LOCUS       NM_003126               8018 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens spectrin alpha, erythrocytic 1 (SPTA1), mRNA.
ACCESSION   NM_003126
VERSION     NM_003126.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 8018)
  AUTHORS   Moreno Toro,N., Gamez Belmonte,A., Alperi Garcia,S., Morillas
            Mingorance,A., Ortega Acosta,M.J., Urrutia Maldonado,E., Bernal
            Sanchez,M. and Pelaez Pleguezuelos,I.
  TITLE     Hereditary elliptocytosis: A novel mutation in the SPTA1 gene and
            diagnosis after a stroke in paediatric patients. A two-case report
  JOURNAL   Pediatr Blood Cancer 70 (7), e30316 (2023)
   PUBMED   37016817
  REMARK    GeneRIF: Hereditary elliptocytosis: A novel mutation in the SPTA1
            gene and diagnosis after a stroke in paediatric patients. A
            two-case report.
REFERENCE   2  (bases 1 to 8018)
  AUTHORS   Anil More,T. and Kedar,P.
  TITLE     Unravelling the genetic and phenotypic heterogeneity of SPTA1 gene
            variants in Hereditary Elliptocytosis and Hereditary
            Pyropoikilocytosis patients using next-generation sequencing
  JOURNAL   Gene 843, 146796 (2022)
   PUBMED   35961434
  REMARK    GeneRIF: Unravelling the genetic and phenotypic heterogeneity of
            SPTA1 gene variants in Hereditary Elliptocytosis and Hereditary
            Pyropoikilocytosis patients using next-generation sequencing.
REFERENCE   3  (bases 1 to 8018)
  AUTHORS   Herrera-Tirado,I.M., Espinoza-Mata,L.L., Rizo-delaTorre,L.D.C.,
            Becerra-Solano,L.E., Ibarra-Cortes,B. and Perea-Diaz,F.J.
  TITLE     Effects of SPTA1 Gene Variants on the Hematological Phenotype of
            Mexican Patients with Hereditary Spherocytosis
  JOURNAL   Genet Test Mol Biomarkers 26 (5), 270-276 (2022)
   PUBMED   35638908
  REMARK    GeneRIF: Effects of SPTA1 Gene Variants on the Hematological
            Phenotype of Mexican Patients with Hereditary Spherocytosis.
REFERENCE   4  (bases 1 to 8018)
  AUTHORS   Andolfo,I., Martone,S., Rosato,B.E., Marra,R., Gambale,A.,
            Forni,G.L., Pinto,V., Goransson,M., Papadopoulou,V., Gavillet,M.,
            Elalfy,M., Panarelli,A., Tomaiuolo,G., Iolascon,A. and Russo,R.
  TITLE     Complex Modes of Inheritance in Hereditary Red Blood Cell
            Disorders: A Case Series Study of 155 Patients
  JOURNAL   Genes (Basel) 12 (7), 958 (2021)
   PUBMED   34201899
  REMARK    GeneRIF: Complex Modes of Inheritance in Hereditary Red Blood Cell
            Disorders: A Case Series Study of 155 Patients.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 8018)
  AUTHORS   Boulanger,L., Sabatino,D.E., Wong,E.Y., Cline,A.P., Garrett,L.J.,
            Garbarz,M., Dhermy,D., Bodine,D.M. and Gallagher,P.G.
  TITLE     Erythroid expression of the human alpha-spectrin gene promoter is
            mediated by GATA-1- and NF-E2-binding proteins
  JOURNAL   J Biol Chem 277 (44), 41563-41570 (2002)
   PUBMED   12196550
  REMARK    GeneRIF: identification and characterization of the gene promoter;
            requires GATA-1- and NF-E2-binding proteins to direct high level
            expression in erythroid cells in vitro.
REFERENCE   6  (bases 1 to 8018)
  AUTHORS   Kanzaki,A., Rabodonirina,M., Yawata,Y., Wilmotte,R., Wada,H.,
            Ata,K., Yamada,O., Akatsuka,J., Iyori,H., Horiguchi,M. et al.
  TITLE     A deletional frameshift mutation of the beta-spectrin gene
            associated with elliptocytosis in spectrin Tokyo (beta 220/216)
  JOURNAL   Blood 80 (8), 2115-2121 (1992)
   PUBMED   1391962
REFERENCE   7  (bases 1 to 8018)
  AUTHORS   Hentati,A., Hu,P., Asgharzadeh,S. and Siddique,T.
  TITLE     Dinucleotide repeat polymorphism at the human erythroid alpha
            spectrin (SPTA1) locus
  JOURNAL   Hum Mol Genet 1 (3), 218 (1992)
   PUBMED   1339473
REFERENCE   8  (bases 1 to 8018)
  AUTHORS   Gallagher,P.G., Tse,W.T., Coetzer,T., Lecomte,M.C., Garbarz,M.,
            Zarkowsky,H.S., Baruchel,A., Ballas,S.K., Dhermy,D., Palek,J. et
            al.
