Based Biomarker
            for Early Detection and a Poor Prognosis
  JOURNAL   Biomolecules 14 (5), 571 (2024)
   PUBMED   38785978
  REMARK    GeneRIF: Hypermethylation of the Gene Body in SRCIN1 Is Involved in
            Breast Cancer Cell Proliferation and Is a Potential Blood-Based
            Biomarker for Early Detection and a Poor Prognosis.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 7065)
  AUTHORS   Salemme,V., Vedelago,M., Sarcinella,A., Moietta,F.,
            Piccolantonio,A., Moiso,E., Centonze,G., Manco,M., Guala,A.,
            Lamolinara,A., Angelini,C., Morellato,A., Natalini,D., Calogero,R.,
            Incarnato,D., Oliviero,S., Conti,L., Iezzi,M., Tosoni,D.,
            Bertalot,G., Freddi,S., Tucci,F.A., De Sanctis,F., Frusteri,C.,
            Ugel,S., Bronte,V., Cavallo,F., Provero,P., Gai,M., Taverna,D.,
            Turco,E., Pece,S. and Defilippi,P.
  TITLE     p140Cap inhibits beta-Catenin in the breast cancer stem cell
            compartment instructing a protective anti-tumor immune response
  JOURNAL   Nat Commun 14 (1), 2350 (2023)
   PUBMED   37169737
  REMARK    GeneRIF: p140Cap inhibits beta-Catenin in the breast cancer stem
            cell compartment instructing a protective anti-tumor immune
            response.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 7065)
  AUTHORS   Salemme,V., Angelini,C., Chapelle,J., Centonze,G., Natalini,D.,
            Morellato,A., Taverna,D., Turco,E., Ala,U. and Defilippi,P.
  TITLE     The p140Cap adaptor protein as a molecular hub to block cancer
            aggressiveness
  JOURNAL   Cell Mol Life Sci 78 (4), 1355-1367 (2021)
   PUBMED   33079227
  REMARK    GeneRIF: The p140Cap adaptor protein as a molecular hub to block
            cancer aggressiveness.
            Review article
REFERENCE   4  (bases 1 to 7065)
  AUTHORS   Hong,W., Yu,S., Zhuang,Y., Zhang,Q., Wang,J. and Gao,X.
  TITLE     SRCIN1 Regulated by circCCDC66/miR-211 Is Upregulated and Promotes
            Cell Proliferation in Non-Small-Cell Lung Cancer
  JOURNAL   Biomed Res Int 2020, 5307641 (2020)
   PUBMED   32964035
  REMARK    GeneRIF: SRCIN1 Regulated by circCCDC66/miR-211 Is Upregulated and
            Promotes Cell Proliferation in Non-Small-Cell Lung Cancer.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 7065)
  AUTHORS   Ji,T., Zhang,Y., Wang,Z., Hou,Z., Gao,X. and Zhang,X.
  TITLE     FOXD3-AS1 suppresses the progression of non-small cell lung cancer
            by regulating miR-150/SRCIN1axis
  JOURNAL   Cancer Biomark 29 (3), 417-427 (2020)
   PUBMED   32924985
  REMARK    GeneRIF: FOXD3-AS1 suppresses the progression of non-small cell
            lung cancer by regulating miR-150/SRCIN1axis.
REFERENCE   6  (bases 1 to 7065)
  AUTHORS   Kennedy,S., Clynes,M., Doolan,P., Mehta,J.P., Rani,S., Crown,J. and
            O'Driscoll,L.
  TITLE     SNIP/p140Cap mRNA expression is an unfavourable prognostic factor
            in breast cancer and is not expressed in normal breast tissue
  JOURNAL   Br J Cancer 98 (10), 1641-1645 (2008)
   PUBMED   18475297
  REMARK    GeneRIF: Expression correlated significantly with unfavourable
            overall survival, suggesting that SNIP/p140Cap may be a useful
            diagnostic and prognostic marker, aas well as therapeutic target,
            in breast cancer.
