LOCUS       NM_020456               3057 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens SPRY domain containing 7 (SPRYD7), transcript variant
            1, mRNA.
ACCESSION   NM_020456
VERSION     NM_020456.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3057)
  AUTHORS   Montero-Calle,A., Jimenez de Ocana,S., Benavente-Naranjo,R.,
            Rejas-Gonzalez,R., Bartolome,R.A., Martinez-Useros,J., Sanz,R.,
            Dziakova,J., Fernandez-Acenero,M.J., Mendiola,M., Casal,J.I.,
            Pelaez-Garcia,A. and Barderas,R.
  TITLE     Functional Proteomics Characterization of the Role of SPRYD7 in
            Colorectal Cancer Progression and Metastasis
  JOURNAL   Cells 12 (21), 2548 (2023)
   PUBMED   37947626
  REMARK    GeneRIF: Functional Proteomics Characterization of the Role of
            SPRYD7 in Colorectal Cancer Progression and Metastasis.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3057)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   3  (bases 1 to 3057)
  AUTHORS   Zouboulis,C.C., Nogueira da Costa,A., Fimmel,S. and Zouboulis,K.C.
  TITLE     Apocrine glands are bystanders in hidradenitis suppurativa and
            their involvement is gender specific
  JOURNAL   J Eur Acad Dermatol Venereol 34 (7), 1555-1563 (2020)
   PUBMED   32031713
REFERENCE   4  (bases 1 to 3057)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 3057)
  AUTHORS   Chen,S., Fragoza,R., Klei,L., Liu,Y., Wang,J., Roeder,K., Devlin,B.
            and Yu,H.
  TITLE     An interactome perturbation framework prioritizes damaging missense
            mutations for developmental disorders
  JOURNAL   Nat Genet 50 (7), 1032-1040 (2018)
   PUBMED   29892012
REFERENCE   6  (bases 1 to 3057)
  AUTHORS   Dunham,A., Matthews,L.H., Burton,J., Ashurst,J.L., Howe,K.L.,
            Ashcroft,K.J., Beare,D.M., Burford,D.C., Hunt,S.E.,
            Griffiths-Jones,S., Jones,M.C., Keenan,S.J., Oliver,K., Scott,C.E.,
            Ainscough,R., Almeida,J.P., Ambrose,K.D., Andrews,D.T.,
            Ashwell,R.I., Babbage,A.K., Bagguley,C.L., Bailey,J., Bannerjee,R.,
            Barlow,K.F., Bates,K., Beasley,H., Bird,C.P., Bray-Allen,S.,
            Brown,A.J., Brown,J.Y., Burrill,W., Carder,C., Carter,N.P.,
            Chapman,J.C., Clamp,M.E., Clark,S.Y., Clarke,G., Clee,C.M.,
            Clegg,S.C., Cobley,V., Collins,J.E., Corby,N., Coville,G.J.,
            Deloukas,P., Dhami,P., Dunham,I., Dunn,M., Earthrowl,M.E.,
            Ellington,A.G., Faulkner,L., Frankish,A.G., Frankland,J.,
            French,L., Garner,P., Garnett,J., Gilbert,J.G., Gilson,C.J.,
            Ghori,J., Grafham,D.V., Gribble,S.M., Griffiths,C., Hall,R.E.,
            Hammond,S., Harley,J.L., Hart,E.A., Heath,P.D., Howden,P.J.,
            Huckle,E.J., Hunt,P.J., Hunt,A.R., Johnson,C., Johnson,D., Kay,M.,
            Kimberley,A.M., King,A., Laird,G.K., Langford,C.J., Lawlor,S.,
            Leongamornlert,D.A., Lloyd,D.M., Lloyd,C., Loveland,J.E.,
            Lovell,J., Martin,S., Mashreghi-Mohammadi,M., McLaren,S.J.,
            McMurray,A., Milne,S., Moore,M.J., Nickerson,T., Palmer,S.A.,
            Pearce,A.V., Peck,A.I., Pelan,S., Phillimore,B., Porter,K.M.,
            Rice,C.M., Searle,S., Sehra,H.K., Shownkeen,R., Skuce,C.D.,
            Smith,M., Steward,C.A., Sycamore,N., Tester,J., Thomas,D.W.,
            Tracey,A., Tromans,A., Tubby,B., Wall,M., Wallis,J.M., West,A.P.,
            Whitehead,S.L., Willey,D.L., Wilming,L., Wray,P.W., Wright,M.W.,
            Young,L., Coulson,A., Durbin,R., Hubbard,T., Sulston,J.E., Beck,S.,
            Bentley,D.R., Rogers,J. and Ross,M.T.