  TITLE     A common type of the spectrin alpha I 46-50a-kD peptide abnormality
            in hereditary elliptocytosis and pyropoikilocytosis is associated
            with a mutation distant from the proteolytic cleavage site.
            Evidence for the functional importance of the triple helical model
            of spectrin
  JOURNAL   J Clin Invest 89 (3), 892-898 (1992)
   PUBMED   1541680
REFERENCE   9  (bases 1 to 8018)
  AUTHORS   Sahr,K.E., Laurila,P., Kotula,L., Scarpa,A.L., Coupal,E.,
            Leto,T.L., Linnenbach,A.J., Winkelmann,J.C., Speicher,D.W.,
            Marchesi,V.T. et al.
  TITLE     The complete cDNA and polypeptide sequences of human erythroid
            alpha-spectrin
  JOURNAL   J Biol Chem 265 (8), 4434-4443 (1990)
   PUBMED   1689726
REFERENCE   10 (bases 1 to 8018)
  AUTHORS   Bennett,V. and Stenbuck,P.J.
  TITLE     The membrane attachment protein for spectrin is associated with
            band 3 in human erythrocyte membranes
  JOURNAL   Nature 280 (5722), 468-473 (1979)
   PUBMED   379653
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL353894.14, M61877.1,
            CD616351.1 and BU665064.1.
            
            On May 17, 2019 this sequence version replaced NM_003126.3.
            
            Summary: This gene encodes a member of a family of molecular
            scaffold proteins that link the plasma membrane to the actin
            cytoskeleton and functions in the determination of cell shape,
            arrangement of transmembrane proteins, and organization of
            organelles. The encoded protein is primarily composed of 22
            spectrin repeats which are involved in dimer formation. It forms a
            component of the erythrocyte plasma membrane. Mutations in this
            gene result in a variety of hereditary red blood cell disorders,
            including elliptocytosis-2, pyropoikilocytosis, and spherocytosis,
            type 3. [provided by RefSeq, Aug 2017].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: M61877.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000643759.2/ ENSP00000495214.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-17                AL353894.14        103055-103071       c
            18-73               M61877.1           1-56
            74-158              M61877.1           58-142
            159-323             M61877.1           147-311
            324-324             AL353894.14        101602-101602       c
            325-506             M61877.1           313-494
            507-507             AL353894.14        99808-99808         c
            508-1112            M61877.1           496-1100
            1113-1140           AL353894.14        94061-94088         c
            1141-1874           M61877.1           1129-1862
            1875-1875           AL353894.14        86065-86065         c
            1876-3684           M61877.1           1864-3672
            3685-3685           AL353894.14        66294-66294         c
            3686-4425           M61877.1           3674-4413
            4426-4426           AL353894.14        60719-60719         c
            4427-4899           M61877.1           4415-4887
            4900-5256           CD616351.1         3-359               c
            5257-5870           M61877.1           5242-5855
            5871-5871           AL353894.14        43355-43355         c
            5872-7396           M61877.1           5857-7381
            7397-7554           BU665064.1         375-532
            7555-7768           AL353894.14        27310-27523         c
            7769-8016           M61877.1           7754-8001
            8017-8018           AL353894.14        27060-27061         c
FEATURES             Location/Qualifiers
     source          1..8018
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q23.1"
     gene            1..8018
                     /gene="SPTA1"
                     /gene_synonym="EL2; HPP; HS3; SPH3; SPTA"
                     /note="spectrin alpha, erythrocytic 1"
