LOCUS       NM_178840               3039 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens steroid receptor associated and regulated protein
            (SRARP), mRNA.
ACCESSION   NM_178840
VERSION     NM_178840.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3039)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 3039)
  AUTHORS   Naderi,A.
  TITLE     Steroid receptor-associated and regulated protein is a biomarker in
            predicting the clinical outcome and treatment response in
            malignancies
  JOURNAL   Cancer Rep (Hoboken) 3 (5), e1267 (2020)
   PUBMED   32706923
  REMARK    GeneRIF: Steroid receptor-associated and regulated protein is a
            biomarker in predicting the clinical outcome and treatment response
            in malignancies.
REFERENCE   3  (bases 1 to 3039)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   4  (bases 1 to 3039)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 3039)
  AUTHORS   Naderi,A.
  TITLE     SRARP and HSPB7 are epigenetically regulated gene pairs that
            function as tumor suppressors and predict clinical outcome in
            malignancies
  JOURNAL   Mol Oncol 12 (5), 724-755 (2018)
   PUBMED   29577611
  REMARK    GeneRIF: SRARP and HSPB7 are tumor suppressors that are commonly
            inactivated in malignancies.
REFERENCE   6  (bases 1 to 3039)
  AUTHORS   Naderi,A.
  TITLE     C1orf64 is a novel androgen receptor target gene and coregulator
            that interacts with 14-3-3 protein in breast cancer
  JOURNAL   Oncotarget 8 (34), 57907-57933 (2017)
   PUBMED   28915724
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 3039)
  AUTHORS   Luo,A. and Zhang,X.
  TITLE     ERRF is essential for Estrogen-Estrogen Receptor alpha signaling
            pathway in ER positive breast cancer cells
  JOURNAL   Biochem Biophys Res Commun 474 (2), 400-405 (2016)
   PUBMED   27125460
  REMARK    GeneRIF: Further mechanism study proved ERRF to be an interacting
            partner of ERalpha. In total, these data revealed that ERRF is
            essential for the activity of E2-ERalpha pathway.
REFERENCE   8  (bases 1 to 3039)
  AUTHORS   Su,D., Fu,X., Fan,S., Wu,X., Wang,X.X., Fu,L., Dong,X.Y., Ni,J.J.,
            Fu,L., Zhu,Z. and Dong,J.T.
  TITLE     Role of ERRF, a novel ER-related nuclear factor, in the growth
            control of ER-positive human breast cancer cells
  JOURNAL   Am J Pathol 180 (3), 1189-1201 (2012)
   PUBMED   22341523
  REMARK    GeneRIF: These results suggest that ERRF plays a role in
            estrogen-ER-mediated growth of breast cancer cells.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA387602.1, AI732325.1, AW299952.1 and AL355994.11.
