LOCUS       NM_080861               1535 bp    mRNA    linear   PRI 23-APR-2024
DEFINITION  Homo sapiens splA/ryanodine receptor domain and SOCS box containing
            3 (SPSB3), transcript variant 1, mRNA.
ACCESSION   NM_080861
VERSION     NM_080861.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1535)
  AUTHORS   Xu,P., Liu,Y., Liu,C., Guey,B., Li,L., Melenec,P., Ricci,J. and
            Ablasser,A.
  TITLE     The CRL5-SPSB3 ubiquitin ligase targets nuclear cGAS for
            degradation
  JOURNAL   Nature 627 (8005), 873-879 (2024)
   PUBMED   38418882
  REMARK    GeneRIF: The CRL5-SPSB3 ubiquitin ligase targets nuclear cGAS for
            degradation.
REFERENCE   2  (bases 1 to 1535)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   3  (bases 1 to 1535)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 1535)
  AUTHORS   Liu,Y., Zhou,H., Zhu,R., Ding,F., Li,Y., Cao,X. and Liu,Z.
  TITLE     SPSB3 targets SNAIL for degradation in GSK-3beta
            phosphorylation-dependent manner and regulates metastasis
  JOURNAL   Oncogene 37 (6), 768-776 (2018)
   PUBMED   29059170
  REMARK    GeneRIF: Low SPSB3 expression is associated with lymph node
            metastasis in Ovarian and esophageal squamous cell carcinoma.
REFERENCE   5  (bases 1 to 1535)
  AUTHORS   Naukkarinen,J., Surakka,I., Pietilainen,K.H., Rissanen,A.,
            Salomaa,V., Ripatti,S., Yki-Jarvinen,H., van Duijn,C.M.,
            Wichmann,H.E., Kaprio,J., Taskinen,M.R. and Peltonen,L.
  CONSRTM   ENGAGE Consortium
  TITLE     Use of genome-wide expression data to mine the 'Gray Zone' of GWA
            studies leads to novel candidate obesity genes
  JOURNAL   PLoS Genet 6 (6), e1000976 (2010)
   PUBMED   20532202
  REMARK    GeneRIF: Observational study and genome-wide association study of
            gene-disease association. (HuGE Navigator)
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1535)
  AUTHORS   Oh,J.H., Yang,J.O., Hahn,Y., Kim,M.R., Byun,S.S., Jeon,Y.J.,
            Kim,J.M., Song,K.S., Noh,S.M., Kim,S., Yoo,H.S., Kim,Y.S. and
            Kim,N.S.
  TITLE     Transcriptome analysis of human gastric cancer
  JOURNAL   Mamm Genome 16 (12), 942-954 (2005)
   PUBMED   16341674
REFERENCE   7  (bases 1 to 1535)
  AUTHORS   Kile,B.T., Schulman,B.A., Alexander,W.S., Nicola,N.A., Martin,H.M.
            and Hilton,D.J.
  TITLE     The SOCS box: a tale of destruction and degradation
  JOURNAL   Trends Biochem Sci 27 (5), 235-241 (2002)
   PUBMED   12076535
  REMARK    Review article
REFERENCE   8  (bases 1 to 1535)
  AUTHORS   Daniels,R.J., Peden,J.F., Lloyd,C., Horsley,S.W., Clark,K.,
            Tufarelli,C., Kearney,L., Buckle,V.J., Doggett,N.A., Flint,J. and
            Higgs,D.R.
  TITLE     Sequence, structure and pathology of the fully annotated terminal 2
            Mb of the short arm of human chromosome 16
  JOURNAL   Hum Mol Genet 10 (4), 339-352 (2001)
   PUBMED   11157797
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BM836743.1, BI768095.1 and AK074190.1.
