LOCUS       NM_001035235            1328 bp    mRNA    linear   PRI 27-NOV-2024
DEFINITION  Homo sapiens steroid receptor RNA activator 1 (SRA1), transcript
            variant 1, mRNA.
ACCESSION   NM_001035235 XR_000132
VERSION     NM_001035235.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1328)
  AUTHORS   Yang,X., Jia,R., Hu,F., Fan,W., Lin,T., Zhang,X., Xu,C., Ruan,S.,
            Jiang,C., Li,Y., Pan,C., Yang,Y., Hu,L., Chen,Q. and Liu,W.T.
  TITLE     Promoting AMPK/SR-A1-mediated clearance of HMGB1 attenuates
            chemotherapy-induced peripheral neuropathy
  JOURNAL   Cell Commun Signal 21 (1), 99 (2023)
   PUBMED   37143083
  REMARK    GeneRIF: Promoting AMPK/SR-A1-mediated clearance of HMGB1
            attenuates chemotherapy-induced peripheral neuropathy.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1328)
  AUTHORS   Kochumon,S., Arefanian,H., Sindhu,S., Thomas,R., Jacob,T.,
            Al-Sayyar,A., Shenouda,S., Al-Rashed,F., Koistinen,H.A.,
            Al-Mulla,F., Tuomilehto,J. and Ahmad,R.
  TITLE     Expression of Steroid Receptor RNA Activator 1 (SRA1) in the
            Adipose Tissue Is Associated with TLRs and IRFs in Diabesity
  JOURNAL   Cells 11 (24), 4007 (2022)
   PUBMED   36552771
  REMARK    GeneRIF: Expression of Steroid Receptor RNA Activator 1 (SRA1) in
            the Adipose Tissue Is Associated with TLRs and IRFs in Diabesity.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1328)
  AUTHORS   Novikova,I.V., Hennelly,S.P. and Sanbonmatsu,K.Y.
  TITLE     Structural architecture of the human long non-coding RNA, steroid
            receptor RNA activator
  JOURNAL   Nucleic Acids Res 40 (11), 5034-5051 (2012)
   PUBMED   22362738
  REMARK    GeneRIF: A report of the first experimentally derived secondary
            structure of a human lncRNA, the steroid receptor RNA activator.
REFERENCE   4  (bases 1 to 1328)
  AUTHORS   Colley,S.M. and Leedman,P.J.
  TITLE     Steroid Receptor RNA Activator - A nuclear receptor coregulator
            with multiple partners: Insights and challenges
  JOURNAL   Biochimie 93 (11), 1966-1972 (2011)
   PUBMED   21807064
  REMARK    Review article
REFERENCE   5  (bases 1 to 1328)
  AUTHORS   Cooper,C., Vincett,D., Yan,Y., Hamedani,M.K., Myal,Y. and Leygue,E.
  TITLE     Steroid Receptor RNA Activator bi-faceted genetic system: Heads or
            Tails?
  JOURNAL   Biochimie 93 (11), 1973-1980 (2011)
   PUBMED   21771633
  REMARK    Review article
REFERENCE   6  (bases 1 to 1328)
  AUTHORS   Chooniedass-Kothari,S., Hamedani,M.K., Troup,S., Hube,F. and
            Leygue,E.
  TITLE     The steroid receptor RNA activator protein is expressed in breast
            tumor tissues
  JOURNAL   Int J Cancer 118 (4), 1054-1059 (2006)
   PUBMED   16152589
  REMARK    GeneRIF: data suggest that the presence of both coding SRA RNA and
            its corresponding SRAP modifies the activity of estrogen receptor
            in breast cancer cells and that SRAP could be a new clinical marker
            for breast cancer
REFERENCE   7  (bases 1 to 1328)
  AUTHORS   Murphy,L.C., Simon,S.L., Parkes,A., Leygue,E., Dotzlaw,H.,
            Snell,L., Troup,S., Adeyinka,A. and Watson,P.H.