REFERENCE   7  (bases 1 to 7065)
  AUTHORS   Di Stefano,P., Damiano,L., Cabodi,S., Aramu,S., Tordella,L.,
            Praduroux,A., Piva,R., Cavallo,F., Forni,G., Silengo,L., Tarone,G.,
            Turco,E. and Defilippi,P.
  TITLE     p140Cap protein suppresses tumour cell properties, regulating Csk
            and Src kinase activity
  JOURNAL   EMBO J 26 (12), 2843-2855 (2007)
   PUBMED   17525734
  REMARK    GeneRIF: provides the first evidence that p140Cap is a novel
            negative regulator of tumour growth
REFERENCE   8  (bases 1 to 7065)
  AUTHORS   DeGiorgis,J.A., Jaffe,H., Moreira,J.E., Carlotti,C.G. Jr.,
            Leite,J.P., Pant,H.C. and Dosemeci,A.
  TITLE     Phosphoproteomic analysis of synaptosomes from human cerebral
            cortex
  JOURNAL   J Proteome Res 4 (2), 306-315 (2005)
   PUBMED   15822905
REFERENCE   9  (bases 1 to 7065)
  AUTHORS   Di Stefano,P., Cabodi,S., Boeri Erba,E., Margaria,V., Bergatto,E.,
            Giuffrida,M.G., Silengo,L., Tarone,G., Turco,E. and Defilippi,P.
  TITLE     P130Cas-associated protein (p140Cap) as a new
            tyrosine-phosphorylated protein involved in cell spreading
  JOURNAL   Mol Biol Cell 15 (2), 787-800 (2004)
   PUBMED   14657239
REFERENCE   10 (bases 1 to 7065)
  AUTHORS   Chin,L.S., Nugent,R.D., Raynor,M.C., Vavalle,J.P. and Li,L.
  TITLE     SNIP, a novel SNAP-25-interacting protein implicated in regulated
            exocytosis
  JOURNAL   J Biol Chem 275 (2), 1191-1200 (2000)
   PUBMED   10625663
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC006449.19, AC129916.6 and AC115090.8.
            
            On Nov 22, 2018 this sequence version replaced NM_025248.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: partial sample support SAMEA1965299, SAMEA1966682
                              [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000617146.5/ ENSP00000484715.1
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-22                AC006449.19        50934-50955         c
            23-269              AC006449.19        50687-50933         c
            270-571             AC129916.6         21976-22277
            572-592             AC129916.6         32541-32561
            593-788             AC129916.6         36471-36666
            789-987             AC129916.6         37263-37461
            988-1081            AC129916.6         37864-37957
            1082-1947           AC129916.6         38456-39321
            1948-2040           AC129916.6         40359-40451
            2041-2084           AC129916.6         40687-40730
            2085-2272           AC129916.6         41012-41199
            2273-2448           AC129916.6         42382-42557
            2449-2579           AC115090.8         2165-2295
            2580-2727           AC115090.8         2426-2573
            2728-2974           AC115090.8         2888-3134
            2975-3209           AC115090.8         3631-3865
            3210-3364           AC115090.8         5810-5964
            3365-3517           AC115090.8         6311-6463