                     /db_xref="GeneID:6708"
                     /db_xref="HGNC:HGNC:11272"
                     /db_xref="MIM:182860"
     exon            1..222
                     /gene="SPTA1"
                     /gene_synonym="EL2; HPP; HS3; SPH3; SPTA"
                     /inference="alignment:Splign:2.1.0"
     CDS             199..7458
                     /gene="SPTA1"
                     /gene_synonym="EL2; HPP; HS3; SPH3; SPTA"
                     /note="alpha-I spectrin; spectrin alpha chain,
                     erythrocyte; erythroid alpha-spectrin; elliptocytosis 2"
                     /codon_start=1
                     /product="spectrin alpha chain, erythrocytic 1"
                     /protein_id="NP_003117.2"
                     /db_xref="CCDS:CCDS41423.1"
                     /db_xref="GeneID:6708"
                     /db_xref="HGNC:HGNC:11272"
                     /db_xref="MIM:182860"
                     /translation="MEQFPKETVVESSGPKVLETAEEIQERRQEVLTRYQSFKERVAE
                     RGQKLEDSYHLQVFKRDADDLGKWIMEKVNILTDKSYEDPTNIQGKYQKHQSLEAEVQ
                     TKSRLMSELEKTREERFTMGHSAHEETKAHIEELRHLWDLLLELTLEKGDQLLRALKF
                     QQYVQECADILEWIGDKEAIATSVELGEDWERTEVLHKKFEDFQVELVAKEGRVVEVN
                     QYANECAEENHPDLPLIQSKQNEVNAAWERLRGLALQRQKALSNAANLQRFKRDVTEA
                     IQWIKEKEPVLTSEDYGKDLVASEGLFHSHKGLERNLAVMSDKVKELCAKAEKLTLSH
                     PSDAPQIQEMKEDLVSSWEHIRALATSRYEKLQATYWYHRFSSDFDELSGWMNEKTAA
                     INADELPTDVAGGEVLLDRHQQHKHEIDSYDDRFQSADETGQDLVNANHEASDEVREK
                     MEILDNNWTALLELWDERHRQYEQCLDFHLFYRDSEQVDSWMSRQEAFLENEDLGNSL
                     GSAEALLQKHEDFEEAFTAQEEKIITVDKTATKLIGDDHYDSENIKAIRDGLLARRDA
                     LREKAATRRRLLKESLLLQKLYEDSDDLKNWINKKKKLADDEDYKDIQNLKSRVQKQQ
                     VFEKELAVNKTQLENIQKTGQEMIEGGHYASDNVTTRLSEVASLWEELLEATKQKGTQ
                     LHEANQQLQFENNAEDLQRWLEDVEWQVTSEDYGKGLAEVQNRLRKHGLLESAVAARQ
                     DQVDILTDLAAYFEEIGHPDSKDIRARQESLVCRFEALKEPLATRKKKLLDLLHLQLI
                     CRDTEDEEAWIQETEPSATSTYLGKDLIASKKLLNRHRVILENIASHEPRIQEITERG
                     NKMVEEGHFAAEDVASRVKSLNQNMESLRARAARRQNDLEANVQFQQYLADLHEAETW
                     IREKEPIVDNTNYGADEEAAGALLKKHEAFLLDLNSFGDSMKALRNQANACQQQQAAP
                     VEGVAGEQRVMALYDFQARSPREVTMKKGDVLTLLSSINKDWWKVEAADHQGIVPAVY
                     VRRLAHDEFPMLPQRRREEPGNITQRQEQIENQYRSLLDRAEERRRRLLQRYNEFLLA
                     YEAGDMLEWIQEKKAENTGVELDDVWELQKKFDEFQKDLNTNEPRLRDINKVADDLLF
                     EGLLTPEGAQIRQELNSRWGSLQRLADEQRQLLGSAHAVEVFHREADDTKEQIEKKCQ
                     ALSAADPGSDLFSVQALQRRHEGFERDLVPLGDKVTILGETAERLSESHPDATEDLQR
                     QKMELNEAWEDLQGRTKDRKESLNEAQKFYLFLSKARDLQNWISSIGGMVSSQELAED
                     LTGIEILLERHQEHRADMEAEAPTFQALEDFSAELIDSGHHASPEIEKKLQAVKLERD
                     DLEKAWEKRKKILDQCLELQMFQGNCDQVESWMVARENSLRSDDKSSLDSLEALMKKR
                     DDLDKAITAQEGKITDLEHFAESLIADEHYAKEEIATRLQRVLDRWKALKAQLIDERT
                     KLGDYANLKQFYRDLEELEEWISEMLPTACDESYKDATNIQRKYLKHQTFAHEVDGRS
                     EQVHGVINLGNSLIECSACDGNEEAMKEQLEQLKEHWDHLLERTNDKGKKLNEASRQQ
                     RFNTSIRDFEFWLSEAETLLAMKDQARDLASAGNLLKKHQLLEREMLAREDALKDLNT
                     LAEDLLSSGTFNVDQIVKKKDNVNKRFLNVQELAAAHHEKLKEAYALFQFFQDLDDEE
                     SWIEEKLIRVSSQDYGRDLQGVQNLLKKHKRLEGELVAHEPAIQNVLDMAEKLKDKAA
                     VGQEEIQLRLAQFVEHWEKLKELAKARGLKLEESLEYLQFMQNAEEEEAWINEKNALA
                     VRGDCGDTLAATQSLLMKHEALENDFAVHETRVQNVCAQGEDILNKVLQEESQNKEIS
                     SKIEALNEKTPSLAKAIAAWKLQLEDDYAFQEFNWKADVVEAWIADKETSLKTNGNGA
                     DLGDFLTLLAKQDTLDASLQSFQQERLPEITDLKDKLISAQHNQSKAIEERYAALLKR
                     WEQLLEASAVHRQKLLEKQLPLQKAEDLFVEFAHKASALNNWCEKMEENLSEPVHCVS
                     LNEIRQLQKDHEDFLASLARAQADFKCLLELDQQIKALGVPSSPYTWLTVEVLERTWK
                     HLSDIIEEREQELQKEEARQVKNFEMCQEFEQNASTFLQWILETRAYFLDGSLLKETG
                     TLESQLEANKRKQKEIQAMKRQLTKIVDLGDNLEDALILDIKYSTIGLAQQWDQLYQL
