LOCUS       NM_032840               2902 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens SPRY domain containing 3 (SPRYD3), mRNA.
ACCESSION   NM_032840
VERSION     NM_032840.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2902)
  AUTHORS   Gaudet,P., Livstone,M.S., Lewis,S.E. and Thomas,P.D.
  TITLE     Phylogenetic-based propagation of functional annotations within the
            Gene Ontology consortium
  JOURNAL   Brief Bioinform 12 (5), 449-462 (2011)
   PUBMED   21873635
REFERENCE   2  (bases 1 to 2902)
  AUTHORS   Kimura,K., Wakamatsu,A., Suzuki,Y., Ota,T., Nishikawa,T.,
            Yamashita,R., Yamamoto,J., Sekine,M., Tsuritani,K., Wakaguri,H.,
            Ishii,S., Sugiyama,T., Saito,K., Isono,Y., Irie,R., Kushida,N.,
            Yoneyama,T., Otsuka,R., Kanda,K., Yokoi,T., Kondo,H., Wagatsuma,M.,
            Murakawa,K., Ishida,S., Ishibashi,T., Takahashi-Fujii,A.,
            Tanase,T., Nagai,K., Kikuchi,H., Nakai,K., Isogai,T. and Sugano,S.
  TITLE     Diversification of transcriptional modulation: large-scale
            identification and characterization of putative alternative
            promoters of human genes
  JOURNAL   Genome Res 16 (1), 55-65 (2006)
   PUBMED   16344560
REFERENCE   3  (bases 1 to 2902)
  AUTHORS   Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G.,
            Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D.,
            Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K.,
            Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F.,
            Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L.,
            Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L.,
            Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S.,
            Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J.,
            Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J.,
            McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S.,
            Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W.,
            Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A.,
            Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S.,
            Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y.,
            Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D.,
            Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M.,
            Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E.,
            Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A.
  CONSRTM   Mammalian Gene Collection Program Team
  TITLE     Generation and initial analysis of more than 15,000 full-length
            human and mouse cDNA sequences
  JOURNAL   Proc Natl Acad Sci U S A 99 (26), 16899-16903 (2002)
   PUBMED   12477932
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA389433.1, BC136312.1 and CA427084.1.
            
            On Nov 23, 2018 this sequence version replaced NM_032840.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.283808.1,
                                           SRR1803611.68355.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2154665 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000301463.9/ ENSP00000301463.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-40                DA389433.1         31-70
            41-2445             BC136312.1         4-2408
            2446-2902           CA427084.1         18-474              c
FEATURES             Location/Qualifiers
     source          1..2902
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q13.13"
     gene            1..2902
                     /gene="SPRYD3"
                     /note="SPRY domain containing 3"
                     /db_xref="GeneID:84926"
                     /db_xref="HGNC:HGNC:25920"
     exon            1..80
                     /gene="SPRYD3"
                     /inference="alignment:Splign:2.1.0"
     CDS             58..1386
                     /gene="SPRYD3"
                     /EC_number="2.7.1.112"
                     /codon_start=1
                     /product="SPRY domain-containing protein 3"
                     /protein_id="NP_116229.1"
                     /db_xref="CCDS:CCDS8845.1"
                     /db_xref="GeneID:84926"