            3518-3664           AC115090.8         11052-11198
            3665-7065           AC115090.8         21590-24990
FEATURES             Location/Qualifiers
     source          1..7065
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q12"
     gene            1..7065
                     /gene="SRCIN1"
                     /gene_synonym="P140; SNIP"
                     /note="SRC kinase signaling inhibitor 1"
                     /db_xref="GeneID:80725"
                     /db_xref="HGNC:HGNC:29506"
                     /db_xref="MIM:610786"
     exon            1..269
                     /gene="SRCIN1"
                     /gene_synonym="P140; SNIP"
                     /inference="alignment:Splign:2.1.0"
     CDS             248..3799
                     /gene="SRCIN1"
                     /gene_synonym="P140; SNIP"
                     /note="SNAP-25-interacting protein; SNAP25-interacting
                     protein; p140Cap; P130Cas-associated protein"
                     /codon_start=1
                     /product="SRC kinase signaling inhibitor 1"
                     /protein_id="NP_079524.2"
                     /db_xref="CCDS:CCDS45660.1"
                     /db_xref="GeneID:80725"
                     /db_xref="HGNC:HGNC:29506"
                     /db_xref="MIM:610786"
                     /translation="MGNAPSQDPERSSPPMLSADDAEYPREYRTLGGGGGGGSGGRRF
                     SNVGLVHTSERRHTVIAAQSLEALSGLQKADADRKRDAFMDHLKSKYPQHALALRGQQ
                     DRMREQPNYWSFKTRSSRHTQGAQPGLADQAAKLSYASAESLETMSEAELPLGFSRMN
                     RFRQSLPLSRSASQTKLRSPGVLFLQFGEETRRVHITHEVSSLDTLHALIAHMFPQKL
                     TMGMLKSPNTAILIKDEARNVFYELEDVRDIQDRSIIKIYRKEPLYAAFPGSHLTNGD
                     LRREMVYASRESSPTRRLNNLSPAPHLASGSPPPGLPSGLPSGLQSGSPSRSRLSYAG
                     GRPPSYAGSPVHHAAERLGGAPAAQGVSPSPSAILERRDVKPDEDLASKAGGMVLVKG
                     EGLYADPYGLLHEGRLSLAAAAGDPFAYPGAGGLYKRGSVRSLSTYSAAALQSDLEDS
                     LYKAAGGGGPLYGDGYGFRLPPSSPQKLADVAAPPGGPPPPHSPYSGPPSRGSPVRQS
                     FRKDSGSSSVFAESPGGKTRSAGSASTAGAPPSELFPGPGERSLVGFGPPVPAKDTET
                     RERMEAMEKQIASLTGLVQSALLRGSEPETPSEKIEGSNGAATPSAPCGSGGRSSGAT
                     PVSGPPPPSASSTPAGQPTAVSRLQMQLHLRGLQNSASDLRGQLQQLRKLQLQNQESV
                     RALLKRTEAELSMRVSEAARRQEDPLQRQRTLVEEERLRYLNDEELITQQLNDLEKSV
                     EKIQRDVSHNHRLVPGPELEEKALVLKQLGETLTELKAHFPGLQSKMRVVLRVEVEAV
                     KFLKEEPQRLDGLLKRCRGVTDTLAQIRRQVDEGVWPPPNNLLSQSPKKVTAETDFNK
                     SVDFEMPPPSPPLNLHELSGPAEGASLTPKGGNPTKGLDTPGKRSVDKAVSVEAAERD
                     WEEKRAALTQYSAKDINRLLEETQAELLKAIPDLDCASKAHPGPAPTPDHKPPKAPHG
                     QKAAPRTEPSGRRGSDELTVPRYRTEKPSKSPPPPPPRRSFPSSHGLTTTRTGEVVVT
                     SKKDSAFIKKAESEELEVQKPQVKLRRAVSEVARPASTPPIMASAIKDEDDEDRIIAE
                     LESGGGSVPPMKVVTPGASRLKAAQGQAGSPDKSKHGKQRAEYMRIQAQQQATKPSKE
                     MSGSNETSSPVSEKPSASRTSIPVLTSFGARNSSISF"
     exon            270..571
                     /gene="SRCIN1"