                     GLRMQHNLEQQIQAKDIKGVSEETLKEFSTIYKHFDENLTGRLTHKEFRSCLRGLNYY
                     LPMVEEDEHEPKFEKFLDAVDPGRKGYVSLEDYTAFLIDKESENIKSSDEIENAFQAL
                     AEGKSYITKEDMKQALTPEQVSFCATHMQQYMDPRGRSHLSGYDYVGFTNSYFGN"
     exon            223..462
                     /gene="SPTA1"
                     /gene_synonym="EL2; HPP; HS3; SPH3; SPTA"
                     /inference="alignment:Splign:2.1.0"
     exon            463..588
                     /gene="SPTA1"
                     /gene_synonym="EL2; HPP; HS3; SPH3; SPTA"
                     /inference="alignment:Splign:2.1.0"
     exon            589..729
                     /gene="SPTA1"
                     /gene_synonym="EL2; HPP; HS3; SPH3; SPTA"
                     /inference="alignment:Splign:2.1.0"
     exon            730..876
                     /gene="SPTA1"
                     /gene_synonym="EL2; HPP; HS3; SPH3; SPTA"
                     /inference="alignment:Splign:2.1.0"
     exon            877..1010
                     /gene="SPTA1"
                     /gene_synonym="EL2; HPP; HS3; SPH3; SPTA"
                     /inference="alignment:Splign:2.1.0"
     exon            1011..1155
                     /gene="SPTA1"
                     /gene_synonym="EL2; HPP; HS3; SPH3; SPTA"
                     /inference="alignment:Splign:2.1.0"
     exon            1156..1310
                     /gene="SPTA1"
                     /gene_synonym="EL2; HPP; HS3; SPH3; SPTA"
                     /inference="alignment:Splign:2.1.0"
     exon            1311..1446
                     /gene="SPTA1"
                     /gene_synonym="EL2; HPP; HS3; SPH3; SPTA"
                     /inference="alignment:Splign:2.1.0"
     exon            1447..1548
                     /gene="SPTA1"
                     /gene_synonym="EL2; HPP; HS3; SPH3; SPTA"
                     /inference="alignment:Splign:2.1.0"
     exon            1549..1686
                     /gene="SPTA1"
                     /gene_synonym="EL2; HPP; HS3; SPH3; SPTA"
                     /inference="alignment:Splign:2.1.0"
     exon            1687..1797
                     /gene="SPTA1"
                     /gene_synonym="EL2; HPP; HS3; SPH3; SPTA"
                     /inference="alignment:Splign:2.1.0"
     exon            1798..1875
                     /gene="SPTA1"
                     /gene_synonym="EL2; HPP; HS3; SPH3; SPTA"
                     /inference="alignment:Splign:2.1.0"
     exon            1876..2031
                     /gene="SPTA1"
                     /gene_synonym="EL2; HPP; HS3; SPH3; SPTA"
                     /inference="alignment:Splign:2.1.0"
     exon            2032..2236
                     /gene="SPTA1"
                     /gene_synonym="EL2; HPP; HS3; SPH3; SPTA"
                     /inference="alignment:Splign:2.1.0"
     exon            2237..2418
                     /gene="SPTA1"
                     /gene_synonym="EL2; HPP; HS3; SPH3; SPTA"
                     /inference="alignment:Splign:2.1.0"
     exon            2419..2662
                     /gene="SPTA1"
                     /gene_synonym="EL2; HPP; HS3; SPH3; SPTA"
                     /inference="alignment:Splign:2.1.0"
     exon            2663..2785
                     /gene="SPTA1"
                     /gene_synonym="EL2; HPP; HS3; SPH3; SPTA"
                     /inference="alignment:Splign:2.1.0"
     exon            2786..3003
                     /gene="SPTA1"
                     /gene_synonym="EL2; HPP; HS3; SPH3; SPTA"
                     /inference="alignment:Splign:2.1.0"
     exon            3004..3096
                     /gene="SPTA1"
                     /gene_synonym="EL2; HPP; HS3; SPH3; SPTA"
                     /inference="alignment:Splign:2.1.0"
     exon            3097..3234
                     /gene="SPTA1"
                     /gene_synonym="EL2; HPP; HS3; SPH3; SPTA"
                     /inference="alignment:Splign:2.1.0"
     exon            3235..3386
                     /gene="SPTA1"
                     /gene_synonym="EL2; HPP; HS3; SPH3; SPTA"
