LOCUS       NM_001130438            7875 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens spectrin alpha, non-erythrocytic 1 (SPTAN1),
            transcript variant 1, mRNA.
ACCESSION   NM_001130438
VERSION     NM_001130438.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7875)
  AUTHORS   Morsy,H., Benkirane,M., Cali,E., Rocca,C., Zhelcheska,K.,
            Cipriani,V., Galanaki,E., Maroofian,R., Efthymiou,S., Murphy,D.,
            O'Driscoll,M., Suri,M., Banka,S., Clayton-Smith,J., Wright,T.,
            Redman,M., Bassetti,J.A., Nizon,M., Cogne,B., Jamra,R.A.,
            Bartolomaeus,T., Heruth,M., Krey,I., Gburek-Augustat,J.,
            Wieczorek,D., Gattermann,F., Mcentagart,M., Goldenberg,A.,
            Guyant-Marechal,L., Garcia-Moreno,H., Giunti,P., Chabrol,B.,
            Bacrot,S., Buissonniere,R., Magry,V., Gowda,V.K., Srinivasan,V.M.,
            Melegh,B., Szabo,A., Sumegi,K., Cossee,M., Ziff,M., Butterfield,R.,
            Hunt,D., Bird-Lieberman,G., Hanna,M., Koenig,M., Stankewich,M.,
            Vandrovcova,J. and Houlden,H.
  CONSRTM   Genomics England Research Consortium
  TITLE     Expanding SPTAN1 monoallelic variant associated disorders: From
            epileptic encephalopathy to pure spastic paraplegia and ataxia
  JOURNAL   Genet Med 25 (1), 76-89 (2023)
   PUBMED   36331550
  REMARK    GeneRIF: Expanding SPTAN1 monoallelic variant associated disorders:
            From epileptic encephalopathy to pure spastic paraplegia and
            ataxia.
REFERENCE   2  (bases 1 to 7875)
  AUTHORS   Van de Vondel,L., De Winter,J., Beijer,D., Coarelli,G., Wayand,M.,
            Palvadeau,R., Pauly,M.G., Klein,K., Rautenberg,M., Guillot-Noel,L.,
            Deconinck,T., Vural,A., Ertan,S., Dogu,O., Uysal,H., Brankovic,V.,
            Herzog,R., Brice,A., Durr,A., Klebe,S., Stock,F., Bischoff,A.T.,
            Rattay,T.W., Sobrido,M.J., De Michele,G., De Jonghe,P.,
            Klopstock,T., Lohmann,K., Zanni,G., Santorelli,F.M., Timmerman,V.,
            Haack,T.B., Zuchner,S., Schule,R., Stevanin,G., Synofzik,M.,
            Basak,A.N. and Baets,J.
  CONSRTM   PREPARE Consortium
  TITLE     De Novo and Dominantly Inherited SPTAN1 Mutations Cause Spastic
            Paraplegia and Cerebellar Ataxia
  JOURNAL   Mov Disord 37 (6), 1175-1186 (2022)
   PUBMED   35150594
  REMARK    GeneRIF: De Novo and Dominantly Inherited SPTAN1 Mutations Cause
            Spastic Paraplegia and Cerebellar Ataxia.
REFERENCE   3  (bases 1 to 7875)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   4  (bases 1 to 7875)
  AUTHORS   Sreeja,J.S., Jyothy,A. and Sengupta,S.
  TITLE     alpha-Fodrin in Cytoskeletal Organization and the Activity of
            Certain Key Microtubule Kinesins
  JOURNAL   Genes (Basel) 12 (5), 750 (2021)
   PUBMED   34067543
  REMARK    GeneRIF: alpha-Fodrin in Cytoskeletal Organization and the Activity
            of Certain Key Microtubule Kinesins.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 7875)
  AUTHORS   Cianci,C.D., Zhang,Z., Pradhan,D. and Morrow,J.S.
  TITLE     Brain and muscle express a unique alternative transcript of alphaII
            spectrin
  JOURNAL   Biochemistry 38 (48), 15721-15730 (1999)
   PUBMED   10625438
REFERENCE   6  (bases 1 to 7875)
  AUTHORS   Bennett,A.F., Hayes,N.V. and Baines,A.J.
  TITLE     Site specificity in the interactions of synapsin 1 with tubulin
  JOURNAL   Biochem J 276 (Pt 3) (Pt 3), 793-799 (1991)
   PUBMED   1905928
REFERENCE   7  (bases 1 to 7875)
  AUTHORS   Frappier,T., Stetzkowski-Marden,F. and Pradel,L.A.
  TITLE     Interaction domains of neurofilament light chain and brain spectrin
  JOURNAL   Biochem J 275 (Pt 2) (Pt 2), 521-527 (1991)
   PUBMED   1902666
REFERENCE   8  (bases 1 to 7875)
  AUTHORS   Davis,L.H. and Bennett,V.
  TITLE     Mapping the binding sites of human erythrocyte ankyrin for the
            anion exchanger and spectrin
  JOURNAL   J Biol Chem 265 (18), 10589-10596 (1990)
   PUBMED   2141335
REFERENCE   9  (bases 1 to 7875)
  AUTHORS   Leto,T.L., Fortugno-Erikson,D., Barton,D., Yang-Feng,T.L.,
            Francke,U., Harris,A.S., Morrow,J.S., Marchesi,V.T. and Benz,E.J.
            Jr.
  TITLE     Comparison of nonerythroid alpha-spectrin genes reveals strict
            homology among diverse species
  JOURNAL   Mol Cell Biol 8 (1), 1-9 (1988)
   PUBMED   3336352
REFERENCE   10 (bases 1 to 7875)
  AUTHORS   McMahon,A.P., Giebelhaus,D.H., Champion,J.E., Bailes,J.A.,
            Lacey,S., Carritt,B., Henchman,S.K. and Moon,R.T.