  TITLE     The DNA sequence and analysis of human chromosome 13
  JOURNAL   Nature 428 (6982), 522-528 (2004)
   PUBMED   15057823
REFERENCE   7  (bases 1 to 3057)
  AUTHORS   Gevaert,K., Goethals,M., Martens,L., Van Damme,J., Staes,A.,
            Thomas,G.R. and Vandekerckhove,J.
  TITLE     Exploring proteomes and analyzing protein processing by mass
            spectrometric identification of sorted N-terminal peptides
  JOURNAL   Nat Biotechnol 21 (5), 566-569 (2003)
   PUBMED   12665801
REFERENCE   8  (bases 1 to 3057)
  AUTHORS   Mertens,D., Wolf,S., Schroeter,P., Schaffner,C., Dohner,H.,
            Stilgenbauer,S. and Lichter,P.
  TITLE     Down-regulation of candidate tumor suppressor genes within
            chromosome band 13q14.3 is independent of the DNA methylation
            pattern in B-cell chronic lymphocytic leukemia
  JOURNAL   Blood 99 (11), 4116-4121 (2002)
   PUBMED   12010815
REFERENCE   9  (bases 1 to 3057)
  AUTHORS   Tiazhelova,T.V., Ivanov,D.V., Makeeva,N.V., Kapanadze,B.I.,
            Nikitin,E.A., Semov,A.B., Sangfeldt,O., Grander,D., Vorob'ev,A.I.,
            Einhorn,S., Iankovskii,N.K. and Baranova,A.V.
  TITLE     [Transcription map of the 13q14 region, frequently deleted in
            B-cell chronic lymphocytic leukemia patients]
  JOURNAL   Genetika 37 (11), 1530-1537 (2001)
   PUBMED   11771308
REFERENCE   10 (bases 1 to 3057)
  AUTHORS   Mabuchi,H., Fujii,H., Calin,G., Alder,H., Negrini,M., Rassenti,L.,
            Kipps,T.J., Bullrich,F. and Croce,C.M.
  TITLE     Cloning and characterization of CLLD6, CLLD7, and CLLD8, novel
            candidate genes for leukemogenesis at chromosome 13q14, a region
            commonly deleted in B-cell chronic lymphocytic leukemia
  JOURNAL   Cancer Res 61 (7), 2870-2877 (2001)
   PUBMED   11306461
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DN992366.1, AF055016.1, BC022519.1, AF334405.1 and BM684781.1.
            
            On Nov 23, 2018 this sequence version replaced NM_020456.3.