                     /inference="alignment:Splign:2.1.0"
     exon            3387..3573
                     /gene="SPTA1"
                     /gene_synonym="EL2; HPP; HS3; SPH3; SPTA"
                     /inference="alignment:Splign:2.1.0"
     exon            3574..3675
                     /gene="SPTA1"
                     /gene_synonym="EL2; HPP; HS3; SPH3; SPTA"
                     /inference="alignment:Splign:2.1.0"
     exon            3676..3767
                     /gene="SPTA1"
                     /gene_synonym="EL2; HPP; HS3; SPH3; SPTA"
                     /inference="alignment:Splign:2.1.0"
     exon            3768..3912
                     /gene="SPTA1"
                     /gene_synonym="EL2; HPP; HS3; SPH3; SPTA"
                     /inference="alignment:Splign:2.1.0"
     exon            3913..4094
                     /gene="SPTA1"
                     /gene_synonym="EL2; HPP; HS3; SPH3; SPTA"
                     /inference="alignment:Splign:2.1.0"
     exon            4095..4194
                     /gene="SPTA1"
                     /gene_synonym="EL2; HPP; HS3; SPH3; SPTA"
                     /inference="alignment:Splign:2.1.0"
     exon            4195..4392
                     /gene="SPTA1"
                     /gene_synonym="EL2; HPP; HS3; SPH3; SPTA"
                     /inference="alignment:Splign:2.1.0"
     exon            4393..4536
                     /gene="SPTA1"
                     /gene_synonym="EL2; HPP; HS3; SPH3; SPTA"
                     /inference="alignment:Splign:2.1.0"
     exon            4537..4640
                     /gene="SPTA1"
                     /gene_synonym="EL2; HPP; HS3; SPH3; SPTA"
                     /inference="alignment:Splign:2.1.0"
     exon            4641..4803
                     /gene="SPTA1"
                     /gene_synonym="EL2; HPP; HS3; SPH3; SPTA"
                     /inference="alignment:Splign:2.1.0"
     exon            4804..4935
                     /gene="SPTA1"
                     /gene_synonym="EL2; HPP; HS3; SPH3; SPTA"
                     /inference="alignment:Splign:2.1.0"
     exon            4936..5073
                     /gene="SPTA1"
                     /gene_synonym="EL2; HPP; HS3; SPH3; SPTA"
                     /inference="alignment:Splign:2.1.0"
     exon            5074..5178
                     /gene="SPTA1"
                     /gene_synonym="EL2; HPP; HS3; SPH3; SPTA"
                     /inference="alignment:Splign:2.1.0"
     exon            5179..5387
                     /gene="SPTA1"
                     /gene_synonym="EL2; HPP; HS3; SPH3; SPTA"
                     /inference="alignment:Splign:2.1.0"
     exon            5388..5508
                     /gene="SPTA1"
                     /gene_synonym="EL2; HPP; HS3; SPH3; SPTA"
                     /inference="alignment:Splign:2.1.0"
     exon            5509..5630
                     /gene="SPTA1"
                     /gene_synonym="EL2; HPP; HS3; SPH3; SPTA"
                     /inference="alignment:Splign:2.1.0"
     exon            5631..5763
                     /gene="SPTA1"
                     /gene_synonym="EL2; HPP; HS3; SPH3; SPTA"
                     /inference="alignment:Splign:2.1.0"
     exon            5764..5862
                     /gene="SPTA1"
                     /gene_synonym="EL2; HPP; HS3; SPH3; SPTA"
                     /inference="alignment:Splign:2.1.0"
     exon            5863..6031
                     /gene="SPTA1"
                     /gene_synonym="EL2; HPP; HS3; SPH3; SPTA"
                     /inference="alignment:Splign:2.1.0"
     exon            6032..6108
                     /gene="SPTA1"
                     /gene_synonym="EL2; HPP; HS3; SPH3; SPTA"
                     /inference="alignment:Splign:2.1.0"
     exon            6109..6318
                     /gene="SPTA1"
                     /gene_synonym="EL2; HPP; HS3; SPH3; SPTA"
                     /inference="alignment:Splign:2.1.0"
     exon            6319..6615
                     /gene="SPTA1"