  TITLE     cDNA cloning, sequencing and chromosome mapping of a non-erythroid
            spectrin, human alpha-fodrin
  JOURNAL   Differentiation 34 (1), 68-78 (1987)
   PUBMED   3038643
  REMARK    Erratum:[Differentiation 1987;34(3):241]
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL356481.16.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Jun 2, 2019 this sequence version replaced NM_001130438.2.
            
            Summary: Spectrins are a family of filamentous cytoskeletal
            proteins that function as essential scaffold proteins that
            stabilize the plasma membrane and organize intracellular
            organelles. Spectrins are composed of alpha and beta dimers that
            associate to form tetramers linked in a head-to-head arrangement.
            This gene encodes an alpha spectrin that is specifically expressed
            in nonerythrocytic cells. The encoded protein has been implicated
            in other cellular functions including DNA repair and cell cycle
            regulation. Mutations in this gene are the cause of early infantile
            epileptic encephalopathy-5. Alternate splicing results in multiple
            transcript variants.[provided by RefSeq, Sep 2010].
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803613.75589.1,
                                           SRR1803617.253053.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000372739.7/ ENSP00000361824.4
            RefSeq Select criteria :: based on manual assertion, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-110               AL356481.16        33223-33332
            111-350             AL356481.16        47374-47613
            351-476             AL356481.16        49408-49533
            477-617             AL356481.16        55311-55451
            618-764             AL356481.16        55835-55981
            765-898             AL356481.16        57459-57592
            899-1043            AL356481.16        57765-57909
            1044-1198           AL356481.16        57988-58142
            1199-1334           AL356481.16        58746-58881
            1335-1436           AL356481.16        60273-60374
            1437-1574           AL356481.16        61558-61695
            1575-1685           AL356481.16        62418-62528
            1686-1763           AL356481.16        63115-63192
            1764-1919           AL356481.16        63330-63485
            1920-2124           AL356481.16        63713-63917
            2125-2306           AL356481.16        64424-64605
            2307-2550           AL356481.16        64918-65161
            2551-2673           AL356481.16        65357-65479
            2674-2891           AL356481.16        66384-66601
            2892-2984           AL356481.16        68242-68334
            2985-3119           AL356481.16        69445-69579
            3120-3268           AL356481.16        72113-72261
            3269-3328           AL356481.16        73619-73678
            3329-3527           AL356481.16        74811-75009
            3528-3632           AL356481.16        79036-79140
            3633-3656           AL356481.16        79599-79622
            3657-3692           AL356481.16        80716-80751
            3693-3740           AL356481.16        84179-84226
            3741-3832           AL356481.16        84962-85053
            3833-3977           AL356481.16        85670-85814
            3978-4159           AL356481.16        85932-86113
            4160-4259           AL356481.16        88240-88339
            4260-4457           AL356481.16        88488-88685
            4458-4604           AL356481.16        88766-88912
            4605-4708           AL356481.16        89510-89613
            4709-4871           AL356481.16        89758-89920
            4872-4886           AL356481.16        90287-90301
            4887-5018           AL356481.16        92350-92481
            5019-5156           AL356481.16        92745-92882
            5157-5261           AL356481.16        94017-94121
            5262-5470           AL356481.16        96268-96476
            5471-5591           AL356481.16        98276-98396
            5592-5713           AL356481.16        98623-98744
            5714-5846           AL356481.16        99507-99639
            5847-5945           AL356481.16        101794-101892
            5946-6105           AL356481.16        104964-105123
            6106-6182           AL356481.16        105739-105815
            6183-6392           AL356481.16        106405-106614
            6393-6689           AL356481.16        107027-107323
            6690-6802           AL356481.16        108022-108134
            6803-6820           AL356481.16        108561-108578
            6821-6875           AL356481.16        110957-111011
