LOCUS       NM_198291               4644 bp    mRNA    linear   PRI 18-NOV-2024
DEFINITION  Homo sapiens SRC proto-oncogene, non-receptor tyrosine kinase
            (SRC), transcript variant 2, mRNA.
ACCESSION   NM_198291
VERSION     NM_198291.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4644)
  AUTHORS   Zhao,W., Ouyang,C., Zhang,L., Wang,J., Zhang,J., Zhang,Y.,
            Huang,C., Xiao,Q., Jiang,B., Lin,F., Zhang,C., Zhu,M., Xie,C.,
            Huang,X., Zhang,B., Zhao,W., He,J., Chen,S., Liu,X., Lin,D., Li,Q.
            and Wang,Z.
  TITLE     The proto-oncogene tyrosine kinase c-SRC facilitates glioblastoma
            progression by remodeling fatty acid synthesis
  JOURNAL   Nat Commun 15 (1), 7455 (2024)
   PUBMED   39198451
  REMARK    GeneRIF: The proto-oncogene tyrosine kinase c-SRC facilitates
            glioblastoma progression by remodeling fatty acid synthesis.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4644)
  AUTHORS   Moye,A.L., Dost,A.F., Ietswaart,R., Sengupta,S., Ya,V., Aluya,C.,
            Fahey,C.G., Louie,S.M., Paschini,M. and Kim,C.F.
  TITLE     Early-stage lung cancer is driven by a transitional cell state
            dependent on a KRAS-ITGA3-SRC axis
  JOURNAL   EMBO J 43 (14), 2843-2861 (2024)
   PUBMED   38755258
  REMARK    GeneRIF: Early-stage lung cancer is driven by a transitional cell
            state dependent on a KRAS-ITGA3-SRC axis.
REFERENCE   3  (bases 1 to 4644)
  AUTHORS   Huo,Z., Zhu,X., Peng,Q., Chen,C., Yang,X., Huang,C., Xiang,Y.,
            Tian,Q., Liu,J., Liu,C. and Zhang,P.
  TITLE     LINC08148 promotes the caveola-mediated endocytosis of Zika virus
            through upregulating transcription of Src
  JOURNAL   J Virol 98 (6), e0170523 (2024)
   PUBMED   38742902
  REMARK    GeneRIF: LINC08148 promotes the caveola-mediated endocytosis of
            Zika virus through upregulating transcription of Src.
REFERENCE   4  (bases 1 to 4644)
  AUTHORS   Hu,J., Cui,Z., Huang,K., Su,R. and Zhao,S.
  TITLE     Role of the GRP78-c-Src signaling pathway on osteoblast
            differentiation of periodontal ligament fibroblasts induced by
            cyclic mechanical stretch
  JOURNAL   Hua Xi Kou Qiang Yi Xue Za Zhi 42 (3), 304-312 (2024)
   PUBMED   39049649
  REMARK    GeneRIF: Role of the GRP78-c-Src signaling pathway on osteoblast
            differentiation of periodontal ligament fibroblasts induced by
            cyclic mechanical stretch.
REFERENCE   5  (bases 1 to 4644)
  AUTHORS   Ruan,Z., Lee,J., Li,Y., Du,J. and Lu,W.
  TITLE     Human pannexin 1 channel is not phosphorylated by Src tyrosine
            kinase at Tyr199 and Tyr309
  JOURNAL   Elife 13, 95118 (2024)
   PUBMED   38780416
  REMARK    GeneRIF: Human pannexin 1 channel is not phosphorylated by Src
            tyrosine kinase at Tyr199 and Tyr309.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4644)
  AUTHORS   Muller,A.J., Pendergast,A.M., Havlik,M.H., Puil,L., Pawson,T. and
            Witte,O.N.
  TITLE     A limited set of SH2 domains binds BCR through a high-affinity
            phosphotyrosine-independent interaction
  JOURNAL   Mol Cell Biol 12 (11), 5087-5093 (1992)
   PUBMED   1383690
REFERENCE   7  (bases 1 to 4644)
  AUTHORS   Alai,M., Mui,A.L., Cutler,R.L., Bustelo,X.R., Barbacid,M. and
            Krystal,G.