                     /gene_synonym="EL2; HPP; HS3; SPH3; SPTA"
                     /inference="alignment:Splign:2.1.0"
     exon            6616..6728
                     /gene="SPTA1"
                     /gene_synonym="EL2; HPP; HS3; SPH3; SPTA"
                     /inference="alignment:Splign:2.1.0"
     exon            6729..6746
                     /gene="SPTA1"
                     /gene_synonym="EL2; HPP; HS3; SPH3; SPTA"
                     /inference="alignment:Splign:2.1.0"
     exon            6747..6798
                     /gene="SPTA1"
                     /gene_synonym="EL2; HPP; HS3; SPH3; SPTA"
                     /inference="alignment:Splign:2.1.0"
     exon            6799..6986
                     /gene="SPTA1"
                     /gene_synonym="EL2; HPP; HS3; SPH3; SPTA"
                     /inference="alignment:Splign:2.1.0"
     exon            6987..7040
                     /gene="SPTA1"
                     /gene_synonym="EL2; HPP; HS3; SPH3; SPTA"
                     /inference="alignment:Splign:2.1.0"
     exon            7041..7187
                     /gene="SPTA1"
                     /gene_synonym="EL2; HPP; HS3; SPH3; SPTA"
                     /inference="alignment:Splign:2.1.0"
     exon            7188..7332
                     /gene="SPTA1"
                     /gene_synonym="EL2; HPP; HS3; SPH3; SPTA"
                     /inference="alignment:Splign:2.1.0"
     exon            7333..8018
                     /gene="SPTA1"
                     /gene_synonym="EL2; HPP; HS3; SPH3; SPTA"
                     /inference="alignment:Splign:2.1.0"
     regulatory      7992..7997
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SPTA1"
                     /gene_synonym="EL2; HPP; HS3; SPH3; SPTA"
                     /note="hexamer: AATAAA"
     polyA_site      8018
                     /gene="SPTA1"
                     /gene_synonym="EL2; HPP; HS3; SPH3; SPTA"
                     /note="major polyA site"
ORIGIN      
        1 atgtcttcta aagataatgt cgattgtgta tggctgatgg gattctagga ccaagcaaga
       61 ggtttttttt tttcccccac atacttaacg tttctatatt tctatttgaa ttcgactgga
      121 cagttccatt tgaattattt ctctctctct ctctctctga cacattttat cttgccaggt
      181 tctaaacctt taggaaaaat ggagcaattt ccaaaggaaa ccgttgtgga gagcagtggg
      241 ccaaaggttt tggaaacagc agaagagatc caggagaggc gtcaggaagt gttgactcgg
      301 tatcaaagtt tcaaggagcg ggtcgctgag aggggtcaga agcttgagga ttcctatcac
      361 ttacaagttt tcaagcgaga tgcagatgat ctggggaagt ggatcatgga gaaagtcaat
      421 atcttaaccg ataagagcta tgaagaccca actaatatac aggggaaata tcagaagcat
      481 caatcccttg aagcagaggt gcaaacaaaa tcaagactca tgtctgaact ggaaaaaaca
      541 agggaagaac gatttaccat gggtcattct gcccacgaag aaacgaaggc ccatatagag
      601 gagctacgcc acctgtggga cctgctgtta gagctgaccc tggagaaggg tgaccagttg
      661 ctgcgggccc tgaagttcca gcagtatgta caggagtgtg ctgacatctt agagtggatt
      721 ggagacaagg aggctatagc gacatcagtg gagctaggtg aagactggga gcgcaccgaa
      781 gttctgcata agaaatttga agacttccaa gtggagctgg tagctaaaga agggagagtt
      841 gttgaagtga accaatatgc caatgagtgt gccgaggaaa accatcctga cctaccctta
      901 attcagtcta agcaaaatga ggtgaatgct gcctgggagc gccttcgtgg tttggctctc
      961 cagagacaga aagctctgtc caatgctgca aacttacaac gattcaaaag ggatgtgact
     1021 gaagccatcc agtggatcaa ggagaaggaa cctgtactca cctctgagga ctatggcaaa
     1081 gaccttgttg cctctgaagg actgtttcac agtcacaagg gacttgagag aaatcttgct
     1141 gtcatgagtg acaaggtgaa ggagttatgt gctaaagcag agaagctgac actttcccat
     1201 ccttcagatg cacctcagat ccaggagatg aaagaagatc tggtctccag ctgggagcat
     1261 attcgtgccc tggccaccag cagatatgaa aaactgcagg ctacttattg gtaccatcga
     1321 ttttcatctg actttgatga actctcaggc tggatgaacg agaagactgc tgcgatcaat
     1381 gctgatgagc tgccaacaga tgtggctggt ggagaagttc tgctggacag gcatcagcag
     1441 cataagcatg agattgactc ttacgatgac cgatttcaat ctgctgatga gactggtcaa
     1501 gacctcgtga atgccaatca tgaagcctct gatgaagttc gggaaaagat ggaaatactt
     1561 gacaacaact ggactgccct gctggaactg tgggacgagc gtcatcgtca gtatgagcag
