LOCUS       NM_025106               3106 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens splA/ryanodine receptor domain and SOCS box containing
            1 (SPSB1), mRNA.
ACCESSION   NM_025106
VERSION     NM_025106.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3106)
  AUTHORS   Benz,C., Ali,M., Krystkowiak,I., Simonetti,L., Sayadi,A.,
            Mihalic,F., Kliche,J., Andersson,E., Jemth,P., Davey,N.E. and
            Ivarsson,Y.
  TITLE     Proteome-scale mapping of binding sites in the unstructured regions
            of the human proteome
  JOURNAL   Mol Syst Biol 18 (1), e10584 (2022)
   PUBMED   35044719
REFERENCE   2  (bases 1 to 3106)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   3  (bases 1 to 3106)
  AUTHORS   Zhou,L., Zheng,L., Hu,K., Wang,X., Zhang,R., Zou,Y., Zhong,L.,
            Wang,S., Wu,Y. and Kang,T.
  TITLE     SUMOylation stabilizes hSSB1 and enhances the recruitment of NBS1
            to DNA damage sites
  JOURNAL   Signal Transduct Target Ther 5 (1), 80 (2020)
   PUBMED   32576812
  REMARK    GeneRIF: SUMOylation stabilizes hSSB1 and enhances the recruitment
            of NBS1 to DNA damage sites.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3106)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 3106)
  AUTHORS   Georgana,I. and Maluquer de Motes,C.
  TITLE     Cullin-5 Adaptor SPSB1 Controls NF-kappaB Activation Downstream of
            Multiple Signaling Pathways
  JOURNAL   Front Immunol 10, 3121 (2020)
   PUBMED   32038638
  REMARK    GeneRIF: Cullin-5 Adaptor SPSB1 Controls NF-kappaB Activation
            Downstream of Multiple Signaling Pathways.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3106)
  AUTHORS   Huang,J., Gong,Z., Ghosal,G. and Chen,J.
  TITLE     SOSS complexes participate in the maintenance of genomic stability
  JOURNAL   Mol Cell 35 (3), 384-393 (2009)
   PUBMED   19683501
  REMARK    GeneRIF: SSB1/2 is part of an ssDNA-binding heterotrimeric complex,
            SOSS which is involved in the maintenance of genome stability.
REFERENCE   7  (bases 1 to 3106)
  AUTHORS   Ebstein,F., Lange,N., Urban,S., Seifert,U., Kruger,E. and
            Kloetzel,P.M.
  TITLE     Maturation of human dendritic cells is accompanied by functional
            remodelling of the ubiquitin-proteasome system
  JOURNAL   Int J Biochem Cell Biol 41 (5), 1205-1215 (2009)
   PUBMED   19028597
REFERENCE   8  (bases 1 to 3106)
  AUTHORS   Woo,J.S., Imm,J.H., Min,C.K., Kim,K.J., Cha,S.S. and Oh,B.H.
  TITLE     Structural and functional insights into the B30.2/SPRY domain
  JOURNAL   EMBO J 25 (6), 1353-1363 (2006)
   PUBMED   16498413
REFERENCE   9  (bases 1 to 3106)
  AUTHORS   Wang,D., Li,Z., Messing,E.M. and Wu,G.
  TITLE     The SPRY domain-containing SOCS box protein 1 (SSB-1) interacts
            with MET and enhances the hepatocyte growth factor-induced
            Erk-Elk-1-serum response element pathway
  JOURNAL   J Biol Chem 280 (16), 16393-16401 (2005)
   PUBMED   15713673
REFERENCE   10 (bases 1 to 3106)
  AUTHORS   Kile,B.T., Schulman,B.A., Alexander,W.S., Nicola,N.A., Martin,H.M.
            and Hilton,D.J.
  TITLE     The SOCS box: a tale of destruction and degradation
  JOURNAL   Trends Biochem Sci 27 (5), 235-241 (2002)
   PUBMED   12076535
  REMARK    Review article
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DB242202.1, AL008734.10, BC015711.1 and AL358252.13.