  TITLE     Steel factor stimulates the tyrosine phosphorylation of the
            proto-oncogene product, p95vav, in human hemopoietic cells
  JOURNAL   J Biol Chem 267 (25), 18021-18025 (1992)
   PUBMED   1381360
REFERENCE   8  (bases 1 to 4644)
  AUTHORS   Redmond,T., Brott,B.K., Jove,R. and Welsh,M.J.
  TITLE     Localization of the viral and cellular Src kinases to perinuclear
            vesicles in fibroblasts
  JOURNAL   Cell Growth Differ 3 (9), 567-576 (1992)
   PUBMED   1384654
REFERENCE   9  (bases 1 to 4644)
  AUTHORS   Cicchetti,P., Mayer,B.J., Thiel,G. and Baltimore,D.
  TITLE     Identification of a protein that binds to the SH3 region of Abl and
            is similar to Bcr and GAP-rho
  JOURNAL   Science 257 (5071), 803-806 (1992)
   PUBMED   1379745
REFERENCE   10 (bases 1 to 4644)
  AUTHORS   Hutchison,K.A., Brott,B.K., De Leon,J.H., Perdew,G.H., Jove,R. and
            Pratt,W.B.
  TITLE     Reconstitution of the multiprotein complex of pp60src, hsp90, and
            p50 in a cell-free system
  JOURNAL   J Biol Chem 267 (5), 2902-2908 (1992)
   PUBMED   1310678
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from HY016645.1, AW135290.1,
            BC051270.1, AL133293.28 and CD364525.1.
            
            On Feb 25, 2020 this sequence version replaced NM_198291.2.
            
            Summary: This gene is highly similar to the v-src gene of Rous
            sarcoma virus. This proto-oncogene may play a role in the
            regulation of embryonic development and cell growth. The protein
            encoded by this gene is a tyrosine-protein kinase whose activity
            can be inhibited by phosphorylation by c-SRC kinase. Mutations in
            this gene could be involved in the malignant progression of colon
            cancer. Two transcript variants encoding the same protein have been
            found for this gene. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. Variants 1 and 2 both encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR11853567.18954.1,
                                           SRR11853566.17358.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA1970526
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000373578.7/ ENSP00000362680.2
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-201               HY016645.1         14-214
            202-537             AW135290.1         1-336               c
            538-1579            BC051270.1         278-1319
            1580-1580           AL133293.28        24970-24970
            1581-4009           BC051270.1         1321-3749
            4010-4026           CD364525.1         19-35               c
            4027-4644           AL133293.28        27867-28484
FEATURES             Location/Qualifiers
     source          1..4644
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="20"
                     /map="20q11.23"
     gene            1..4644
                     /gene="SRC"
                     /gene_synonym="ASV; c-SRC; p60-Src; SRC1; THC6"
                     /note="SRC proto-oncogene, non-receptor tyrosine kinase"
                     /db_xref="GeneID:6714"
                     /db_xref="HGNC:HGNC:11283"
                     /db_xref="MIM:190090"
     exon            1..116
                     /gene="SRC"
                     /gene_synonym="ASV; c-SRC; p60-Src; SRC1; THC6"
                     /inference="alignment:Splign:2.1.0"
     exon            117..190
                     /gene="SRC"