            6876-7072           AL356481.16        112763-112959
            7073-7126           AL356481.16        113067-113120
            7127-7273           AL356481.16        113208-113354
            7274-7421           AL356481.16        113444-113591
            7422-7875           AL356481.16        113845-114298
FEATURES             Location/Qualifiers
     source          1..7875
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9q34.11"
     gene            1..7875
                     /gene="SPTAN1"
                     /gene_synonym="DEE5; DEVEP; EIEE5; HMN11; HMND11; NEAS;
                     SPG91; SPTA2"
                     /note="spectrin alpha, non-erythrocytic 1"
                     /db_xref="GeneID:6709"
                     /db_xref="HGNC:HGNC:11273"
                     /db_xref="MIM:182810"
     exon            1..110
                     /gene="SPTAN1"
                     /gene_synonym="DEE5; DEVEP; EIEE5; HMN11; HMND11; NEAS;
                     SPG91; SPTA2"
                     /inference="alignment:Splign:2.1.0"
     exon            111..350
                     /gene="SPTAN1"
                     /gene_synonym="DEE5; DEVEP; EIEE5; HMN11; HMND11; NEAS;
                     SPG91; SPTA2"
                     /inference="alignment:Splign:2.1.0"
     CDS             114..7547
                     /gene="SPTAN1"
                     /gene_synonym="DEE5; DEVEP; EIEE5; HMN11; HMND11; NEAS;
                     SPG91; SPTA2"
                     /note="isoform 1 is encoded by transcript variant 1;
                     alpha-II spectrin; fodrin alpha chain; spectrin,
                     non-erythroid alpha chain; alpha-fodrin; spectrin,
                     non-erythroid alpha subunit; spectrin alpha chain,
                     non-erythrocytic 1; epididymis secretory sperm binding
                     protein"
                     /codon_start=1
                     /product="spectrin alpha chain, non-erythrocytic 1 isoform
                     1"
                     /protein_id="NP_001123910.1"
                     /db_xref="CCDS:CCDS48036.1"
                     /db_xref="GeneID:6709"
                     /db_xref="HGNC:HGNC:11273"
                     /db_xref="MIM:182810"
                     /translation="MDPSGVKVLETAEDIQERRQQVLDRYHRFKELSTLRRQKLEDSY
                     RFQFFQRDAEELEKWIQEKLQIASDENYKDPTNLQGKLQKHQAFEAEVQANSGAIVKL
                     DETGNLMISEGHFASETIRTRLMELHRQWELLLEKMREKGIKLLQAQKLVQYLRECED
                     VMDWINDKEAIVTSEELGQDLEHVEVLQKKFEEFQTDMAAHEERVNEVNQFAAKLIQE
                     QHPEEELIKTKQDEVNAAWQRLKGLALQRQGKLFGAAEVQRFNRDVDETISWIKEKEQ
                     LMASDDFGRDLASVQALLRKHEGLERDLAALEDKVKALCAEADRLQQSHPLSATQIQV
                     KREELITNWEQIRTLAAERHARLNDSYRLQRFLADFRDLTSWVTEMKALINADELASD
                     VAGAEALLDRHQEHKGEIDAHEDSFKSADESGQALLAAGHYASDEVREKLTVLSEERA
                     ALLELWELRRQQYEQCMDLQLFYRDTEQVDNWMSKQEAFLLNEDLGDSLDSVEALLKK
                     HEDFEKSLSAQEEKITALDEFATKLIQNNHYAMEDVATRRDALLSRRNALHERAMRRR
                     AQLADSFHLQQFFRDSDELKSWVNEKMKTATDEAYKDPSNLQGKVQKHQAFEAELSAN
                     QSRIDALEKAGQKLIDVNHYAKDEVAARMNEVISLWKKLLEATELKGIKLREANQQQQ
                     FNRNVEDIELWLYEVEGHLASDDYGKDLTNVQNLQKKHALLEADVAAHQDRIDGITIQ
                     ARQFQDAGHFDAENIKKKQEALVARYEALKEPMVARKQKLADSLRLQQLFRDVEDEET
                     WIREKEPIAASTNRGKDLIGVQNLLKKHQALQAEIAGHEPRIKAVTQKGNAMVEEGHF
                     AAEDVKAKLHELNQKWEALKAKASQRRQDLEDSLQAQQYFADANEAESWMREKEPIVG
                     STDYGKDEDSAEALLKKHEALMSDLSAYGSSIQALREQAQSCRQQVAPTDDETGKELV
                     LALYDYQEKSPREVTMKKGDILTLLNSTNKDWWKVEVNDRQGFVPAAYVKKLDPAQSA
                     SRENLLEEQGSIALRQEQIDNQTRITKEAGSVSLRMKQVEELYHSLLELGEKRKGMLE
                     KSCKKFMLFREANELQQWINEKEAALTSEEVGADLEQVEVLQKKFDDFQKDLKANESR
                     LKDINKVAEDLESEGLMAEEVQAVQQQEVYGMMPRDETDSKTASPWKSARLMVHTVAT
                     FNSIKELNERWRSLQQLAEERSQLLGSAHEVQRFHRDADETKEWIEEKNQALNTDNYG
                     HDLASVQALQRKHEGFERDLAALGDKVNSLGETAERLIQSHPESAEDLQEKCTELNQA
                     WSSLGKRADQRKAKLGDSHDLQRFLSDFRDLMSWINGIRGLVSSDELAKDVTGAEALL
                     ERHQEHRTEIDARAGTFQAFEQFGQQLLAHGHYASPEIKQKLDILDQERADLEKAWVQ
                     RRMMLDQCLELQLFHRDCEQAENWMAAREAFLNTEDKGDSLDSVEALIKKHEDFDKAI
                     NVQEEKIAALQAFADQLIAAGHYAKGDISSRRNEVLDRWRRLKAQMIEKRSKLGESQT
                     LQQFSRDVDEIEAWISEKLQTASDESYKDPTNIQLSKLLSKHQKHQAFEAELHANADR
                     IRGVIDMGNSLIERGACAGSEDAVKARLAALADQWQFLVQKSAEKSQKLKEANKQQNF
                     NTGIKDFDFWLSEVEALLASEDYGKDLASVNNLLKKHQLLEADISAHEDRLKDLNSQA
                     DSLMTSSAFDTSQVKDKRDTINGRFQKIKSMAASRRAKLNESHRLHQFFRDMDDEESW
                     IKEKKLLVGSEDYGRDLTGVQNLRKKHKRLEAELAAHEPAIQGVLDTGKKLSDDNTIG
                     KEEIQQRLAQFVEHWKELKQLAAARGQRLEESLEYQQFVANVEEEEAWINEKMTLVAS