            
            On May 17, 2019 this sequence version replaced NM_178840.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK127425.1, SRR7346977.777561.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968189, SAMEA1968832
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000329454.2/ ENSP00000332162.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-580               DA387602.1         1-580
            581-885             AI732325.1         39-343              c
            886-927             AW299952.1         8-49                c
            928-3039            AL355994.11        37924-40035
FEATURES             Location/Qualifiers
     source          1..3039
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p36.13"
     gene            1..3039
                     /gene="SRARP"
                     /gene_synonym="C1orf64; ERRF"
                     /note="steroid receptor associated and regulated protein"
                     /db_xref="GeneID:149563"
                     /db_xref="HGNC:HGNC:28339"
                     /db_xref="MIM:619448"
     exon            1..150
                     /gene="SRARP"
                     /gene_synonym="C1orf64; ERRF"
                     /inference="alignment:Splign:2.1.0"
     CDS             69..578
                     /gene="SRARP"
                     /gene_synonym="C1orf64; ERRF"
                     /note="ER-related factor; uncharacterized protein C1orf64;
                     steroid receptor-regulated protein; estrogen
                     receptor-related factor"
                     /codon_start=1
                     /product="steroid receptor-associated and regulated
                     protein"
                     /protein_id="NP_849162.1"
                     /db_xref="CCDS:CCDS166.1"
                     /db_xref="GeneID:149563"
                     /db_xref="HGNC:HGNC:28339"
                     /db_xref="MIM:619448"
                     /translation="MAPSEDPRDWRANLKGTIRETGLETSSGGKLAGHQKTVPTAHLT
                     FVIDCTHGKQLSLAATASPPQAPSPNRGLVTPPMKTYIVFCGENWPHLTRVTPMGGGC
                     LAQARATLPLCRGSVASASFPVSPLCPQEVPEAKGKPVKAAPVRSSTWGTVKDSLKAL
                     SSCVCGQAD"
     exon            151..3039
                     /gene="SRARP"
                     /gene_synonym="C1orf64; ERRF"
                     /inference="alignment:Splign:2.1.0"
     regulatory      880..885
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SRARP"
                     /gene_synonym="C1orf64; ERRF"
                     /note="hexamer: AATAAA"
     regulatory      884..889
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SRARP"
                     /gene_synonym="C1orf64; ERRF"
                     /note="hexamer: AATAAA"
     polyA_site      898
                     /gene="SRARP"
                     /gene_synonym="C1orf64; ERRF"
     regulatory      901..906
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SRARP"
                     /gene_synonym="C1orf64; ERRF"
                     /note="hexamer: AATAAA"
     polyA_site      909
                     /gene="SRARP"
                     /gene_synonym="C1orf64; ERRF"
     polyA_site      927
                     /gene="SRARP"
                     /gene_synonym="C1orf64; ERRF"
                     /note="major polyA site"
     regulatory      1388..1393
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SRARP"
                     /gene_synonym="C1orf64; ERRF"
                     /note="hexamer: AATAGA"
     polyA_site      1417
                     /gene="SRARP"
                     /gene_synonym="C1orf64; ERRF"
ORIGIN      
        1 acatcctgga agagtggcct aggacagctc ctctcctgcc agagctaggc aggcgccgaa
