LOCUS       NM_032567               1841 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens spermatogenic leucine zipper 1 (SPZ1), mRNA.
ACCESSION   NM_032567
VERSION     NM_032567.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1841)
  AUTHORS   Goos,H., Kinnunen,M., Salokas,K., Tan,Z., Liu,X., Yadav,L.,
            Zhang,Q., Wei,G.H. and Varjosalo,M.
  TITLE     Human transcription factor protein interaction networks
  JOURNAL   Nat Commun 13 (1), 766 (2022)
   PUBMED   35140242
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1841)
  AUTHORS   Xiao,C., Lv,C., Sun,S., Zhao,H., Ling,H., Li,M., Qin,Y., Zhang,J.,
            Wang,J. and Yang,X.
  TITLE     TSP1 is the essential domain of SEMA5A involved in pannus formation
            in rheumatoid arthritis
  JOURNAL   Rheumatology (Oxford) 60 (12), 5833-5842 (2021)
   PUBMED   33616619
  REMARK    GeneRIF: TSP1 is the essential domain of SEMA5A involved in pannus
            formation in rheumatoid arthritis.
REFERENCE   3  (bases 1 to 1841)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 1841)
  AUTHORS   Di,C., Liang,J., Wang,Y., Zhao,G. and Zhao,Y.
  TITLE     SPZ1 promotes glioma aggravation via targeting CXXC4
  JOURNAL   J BUON 26 (2), 373-379 (2021)
   PUBMED   34076982
  REMARK    GeneRIF: SPZ1 promotes glioma aggravation via targeting CXXC4.
REFERENCE   5  (bases 1 to 1841)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   6  (bases 1 to 1841)
  AUTHORS   Hsu,S.H., Hsieh-Li,H.M., Huang,H.Y., Huang,P.H. and Li,H.
  TITLE     bHLH-zip transcription factor Spz1 mediates mitogen-activated
            protein kinase cell proliferation, transformation, and
            tumorigenesis
  JOURNAL   Cancer Res 65 (10), 4041-4050 (2005)
   PUBMED   15899793
REFERENCE   7  (bases 1 to 1841)
  AUTHORS   Horowitz,E., Zhang,Z., Jones,B.H., Moss,S.B., Ho,C., Wood,J.R.,
            Wang,X., Sammel,M.D. and Strauss,J.F. 3rd.
  TITLE     Patterns of expression of sperm flagellar genes: early expression
            of genes encoding axonemal proteins during the spermatogenic cycle
            and shared features of promoters of genes encoding central
            apparatus proteins
  JOURNAL   Mol Hum Reprod 11 (4), 307-317 (2005)
   PUBMED   15829580
  REMARK    Erratum:[Mol Hum Reprod. 2005 Jul;11(7):535]
REFERENCE   8  (bases 1 to 1841)
  AUTHORS   Hrabchak,C. and Varmuza,S.
  TITLE     Identification of the spermatogenic zip protein Spz1 as a putative
            protein phosphatase-1 (PP1) regulatory protein that specifically
            binds the PP1cgamma2 splice variant in mouse testis
  JOURNAL   J Biol Chem 279 (35), 37079-37086 (2004)
   PUBMED   15226296
REFERENCE   9  (bases 1 to 1841)
  AUTHORS   Sha,J.H., Zhou,Z.M., Li,J.M., Lin,M., Zhu,H., Zhu,H., Zhou,Y.D.,
            Wang,L.L., Wang,Y.Q. and Zhou,K.Y.
  TITLE     Expression of a novel bHLH-Zip gene in human testis
  JOURNAL   Asian J Androl 5 (2), 83-88 (2003)
   PUBMED   12778315
  REMARK    GeneRIF: highly expressed in adult testis; may play an important
            role in spermatogenesis in the humans
REFERENCE   10 (bases 1 to 1841)
  AUTHORS   Hsu,S.H., Shyu,H.W., Hsieh-Li,H.M. and Li,H.
  TITLE     Spz1, a novel bHLH-Zip protein, is specifically expressed in testis
  JOURNAL   Mech Dev 100 (2), 177-187 (2001)
   PUBMED   11165476
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BG723698.1, BU853967.1,
            BC033798.1 and AI138399.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On May 17, 2019 this sequence version replaced NM_032567.3.