                     EDYGDTLAAIQGLLKKHEAFETDFTVHKDRVNDVCTNGQDLIKKNNHHEENISSKMKG
                     LNGKVSDLEKAAAQRKAKLDENSAFLQFNWKADVVESWIGEKENSLKTDDYGRDLSSV
                     QTLLTKQETFDAGLQAFQQEGIANITALKDQLLAAKHVQSKAIEARHASLMKRWSQLL
                     ANSAARKKKLLEAQSHFRKVEDLFLTFAKKASAFNSWFENAEEDLTDPVRCNSLEEIK
                     ALREAHDAFRSSLSSAQADFNQLAELDRQIKSFRVASNPYTWFTMEALEETWRNLQKI
                     IKERELELQKEQRRQEENDKLRQEFAQHANAFHQWIQETRTYLLDGSCMVEESGTLES
                     QLEATKRKHQEIRAMRSQLKKIEDLGAAMEEALILDNKYTEHSTVGLAQQWDQLDQLG
                     MRMQHNLEQQIQARNTTGVTEEALKEFSMMFKHFDKDKSGRLNHQEFKSCLRSLGYDL
                     PMVEEGEPDPEFEAILDTVDPNRDGHVSLQEYMAFMISRETENVKSSEEIESAFRALS
                     SEGKPYVTKEELYQNLTREQADYCVSHMKPYVDGKGRELPTAFDYVEFTRSLFVN"
     exon            351..476
                     /gene="SPTAN1"
                     /gene_synonym="DEE5; DEVEP; EIEE5; HMN11; HMND11; NEAS;
                     SPG91; SPTA2"
                     /inference="alignment:Splign:2.1.0"
     exon            477..617
                     /gene="SPTAN1"
                     /gene_synonym="DEE5; DEVEP; EIEE5; HMN11; HMND11; NEAS;
                     SPG91; SPTA2"
                     /inference="alignment:Splign:2.1.0"
     exon            618..764
                     /gene="SPTAN1"
                     /gene_synonym="DEE5; DEVEP; EIEE5; HMN11; HMND11; NEAS;
                     SPG91; SPTA2"
                     /inference="alignment:Splign:2.1.0"
     exon            765..898
                     /gene="SPTAN1"
                     /gene_synonym="DEE5; DEVEP; EIEE5; HMN11; HMND11; NEAS;
                     SPG91; SPTA2"
                     /inference="alignment:Splign:2.1.0"
     exon            899..1043
                     /gene="SPTAN1"
                     /gene_synonym="DEE5; DEVEP; EIEE5; HMN11; HMND11; NEAS;
                     SPG91; SPTA2"
                     /inference="alignment:Splign:2.1.0"
     exon            1044..1198
                     /gene="SPTAN1"
                     /gene_synonym="DEE5; DEVEP; EIEE5; HMN11; HMND11; NEAS;
                     SPG91; SPTA2"
                     /inference="alignment:Splign:2.1.0"
     exon            1199..1334
                     /gene="SPTAN1"
                     /gene_synonym="DEE5; DEVEP; EIEE5; HMN11; HMND11; NEAS;
                     SPG91; SPTA2"
                     /inference="alignment:Splign:2.1.0"
     exon            1335..1436
                     /gene="SPTAN1"
                     /gene_synonym="DEE5; DEVEP; EIEE5; HMN11; HMND11; NEAS;
                     SPG91; SPTA2"
                     /inference="alignment:Splign:2.1.0"
     exon            1437..1574
                     /gene="SPTAN1"
                     /gene_synonym="DEE5; DEVEP; EIEE5; HMN11; HMND11; NEAS;
                     SPG91; SPTA2"
                     /inference="alignment:Splign:2.1.0"
     exon            1575..1685
                     /gene="SPTAN1"
                     /gene_synonym="DEE5; DEVEP; EIEE5; HMN11; HMND11; NEAS;
                     SPG91; SPTA2"
                     /inference="alignment:Splign:2.1.0"
     exon            1686..1763
                     /gene="SPTAN1"
                     /gene_synonym="DEE5; DEVEP; EIEE5; HMN11; HMND11; NEAS;
                     SPG91; SPTA2"
                     /inference="alignment:Splign:2.1.0"
     exon            1764..1919
                     /gene="SPTAN1"
                     /gene_synonym="DEE5; DEVEP; EIEE5; HMN11; HMND11; NEAS;
                     SPG91; SPTA2"
                     /inference="alignment:Splign:2.1.0"
     exon            1920..2124
                     /gene="SPTAN1"
                     /gene_synonym="DEE5; DEVEP; EIEE5; HMN11; HMND11; NEAS;
                     SPG91; SPTA2"
                     /inference="alignment:Splign:2.1.0"
     exon            2125..2306
                     /gene="SPTAN1"
                     /gene_synonym="DEE5; DEVEP; EIEE5; HMN11; HMND11; NEAS;
                     SPG91; SPTA2"
                     /inference="alignment:Splign:2.1.0"
     exon            2307..2550
                     /gene="SPTAN1"
                     /gene_synonym="DEE5; DEVEP; EIEE5; HMN11; HMND11; NEAS;
                     SPG91; SPTA2"
                     /inference="alignment:Splign:2.1.0"
     exon            2551..2673
                     /gene="SPTAN1"
                     /gene_synonym="DEE5; DEVEP; EIEE5; HMN11; HMND11; NEAS;
                     SPG91; SPTA2"
                     /inference="alignment:Splign:2.1.0"
     exon            2674..2891
                     /gene="SPTAN1"
                     /gene_synonym="DEE5; DEVEP; EIEE5; HMN11; HMND11; NEAS;
                     SPG91; SPTA2"
                     /inference="alignment:Splign:2.1.0"