                     /gene_synonym="P140; SNIP"
                     /inference="alignment:Splign:2.1.0"
     exon            572..592
                     /gene="SRCIN1"
                     /gene_synonym="P140; SNIP"
                     /inference="alignment:Splign:2.1.0"
     exon            593..788
                     /gene="SRCIN1"
                     /gene_synonym="P140; SNIP"
                     /inference="alignment:Splign:2.1.0"
     exon            789..987
                     /gene="SRCIN1"
                     /gene_synonym="P140; SNIP"
                     /inference="alignment:Splign:2.1.0"
     exon            988..1081
                     /gene="SRCIN1"
                     /gene_synonym="P140; SNIP"
                     /inference="alignment:Splign:2.1.0"
     exon            1082..1947
                     /gene="SRCIN1"
                     /gene_synonym="P140; SNIP"
                     /inference="alignment:Splign:2.1.0"
     exon            1948..2040
                     /gene="SRCIN1"
                     /gene_synonym="P140; SNIP"
                     /inference="alignment:Splign:2.1.0"
     exon            2041..2084
                     /gene="SRCIN1"
                     /gene_synonym="P140; SNIP"
                     /inference="alignment:Splign:2.1.0"
     exon            2085..2272
                     /gene="SRCIN1"
                     /gene_synonym="P140; SNIP"
                     /inference="alignment:Splign:2.1.0"
     exon            2273..2448
                     /gene="SRCIN1"
                     /gene_synonym="P140; SNIP"
                     /inference="alignment:Splign:2.1.0"
     exon            2449..2579
                     /gene="SRCIN1"
                     /gene_synonym="P140; SNIP"
                     /inference="alignment:Splign:2.1.0"
     exon            2580..2727
                     /gene="SRCIN1"
                     /gene_synonym="P140; SNIP"
                     /inference="alignment:Splign:2.1.0"
     exon            2728..2974
                     /gene="SRCIN1"
                     /gene_synonym="P140; SNIP"
                     /inference="alignment:Splign:2.1.0"
     exon            2975..3209
                     /gene="SRCIN1"
                     /gene_synonym="P140; SNIP"
                     /inference="alignment:Splign:2.1.0"
     exon            3210..3364
                     /gene="SRCIN1"
                     /gene_synonym="P140; SNIP"
                     /inference="alignment:Splign:2.1.0"
     exon            3365..3517
                     /gene="SRCIN1"
                     /gene_synonym="P140; SNIP"
                     /inference="alignment:Splign:2.1.0"
     exon            3518..3664
                     /gene="SRCIN1"
                     /gene_synonym="P140; SNIP"
                     /inference="alignment:Splign:2.1.0"
     exon            3665..7065
                     /gene="SRCIN1"
                     /gene_synonym="P140; SNIP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      7042..7047
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SRCIN1"