            
            On Nov 22, 2018 this sequence version replaced NM_025106.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803611.488534.1, AK026046.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000328089.11/ ENSP00000330221.6
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-73                DB242202.1         13-85
            74-79               AL008734.10        73669-73674         c
            80-2283             BC015711.1         43-2246
            2284-2284           AL358252.13        2170-2170
            2285-3106           BC015711.1         2248-3069
FEATURES             Location/Qualifiers
     source          1..3106
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p36.22"
     gene            1..3106
                     /gene="SPSB1"
                     /gene_synonym="SSB-1; SSB1"
                     /note="splA/ryanodine receptor domain and SOCS box
                     containing 1"
                     /db_xref="GeneID:80176"
                     /db_xref="HGNC:HGNC:30628"
                     /db_xref="MIM:611657"
     exon            1..178
                     /gene="SPSB1"
                     /gene_synonym="SSB-1; SSB1"
                     /inference="alignment:Splign:2.1.0"
     exon            179..1021
                     /gene="SPSB1"
                     /gene_synonym="SSB-1; SSB1"
                     /inference="alignment:Splign:2.1.0"
     CDS             328..1149
                     /gene="SPSB1"
                     /gene_synonym="SSB-1; SSB1"
                     /note="SPRY domain-containing SOCS box protein SSB-1;
                     novel SPRY domain containing protein"
                     /codon_start=1
                     /product="SPRY domain-containing SOCS box protein 1"
                     /protein_id="NP_079382.2"
                     /db_xref="CCDS:CCDS102.1"
                     /db_xref="GeneID:80176"
                     /db_xref="HGNC:HGNC:30628"
                     /db_xref="MIM:611657"
                     /translation="MGQKVTGGIKTVDMRDPTYRPLKQELQGLDYCKPTRLDLLLDMP
                     PVSYDVQLLHSWNNNDRSLNVFVKEDDKLIFHRHPVAQSTDAIRGKVGYTRGLHVWQI
                     TWAMRQRGTHAVVGVATADAPLHSVGYTTLVGNNHESWGWDLGRNRLYHDGKNQPSKT
                     YPAFLEPDETFIVPDSFLVALDMDDGTLSFIVDGQYMGVAFRGLKGKKLYPVVSAVWG
                     HCEIRMRYLNGLDPEPLPLMDLCRRSVRLALGRERLGEIHTLPLPASLKAYLLYQ"
     exon            1022..3106
                     /gene="SPSB1"
                     /gene_synonym="SSB-1; SSB1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3078..3083
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SPSB1"
                     /gene_synonym="SSB-1; SSB1"
                     /note="hexamer: AATAAA"
     polyA_site      3106
                     /gene="SPSB1"
                     /gene_synonym="SSB-1; SSB1"
                     /note="major polyA site"
ORIGIN      
        1 gcacagaagt cgcgctcggg cagcctgcgc gctcgcagca ggaaccaggc tccaggcgcc
       61 ggcgccgggg ccggggccgc ggggaggagg cgacttcgct ccctgcggcg ggcgcggccc
      121 gggcgcccga gcctcctcgg ccttggagag cagcggcggc ggcggcaccc cgggcgcggc
      181 aatactgaac actgcgcagc ttgcagaggt ctcctggcag ccctcattag gaattctgtc
      241 tggccccgat cagaatactg gagacgagac cacgagattg atgagtttgc cttgggagtc
      301 ggtaagaagg tgaagccagg ggcgaacatg ggtcagaagg tcactggagg gatcaagact
      361 gtggacatga gggaccccac gtacaggccc ctgaagcagg agctccaggg tctggattac