     exon            2892..2984
                     /gene="SPTAN1"
                     /gene_synonym="DEE5; DEVEP; EIEE5; HMN11; HMND11; NEAS;
                     SPG91; SPTA2"
                     /inference="alignment:Splign:2.1.0"
     exon            2985..3119
                     /gene="SPTAN1"
                     /gene_synonym="DEE5; DEVEP; EIEE5; HMN11; HMND11; NEAS;
                     SPG91; SPTA2"
                     /inference="alignment:Splign:2.1.0"
     exon            3120..3268
                     /gene="SPTAN1"
                     /gene_synonym="DEE5; DEVEP; EIEE5; HMN11; HMND11; NEAS;
                     SPG91; SPTA2"
                     /inference="alignment:Splign:2.1.0"
     exon            3269..3328
                     /gene="SPTAN1"
                     /gene_synonym="DEE5; DEVEP; EIEE5; HMN11; HMND11; NEAS;
                     SPG91; SPTA2"
                     /inference="alignment:Splign:2.1.0"
     exon            3329..3527
                     /gene="SPTAN1"
                     /gene_synonym="DEE5; DEVEP; EIEE5; HMN11; HMND11; NEAS;
                     SPG91; SPTA2"
                     /inference="alignment:Splign:2.1.0"
     exon            3528..3632
                     /gene="SPTAN1"
                     /gene_synonym="DEE5; DEVEP; EIEE5; HMN11; HMND11; NEAS;
                     SPG91; SPTA2"
                     /inference="alignment:Splign:2.1.0"
     exon            3633..3656
                     /gene="SPTAN1"
                     /gene_synonym="DEE5; DEVEP; EIEE5; HMN11; HMND11; NEAS;
                     SPG91; SPTA2"
                     /inference="alignment:Splign:2.1.0"
     exon            3657..3692
                     /gene="SPTAN1"
                     /gene_synonym="DEE5; DEVEP; EIEE5; HMN11; HMND11; NEAS;
                     SPG91; SPTA2"
                     /inference="alignment:Splign:2.1.0"
     exon            3693..3740
                     /gene="SPTAN1"
                     /gene_synonym="DEE5; DEVEP; EIEE5; HMN11; HMND11; NEAS;
                     SPG91; SPTA2"
                     /inference="alignment:Splign:2.1.0"
     exon            3741..3832
                     /gene="SPTAN1"
                     /gene_synonym="DEE5; DEVEP; EIEE5; HMN11; HMND11; NEAS;
                     SPG91; SPTA2"
                     /inference="alignment:Splign:2.1.0"
     exon            3833..3977
                     /gene="SPTAN1"
                     /gene_synonym="DEE5; DEVEP; EIEE5; HMN11; HMND11; NEAS;
                     SPG91; SPTA2"
                     /inference="alignment:Splign:2.1.0"
     exon            3978..4159
                     /gene="SPTAN1"
                     /gene_synonym="DEE5; DEVEP; EIEE5; HMN11; HMND11; NEAS;
                     SPG91; SPTA2"
                     /inference="alignment:Splign:2.1.0"
     exon            4160..4259
                     /gene="SPTAN1"
                     /gene_synonym="DEE5; DEVEP; EIEE5; HMN11; HMND11; NEAS;
                     SPG91; SPTA2"
                     /inference="alignment:Splign:2.1.0"
     exon            4260..4457
                     /gene="SPTAN1"
                     /gene_synonym="DEE5; DEVEP; EIEE5; HMN11; HMND11; NEAS;
                     SPG91; SPTA2"
                     /inference="alignment:Splign:2.1.0"
     exon            4458..4604
                     /gene="SPTAN1"
                     /gene_synonym="DEE5; DEVEP; EIEE5; HMN11; HMND11; NEAS;
                     SPG91; SPTA2"
                     /inference="alignment:Splign:2.1.0"
     exon            4605..4708
                     /gene="SPTAN1"
                     /gene_synonym="DEE5; DEVEP; EIEE5; HMN11; HMND11; NEAS;
                     SPG91; SPTA2"
                     /inference="alignment:Splign:2.1.0"
     exon            4709..4871
                     /gene="SPTAN1"
                     /gene_synonym="DEE5; DEVEP; EIEE5; HMN11; HMND11; NEAS;
                     SPG91; SPTA2"
                     /inference="alignment:Splign:2.1.0"
     exon            4872..4886
                     /gene="SPTAN1"
                     /gene_synonym="DEE5; DEVEP; EIEE5; HMN11; HMND11; NEAS;
                     SPG91; SPTA2"
                     /inference="alignment:Splign:2.1.0"
     exon            4887..5018
                     /gene="SPTAN1"
                     /gene_synonym="DEE5; DEVEP; EIEE5; HMN11; HMND11; NEAS;
                     SPG91; SPTA2"
                     /inference="alignment:Splign:2.1.0"
     exon            5019..5156
                     /gene="SPTAN1"
                     /gene_synonym="DEE5; DEVEP; EIEE5; HMN11; HMND11; NEAS;
                     SPG91; SPTA2"
                     /inference="alignment:Splign:2.1.0"
     exon            5157..5261
                     /gene="SPTAN1"
                     /gene_synonym="DEE5; DEVEP; EIEE5; HMN11; HMND11; NEAS;