                     /gene_synonym="ASV; c-SRC; p60-Src; SRC1; THC6"
                     /inference="alignment:Splign:2.1.0"
     exon            191..358
                     /gene="SRC"
                     /gene_synonym="ASV; c-SRC; p60-Src; SRC1; THC6"
                     /inference="alignment:Splign:2.1.0"
     exon            359..612
                     /gene="SRC"
                     /gene_synonym="ASV; c-SRC; p60-Src; SRC1; THC6"
                     /inference="alignment:Splign:2.1.0"
     CDS             363..1973
                     /gene="SRC"
                     /gene_synonym="ASV; c-SRC; p60-Src; SRC1; THC6"
                     /EC_number="2.7.10.2"
                     /note="tyrosine-protein kinase SRC-1; tyrosine kinase
                     pp60c-src; protooncogene SRC, Rous sarcoma; proto-oncogene
                     c-Src; v-src avian sarcoma (Schmidt-Ruppin A-2) viral
                     oncogene homolog"
                     /codon_start=1
                     /product="proto-oncogene tyrosine-protein kinase Src"
                     /protein_id="NP_938033.1"
                     /db_xref="CCDS:CCDS13294.1"
                     /db_xref="GeneID:6714"
                     /db_xref="HGNC:HGNC:11283"
                     /db_xref="MIM:190090"
                     /translation="MGSNKSKPKDASQRRRSLEPAENVHGAGGGAFPASQTPSKPASA
                     DGHRGPSAAFAPAAAEPKLFGGFNSSDTVTSPQRAGPLAGGVTTFVALYDYESRTETD
                     LSFKKGERLQIVNNTEGDWWLAHSLSTGQTGYIPSNYVAPSDSIQAEEWYFGKITRRE
                     SERLLLNAENPRGTFLVRESETTKGAYCLSVSDFDNAKGLNVKHYKIRKLDSGGFYIT
                     SRTQFNSLQQLVAYYSKHADGLCHRLTTVCPTSKPQTQGLAKDAWEIPRESLRLEVKL
                     GQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVSE
                     EPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRA
                     ANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWS
                     FGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHDLMCQCWRKEPEE
                     RPTFEYLQAFLEDYFTSTEPQYQPGENL"
     exon            613..712
                     /gene="SRC"
                     /gene_synonym="ASV; c-SRC; p60-Src; SRC1; THC6"
                     /inference="alignment:Splign:2.1.0"
     exon            713..811
                     /gene="SRC"
                     /gene_synonym="ASV; c-SRC; p60-Src; SRC1; THC6"
                     /inference="alignment:Splign:2.1.0"
     exon            812..915
                     /gene="SRC"
                     /gene_synonym="ASV; c-SRC; p60-Src; SRC1; THC6"
                     /inference="alignment:Splign:2.1.0"
     exon            916..1065
                     /gene="SRC"
                     /gene_synonym="ASV; c-SRC; p60-Src; SRC1; THC6"
                     /inference="alignment:Splign:2.1.0"
     exon            1066..1221
                     /gene="SRC"
                     /gene_synonym="ASV; c-SRC; p60-Src; SRC1; THC6"
                     /inference="alignment:Splign:2.1.0"
     exon            1222..1401
                     /gene="SRC"
                     /gene_synonym="ASV; c-SRC; p60-Src; SRC1; THC6"
                     /inference="alignment:Splign:2.1.0"
     exon            1402..1478
                     /gene="SRC"
                     /gene_synonym="ASV; c-SRC; p60-Src; SRC1; THC6"
                     /inference="alignment:Splign:2.1.0"
     exon            1479..1632
                     /gene="SRC"
                     /gene_synonym="ASV; c-SRC; p60-Src; SRC1; THC6"