  TITLE     Altered expression of estrogen receptor coregulators during human
            breast tumorigenesis
  JOURNAL   Cancer Res 60 (22), 6266-6271 (2000)
   PUBMED   11103781
REFERENCE   8  (bases 1 to 1328)
  AUTHORS   Leygue,E., Dotzlaw,H., Watson,P.H. and Murphy,L.C.
  TITLE     Expression of the steroid receptor RNA activator in human breast
            tumors
  JOURNAL   Cancer Res 59 (17), 4190-4193 (1999)
   PUBMED   10485452
REFERENCE   9  (bases 1 to 1328)
  AUTHORS   Lanz,R.B., McKenna,N.J., Onate,S.A., Albrecht,U., Wong,J.,
            Tsai,S.Y., Tsai,M.J. and O'Malley,B.W.
  TITLE     A steroid receptor coactivator, SRA, functions as an RNA and is
            present in an SRC-1 complex
  JOURNAL   Cell 97 (1), 17-27 (1999)
   PUBMED   10199399
REFERENCE   10 (bases 1 to 1328)
  AUTHORS   Balasubramanian,R. and Crowley,W.F. Jr.
  TITLE     Isolated Gonadotropin-Releasing Hormone (GnRH) Deficiency
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301509
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC011399.6 and BC040043.2.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Jun 12, 2020 this sequence version replaced NM_001035235.3.
            
            Summary: Both long non-coding and protein-coding RNAs are
            transcribed from this gene, and they represent alternatively
            spliced transcript variants. This gene was initially defined as a
            non-coding RNA, which is a coactivator for several nuclear
            receptors (NRs) and is associated with breast cancer. It has now
            been found that this gene is involved in the regulation of many NR
            and non-NR activities, including metabolism, adipogenesis and
            chromatin organization. The long non-coding RNA transcripts
            interact with a variety of proteins, including the protein encoded
            by this gene. The encoded protein acts as a transcriptional
            repressor by binding to the non-coding RNA. [provided by RefSeq,
            Mar 2012].
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189655.219059.1, AK054960.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match              :: ENST00000336283.9/
                                               ENSP00000337513.6
            multifunctional gene product(s) :: PMID: 21771633
            RefSeq Select criteria          :: based on manual assertion,
                                               conservation, expression,
                                               longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-46                AC011399.6         8418-8463
            47-71               AC011399.6         8619-8643
            72-890              BC040043.2         24-842
            891-1328            AC011399.6         15386-15823
FEATURES             Location/Qualifiers
     source          1..1328
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q31.3"
     gene            1..1328
                     /gene="SRA1"
                     /gene_synonym="pp7684; SRA; SRAP; STRAA1"
                     /note="steroid receptor RNA activator 1"
                     /db_xref="GeneID:10011"
                     /db_xref="HGNC:HGNC:11281"
                     /db_xref="MIM:603819"
     exon            1..46
                     /gene="SRA1"
                     /gene_synonym="pp7684; SRA; SRAP; STRAA1"
                     /inference="alignment:Splign:2.1.0"
     CDS             22..696
                     /gene="SRA1"
                     /gene_synonym="pp7684; SRA; SRAP; STRAA1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     steroid receptor coactivator; steroid receptor RNA
                     activator 1 (complexes with NCOA1); steroid receptor RNA
                     activator protein; lncRNA SRA"
                     /codon_start=1
                     /product="steroid receptor RNA activator 1 isoform 1"