                     /gene_synonym="P140; SNIP"
                     /note="hexamer: AATAAA"
     polyA_site      7065
                     /gene="SRCIN1"
                     /gene_synonym="P140; SNIP"
                     /note="major polyA site"
ORIGIN      
        1 agacacacac tcaaacacac acacactcgc tctcgcacac tcggtgacac gcccgcgcgc
       61 gcgctcaccc acacgcccgg ccgccggcgc cctcccagct ggtccacccc ggcggggccc
      121 gcgcccccgg cccgcccgcc tggcaccgcg ccccggggct ggggccgagc gaggagcccg
      181 cgaggcggcg agagggcgag cgccaggcag gccggcccgg ggcccccgcc ccccgcgccc
      241 ccgcccgatg gggaacgctc cgtcccaaga tccggagcgg agcagccccc ccatgctgtc
      301 tgcggacgat gcggagtacc cgcgggagta ccggaccctg gggggcgggg gcggcggggg
      361 cagcgggggc cggcgcttct ccaacgtggg gctggtgcac acgtccgagc ggcggcacac
      421 ggtgatcgcg gcccagagtc tggaggcgct cagcgggctc cagaaggcgg acgccgaccg
      481 caagcgtgat gccttcatgg accacctgaa gagcaagtac ccacagcacg ccctggccct
      541 gcgaggccag caggacagga tgcgagagca gccaaactac tggagtttca agacccgcag
      601 ctcacgccac actcagggag cccagcccgg gctggcagac caggcggcaa agctgtccta
      661 cgcctccgcc gagtcgctgg agaccatgtc ggaggccgag ctgcccctgg gcttcagcag
      721 gatgaaccgc ttccgacaga gcctgcctct ctcccgctcg gccagccaga ccaagctgcg
      781 ctccccaggg gtgctgttcc tgcagttcgg ggaggagact cggcgcgtgc acatcacgca
      841 cgaggtcagc agcctggaca cgctgcacgc actcatcgcg cacatgttcc cgcagaagct
      901 caccatgggc atgcttaagt cgcccaatac cgccatcctc atcaaagacg aggctcgcaa
      961 cgtcttctac gagctggagg acgtccggga catccaggac cgcagtatta tcaagatcta
     1021 cagaaaggag cccctctacg ctgccttccc tggctcacat ctcaccaacg gggacctccg
     1081 gagagagatg gtgtacgcat cgcgggagtc ctcgcccacg cggcgcctca acaacctgtc
     1141 accagcgccg cacctggcat ccggctcgcc gccgcccggg ctgccgtcgg ggctgccgtc
     1201 cgggctgcag tccggttcgc cgtcgcgttc gcgcctatcg tacgccgggg ggcgcccgcc
     1261 ttcgtacgcc ggcagcccgg tgcaccacgc ggccgagagg ctgggaggcg ccccggccgc
     1321 ccagggcgtc agccccagcc ccagcgccat cctggagcgg cgcgacgtga agccggacga
     1381 ggacctggcg agcaaggcgg gcggcatggt gctggtgaaa ggcgagggcc tctatgctga
     1441 cccctacggg ctgctgcacg agggccgtct gagcctggcc gcggccgccg gcgacccgtt
     1501 cgcctacccg ggcgccggcg gcctctacaa gcgcggctcg gtgcgctcgc tcagcaccta
     1561 ctcggccgcc gcgctgcagt ccgatctgga ggactccctg tacaaggcgg cgggcggcgg
     1621 cggcccgctg tacggcgacg gctacggctt ccgcctgccg ccttcgtcac cgcagaagct
     1681 ggccgacgtg gcagcacccc ccggaggtcc cccgccaccg cacagcccct actcggggcc
     1741 gcccagccgc ggctcgccag tgcgccagtc cttccgcaag gactcgggct cctcgtccgt
     1801 ctttgccgag agtcctggag ggaagacccg cagcgcgggg agcgcctcga cggccggagc
     1861 tcccccttcg gagctcttcc ctgggcctgg ggaacgctcg ctggttgggt tcgggccgcc
     1921 agtgccagcc aaggacacgg agaccaggga gcgcatggag gccatggaga agcagattgc
     1981 cagcctcaca ggcctggtgc agagcgcctt actgcgaggc tctgagcctg agacccccag
     2041 cgagaagatt gaaggctcca atggagcagc caccccctca gcaccctgtg ggtcaggcgg
     2101 ccggagcagc ggggccaccc cggtgtccgg cccgcccccg ccctcggcca gcagcacccc
     2161 cgcaggtcag cctaccgccg ttagccggct gcagatgcag cttcacctgc gaggcctgca