                     /inference="alignment:Splign:2.1.0"
     exon            1633..1764
                     /gene="SRC"
                     /gene_synonym="ASV; c-SRC; p60-Src; SRC1; THC6"
                     /inference="alignment:Splign:2.1.0"
     exon            1765..4644
                     /gene="SRC"
                     /gene_synonym="ASV; c-SRC; p60-Src; SRC1; THC6"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3989..3994
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SRC"
                     /gene_synonym="ASV; c-SRC; p60-Src; SRC1; THC6"
                     /note="hexamer: ATTAAA"
     polyA_site      4009
                     /gene="SRC"
                     /gene_synonym="ASV; c-SRC; p60-Src; SRC1; THC6"
                     /note="major polyA site"
     regulatory      4619..4624
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SRC"
                     /gene_synonym="ASV; c-SRC; p60-Src; SRC1; THC6"
                     /note="hexamer: ATTAAA"
     polyA_site      4644
                     /gene="SRC"
                     /gene_synonym="ASV; c-SRC; p60-Src; SRC1; THC6"
ORIGIN      
        1 attccggcct gggagccgga gcggccaggc cgccgtctgc ccgtcccgct ggacgtcccg
       61 cggtccgccc tcccgtgcgt ccgtctgccg gtgagcccgc ccgcccgccg gcccagaaca
      121 gagaacagaa gctcagagaa gtgaagcaac ttgcccagct atgagagaca gagccaggat
      181 ttgaaaccag atgaggacgc tgaggcccag agagggaaag ccacttgcct agggacacac
      241 agcggggaga ggtggagcag ggcctctatt tcgagacccc tgactccaca cctggtgttt
      301 gtgccaagac cccaggctgc ctcccaggtc ctctgggaca gcccctgcct tctaccagga
      361 ccatgggtag caacaagagc aagcccaagg atgccagcca gcggcgccgc agcctggagc
      421 ccgccgagaa cgtgcacggc gctggcgggg gcgctttccc cgcctcgcag acccccagca
      481 agccagcctc ggccgacggc caccgcggcc ccagcgcggc cttcgccccc gcggccgccg
      541 agcccaagct gttcggaggc ttcaactcct cggacaccgt cacctccccg cagagggcgg
      601 gcccgctggc cggtggagtg accacctttg tggccctcta tgactatgag tctaggacgg
      661 agacagacct gtccttcaag aaaggcgagc ggctccagat tgtcaacaac acagagggag
      721 actggtggct ggcccactcg ctcagcacag gacagacagg ctacatcccc agcaactacg
      781 tggcgccctc cgactccatc caggctgagg agtggtattt tggcaagatc accagacggg
      841 agtcagagcg gttactgctc aatgcagaga acccgagagg gaccttcctc gtgcgagaaa
      901 gtgagaccac gaaaggtgcc tactgcctct cagtgtctga cttcgacaac gccaagggcc
      961 tcaacgtgaa gcactacaag atccgcaagc tggacagcgg cggcttctac atcacctccc
     1021 gcacccagtt caacagcctg cagcagctgg tggcctacta ctccaaacac gccgatggcc
     1081 tgtgccaccg cctcaccacc gtgtgcccca cgtccaagcc gcagactcag ggcctggcca
     1141 aggatgcctg ggagatccct cgggagtcgc tgcggctgga ggtcaagctg ggccagggct
     1201 gctttggcga ggtgtggatg gggacctgga acggtaccac cagggtggcc atcaaaaccc
     1261 tgaagcctgg cacgatgtct ccagaggcct tcctgcagga ggcccaggtc atgaagaagc
     1321 tgaggcatga gaagctggtg cagttgtatg ctgtggtttc agaggagccc atttacatcg
     1381 tcacggagta catgagcaag gggagtttgc tggactttct caagggggag acaggcaagt
     1441 acctgcggct gcctcagctg gtggacatgg ctgctcagat cgcctcaggc atggcgtacg
     1501 tggagcggat gaactacgtc caccgggacc ttcgtgcagc caacatcctg gtgggagaga
     1561 acctggtgtg caaagtggcg gactttgggc tggctcggct cattgaagac aatgagtaca
     1621 cggcgcggca aggtgccaaa ttccccatca agtggacggc tccagaagct gccctctatg
     1681 gccgcttcac catcaagtcg gacgtgtggt ccttcgggat cctgctgact gagctcacca
     1741 caaagggacg ggtgccctac cctgggatgg tgaaccgcga ggtgctggac caggtggagc
     1801 ggggctaccg gatgccctgc ccgccggagt gtcccgagtc cctgcacgac ctcatgtgcc