                     SPG91; SPTA2"
                     /inference="alignment:Splign:2.1.0"
     exon            5262..5470
                     /gene="SPTAN1"
                     /gene_synonym="DEE5; DEVEP; EIEE5; HMN11; HMND11; NEAS;
                     SPG91; SPTA2"
                     /inference="alignment:Splign:2.1.0"
     exon            5471..5591
                     /gene="SPTAN1"
                     /gene_synonym="DEE5; DEVEP; EIEE5; HMN11; HMND11; NEAS;
                     SPG91; SPTA2"
                     /inference="alignment:Splign:2.1.0"
     exon            5592..5713
                     /gene="SPTAN1"
                     /gene_synonym="DEE5; DEVEP; EIEE5; HMN11; HMND11; NEAS;
                     SPG91; SPTA2"
                     /inference="alignment:Splign:2.1.0"
     exon            5714..5846
                     /gene="SPTAN1"
                     /gene_synonym="DEE5; DEVEP; EIEE5; HMN11; HMND11; NEAS;
                     SPG91; SPTA2"
                     /inference="alignment:Splign:2.1.0"
     exon            5847..5945
                     /gene="SPTAN1"
                     /gene_synonym="DEE5; DEVEP; EIEE5; HMN11; HMND11; NEAS;
                     SPG91; SPTA2"
                     /inference="alignment:Splign:2.1.0"
     exon            5946..6105
                     /gene="SPTAN1"
                     /gene_synonym="DEE5; DEVEP; EIEE5; HMN11; HMND11; NEAS;
                     SPG91; SPTA2"
                     /inference="alignment:Splign:2.1.0"
     exon            6106..6182
                     /gene="SPTAN1"
                     /gene_synonym="DEE5; DEVEP; EIEE5; HMN11; HMND11; NEAS;
                     SPG91; SPTA2"
                     /inference="alignment:Splign:2.1.0"
     exon            6183..6392
                     /gene="SPTAN1"
                     /gene_synonym="DEE5; DEVEP; EIEE5; HMN11; HMND11; NEAS;
                     SPG91; SPTA2"
                     /inference="alignment:Splign:2.1.0"
     exon            6393..6689
                     /gene="SPTAN1"
                     /gene_synonym="DEE5; DEVEP; EIEE5; HMN11; HMND11; NEAS;
                     SPG91; SPTA2"
                     /inference="alignment:Splign:2.1.0"
     exon            6690..6802
                     /gene="SPTAN1"
                     /gene_synonym="DEE5; DEVEP; EIEE5; HMN11; HMND11; NEAS;
                     SPG91; SPTA2"
                     /inference="alignment:Splign:2.1.0"
     exon            6803..6820
                     /gene="SPTAN1"
                     /gene_synonym="DEE5; DEVEP; EIEE5; HMN11; HMND11; NEAS;
                     SPG91; SPTA2"
                     /inference="alignment:Splign:2.1.0"
     exon            6821..6875
                     /gene="SPTAN1"
                     /gene_synonym="DEE5; DEVEP; EIEE5; HMN11; HMND11; NEAS;
                     SPG91; SPTA2"
                     /inference="alignment:Splign:2.1.0"
     exon            6876..7072
                     /gene="SPTAN1"
                     /gene_synonym="DEE5; DEVEP; EIEE5; HMN11; HMND11; NEAS;
                     SPG91; SPTA2"
                     /inference="alignment:Splign:2.1.0"
     exon            7073..7126
                     /gene="SPTAN1"
                     /gene_synonym="DEE5; DEVEP; EIEE5; HMN11; HMND11; NEAS;
                     SPG91; SPTA2"
                     /inference="alignment:Splign:2.1.0"
     exon            7127..7273
                     /gene="SPTAN1"
                     /gene_synonym="DEE5; DEVEP; EIEE5; HMN11; HMND11; NEAS;
                     SPG91; SPTA2"
                     /inference="alignment:Splign:2.1.0"
     exon            7274..7421
                     /gene="SPTAN1"
                     /gene_synonym="DEE5; DEVEP; EIEE5; HMN11; HMND11; NEAS;
                     SPG91; SPTA2"
                     /inference="alignment:Splign:2.1.0"
     exon            7422..7875
                     /gene="SPTAN1"
                     /gene_synonym="DEE5; DEVEP; EIEE5; HMN11; HMND11; NEAS;
                     SPG91; SPTA2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      7853..7858
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SPTAN1"
                     /gene_synonym="DEE5; DEVEP; EIEE5; HMN11; HMND11; NEAS;
                     SPG91; SPTA2"
                     /note="hexamer: AATAAA"
     polyA_site      7875
                     /gene="SPTAN1"
                     /gene_synonym="DEE5; DEVEP; EIEE5; HMN11; HMND11; NEAS;
                     SPG91; SPTA2"
                     /note="major polyA site"
ORIGIN      
        1 gccactaccc gctgcggagt gaacggtgtg gagcggaggc cgcggaggct cctcggtcct
       61 tcagcacccc tcggcccgac gcacccacgc ccctcacccc ccgagagccg aaaatggacc
      121 caagtggggt caaagtgctg gaaacagcag aggacatcca ggagaggcgg cagcaggtcc