     1621 tgcttggact ttcatctctt ctacagagac agtgagcaag tggacagttg gatgagtaga
     1681 caagaggcct tcctggaaaa cgaggatctg ggaaactcac tgggcagtgc agaagccctt
     1741 cttcagaagc atgaagactt tgaggaagcc tttactgccc aggaagagaa gatcataact
     1801 gtagacaaga ctgcaaccaa attgattggt gatgaccatt atgattcaga gaacatcaag
     1861 gctatccgtg acgggctgtt agcccggcgg gatgccctac gtgaaaaggc tgccactaga
     1921 cgtagattgc tgaaggagtc attgcttctg caaaaactgt atgaggactc agatgaccta
     1981 aagaactgga tcaacaagaa gaaaaagttg gcagatgatg aagattacaa ggacatacag
     2041 aacttgaaga gcagggttca aaagcagcaa gtctttgaaa aggagttggc agttaataag
     2101 acccagctgg aaaacataca gaaaactggc caagagatga ttgagggtgg tcactatgcc
     2161 tctgacaatg tgaccactcg tctgagtgaa gttgccagcc tctgggagga gttgctggag
     2221 gctacaaaac agaaagggac ccagttgcat gaggccaacc agcagctgca atttgaaaat
     2281 aatgcagaag atttgcagcg ctggctggag gatgttgagt ggcaagtcac ctctgaggat
     2341 tatgggaaag gcctggccga ggtacagaat cgactcagga aacacggcct cctggagtcg
     2401 gctgtggctg ctcgtcagga tcaggtggat atccttacag acctggctgc atattttgaa
     2461 gaaataggcc atcctgattc taaggatata agggcaaggc aagagtcctt ggtatgccga
     2521 tttgaagctc tgaaagagcc actggccacc cgaaagaaga agctcttaga ccttctccat
     2581 ctgcagctga tttgtagaga cacagaggat gaggaggcct ggatccaaga gactgaaccc
     2641 tcagctactt ccacctacct tggaaaggac ctgattgctt ccaaaaagct tctgaatagg
     2701 catagagtca tcctggagaa cattgccagc catgaaccac gcattcaaga gataacagaa
     2761 aggggaaaca aaatggtaga ggaaggacac tttgctgcag aagatgtggc ctctagggtc
     2821 aagagtttga accagaatat ggagtctctc cgtgctcgag ctgctaggcg acaaaatgat
     2881 cttgaagcca atgtccagtt ccagcagtac ctggctgacc tgcatgaagc agaaacatgg
     2941 atcagagaga aggaacctat tgtagataat actaactatg gtgctgatga agaagcagct
     3001 ggggctcttc taaagaagca tgaggccttt ctattagatc tcaattcatt tggagacagt
     3061 atgaaagctc tgcggaatca ggcaaacgcc tgccagcaac aacaggctgc accagtggag
     3121 ggagttgctg gagaacaaag ggtcatggct ttatatgact tccaggcccg cagcccccga
     3181 gaagtcacca tgaagaaagg tgatgtctta acgctgctca gttccatcaa taaggactgg
     3241 tggaaggtgg aagctgctga tcatcagggc attgtcccag ctgtctatgt cagaagactg
     3301 gcccacgatg agttcccgat gctcccacag cggcgacgag aagagccagg aaacatcacc
     3361 cagcgccagg agcagattga gaaccaatac cgctccctct tggatcgggc agaagaacgc
     3421 agacgtcgtc tattgcaacg ttataatgaa tttttattgg cctatgaggc aggagacatg
     3481 ctggaatgga ttcaagagaa aaaggcagaa aacactggag tggaactaga tgatgtttgg
     3541 gagctgcaga aaaagtttga tgagttccaa aaggatttga ataccaatga gcctcggcta
     3601 agggatatca acaaggtagc tgatgatcta ctatttgaag gacttctaac accagaagga
     3661 gctcaaatcc ggcaggaatt gaattcccgc tggggttctt tgcagaggct tgcagatgaa
     3721 cagcggcagc tgctgggcag tgcccatgct gttgaagtgt ttcacagaga agcagatgac
     3781 acgaaggagc agattgagaa gaaatgccag gccctcagtg ctgcagaccc tggctcagat
     3841 ctgttcagtg ttcaggctct tcagcgacgg catgagggct ttgaaaggga cctcgtaccc
     3901 ctgggagata aggtgaccat actgggggag acagcagagc ggctcagtga gtcccatcca
     3961 gatgccactg aggacctgca gagacagaaa atggagctga atgaggcctg ggaagacctg
     4021 caggggcgta caaaggatcg taaggagagc ctaaatgagg cccagaaatt ctacctgttc
     4081 ctcagcaagg ccagggatct gcagaactgg atcagtagca ttggtggcat ggtatcatca
     4141 caggagctgg ccgaagactt aactggcata gagatcttgc tggagagaca tcaggagcac
     4201 cgtgctgaca tggaggcaga ggctcccacc ttccaggcct tagaggactt cagtgcagaa
     4261 cttatcgaca gtgggcacca tgctagccct gaaattgaaa aaaagcttca agctgtcaag
     4321 ctagagagag atgatttgga gaaggcttgg gaaaaacgca agaagatcct agaccagtgc
     4381 ctggagttgc agatgttcca ggggaactgt gatcaagttg agagctggat ggtggcacgt
     4441 gagaattccc tgaggtcaga tgacaaaagt tccttagaca gtctggaggc tttgatgaag
     4501 aaacgggacg atttggacaa agcaatcact gcccaggaag ggaagatcac tgacctagaa
     4561 cattttgctg agagcctcat tgctgatgaa cactatgcca aagaagagat tgctacgcgg
     4621 ctccaacgtg tactagacag gtggaaggct ctcaaagcac aactgattga tgagcggaca
     4681 aagcttggag actatgccaa cctaaaacaa ttctaccgag accttgagga gctggaagaa
     4741 tggatcagtg agatgctgcc cacagcctgt gatgaatcct acaaagacgc cactaacatt
     4801 cagaggaaat acctgaaaca ccagaccttt gcacatgaag tcgatggccg atctgagcag