     1861 agtgctggcg gaaggagcct gaggagcggc ccaccttcga gtacctgcag gccttcctgg
     1921 aggactactt cacgtccacc gagccccagt accagcccgg ggagaacctc taggcacagg
     1981 cgggcccaga ccggcttctc ggcttggatc ctgggctggg tggcccctgt ctcggggctt
     2041 gccccactct gcctgcctgc tgttggtcct ctctctgtgg ggctgaattg ccaggggcga
     2101 ggcccttcct ctttggtggc atggaagggg cttctggacc tagggtggcc tgagagggcg
     2161 gtgggtatgc gagaccagca cggtgactct gtccagctcc cgctgtggcc gcacgcctct
     2221 ccctgcactc cctcctggag ctctgtgggt ctctggaaga ggaaccagga gaagggctgg
     2281 ggccggggct gagggtgccc ttttccagcc tcagcctact ccgctcactg aactccttcc
     2341 ccacttctgt gccacccccg gtctatgtcg agagctggcc aaagagcctt tccaaagagg
     2401 agcgatgggc ccctggcccc gcctgcctgc caccctgccc cttgccatcc attctggaaa
     2461 cacctgtagg cagaggctgc cgagacagac cctctgccgc tgcttccagg ctgggcagca
     2521 caaggccttg cctggcctga tgatggtggg tgggtgggat gagtaccccc tcaaaccctg
     2581 ccctccttag acctgaggga cccttcgaga tcatcacttc cttgccccca tttcacccat
     2641 ggggagacag ttgagagcgg ggatgtgaca tgcccaaggc cacggagcag ttcagagtgg
     2701 aggcgggctt ggaacccggt gctccctctg tcatcctcag gaaccaacaa ttcgtcggag
     2761 gcatcatgga aagactggga cagcccagga aacaaggggt ctgaggatgc attcgagatg
     2821 gcagattccc actgccgctg cccgctcagc ccagctgttg ggaacagcat ggaggcagat
     2881 gtggggctga gctggggaat cagggtaaaa ggtgcaggtg tggagagaga ggcttcaatc
     2941 ggcttgtggg tgatgtttga ccttcagagc cagccggcta tgaaagggag cgagcccctc
     3001 ggctctggag gcaatcaagc agacatagaa gagccaagag tccaggaggc cctggtcctg
     3061 gcctccttcc ccgtactttg tcccgtggca tttcaattcc tggccctgtt ctcctcccca
     3121 agtcggcacc ctttaactca tgaggaggga aaagagtgcc taagcggggg tgaaagagga
     3181 cgtgttaccc actgccatgc accaggactg gctgtgtaac cttgggtggc ccctgctgtc
     3241 tctctgggct gcagagtctg ccccacatgt ggccatggcc tctgcaactg ctcagctctg
     3301 gtccaggccc tgtggcagga cacacatggt gagcctagcc ctgggacatc aggagactgg
     3361 gctctggctc tgttcggcct ttgggtgtgt ggtggattct ccctgggcct cagtgtgccc
     3421 atctgtaaag gggcagctga cagtttgtgg catcttgcca agggtccctg tgtgtgtgta
     3481 tgtgtgtgca tgtgtgcgtg tctccatgtg cgtccatatt taacatgtaa aaatgtcccc
     3541 cccgctccgt cccccaaaca tgttgtacat ttcaccatgg ccccctcatc atagcaataa
     3601 cattcccact gccaggggtt cttgagccag ccaggccctg ccagtgggga aggaggccaa
     3661 gcagtgcctg cctatgaaat ttcaactttt cctttcatac gtctttatta cccaagtctt
     3721 ctcccgtcca ttccagtcaa atctgggctc actcacccca gcgagctctc aaatccctct
     3781 ccaactgcct aaggcccttt gtgtaaggtg tcttaatact gtcctttttt tttttttaac
     3841 agtgttttgt agatttcaga tgactatgca gaggcctggg ggacccctgg ctctgggccg
     3901 ggcctggggc tccgaaattc caaggcccag acttgcgggg ggtggggggg tatccagaat
     3961 tggttgtaaa tactttgcat attgtctgat taaacacaaa cagacctcag aatctgatca
     4021 acagtttatt gaacatctac tgtgtgctgg aaagcgagat ggggcggaat gcgagaacaa
     4081 actacccctt gaggggtctt tgggcagcac tagtagctgg agggcttcag gccaaggcag
     4141 gggtgacatc agattggaga cagctacggc agaatgtggc tgtttgtgaa catctgcacc
     4201 tgtgttaggg ggtgagcacc tgggagaagg acaaggcaca tcacaggact tccctgagca
     4261 tgacaagttc aggactcaaa tgtccgtggt ggatggtagc agtgacattg gggagtgggt
     4321 ggggctgtca agcctgccta gaggagatca caaatacacg acgagaatac cgttgtgtgt
     4381 gctcttcgtg tgtttcctag gagtgcaggg caggggtgct gggtcgatcc acaaaagtcc
     4441 tgaaaacgct gaagaaaaat ccaaagaccc ttcccctcct ccctccttcc ccaccaccga
     4501 agcacacagt cttgaaggtt gatttgcaac cgtctataca aacacattta ttttacacaa
     4561 atatacatca gatcacacac ctgtgcaccg gagtcaactc tggccacgac attgcttaat
     4621 taaaaacaaa tttcaaaaac tgga
//
