LOCUS       NM_001040100            1734 bp    mRNA    linear   PRI 10-JUN-2024
DEFINITION  Homo sapiens serine palmitoyltransferase small subunit B (SPTSSB),
            transcript variant 2, mRNA.
ACCESSION   NM_001040100
VERSION     NM_001040100.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1734)
  AUTHORS   Wang,Y., Niu,Y., Zhang,Z., Gable,K., Gupta,S.D., Somashekarappa,N.,
            Han,G., Zhao,H., Myasnikov,A.G., Kalathur,R.C., Dunn,T.M. and
            Lee,C.H.
  TITLE     Structural insights into the regulation of human serine
            palmitoyltransferase complexes
  JOURNAL   Nat Struct Mol Biol 28 (3), 240-248 (2021)
   PUBMED   33558761
REFERENCE   2  (bases 1 to 1734)
  AUTHORS   Han,G., Gupta,S.D., Gable,K., Niranjanakumari,S., Moitra,P.,
            Eichler,F., Brown,R.H. Jr., Harmon,J.M. and Dunn,T.M.
  TITLE     Identification of small subunits of mammalian serine
            palmitoyltransferase that confer distinct acyl-CoA substrate
            specificities
  JOURNAL   Proc Natl Acad Sci U S A 106 (20), 8186-8191 (2009)
   PUBMED   19416851
  REMARK    Erratum:[Proc Natl Acad Sci U S A. 2009 Jun 16;106(24):9931]
REFERENCE   3  (bases 1 to 1734)
  AUTHORS   Singh,J., Young,L., Handelsman,D.J. and Dong,Q.
  TITLE     Molecular cloning and characterization of a novel androgen
            repressible gene expressed in the prostate epithelium
  JOURNAL   Gene 348, 55-63 (2005)
   PUBMED   15777716
  REMARK    GeneRIF: ADMP expression was seen predominantly in the prostate
            epithelium with weaker expression in the fibroblasts and
            endothelial cells.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC112491.4.
            
            On Sep 25, 2020 this sequence version replaced NM_001040100.1.
            
            Summary: Serine palmitoyltransferase (SPT; EC 2.3.1.50) catalyzes
            the first committed and rate-limiting step in sphingolipid
            biosynthesis. SSSPTB is a small SPT subunit that stimulates SPT
            activity and confers acyl-CoA preference to the SPT catalytic
            heterodimer of SPTLC1 (MIM 605712) and either SPTLC2 (MIM 605713)
            or SPTLC3 (MIM 611120) (Han et al., 2009 [PubMed
            19416851]).[supplied by OMIM, Nov 2010].
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. Both variants 1 and 2 encode the same protein.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC037817.2, AK123348.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000620149.2/ ENSP00000480827.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-83                AC112491.4         113254-113336
            84-176              AC112491.4         124877-124969
            177-1734            AC112491.4         138416-139973
FEATURES             Location/Qualifiers
     source          1..1734
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q26.1"
     gene            1..1734
                     /gene="SPTSSB"
                     /gene_synonym="ADMP; C3orf57; SSSPTB"
                     /note="serine palmitoyltransferase small subunit B"
                     /db_xref="GeneID:165679"
                     /db_xref="HGNC:HGNC:24045"
                     /db_xref="MIM:610412"
     exon            1..83
                     /gene="SPTSSB"
                     /gene_synonym="ADMP; C3orf57; SSSPTB"
                     /inference="alignment:Splign:2.1.0"
     exon            84..176
                     /gene="SPTSSB"
                     /gene_synonym="ADMP; C3orf57; SSSPTB"
                     /inference="alignment:Splign:2.1.0"
     exon            177..1734