                     /protein_id="NP_001030312.3"
                     /db_xref="CCDS:CCDS34245.2"
                     /db_xref="GeneID:10011"
                     /db_xref="HGNC:HGNC:11281"
                     /db_xref="MIM:603819"
                     /translation="MAELYVKPGNKERGWNDPPQFSYGLQTQAGGPRRSLLTKRVAAP
                     QDGSPRVPASETSPGPPPMGPPPPSSKAPRSPPVGSGPASGVEPTSFPVESEAVMEDV
                     LRPLEQALEDCRGHTRKQVCDDISRRLALLQEQWAGGKLSIPVKKRMALLVQELSSHR
                     WDAADDIHRSLMVDHVTEVSQWMVGVKRLIAEKRSLFSEEAANEEKSAATAEKNHTIP
                     GFQQAS"
     exon            47..172
                     /gene="SRA1"
                     /gene_synonym="pp7684; SRA; SRAP; STRAA1"
                     /inference="alignment:Splign:2.1.0"
     exon            173..375
                     /gene="SRA1"
                     /gene_synonym="pp7684; SRA; SRAP; STRAA1"
                     /inference="alignment:Splign:2.1.0"
     exon            376..484
                     /gene="SRA1"
                     /gene_synonym="pp7684; SRA; SRAP; STRAA1"
                     /inference="alignment:Splign:2.1.0"
     exon            485..1328
                     /gene="SRA1"
                     /gene_synonym="pp7684; SRA; SRAP; STRAA1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      870..875
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SRA1"
                     /gene_synonym="pp7684; SRA; SRAP; STRAA1"
                     /note="hexamer: AATAAA"
     polyA_site      890
                     /gene="SRA1"
                     /gene_synonym="pp7684; SRA; SRAP; STRAA1"
                     /note="major polyA site"
     polyA_site      927
                     /gene="SRA1"
                     /gene_synonym="pp7684; SRA; SRAP; STRAA1"
     regulatory      1312..1317
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SRA1"
                     /gene_synonym="pp7684; SRA; SRAP; STRAA1"
                     /note="hexamer: AACAAA"
     polyA_site      1317
                     /gene="SRA1"
                     /gene_synonym="pp7684; SRA; SRAP; STRAA1"
     polyA_site      1328
                     /gene="SRA1"
                     /gene_synonym="pp7684; SRA; SRAP; STRAA1"
ORIGIN      
        1 gctggccaag cggaagtgga gatggcggag ctgtacgtga agccgggcaa caaggaacgc
       61 ggctggaacg acccgccgca gttctcatac gggctgcaga cccaggccgg cggacccagg
      121 cgctcgctgc ttaccaagag ggtcgccgca ccccaggatg gatcccccag agtccccgca
      181 tcagagactt ctcctgggcc tcccccaatg gggcctccac ctccttcaag taaggctccc
      241 aggtccccac ctgtggggag tggtcctgcc tctggcgtgg agcccacaag tttcccagtc
      301 gagtctgagg ctgtgatgga ggatgtgctg agacctttgg aacaggcatt ggaagactgc
      361 cgtggccaca caaggaagca ggtatgtgat gacatcagcc gacgcctggc actgctgcag
      421 gaacagtggg ctggaggaaa gttgtcaata cctgtaaaga agagaatggc tctactggtg
      481 caagagcttt caagccaccg gtgggacgca gcagatgaca tccaccgctc cctcatggtt
      541 gaccatgtga ctgaggtcag tcagtggatg gtaggagtta aaagattaat tgcagaaaag
      601 aggagtctgt tttcagagga ggcagccaat gaagagaaat ctgcagccac agctgagaag
      661 aaccatacca taccaggctt ccagcaggct tcataatcct cggttcccca gactcaccgg
      721 acaccatctc ctatgccttg gagaccttct gtcacttggc tcccttctta ccaccaccaa
      781 gactgtccca ctgggcctga cccacctatg agggaagaag tcccacctgg gccagaggga
      841 gttcatgtgt tactcataac atgcatttca ataaaaacat ctctgcggtg ggccttgggt
      901 aggagagatg aacccttccg gtgccaagct agtcccctct ggtgtcctcg actgccctgc
      961 tccctgtgta tctgcaaacc tctgttctcc cttctccatt catcaggaag ggatctgctg
     1021 ggtaaagtca gactactgcc taccactttt tcccaaagta gactgaaagc acatcctgtg
     1081 ctgggcggag cagctgtgtt tggatggttt catttcagca tgagaacaga ctcaaataga
     1141 acggggagac ttttccctca acaaaaggaa agacagtcct atttgcactg tatcaccctt
     1201 gagatactac tgttacagag attagaacca cattgagtgg ggttttctgt gtaaatcgaa
     1261 ggagaaaaag accagattac tgagattggg gattgtaact ctgacttgcc aaacaaactg
     1321 ctgcctca
//