     4861 gtgcatggcg tcatcaacct ggggaactcc ctgattgagt gtagcgcttg tgatggcaat
     4921 gaagaggcca tgaaggagca actggaacag ctgaaggaac attgggatca tctgcttgag
     4981 agaacaaatg acaaagggaa gaagctcaat gaggccagtc gtcaacagag gttcaacaca
     5041 agcatccggg actttgagtt ctggctctca gaggcagaga cattgctggc catgaaagat
     5101 caggccaggg acttggcttc agcaggaaac ctactcaaga agcatcagct attggagaga
     5161 gagatgttgg ctcgagagga tgcactcaag gacctgaata cattggctga agatttgctc
     5221 tccagcggga ctttcaacgt tgatcagatt gtgaagaaaa aagataatgt caacaagcgt
     5281 ttcctgaatg tccaagaatt ggcagctgca caccacgaaa aattgaaaga ggcctatgcc
     5341 ttgttccagt tcttccagga tctagatgat gaggaatcct ggatagagga gaagttgata
     5401 cgagtgagct cccaggacta tgggagagat cttcaggggg ttcagaactt gctgaagaag
     5461 cacaaacgcc tagaggggga gctggtggcc catgagcctg ccatccagaa tgtgctggat
     5521 atggcagaga agctgaaaga caaggctgct gtggggcaag aggagatcca gttgcggctg
     5581 gctcagtttg ttgaacactg ggagaagctc aaagagttgg ccaaggcccg aggacttaag
     5641 ttggaagaat ccctagaata cttgcaattc atgcagaatg ctgaggaaga ggaagcttgg
     5701 atcaatgaaa agaatgcttt ggctgtccga ggagattgtg gagatacatt agctgctact
     5761 cagagcttgc taatgaagca tgaagctttg gaaaatgact ttgctgtcca tgagacccga
     5821 gtacaaaatg tgtgtgcaca aggagaagac atcctaaata aggtgttgca ggaggaaagt
     5881 cagaacaaag agatttcttc caagatagag gctctgaatg aaaagacccc ttctctggct
     5941 aaggcaatag ctgcttggaa gttgcaattg gaagacgatt atgcctttca ggaattcaac
     6001 tggaaggctg atgtggtaga ggcttggata gctgataagg aaacaagcct aaagaccaat
     6061 ggcaatggtg cagaccttgg tgacttcctc actcttctgg caaaacagga cactctggat
     6121 gccagtctgc agagtttcca gcaagagaga cttcccgaga tcactgacct gaaggacaaa
     6181 ctgatttctg ctcaacacaa ccagtctaaa gccattgaag agcgttatgc cgctctgctg
     6241 aagcgctggg aacagttgct ggaagcctcg gcagtccaca gacagaaatt gctggagaaa
     6301 cagctgcctc tacagaaggc tgaggacctg ttcgtggaat ttgcacataa ggcttcagct
     6361 ttgaacaact ggtgtgaaaa gatggaagaa aacttgtcag agcctgtgca ctgtgtctcc
     6421 ctgaatgaaa ttcggcagct gcagaaagac catgaggact tcttggcctc cctggctagg
     6481 gctcaagcag actttaaatg tttgctggag ctagaccagc agattaaggc cttaggtgtg
     6541 ccttccagcc cttatacctg gttaacagtg gaggtgctgg aaaggacctg gaagcaccta
     6601 tctgacatca ttgaggaacg ggagcaggag ctgcaaaagg aagaggcaag acaggtcaag
     6661 aactttgaga tgtgtcagga gtttgaacag aatgccagta ccttccttca atggatcctg
     6721 gaaaccaggg cttactttct ggatggatca ttgctcaaag aaacaggaac tctggaatct
     6781 cagctggaag caaataaaag aaaacagaag gagatccagg cgatgaagcg tcaactaacc
     6841 aagattgtgg acctggggga caacttggaa gacgctctga tccttgatat caaatacagc
     6901 accattggat tggctcagca gtgggaccag ctctaccagc ttgggttgcg gatgcaacac
     6961 aacctggagc aacagatcca ggccaaggac atcaaaggtg tgagtgaaga gactctaaag
     7021 gaatttagca caatctataa acactttgat gagaatttga cagggcgcct gactcacaaa
     7081 gagttccggt cctgcctgag aggactcaat tactacttgc ccatggtgga ggaggatgaa
     7141 catgagccca agtttgagaa gttcctggat gctgtggatc cagggaggaa gggctatgtc
     7201 tcactggagg actatactgc tttcctgatt gacaaggagt cagaaaacat caagtccagt
     7261 gatgaaatag agaatgcctt ccaagccctg gcagagggca agtcatatat taccaaagaa
     7321 gacatgaagc aggcccttac cccagagcaa gtgtcattct gtgccacaca tatgcagcaa
     7381 tatatggacc cacggggtcg aagccatctc tctggctatg actacgttgg cttcaccaat
     7441 tcctactttg gcaactaata agcagctcct cgtggatcgt agaaaatctt agtgtcgtgg
     7501 gaaatttact ggggggcaaa gagtacaggc aaatgtggaa gataaagatg gcctcgtgtg
     7561 tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg cttgtgtttg tgtgcatatt acatttattg
     7621 taggatctta aaaaatctca agggtgggag atagaaaggt taatagagtt ggaggagtgg
     7681 aagctatttt gtatgcaact agtcactgct gaggggtgtc aaagtttcta tttttatttg
     7741 ttctgttttg cacgtcttta tcattttgct ttattccgat tatagaataa agtaattctt
     7801 tttaaaaata ttttttgggg caaagttaag taaaatgttg agcttctata tttctgggaa
     7861 ctgtactcat ataagagtgg gcagctaatt ttactgtaaa gaagggccat ggtatagtag
     7921 ataaataaaa tccaaggcaa ttttcaaaca atttttttaa actttggaat gtgtttaaat
     7981 ttaaatttga aaataaagat atttgatttt ctggggaa
//