                     /gene="SPTSSB"
                     /gene_synonym="ADMP; C3orf57; SSSPTB"
                     /inference="alignment:Splign:2.1.0"
     CDS             209..439
                     /gene="SPTSSB"
                     /gene_synonym="ADMP; C3orf57; SSSPTB"
                     /note="likely ortholog of androgen down regulated gene
                     expressed in mouse prostate; androgen down regulated in
                     mouse prostate; small subunit of serine
                     palmitoyltransferase B"
                     /codon_start=1
                     /product="serine palmitoyltransferase small subunit B"
                     /protein_id="NP_001035189.1"
                     /db_xref="CCDS:CCDS33887.1"
                     /db_xref="GeneID:165679"
                     /db_xref="HGNC:HGNC:24045"
                     /db_xref="MIM:610412"
                     /translation="MDLRRVKEYFSWLYYQYQIISCCAVLEPWERSMFNTILLTIIAM
                     VVYTAYVFIPIHIRLAWEFFSKICGYHSTISN"
     regulatory      1711..1716
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SPTSSB"
                     /gene_synonym="ADMP; C3orf57; SSSPTB"
                     /note="hexamer: AATAAA"
     polyA_site      1734
                     /gene="SPTSSB"
                     /gene_synonym="ADMP; C3orf57; SSSPTB"
                     /note="major polyA site"
ORIGIN      
        1 gcagtgggaa gctcgcagca gctggggagg agccaaagcc tcggcgctca cctaagccgc
       61 agggagatac acccaactgg gagatgagga aacagcaacc cagagaggag aactaaccca
      121 cacaggatca tttcgtgaag gagcaaggct gaagaaccag acctggactt tcttaggaca
      181 aacttactgc agcttgaagg agccaaccat ggatttgagg cgtgtgaagg aatatttctc
      241 ctggctctac tatcaatacc aaatcattag ctgctgtgct gttttagagc cctgggagcg
      301 atctatgttt aacaccatct tactaaccat tattgctatg gtggtataca ctgcctatgt
      361 ctttattcca atccacattc gcctggcttg ggaatttttc tcaaaaatat gtggatatca
      421 cagtacaatt tctaattgat cctgttcaca ttcagtgaaa tggcattgca tatttatatg
      481 ttgcttacag cttattgatt taggtaacta ttgtgtcttc cttcactatc tgacctgaaa
      541 agcactctct tctctatgca ctcttatatt ctgcctttct gcctggagtt tgaaatacat
      601 gtctctttag tttcttttgc acatgctaca ttgtgcttta gaccggagat aatacagtga
      661 ctttacctca caaatcatat tctgtcaaca caaatctatg aatttagttt atttaaaatc
      721 agaacaattt cctacaaaat ttttctggaa aatagactcc taacagacct accagaatca
      781 tgcttaaagt gctcccttga cacttattct atactaaagg ataaatttta aaaaatcttt
      841 ataggctact gtcagaagta tcctatcctt gtttacgatg tataaaaaga tgtgaataaa
      901 ttatatggac cccctaagtc ttattttcta gtaaactgat gatactggaa attcttttac
      961 ttcaaatgca aaagaataag ctggaggcaa ttatttcctt tcatacagag ttcatgaatt
     1021 gttttaaatg cttcttaaag tctggcttta taaccgttta aaatcaacaa tgttgatttt
     1081 agataaccaa gtaagtatta taatacaaaa taattttaag tgtaagaaac taaagtataa
     1141 tcaaagtaaa ttcagttatt gtatttgtgg tgttgccttg ccttgcatga tgctggggga
     1201 aaaagagaaa agaaatggtt ttctttttgt actttcattc agtgtagagg gaaaaaagca
     1261 tgtattgggc caccggaaga caagctaata aataggctgg aagtaatatt ctaccagcag
     1321 gaactcaaca gctccagtta aatgctttga tatagtggct cctttgcaga gccaaaacaa
     1381 gatttattaa atttccttca aactgtttat ctttaaaaca aatataaggt tttaattata
     1441 ctgctgaagc aaatgtgaat gccaaagact acgttttgca gttttgcttt cctcccaata
     1501 aatattaatg tatgtaattc tagagggtaa aaatgtaaat aggtttggac aatatttgca
     1561 cccttgtttg tgttatgaaa aaaatttttc caaggtgagc tagagagaaa gatgtttggc
     1621 atgccaaatt aacttgcatg tttgttaaaa aaacaaacac atgttttgaa gagaaaccag
     1681 atctgaacat gtatttgttg agttttgcaa aataaaatta attttgtaag taaa
//
