LOCUS       NP_001035189              76 aa            linear   PRI 10-JUN-2024
DEFINITION  serine palmitoyltransferase small subunit B [Homo sapiens].
ACCESSION   NP_001035189
VERSION     NP_001035189.1
DBSOURCE    REFSEQ: accession NM_001040100.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 76)
  AUTHORS   Wang,Y., Niu,Y., Zhang,Z., Gable,K., Gupta,S.D., Somashekarappa,N.,
            Han,G., Zhao,H., Myasnikov,A.G., Kalathur,R.C., Dunn,T.M. and
            Lee,C.H.
  TITLE     Structural insights into the regulation of human serine
            palmitoyltransferase complexes
  JOURNAL   Nat Struct Mol Biol 28 (3), 240-248 (2021)
   PUBMED   33558761
REFERENCE   2  (residues 1 to 76)
  AUTHORS   Han,G., Gupta,S.D., Gable,K., Niranjanakumari,S., Moitra,P.,
            Eichler,F., Brown,R.H. Jr., Harmon,J.M. and Dunn,T.M.
  TITLE     Identification of small subunits of mammalian serine
            palmitoyltransferase that confer distinct acyl-CoA substrate
            specificities
  JOURNAL   Proc Natl Acad Sci U S A 106 (20), 8186-8191 (2009)
   PUBMED   19416851
  REMARK    Erratum:[Proc Natl Acad Sci U S A. 2009 Jun 16;106(24):9931]
REFERENCE   3  (residues 1 to 76)
  AUTHORS   Singh,J., Young,L., Handelsman,D.J. and Dong,Q.
  TITLE     Molecular cloning and characterization of a novel androgen
            repressible gene expressed in the prostate epithelium
  JOURNAL   Gene 348, 55-63 (2005)
   PUBMED   15777716
  REMARK    GeneRIF: ADMP expression was seen predominantly in the prostate
            epithelium with weaker expression in the fibroblasts and
            endothelial cells.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC112491.4.
            
            Summary: Serine palmitoyltransferase (SPT; EC 2.3.1.50) catalyzes
            the first committed and rate-limiting step in sphingolipid
            biosynthesis. SSSPTB is a small SPT subunit that stimulates SPT
            activity and confers acyl-CoA preference to the SPT catalytic
            heterodimer of SPTLC1 (MIM 605712) and either SPTLC2 (MIM 605713)
            or SPTLC3 (MIM 611120) (Han et al., 2009 [PubMed
            19416851]).[supplied by OMIM, Nov 2010].
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. Both variants 1 and 2 encode the same protein.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC037817.2, AK123348.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000620149.2/ ENSP00000480827.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..76
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q26.1"
     Protein         1..76
                     /product="serine palmitoyltransferase small subunit B"
                     /note="likely ortholog of androgen down regulated gene
                     expressed in mouse prostate; androgen down regulated in
                     mouse prostate; small subunit of serine
                     palmitoyltransferase B"
                     /calculated_mol_wt=9067
     Region          7..60
                     /region_name="SPT_ssu-like"
                     /note="Small subunit of serine palmitoyltransferase-like;
                     pfam11779"
                     /db_xref="CDD:463347"
     Site            12..29
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8NFR3.1)"
     Site            37..57
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8NFR3.1)"
     CDS             1..76
                     /gene="SPTSSB"
                     /gene_synonym="ADMP; C3orf57; SSSPTB"
                     /coded_by="NM_001040100.2:209..439"
                     /db_xref="CCDS:CCDS33887.1"
                     /db_xref="GeneID:165679"
                     /db_xref="HGNC:HGNC:24045"
                     /db_xref="MIM:610412"
ORIGIN      
        1 mdlrrvkeyf swlyyqyqii sccavlepwe rsmfntillt iiamvvytay vfipihirla
       61 weffskicgy hstisn
//