      181 tagaccgata ccaccgcttc aaggaactct caacccttag gcgtcagaag ctggaagatt
      241 cctatcgatt ccagttcttt caaagagatg ctgaagagct ggagaaatgg atacaggaaa
      301 aacttcagat tgcatctgat gagaattata aagacccaac caacttgcag ggaaagcttc
      361 agaagcatca agcatttgaa gctgaagtgc aggccaactc aggagccatt gttaagctgg
      421 atgaaactgg aaacctgatg atctcagaag ggcattttgc atctgaaacc atacggaccc
      481 gtttgatgga gctgcaccgc cagtgggaat tacttttgga gaagatgcga gaaaaaggaa
      541 tcaaactgct gcaggcccag aagttggtgc agtacttacg agaatgtgag gacgtgatgg
      601 actggatcaa tgacaaggaa gcaattgtta cttctgaaga gctgggccag gatctggagc
      661 atgtagaggt tttacagaag aaatttgaag agtttcaaac agatatggct gctcatgaag
      721 aaagagttaa tgaagtgaac cagtttgctg ccaaactcat acaggagcag caccctgagg
      781 aggaactgat caagactaag caggatgaag tcaatgcagc ctggcagcgg ctgaagggcc
      841 tggctctgca gaggcagggg aagctctttg gggcagcaga agttcagcgc tttaacaggg
      901 atgtggatga gactatcagt tggattaagg aaaaggagca gttaatggcc tctgatgatt
      961 ttggccgaga cctggcaagt gttcaggctc tgcttcggaa gcacgagggt ctggagagag
     1021 atcttgctgc tctagaagac aaggtcaaag ccctgtgtgc tgaggctgac cgcctgcaac
     1081 agtcccaccc tctgagtgca acacagattc aagtgaagcg agaggaactg attacaaact
     1141 gggagcagat ccgcaccttg gcggcagaga gacatgcacg gctcaatgat tcatacaggc
     1201 ttcaacgctt ccttgctgac ttccgtgacc tcaccagctg ggtgactgag atgaaagccc
     1261 tcatcaatgc agatgagctt gccagtgatg tggctggggc tgaagccctg ctagatagac
     1321 accaagagca caagggtgaa attgatgccc atgaagacag cttcaaatct gcagatgaat
     1381 ctggacaggc actgcttgct gctggtcact atgcctcaga tgaagtgagg gagaagctga
     1441 ccgtcctttc cgaggagaga gcggcgctgc tggagctgtg ggagctgcgc aggcagcagt
     1501 acgagcagtg catggacctg cagctcttct accgggacac tgagcaggtg gacaactgga
     1561 tgagcaagca ggaggcgttc ctgttgaatg aagacttggg agattccttg gatagtgtgg
     1621 aagcgcttct taagaagcac gaagactttg agaaatccct tagtgcccag gaggaaaaga
     1681 ttacagcatt agatgaattt gcaaccaagc taattcagaa caaccactat gcaatggaag
     1741 atgtggccac tcgccgagat gctctgttga gccgccgcaa tgcccttcac gagagagcca
     1801 tgcgtcgccg ggcccagcta gccgattctt tccatctgca gcagtttttc cgtgattctg
     1861 atgagctcaa gagttgggtc aatgagaaga tgaaaactgc cacagatgaa gcttataaag
     1921 atccatccaa cctacaagga aaagtacaga agcatcaggc ttttgaggct gagctctcag
     1981 caaaccagag ccgaattgat gccttggaga aagctggcca aaagctgatt gatgtcaacc
     2041 actatgccaa ggatgaagtg gcagctcgta tgaatgaggt gatcagtttg tggaagaaac
     2101 tgctagaggc cactgaactg aaaggaataa agcttcgtga agccaaccag caacagcaat
     2161 ttaatcgcaa tgttgaggat attgaattgt ggctatatga agtagaaggt cacttggctt
     2221 cggatgatta cggcaaagat cttaccaatg tgcagaacct ccagaagaaa catgcactgc
     2281 tagaggcaga tgtggctgct caccaggacc gaattgatgg catcaccatt caggcccgcc
     2341 agttccaaga tgctggccat tttgatgcag aaaacatcaa gaagaaacag gaagccctcg
     2401 tggctcgcta tgaggcactc aaggagccca tggttgcccg gaagcagaag ctggccgatt
     2461 ctctgcggtt gcagcagctc ttccgggatg ttgaggatga ggagacgtgg attcgagaga
     2521 aagagcccat tgccgcatct accaacagag gtaaggattt aattggggtc cagaatctgc
     2581 taaagaaaca tcaagcctta caagcagaaa ttgctggaca tgaaccacgc atcaaagcag
     2641 ttacacagaa ggggaatgcc atggtggagg aaggccattt tgctgcagag gatgtgaagg
     2701 ccaagcttca cgagctgaac caaaagtggg aggcactgaa agccaaagct tcccagcgtc
     2761 ggcaggacct ggaggactct ctgcaggccc agcagtactt tgctgatgct aacgaggctg
     2821 aatcctggat gcgggagaag gaacccattg tgggcagcac tgactatggc aaggacgaag
     2881 actctgctga ggctctactg aagaaacacg aagctttgat gtcagatctc agtgcctacg
     2941 gcagcagcat ccaggctttg cgagaacaag cacagtcctg ccggcaacaa gtggccccca
     3001 cggatgatga gactgggaag gagctggtct tggctctcta cgactatcag gagaagagtc
     3061 cccgagaggt caccatgaag aagggagata tccttacctt actcaacagc accaacaagg
     3121 attggtggaa agtggaagtg aacgatcgtc agggttttgt gccggctgcg tacgtgaaga
     3181 aattggaccc cgcccagtca gcctcccggg agaatctcct ggaggagcaa ggcagcatag
     3241 cactgcggca ggagcagatt gacaatcaga cacgcataac taaggaggcc ggcagtgtat
     3301 ctctgcgtat gaagcaggtg gaagaactat atcattctct gctggaactg ggtgagaagc
     3361 gtaaaggcat gttggagaag agttgcaaga agtttatgtt gttccgtgaa gcgaatgaac
     3421 tacagcaatg gatcaatgag aaggaagccg ctctgacaag tgaggaggtc ggagcagact
     3481 tggagcaggt tgaggtgctc cagaagaagt ttgatgactt ccagaaggac ctgaaggcca
     3541 atgagtcacg gttgaaggac attaacaagg tagctgaaga cctggagtct gaaggtctca
     3601 tggcagagga ggtgcaggct gtgcaacaac aggaagtgta tggcatgatg cccagggatg
     3661 aaactgattc caagacagcc tccccgtgga agtctgctcg tctgatggtt cacaccgtgg
     3721 ccacctttaa ttccatcaag gagctgaatg agcgctggcg gtccctacag cagctggccg
     3781 aggaacggag ccagctcttg ggcagcgccc atgaagtaca gaggttccac agagatgctg
     3841 atgaaaccaa agaatggatt gaagagaaga atcaagctct aaacacagac aattatggac
     3901 atgatctcgc cagtgtccag gccctgcaac gcaagcatga gggcttcgag agggaccttg
     3961 cggctctcgg tgacaaggta aactcccttg gtgaaacagc agagcgcctg atccagtccc