            
            Summary: This gene encodes a bHLH-zip transcription factor which
            functions in the mitogen-activate protein kinase (MAPK) signaling
            pathway. Because of its role in the upregulation of cell
            proliferation and tumorigenesis, this gene may serve as a target
            for Ras-induced tumor treatments. [provided by RefSeq, Oct 2011].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: BC033798.1, HM005645.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000296739.6/ ENSP00000369611.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-262               BG723698.1         40-301
            263-263             BU853967.1         264-264
            264-1807            BC033798.1         242-1785
            1808-1841           AI138399.1         2-35                c
FEATURES             Location/Qualifiers
     source          1..1841
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q14.1"
     gene            1..1841
                     /gene="SPZ1"
                     /gene_synonym="CILD38; NYD-TSP1; PPP1R148"
                     /note="spermatogenic leucine zipper 1"
                     /db_xref="GeneID:84654"
                     /db_xref="HGNC:HGNC:30721"
                     /db_xref="MIM:618068"
     exon            1..1841
                     /gene="SPZ1"
                     /gene_synonym="CILD38; NYD-TSP1; PPP1R148"
                     /inference="alignment:Splign:2.1.0"
     CDS             215..1507
                     /gene="SPZ1"
                     /gene_synonym="CILD38; NYD-TSP1; PPP1R148"
                     /note="spermatogenic zip 1; testis-specific protein 1;
                     protein phosphatase 1, regulatory subunit 148; testis
                     secretory sperm-binding protein Li 232m"
                     /codon_start=1
                     /product="spermatogenic leucine zipper protein 1"
                     /protein_id="NP_115956.3"
                     /db_xref="CCDS:CCDS43336.1"
                     /db_xref="GeneID:84654"
                     /db_xref="HGNC:HGNC:30721"
                     /db_xref="MIM:618068"
                     /translation="MASSAKSAEMPTISKTVNPTPDPHQEYLDPRITIALFEIGSHSP
                     SSWGSLPFLKNSSHQVTEQQTAQKFNNLLKEIKDILKNMAGFEEKITEAKELFEETNI
                     TEDVSAHKENIRGLDKINEMLSTNLPVSLAPEKEDNEKKQEMILETNITEDVSAHKEN
                     IRGLDKINEMLSTNLPVSLAPEKEDNEKKQQMIMENQNSENTAQVFARDLVNRLEEKK
                     VLNETQQSQEKAKNRLNVQEETMKIRNNMEQLLQEAEHWSKQHTELSKLIKSYQKSQK
                     DISETLGNNGVGFQTQPNNEVSAKHELEEQVKKLSHDTYSLQLMAALLENECQILQQR
                     VEILKELHHQKQGTLQEKPIQINYKQDKKNQKPSEAKKVEMYKQNKQAMKGTFWKKDR
                     SCRSLDVCLNKKACNTQFNIHVARKALRGKMRSASSLR"
     regulatory      1817..1822
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SPZ1"
                     /gene_synonym="CILD38; NYD-TSP1; PPP1R148"
                     /note="hexamer: AATAAA"
     polyA_site      1841
                     /gene="SPZ1"
                     /gene_synonym="CILD38; NYD-TSP1; PPP1R148"
                     /note="major polyA site"
ORIGIN      
        1 atggagcccc agccttggtc ccctttccca cccttcctcc ccacaaggct gtctgagatg
       61 ccaccttcca cctaaacatc atctcccaaa ttttaatcct taactttggt ctctgacttc
      121 tgcttgattc cacagtctcc acccacattt gcacaaagga ccatcacctg tccttcctgg
      181 aatctctaaa gttttctgct ttccttctgt cctgatggcc agctctgcta agtcagctga
      241 gatgcccacc atctccaaaa ccgttaaccc tactcctgat cctcatcaag aatatctgga
      301 ccctaggatt accattgcct tattcgaaat tggatcacat tccccttcct cctggggctc
      361 tctccctttc ctaaagaata gcagccatca agttacagaa caacagactg cacagaagtt
      421 taacaatctc ttaaaagaaa ttaaagatat tcttaaaaat atggcaggtt ttgaagagaa
      481 gatcacagaa gcaaaagaac tttttgagga aaccaatatt actgaggatg tgtcagccca
      541 caaagaaaat atcagaggac ttgacaaaat caatgaaatg ttatcaacaa acctgcctgt
      601 tagtttagcc ccagagaaag aagacaatga aaagaaacag gagatgatat tggaaaccaa
      661 tattactgag gatgtgtcag cccacaaaga aaatatcaga ggacttgaca aaatcaatga
      721 aatgttatca acaaacctgc ctgttagttt agccccagag aaagaagaca atgaaaagaa
      781 acagcagatg ataatggaaa accagaactc tgagaacacc gcacaagttt ttgcaagaga
      841 tttggtaaat cgtttagaag aaaaaaaagt ccttaacgaa actcaacaaa gtcaggaaaa
      901 agcaaaaaac agacttaatg ttcaagaaga aactatgaaa attaggaaca acatggagca
      961 gttactacag gaagcagaac actggagtaa acaacatact gagctcagta aactgataaa
     1021 atcctatcag aaatctcaga aagacataag tgaaactctt ggaaataatg gagtcggttt
     1081 ccaaacccag ccaaataatg aagtgtcggc taagcatgag ctggaggaac aggtgaagaa
     1141 actgagccat gacacctatt cattgcagtt gatggcagct ttgctagaga atgaatgcca
     1201 aatcttacag cagagagtag agattctcaa ggaactccat catcagaaac agggaactct
     1261 gcaagagaag ccaattcaga taaactataa acaggacaag aaaaatcaga agccatcaga
     1321 agcaaagaaa gtagaaatgt ataagcagaa caagcaagca atgaagggta cattttggaa
     1381 aaaagacaga tcctgtagaa gcctggatgt ttgtcttaat aagaaagctt gcaataccca
     1441 gttcaatatt catgttgcaa gaaaagctct taggggaaaa atgaggtcag ctagcagcct
     1501 aagatagaaa ataccaaaag cagatgaaaa ggtgaatcct taaaaaacta catctgttac
     1561 ctccaacttg tcagtcatga tcaatcatca aaccttgggc agatctgctg gttcaaccaa
     1621 gaaagagcta tagaataagg agattgacac ttatattact cattacttca gcagttatgt
     1681 aagtctggtc tttaatgacc attgtgtcta catcaagttc ataacttttc acctttacaa
     1741 tctgcttgtt ttttttgtaa ttattagata gacagcctag agtgagaagt taaaggtcca
     1801 attaagtaaa gatctaaata aaaaccagaa tacaagggaa a
//