     2221 gaacagcgcc agtgacttgc gcggccagct ccagcagttg cgcaagctcc agctacagaa
     2281 ccaggagtcg gtgcgcgcgc tgctgaagcg cacggaggca gagctgagca tgcgcgtgtc
     2341 ggaggcggcg cggcggcagg aggacccgct gcagcggcag cgcaccctgg tggaagagga
     2401 acggctgcgc tatctcaacg acgaggagct tattacccag cagctcaatg acctggagaa
     2461 atcggtggag aagatccaga gagacgtgtc ccacaaccac cggctggtgc ccggccctga
     2521 gctggaggag aaggcactgg tgctgaagca gctcggggag acgctgacag agctcaaggc
     2581 tcacttcccg ggcctgcaga gcaagatgcg ggtggtgctg cgcgtggagg tggaggcggt
     2641 gaagttcctg aaggaggagc cccagcgcct ggatgggctc ctcaagcgct gccgcggggt
     2701 cacggacacg ctggcccaga tccgaaggca agtggatgag ggtgtgtggc caccccccaa
     2761 caatctcctg agtcagtccc ccaagaaggt gacggcagag actgacttca acaagagcgt
     2821 ggacttcgaa atgccacccc ccagcccccc gctgaacctg catgagctga gcgggccagc
     2881 tgaaggagcc tctcttaccc ccaagggggg caaccccacc aaaggcctgg acactcctgg
     2941 caagagaagc gtggacaaag ctgtgtctgt tgaggctgca gagcgagact gggaggagaa
     3001 gcgggcagcc ctgacccagt acagtgccaa ggacatcaac cggctgctgg aagagacaca
     3061 ggcagagctg ctcaaggcca tccctgacct ggactgtgcc agcaaggccc atccaggccc
     3121 ggcccccact ccagatcaca agccccccaa ggccccccac ggccagaagg cagccccccg
     3181 aacggagccc agtgggagga ggggctcaga tgagttgacc gtgccccgat accgcacaga
     3241 gaagccctcc aagtcgcccc caccgccccc tccccgccgg agcttcccct cctcccatgg
     3301 cctgaccacc acacgtaccg gagaggtggt ggtcaccagc aagaaggact cggccttcat
     3361 caagaaggct gagtccgagg agctggaggt gcagaagccc caggtgaagc tgcgccgggc
     3421 tgtgtctgag gtggcccgcc cagcctccac accacccatc atggcctcgg ccatcaagga
     3481 cgaggatgac gaggatcgca tcatcgcaga gctagagagt ggcggaggca gtgtaccacc
     3541 catgaaggtg gtgactccgg gggcctctcg gctgaaggcg gcccagggcc aggcgggcag
     3601 ccccgacaaa agcaaacatg gcaagcagag ggccgagtac atgcggatcc aggcccagca
     3661 gcaggccact aaaccatcta aagagatgag cgggtcgaat gagacctcga gcccagtctc
     3721 agaaaagccc tcggcttcca gaacctctat ccctgtattg acttcctttg gggcaaggaa
     3781 ttcttccatc tccttctaga agcccctcac cccgctgccc cgcctgtccc cctccctcac
     3841 tcctgccatt tctcccctct cttccttcat ctccacccca ccccacccta ctctccagac
     3901 gccctgaggg gtgtgccctg aagaggaggg tgcggccctc ctcagcgacc cctacccatc
     3961 atctgttggt gtttttggtt ttgttttttt tttttttttt aacaattaac ttttaattat
     4021 ctttttttaa acagtaaaac taaaaaccaa acacaccacc ttccttgatc ccagctggcc
     4081 tctcgctggc cgcacctgtc acatctctcc ttcttctctt tcaccactct ttcccccagt
     4141 ccatcctgaa gctcctgcac ccccttcccg ccttcccctc acttcccaag aatactccaa
     4201 acaaactctg aaccacggag acttggagca gtgggagacc cctctcccgt ttctcgatac
     4261 cttcctggag gaacgcgggg acatcggacc aacccataca tcaagccaga gagcggggct
     4321 tagggagact ggccttggag atgccccact ccctgtctaa gctccgacaa gactgtgact
     4381 tcctctgtgg ctgctctgcc tcctcccact cacacccaag tgggcctgga gtagagacgg
     4441 acaggctgga gacgaggccg gagtttgaga ggcctcaggg tgggtgtgag gccatggagt
     4501 ctgtatccct ggggaggcgc tggcctcctg ggccttgccg tccagtgggg agtggagggc
     4561 agaggccctt tggtctgctg gctgtggagg gtgggttgca cggacagccg gatatcgggg