            
            Transcript Variant: This variant (1) encodes the predicted full
            length protein isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF334405.1, SRR3476690.587712.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2142586, SAMEA2155590
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000361840.8/ ENSP00000354774.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-76                DN992366.1         158-233
            77-811              AF055016.1         37-771
            812-1901            BC022519.1         662-1751
            1902-2226           AF334405.1         1901-2225
            2227-3053           AF334405.1         2227-3053
            3054-3057           BM684781.1         18-21               c
FEATURES             Location/Qualifiers
     source          1..3057
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="13"
                     /map="13q14.2"
     gene            1..3057
                     /gene="SPRYD7"
                     /gene_synonym="C13orf1; CLLD6"
                     /note="SPRY domain containing 7"
                     /db_xref="GeneID:57213"
                     /db_xref="HGNC:HGNC:14297"
                     /db_xref="MIM:607866"
     exon            1..211
                     /gene="SPRYD7"
                     /gene_synonym="C13orf1; CLLD6"
                     /inference="alignment:Splign:2.1.0"
     CDS             106..696
                     /gene="SPRYD7"
                     /gene_synonym="C13orf1; CLLD6"
                     /note="isoform 1 is encoded by transcript variant 1;
                     chronic lymphocytic leukemia deletion region gene 6
                     protein; CLL deletion region gene 6 protein; SPRY
                     domain-containing protein 7; epididymis secretory sperm
                     binding protein"
                     /codon_start=1
                     /product="SPRY domain-containing protein 7 isoform 1"
                     /protein_id="NP_065189.1"
                     /db_xref="CCDS:CCDS9422.1"
                     /db_xref="GeneID:57213"
                     /db_xref="HGNC:HGNC:14297"
                     /db_xref="MIM:607866"
                     /translation="MATSVLCCLRCCRDGGTGHIPLKEMPAVQLDTQHMGTDVVIVKN
                     GRRICGTGGCLASAPLHQNKSYFEFKIQSTGIWGIGVATQKVNLNQIPLGRDMHSLVM
                     RNDGALYHNNEEKNRLPANSLPQEGDVVGITYDHVELNVYLNGKNMHCPASGIRGTVY
                     PVVYVDDSAILDCQFSEFYHTPPPGFEKILFEQQIF"
     exon            212..328
                     /gene="SPRYD7"
                     /gene_synonym="C13orf1; CLLD6"
                     /inference="alignment:Splign:2.1.0"
     exon            329..495
                     /gene="SPRYD7"
                     /gene_synonym="C13orf1; CLLD6"
                     /inference="alignment:Splign:2.1.0"
     exon            496..598
                     /gene="SPRYD7"
                     /gene_synonym="C13orf1; CLLD6"
                     /inference="alignment:Splign:2.1.0"
     exon            599..3057
                     /gene="SPRYD7"
                     /gene_synonym="C13orf1; CLLD6"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1071..1076
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SPRYD7"
                     /gene_synonym="C13orf1; CLLD6"
                     /note="hexamer: ATTAAA"
     polyA_site      1100
                     /gene="SPRYD7"
                     /gene_synonym="C13orf1; CLLD6"
                     /note="major polyA site"
     regulatory      1275..1280
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SPRYD7"
                     /gene_synonym="C13orf1; CLLD6"
                     /note="hexamer: GATAAA"
     polyA_site      1302
                     /gene="SPRYD7"
                     /gene_synonym="C13orf1; CLLD6"
     regulatory      3029..3034
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SPRYD7"
                     /gene_synonym="C13orf1; CLLD6"
                     /note="hexamer: ATTAAA"