       61 gtagccgcat ggccccgtca gaagacccca gggactggag agccaacctc aaaggcacca
      121 tccgtgagac aggcctggag accagctccg gtgggaagct ggctggccat cagaagaccg
      181 tccccacggc tcacctgact tttgttattg actgcaccca cgggaagcag ctctccctgg
      241 cagcaaccgc atcaccaccc caagccccca gtcccaatcg agggcttgtc accccaccaa
      301 tgaagaccta catcgtgttc tgtggggaaa actggcccca tctgactcgg gtgaccccca
      361 tgggtggggg atgccttgcc caggccaggg ccaccctgcc gctctgcaga gggtctgtgg
      421 cctcagcttc cttcccagtc agcccgctct gcccccagga ggttcccgag gctaagggga
      481 aacccgtgaa ggctgcgcct gtgaggtctt caacttgggg aacagtcaag gactcactga
      541 aagccctctc ctcttgtgtc tgtgggcagg ccgattagct ggaagggccg ggctctgatg
      601 cccagaggct gcaattccca gggcctggcc ctgcttcccc agctaagcag gagtcttttg
      661 tgcttgagcc aaggaaacat cattagatcc gctaaggggc atctgaaaca tccgtcgagt
      721 ggcagaggca ggataagtca cctgcacatg aagagactca ttcattcata cagcaaatat
      781 tactggtaca tcttccacat gccaggccct gcaaagtgct ggggagatac catggttttc
      841 ctggagctgg tatttttggg gtggagggaa cccaccctga ataaataaag taacccaata
      901 aataaagaag atgattttga acagcgatga atgctctgca ggaactgaaa caggatgcta
      961 gagggagagt gattggggtg aagacctttc ctgatgcagt gcttggtaag ggcctctctg
     1021 cgcaggcaac aaagtgtgat ctaaaagatg agaaggggcc agccctgaga aaatccaccc
     1081 tccccagggc cacctgctgt catcttaccc cagggcaggc cagagcagtg gtcagaatgc
     1141 cccagcatga cggggagggg caacgggttt cttgctgcca tcttggctca gaggcgagtg
     1201 tgtaggtcac tgcaaaggca ggggatacca cgtggggaga ctcgagggcc atgccagttg
     1261 gggctgggag gctcagggaa gttggctcca ggagactcca tcccataagg cagcccaggt
     1321 gggacctggg gatctgagat gggaaataag gggatctggc ttctcaaaag ggagggaggt
     1381 actcaaaaat agagtatcat gtttgaacga atgaaaacaa gacatgttat ttattgagca
     1441 tctactgcat accaggctca tgctgccctc tagggatagc aaaaaaaaaa aaaaaaggtg
     1501 gggggaggag gttcacccct cagggcaatc gtgttccctg agcaggaggt ggagttactg
     1561 gtgtgggtgt gaaggtgtct gtgagtctaa ggcatgcaca gcactgtgag aaaccctaaa
     1621 gcaacctatt taaggaagtc agtctcaaag ctcccagata aaaatcactg ggtttttctg
     1681 tatttatttt agagacagag tctcactcta tcacccaggc tggagtgcag tggaacaatc
     1741 acagctcact gcagcctcaa actcctgggc tcaagtgatc ctcctgcctc agcctcccga
     1801 gtagctgaga ctataggtgc accactacgc ccagcttgac ttcttttagt agagaagagg
     1861 tctcactgtg ctgcccaggc tggtcttgaa ctcctggcct caagctatcc tcccgcttca
     1921 gcttccctaa gtgcttggat tataggtgtg agccaccgta tctggtcatt aatttattca
     1981 atgactattt tactaggttc ctacaaatac tagctgctaa catttaacat gtaattgacc
     2041 atttactctg tgtcagagaa acaacatggg cactgtattt gtgaccattt tatagattag
     2101 agagctgagg cacagagagg ttgaagaatg gactcaaagt tccatagact ggtaccattg
     2161 agattagaac tcaggcaagt ctggtgccca tattcttgct tgtaactgta aggtatatac
     2221 cctctcatcc tggtagcgtc tcttctaggc agaggggaca cacagaggat aaatgtaacc
     2281 ctgtcctcaa ggagctcaca gccaggtggg ggaggccaga aagaaagcac acaattgcca
     2341 tagcttctga gaagtgcaac agtaagggca acacagaatg atgctggagg acaaccagcc
     2401 cactctagag agaggagatc agggaggact tcctgcagga agtgatgccg aaaatgagat
     2461 ctgaccggtg actaagctat acaaaagggt ggggtggggg agcaagtggg gagtgctctg
     2521 ggcagaagga ccagtcgttc agtctggcta gggtaattgt cattcattca tttattcacc
     2581 aagtatttat tgggcatcca ctgaatgcca ggctttgggc taaaccatga gatggagcaa
     2641 tgaataagac aatgaggccc agccacaaaa tagtttatcc tctagttggg ggagacaggc
     2701 aatgcacaca cacaaaacaa acagatcaga aaggtggcag gaggccaggc gcggtggctc
     2761 atgcctgtaa tcccagcact ttgggaggcc aaggaggggg aggcgggggg agatcacctg
     2821 aggtcaggag ttcgagacca gcctggccaa cttggcgaaa acccgtctct actaaaaata
     2881 taaaaattag ctgggcgtgg tggtgggcac ctataatccc agctacttgg gaagctgagg
     2941 tgagagaatt gcttgaacct agaaggcaga ggttgcagtg agccgagatc tcgccactgc
     3001 actccggcct gggtgacaga gcaagagcaa gactgtctc
//