     4621 acactgcctt gggagagggc ggcccggacg ggtatttggt acttttagtt tcctgattta
     4681 gcactttaaa tggcattaac ttattgaatg gggatggggt gggcaagagt gaggggccta
     4741 gaaaaccagg ttttgtggct tgcagttggg ggaagggtct ggtttgaggg aaatgggagg
     4801 gtcgagaggg gcttgacggg gagcactgaa gacacctggg acccgcaggt ggggtgactt
     4861 gaacttcagt catcctcttg gcaatttgag ggttttccca ggaaaggatg agacgtagtt
     4921 tttcaatggg gctctggtga ccctggtgag atgtctgaag gtccctgagg cctgaccatc
     4981 cagccagcgc ccctggcctg tggacgccct gcctgccctg cagaggcggt tggcagtgcc
     5041 gcctggcttt tggccgggtc ctggggaggc agagagaggc caattttggt tctcactcct
     5101 ggccccccag agggcacagt gaggagccgg tagggagagg ataggagaag aggaggagga
     5161 ggagcggggt ccccggccgc aggattccca cttggagcac aaagtgaagt aagcacaggg
     5221 gagggggact agaatcagtc ccccatagca agcacagaaa ggaggagctg cgcagaaggc
     5281 agagcccccc agaccctggg gcctggctgg ggaaggtccg cacctgggga gagctgggag
     5341 ctgttgaagg tttgggggga ggggaaacgg gttgtgtttc ttcatttctt tttttgtttt
     5401 tgcctttgtt ggttcatcct tgttttctag ctttggatca tttttgtacc aaggcgagca
     5461 agcctttttg aaaaataaca aaagaggaaa aaaaaaatcc ctcctggaaa aaaaaaaaaa
     5521 ccctggaaaa tagaaaaaaa aaaaaggacc tcataaatga tgcaattact tttaattgca
     5581 ggcaactctt tacatttaag tgaagtgtct taacatttta tattgtttta aaaatatatt
     5641 tacatattat atatataata tacgtaatat aaatatatat aaatatttaa aaaagaaaaa
     5701 aaaaagaaaa ccacggcact ctccctggcc actgttttgg cgggggaggg gggctggggg
     5761 gcgggcacgt cggcctggct tctgtggtcc cagtgaaatg gtctggtttg atttggctgt
     5821 acagagaccc cctgacttgg gaggggaggg gggagtggtg ccccctcctc cctccactcc
     5881 attactctct gcttgctact tcgcttgccc ccagctccca ccctcagccc tgtgactgga
     5941 atgtgtgccc caccgtcatt gtcctgagtt gaatgtccct ttgtggggga ggtggggggg
     6001 gcagtgtcca tccacgaagg ggcagaagga gggagccacg tgccccgccc cacccgctcg
     6061 ggtgaagccc agtgggattt gcatctttct ttctctttgg ttcctgcaca tttatgggct
     6121 gggaggcatc cgtgtggaat tgcgtgcagc ctgtgtgtgt gctggcacaa gcccatgcac
     6181 tgtgtgtgca gacgcatggg gcctgcaccc acaggcatgg ccgagcacat gtgtggggga
     6241 aggcgtgggc acataggtgc atgtaacctg tttgggcatt ggcacgtgcc tacctgcatg
     6301 ttagcgtgag aggagctttg tgtgtgagaa catgtgtaat gtgtgtgcag acatgccgag
     6361 agccagagac ttgtgtgtgg gccacgtaca tgtggataga gacgcataca tggaggtgca
     6421 tgtaatctgt gtctccgagt gtgtgtgtgc aggtatgtgt gctggtgcag acccaagtgt
     6481 gtgggtgtgc ctctgtgtgc gtgtgttcca tcatccctgc accactggct ccagatccct
     6541 tcctgagccc ccgtccccgc tggccctctc acagcctgca gcacatcagt gcccccagct
     6601 gcatgcgcct cgctgctctg tccatcagtg tgtgcttgac caagagaaaa ctaagacgtc
     6661 tcgggggacc cctgtacctg gtcctctcag cccccgccca ctgtgctgtg ttactcgcat
     6721 gggggatttc ctgccccttc cacaatatgc tgtttcccca ggagcctcag gcctgaggct
     6781 ctgagtgggg tccccagggg gccccccggg gtgagccccg gctccacacc ctgccccatc
     6841 caccctgtag ggcccatgtt ggtgtagcag tgatggcttc tgtggatatt ctgtgacctc
     6901 tgtcggtgta acttgacaat ttctaaatgg aaaagggttg ctgtgttttc tctgtctctc
     6961 ttttttaatg tccttttttc ttctcccccg ctccctgctc tctttccttt tcagtttttc
     7021 tagccaagtg tttggggctt taataaaact tgtttctttt tcctc
//