            
            On Nov 22, 2018 this sequence version replaced NM_080861.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK074190.1, BC024244.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000566339.6/ ENSP00000457206.1
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-280               BM836743.1         34-313
            281-815             BI768095.1         244-778
            816-1535            AK074190.1         789-1508
FEATURES             Location/Qualifiers
     source          1..1535
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16p13.3"
     gene            1..1535
                     /gene="SPSB3"
                     /gene_synonym="C16orf31; SSB3"
                     /note="splA/ryanodine receptor domain and SOCS box
                     containing 3"
                     /db_xref="GeneID:90864"
                     /db_xref="HGNC:HGNC:30629"
                     /db_xref="MIM:611659"
     exon            1..70
                     /gene="SPSB3"
                     /gene_synonym="C16orf31; SSB3"
                     /inference="alignment:Splign:2.1.0"
     exon            71..208
                     /gene="SPSB3"
                     /gene_synonym="C16orf31; SSB3"
                     /inference="alignment:Splign:2.1.0"
     CDS             83..1150
                     /gene="SPSB3"
                     /gene_synonym="C16orf31; SSB3"
                     /note="SPRY domain-containing SOCS box protein SSB-3"
                     /codon_start=1
                     /product="SPRY domain-containing SOCS box protein 3"
                     /protein_id="NP_543137.2"
                     /db_xref="CCDS:CCDS32365.1"
                     /db_xref="GeneID:90864"
                     /db_xref="HGNC:HGNC:30629"
                     /db_xref="MIM:611659"
                     /translation="MARRPRNSRAWHFVLSAARRDADARAVALAGSTNWGYDSDGQHS
                     DSDSDPEYSTLPPSIPSAVPVTGESFCDCAGQSEASFCSSLHSAHRGRDCRCGEEDEY
                     FDWVWDDLNKSSATLLSCDNRKVSFHMEYSCGTAAIRGTKELGEGQHFWEIKMTSPVY
                     GTDMMVGIGTSDVDLDKYRHTFCSLLGRDEDSWGLSYTGLLHHKGDKTSFSSRFGQGS
                     IIGVHLDTWHGTLTFFKNRKCIGVAATKLQNKRFYPMVCSTAARSSMKVTRSCASATS
                     LQYLCCHRLRQLRPDSGDTLEGLPLPPGLKQVLHNKLGWVLSMSCSRRKAPVSDPQAA
                     TSAHPSSREPRPCQRKRCRRT"
     exon            209..386
                     /gene="SPSB3"
                     /gene_synonym="C16orf31; SSB3"
                     /inference="alignment:Splign:2.1.0"
     exon            387..574
                     /gene="SPSB3"
                     /gene_synonym="C16orf31; SSB3"
                     /inference="alignment:Splign:2.1.0"
     exon            575..677
                     /gene="SPSB3"
                     /gene_synonym="C16orf31; SSB3"
                     /inference="alignment:Splign:2.1.0"
     exon            678..803
                     /gene="SPSB3"
                     /gene_synonym="C16orf31; SSB3"
                     /inference="alignment:Splign:2.1.0"
     exon            804..1535
                     /gene="SPSB3"
                     /gene_synonym="C16orf31; SSB3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1506..1511
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SPSB3"
                     /gene_synonym="C16orf31; SSB3"
                     /note="hexamer: AATAAA"
     polyA_site      1535
                     /gene="SPSB3"
                     /gene_synonym="C16orf31; SSB3"
                     /note="major polyA site"
ORIGIN      
        1 gtttacgtct cgctccgggg cggaaagtgg gtcagggccg ggccggcgga gcgcgcagcg
       61 ggggctgcag attctttcca ccatggccag acgcccccgg aacagcaggg cctggcactt
      121 cgtcctgagt gcagcccgcc gagacgcaga tgcccgggcc gtggctctag caggctccac
      181 taactggggc tacgactctg atgggcagca cagcgactcg gactccgacc ccgagtactc
      241 cacgctgccg ccatccatcc ccagtgcggt gcccgtgacc ggcgagtcct tctgtgactg
      301 tgctgggcag agcgaggcct ccttctgtag cagcctgcac tcggcccacc ggggcaggga
      361 ctgccgctgc ggagaggaag acgagtattt cgactgggtc tgggatgact taaataagtc
      421 atcagccacc ctgctgagct gtgacaaccg taaggtcagc ttccacatgg agtacagctg
      481 cggcacagcg gccatccggg gcaccaagga gctgggggag ggccagcact tctgggagat
      541 caagatgacc tctcccgtct acggcaccga catgatggtg ggcatcggga cgtcggatgt
      601 ggacctggac aaataccgcc acacgttctg cagcctgctg ggcagggatg aggacagctg
      661 gggcctctcc tacacgggcc tcctccacca caagggcgac aagaccagct tctcatcgcg
      721 gttcggccag ggctccatca ttggcgtgca cctggacacc tggcacggca cactcacctt
      781 tttcaagaac aggaagtgta taggtgtggc agccaccaag ctgcagaaca agagattcta
      841 cccgatggtg tgctccacgg cggcccggag cagcatgaag gtcacccgct cctgtgccag
      901 cgccacttcc ctccagtacc tgtgctgcca ccgcctgcgc cagctgcggc cagactcggg
      961 agacacgctg gagggtctgc cgctgccgcc gggcctcaag caggtgctac acaacaagct
     1021 gggctgggtc ctgagcatga gttgcagccg ccgcaaggct ccagtgtccg atccccaggc
     1081 agcgacctcc gcccacccca gcagtcgcga gcctcggccc tgccagagga agcgctgccg
     1141 ccggacctga ctgacttccc agtggaactg ccttcttggg ctgggacagc ccctttcctc
     1201 tgtcccttct ttctctgtcc cttccttcca gccacactcc agggcggagt tggatgaggc
     1261 ccgtccggag ggagccatct cttgctcccg aggctgggac agtcctttct gtgggggctc
     1321 tagggcccct ctgctgctgt gctgggtggg gaagcggctg ccctgagccc caggtcttgt
     1381 gggaggctgc gaggacgaga gcctggctgg agcccgcgtt gctgttccca cagggcctcg
     1441 gtttttccta acttgctctg catgctgtca gcggctgccc cgccgtcata gacttaaagg
     1501 actgcaataa atgtagagtt gatgtctaac accca
//