     4021 atcccgagtc agcagaagac ctgcaggaaa agtgcacaga gttaaaccag gcctggagca
     4081 gcctggggaa acgtgcagat cagcgcaagg caaagttggg tgactcccac gacctgcagc
     4141 gcttccttag cgatttccgg gacctcatgt cttggatcaa tggaatacgg gggttggtgt
     4201 cctcagatga gctagccaag gatgtcaccg gagctgaggc attgctggag cgacaccagg
     4261 aacaccggac agaaatcgat gccagggctg gcactttcca ggcatttgag cagtttggac
     4321 agcagctgtt ggctcacgga cactatgcca gccctgagat caagcagaaa cttgatattc
     4381 ttgaccagga gcgtgcagac ctggagaagg cctgggttca gcgcaggatg atgctggatc
     4441 agtgccttga actgcagctg ttccatcggg actgtgagca agctgagaac tggatggctg
     4501 cccgggaggc cttcttgaat accgaagaca aaggagactc actggacagc gtagaggctc
     4561 tgatcaaaaa acatgaagac tttgacaaag cgattaacgt ccaggaagag aagattgctg
     4621 ctctgcaggc ctttgccgac cagctcatcg ctgccggcca ttatgccaag ggagacattt
     4681 ctagccggcg caatgaggtc ttggacaggt ggcgacgtct gaaagcccag atgattgaga
     4741 aaaggtcaaa gctaggagaa tctcaaaccc tccaacagtt cagccgggat gtggatgaga
     4801 ttgaggcttg gatcagtgaa aaattgcaaa cagcgagtga tgagtcgtac aaggatccca
     4861 ccaacatcca gctttccaag ctgctgagca agcaccagaa gcaccaggct tttgaagcag
     4921 agctgcatgc caacgctgac cggatccgtg gggttatcga catgggcaac tccctcattg
     4981 aacgtggagc ctgtgccggc agtgaggatg ctgtcaaggc ccgcctggct gccttagctg
     5041 accagtggca gttcttggtg caaaagtcag cggaaaagag ccagaaactg aaagaagcca
     5101 acaagcagca gaacttcaac acagggatca aggactttga cttctggctg tctgaggtgg
     5161 aggccctgct ggcatccgaa gattatggca aagacctagc ttctgtgaac aacctgctga
     5221 aaaagcatca actgctggaa gcagatatat ctgcccatga ggatcgcctg aaggacctga
     5281 acagccaggc agacagcctg atgaccagca gtgccttcga cacctcccaa gtaaaggaca
     5341 agagggacac catcaacggg cgcttccaga agatcaagag catggcggcc tcccggcgag
     5401 ccaagctgaa tgaatcccat cgcctgcacc agttcttccg ggacatggat gacgaggagt
     5461 cctggatcaa ggagaagaag ctgctggtgg gctcagagga ctacggccgg gacctaaccg
     5521 gcgtgcagaa cctgaggaag aagcacaagc ggctggaagc agaactggct gcgcatgagc
     5581 cggctattca gggtgtcctg gacactggca agaagctgtc cgatgacaac accatcggga
     5641 aagaggagat ccagcagcgg ctggcgcagt ttgtggagca ctggaaagag ctgaagcagc
     5701 tggcagctgc ccggggtcag cggctggaag agtccttgga atatcagcag tttgtagcca
     5761 atgtggaaga ggaagaagcc tggatcaatg agaaaatgac cctggtggcc agcgaagatt
     5821 atggcgacac tcttgccgcc atccagggct tactgaagaa acatgaagct tttgagacag
     5881 acttcaccgt ccacaaggat cgcgtgaatg atgtctgcac caatggacaa gacctcatta
     5941 agaagaacaa tcaccatgag gagaacatct cttcaaagat gaagggcctg aacgggaaag
     6001 tgtcagacct ggagaaagct gcagcccaga gaaaggcgaa gctggatgag aactcggcct
     6061 tccttcagtt caactggaag gcggacgtgg tggagtcctg gatcggtgaa aaggagaaca
     6121 gcttgaagac agatgattat ggccgagacc tgtcttctgt gcagacgctc ctcaccaaac
     6181 aggaaacttt tgacgctggg ctgcaggcct tccagcagga aggcattgcc aacatcactg
     6241 ccctcaaaga tcagcttctc gccgccaaac acgttcagtc caaggccatc gaggcccggc
     6301 acgcctccct catgaagagg tggagccagc ttctggccaa ctcagccgcc cgcaagaaga
     6361 agcttctgga ggctcagagt cacttccgca aggtggagga cctcttcctg accttcgcca
     6421 aaaaggcttc tgccttcaac agctggtttg aaaatgcaga ggaggactta acagaccccg
     6481 tgcgctgcaa ctccttggaa gaaatcaaag ctttgcgcga ggcccacgac gccttccgct
     6541 cctccctcag ctctgcccag gctgacttca accagctggc cgagctggac cgccagatca
     6601 agagcttccg cgtagcctcc aacccctaca cctggtttac catggaggcc ctggaggaga
     6661 cctggaggaa cctacagaaa atcatcaagg agagggagct ggagctgcag aaggaacagc
     6721 ggcggcagga ggagaacgac aagctgcgcc aggagtttgc ccagcacgcc aacgccttcc
     6781 accagtggat ccaagagacc aggacatacc tcctcgatgg gtcctgtatg gtggaagagt
     6841 cggggaccct cgaatcccag cttgaagcta ccaaacgcaa gcaccaggaa atccgagcca
     6901 tgagaagtca gctcaaaaag atcgaggacc tgggggccgc catggaggag gccctcatcc
     6961 tggacaacaa gtacacggag cacagcaccg tgggcctcgc ccagcagtgg gaccagctgg
     7021 accagctggg catgcgcatg cagcacaacc tggagcagca gatccaggcc aggaacacaa
     7081 caggtgtgac tgaggaggcc ctcaaagaat tcagcatgat gtttaaacac tttgacaagg
     7141 acaagtctgg caggctgaac catcaggagt tcaaatcttg cctgcgctcc ctgggctatg
     7201 acctgcccat ggtggaggaa ggggaacctg accctgagtt cgaggcaatc ctggacacgg
     7261 tggatccgaa cagagatggc catgtctcct tgcaagaata catggctttc atgatcagcc
     7321 gcgaaactga gaacgtcaag tccagcgagg agattgagag cgccttccgg gccctcagct
     7381 cagagggaaa gccttacgtg accaaggagg agctctacca gaacctgacc cgggaacaag
     7441 ccgactactg cgtctcccac atgaagccct acgtggacgg caagggccgc gagctcccca
     7501 ccgcgttcga ctacgtggag ttcacccgct cgcttttcgt gaactgagcc actccctggg
     7561 tcacccaccc ctcgctgctt gccctgcgtc gccttgctgc atgtccgctc ctctgtgtgc
     7621 tctcactttc cactgtaacc ttaagcctgc ttagcttgga ataagactta ggagaaaatg
     7681 gtgcttcact aacccgcttc cggtccagtc acaatcatca tgtcactgtg gggacccaga
     7741 tctgtgtctt gaagcagctg ccctcattcc gacttcagaa aatcgaagca gctggctcct
     7801 ccccttgttc tctctcccac cctcccccaa atctgttttc atgtaaaaga caaataaatg
     7861 atgacttccc ccaaa
//