     polyA_site      3057
                     /gene="SPRYD7"
                     /gene_synonym="C13orf1; CLLD6"
                     /note="major polyA site"
ORIGIN      
        1 atagacaagt ccggacctcg ggcgggggca ggagacggag ctgagcggcg gggggcagtg
       61 tcgcctcggt ctagggacgg cggcggagtc ggtggtccct gcgcgatggc cacctcggtg
      121 ttgtgctgcc tgcggtgctg cagagacggg gggactggcc acatccctct gaaggagatg
      181 ccggccgtgc agctggacac gcagcacatg ggaacagatg ttgttattgt aaagaatgga
      241 agaagaatat gtggaacagg aggttgttta gccagcgcac ctttacatca aaacaaaagc
      301 tattttgaat tcaaaatcca gtccacagga atctggggta ttggtgttgc aactcagaag
      361 gttaacttga atcagattcc tcttggccga gatatgcaca gtctggtgat gagaaatgat
      421 ggagcccttt accacaacaa tgaagagaaa aataggctgc cagcaaacag tcttccgcag
      481 gaaggagatg tggtgggtat tacttatgac catgtcgaat taaatgtata cttgaatgga
      541 aaaaacatgc attgtccagc atcaggtata cgagggacag tgtatccagt tgtttatgtt
      601 gatgacagtg caattttgga ttgccagttc agtgagtttt atcatacgcc tccacctggt
      661 tttgaaaaaa tattatttga acagcaaatc ttctgaatgt atttgttttt aaaacttgta
      721 tttctgcact gttaaaaaat gttcatcatt taataaaact ttacctggcc tatagatgaa
      781 aatatattct taaaaatatg cttgttgatg ctgtctaagg aaccaatgta ttcagtatac
      841 caccctgaag ttgtgattta aaatacttta tgttttgtga aatgaaaata agcatttggg
      901 cagtttattt aattcttatt taaataaata gaattatggg tttaattaac agtataacat
      961 gactatatat acatatatat ttaaagggaa ttctttctta cataatatat ttgttttgat
     1021 agagatgtag agttgggtgg gtgtttttgt cactctgaag tttagacctc attaaatatt
     1081 tgacatctac agttggataa ttttgccgct tagtgtcctt ttttatatac aatataacaa
     1141 agtgagagaa atttatatta ctggcaattt catttttggc agtctatttc tgtatcatgt
     1201 accgcttttc ttaaaactta aattgcttat tttgttgtgt aatgtcattg cttttgattt
     1261 gctttgtgaa aggagataaa cgtttcagta attgtcagag cattttgttg cctcaggctg
     1321 tgttacctca atttcagagt aagtagtggt tgattagtaa tgtagtatac actggcagac
     1381 atctagaata gtatgatgct ttacatttaa atgaggttat tcttttaagg acttttattt
     1441 gtatgttttc tgtaaggaat aataaaataa ttgtaattaa ggaatatacc atactatatt
     1501 aaacacattc ttcctatttt gttagttata cactaaattc acatcacccg tgattatttc
     1561 agttcagaga taagtgaatc ctcttcatga ccctgagtct ttgcctggtt cttaagaatc
     1621 actgtccttt agttaacgcc ctgtgacctg aaccaatcac tctatacatc tttagatacg
     1681 ttgtctgttt tcaaatgagc atggcaagga tgcatacatt tccctccttt atcaactaga
     1741 aacagtacat tgttcaggaa aacatgagtg ttagaattag aaagagatcc aaattgtagt
     1801 tttgctgctc atcctatttt ctcctctcca agtctcagat tcccatttat aaaaggagca
     1861 atcatactga cataagattc tatgattaaa taaggtaata catatataac accttaataa
     1921 tcataggcac ttgcgccagg cgcggtggct cacacctgta atcccagcac tttgggaggc
     1981 tgaggcggga ggatcacaag gtcaggagat cgagaccatc gtggctaaca tggtgaaacc
     2041 ctggctctac taaaaaaata caaaaaaaat tagccaggtg tggtggcggg cgcctgtagt
     2101 tctagctact ctggaggctg aggcaggaga atggcttgaa cccgggagac ggcgcttgca
     2161 gtgagccgag attgccccac tgcactccag cctaggcaac agagtgagac tctgtctcaa
     2221 aaaaaattaa aataaaataa aataaaaatc ataggcactt agtaagtgta gtttcctgga
     2281 tggtaaagta tcagggaaag tggttttctt tctttttttt tttttctcgt tttttttttg
     2341 agacagagtc tcaccttgtc acccaggcta gagtgcagtg gcacgatctt ggctcactgc
     2401 aacctctgct tcccaggttt aagcgattct cttgcctcag cctcccgagt aggtgggact
     2461 acaggtgccc gccaccacgc ccgtgtaatt tttgtatttt tagtagagat ggggtttcac
     2521 catgttgtcc aggctggtct caaactcctg acctcatgat ccacctccct cagcctccca
     2581 aagtgctgga attataggcg taagccacca cacccagcca gaaagtggtt ctcatgatgc
     2641 ttctcagacc ggcaacatca gcatcactgg aacttgttaa aaatggacac tctcagaacc
     2701 cacaccagac ccaccaaatc agtttgagaa ctgccattca gtagagaatt atttgcctac
     2761 tgtaaatttt ctaaggattt atgatgggct atttttgacc cataggctca gagaatcctg
     2821 caaaatcctt ttttattgtt tattctgcag acaaaaatgt gacaatatgc tttgaaaaca
     2881 tagatatact tgagtaacat ttatttacat aaatcccaaa ttctacctct gaaggtatat
     2941 gaaatttaac tatgtatgta ttatgcattt tgtctggctt tctatcataa ttttaatttg
     3001 taaagaatgt gcttacttgg gaaagcaaat taaagtgact actgtttgct atcgtta
//