      421 tgcaagccca cccggctgga tctgctactg gacatgcccc ctgtgtccta tgatgtccag
      481 ctgctgcatt catggaacaa caacgaccga tcgctcaatg tctttgtgaa ggaggacgac
      541 aagctcatct ttcaccggca tccggtggcc cagagcacgg acgctatcag gggcaaagtc
      601 gggtataccc gtgggctgca cgtgtggcag atcacgtggg ccatgagaca gcggggcaca
      661 cacgccgtgg tgggggtggc gacggcagac gcccccctgc actctgtcgg gtacacaacc
      721 ctcgtgggga ataaccacga gtcctggggc tgggacttgg ggcgcaaccg gctctaccac
      781 gatggcaaga accagccaag caaaacatac ccagcctttc tggaaccaga tgagacattc
      841 attgtccctg actccttcct ggtagccctg gacatggacg acgggactct gagcttcatt
      901 gtggatggac agtacatggg agtggctttt cggggactca agggcaaaaa actgtatcct
      961 gtagtgagtg ccgtctgggg ccactgtgag atccgaatgc gctacttgaa cggactcgat
     1021 cccgagccgc tgccgctcat ggatttgtgc cgtcgctcgg tgcgcctggc cctggggagg
     1081 gagcgcctgg gggagatcca cacgctgccg ctgccggctt ccctcaaggc ctacctcctc
     1141 taccagtgac gttcgccatc ataccgccag cgcgacagcc acctggtgcc aactcactga
     1201 gccgcctgcc gctggggccg ccgcaccctg caccttggac cggcatccgt agccatggac
     1261 agaggtccct ggtcttccct catcctccgt ggctgcctcc atgggacaag gaccgattcc
     1321 aacacaggct cctctttccc ccttcccgac atcagcagaa ggcagcatcc ctgcatgccg
     1381 tccgtataca acccctcttt gaaaaaagac acagagaata aactcctacg aaagccctac
     1441 attgagctcc aatctgctcg gggtgggacg ggtgcttccc acacctctgg gagaaggctg
     1501 cagccacctg ggggtcccag ggtggtgggg gtggcaggtg gtaccacagc tctgagagca
     1561 gataccaggg gtactaagag gtgcttagac aagggctggt gcccggccca gggtgcccag
     1621 cggggccatg ccatggcaga taaagctcag gacgtcaaaa actcaccatg gaccccaagg
     1681 cagaaaccaa gaactgtctg caggcaaata agcacccagc acccatcctg gctgccggtg
     1741 ccccgtaccc tgtatttatt cttttaacaa taacaaaagc catttattta ttccatctag
     1801 aaaggaaacc ctgtttcagt cccctctctc tggctgttct gttactttcc ttccacctgt
     1861 gccctccctg ggatatgtat gcctcgcccg ccctccctgg gcacatgtgc acacgtgccc
     1921 aggcacaagt atgtctctgg gtcccttgcc ctgcagtttc cagggggctc tgctccaagt
     1981 tccctagcgg gcccctcagg gagaaatagc ctcacgtgca atctgggtgt cttcgggggc
     2041 ccgtctggaa gggctgcagc aattcccctg tgtctccagg taaccagcta actcttgggc
     2101 tcaggcaccc ttgcacaggg ttgcatttct ttagtcttct gtgggtcttt tgatgtgggt
     2161 ttgattttgc ttttgctttt ctagctgaga tttcccaagt gcatcctcag aagctctggg
     2221 tgtgccagag gacccccaga actaagaagg gagggcgagt gggtctccat tccccgagaa
     2281 gccgggggca gggtgggatg gggaagacca ggagcagagt cgagcctcac agaagccagc
     2341 gcgggtctct gctcagcacc ccagccgggg ctctggaccc agggtaacag ccccagttca
     2401 tcccaacccc tctcagagcc tcaagagggg tagctcggct gccggaagag aggggtgccc
     2461 tatccctggc aacccctcca cgtagcgtac cccagcacct gccaccgcct ttgccatttc
     2521 tttgagcttg aagttaactc tcttagagtc taactttggt tcatttctgc acaggtacaa
     2581 tagatgactt tatttgttta aaatgtttaa tatatataca tacatatata tatatttgtc
     2641 tgtaagaatt atgttttaaa cagctgctgt agagtacctt tttttaagta aatcttacag
     2701 tggagtatat tttttaaagc acaaaattgg tgccaagact gggtgagaaa tgtacattac
     2761 ccccttatta ttttgacggt tttttttttc ggggcagggg accttacctg taagactttt
     2821 aaagattttc ctccctcctg tttcaggtgg gtcacattct gatgaatgtt tcccttgtac
     2881 agatcccagc ttatggcctt gacccagccg tcctcacaga tgccgggtga ccctctagct
     2941 ctctctgcat ctcccacccc ccgacaccct gggaccctcg accccaccct tctttcctac
     3001 cagcccagag ccttgtggct tgtacagttt tgaaactccc gttctatttt atgatggttg
     3061 ataatagtca gtaacctaat aaaggaacgt ttgttaaaat atcaaa
//