                     /db_xref="HGNC:HGNC:25920"
                     /translation="MRRTRRPRFVLMNKMDDLNLHYRFLNWRRRIREIREVRAFRYQE
                     RFKHILVDGDTLSYHGNSGEVGCYVASRPLTKDSNYFEVSIVDSGVRGTIAVGLVPQY
                     YSLDHQPGWLPDSVAYHADDGKLYNGRAKGRQFGSKCNSGDRIGCGIEPVSFDVQTAQ
                     IFFTKNGKRVGSTIMPMSPDGLFPAVGMHSLGEEVRLHLNAELGREDDSVMMVDSYED
                     EWGRLHDVRVCGTLLEYLGKGKSIVDVGLAQARHPLSTRSHYFEVEIVDPGEKCYIAL
                     GLARKDYPKNRHPGWSRGSVAYHADDGKIFHGSGVGDPFGPRCYKGDIMGCGIMFPRD
                     YILDSEGDSDDSCDTVILSPTARAVRNVRNVMYLHQEGEEEEEEEEEEEDGEEIEPEH
                     EGRKVVVFFTRNGKIIGKKDAVVPSGGFFPTIGMLSCGEKVKVDLHPLSG"
     exon            81..227
                     /gene="SPRYD3"
                     /inference="alignment:Splign:2.1.0"
     exon            228..303
                     /gene="SPRYD3"
                     /inference="alignment:Splign:2.1.0"
     exon            304..428
                     /gene="SPRYD3"
                     /inference="alignment:Splign:2.1.0"
     exon            429..564
                     /gene="SPRYD3"
                     /inference="alignment:Splign:2.1.0"
     exon            565..750
                     /gene="SPRYD3"
                     /inference="alignment:Splign:2.1.0"
     exon            751..900
                     /gene="SPRYD3"
                     /inference="alignment:Splign:2.1.0"
     exon            901..958
                     /gene="SPRYD3"
                     /inference="alignment:Splign:2.1.0"
     exon            959..1078
                     /gene="SPRYD3"
                     /inference="alignment:Splign:2.1.0"
     exon            1079..1251
                     /gene="SPRYD3"
                     /inference="alignment:Splign:2.1.0"
     exon            1252..2902
                     /gene="SPRYD3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2594..2599
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SPRYD3"
                     /note="hexamer: GATAAA"
     polyA_site      2614
                     /gene="SPRYD3"
                     /note="major polyA site"
     regulatory      2880..2885
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SPRYD3"
                     /note="hexamer: AATAGA"
     polyA_site      2902
                     /gene="SPRYD3"
ORIGIN      
        1 ggatgtgtgt ggtggcggcg gccgaagagc ttgtgtgcgg agctgagagg cctatggatg
       61 aggaggacgc ggcggccccg gtttgttctc atgaacaaga tggatgacct caacctgcac
      121 taccggtttc tgaattggcg ccggcggatc cgggagattc gagaggtccg agctttccga
      181 tatcaggaga ggttcaaaca tatccttgta gatggagata ctttaagtta tcatggaaac
      241 tctggtgaag ttggctgcta cgtggcttct cgacccctga ccaaggacag caattatttt
      301 gaggtgtcta ttgtggacag tggagtccgg ggcaccattg ctgtggggct ggtccctcag
      361 tactacagct tggatcacca gcctggctgg ttgcctgact ctgtagccta ccatgctgat
      421 gatggcaagc tgtacaatgg ccgagccaag ggccgccagt ttgggtcaaa gtgcaactcc
      481 ggggaccgga ttggctgtgg cattgagcct gtgtcctttg atgtgcagac cgcccagatc
      541 ttcttcacca aaaatgggaa gcgggtgggc tctaccatca tgcccatgtc cccagatgga
      601 ctgttcccag cagtgggcat gcactccctg ggtgaggagg tgcggctgca cctcaacgct
      661 gagctgggcc gtgaggacga cagcgtcatg atggtggaca gttacgagga tgaatggggc
      721 cggctacatg atgtcagagt ctgtgggact ctgctggagt acttagggaa gggcaaaagc
      781 atcgtggatg tggggctggc ccaggcccgg cacccactca gcacccgcag ccactacttc
      841 gaggtggaga tcgtggaccc tggagagaaa tgctacatcg ccctggggct ggcacggaag
      901 gactatccca agaacaggca ccctggctgg agcagagggt ctgtggctta tcatgcagac
      961 gatgggaaga tcttccatgg cagtggtgtg ggggacccct ttgggccacg ctgttacaaa
     1021 ggggacatca tgggctgtgg aatcatgttc ccccgggact acattttgga cagtgagggg
     1081 gacagtgatg acagttgtga cacagtgatc ctgtctccga ctgcccgggc cgtccggaac
     1141 gtgcggaatg tcatgtacct gcaccaggaa ggggaagagg aagaggagga agaggaagag
     1201 gaagaggatg gggaagagat agagccggag catgagggca ggaaggtggt ggttttcttc
     1261 actcggaatg gcaagatcat tgggaagaag gatgctgttg ttccttctgg aggcttcttc
     1321 cccaccattg gaatgctgag ctgcggggag aaagtcaaag tagatctgca ccccttgagt
     1381 ggctagggcc tcccctccag acctgctcct tctccctgct caccctctgc tgggccaggc
     1441 acccagttcc tgacttccca gaggcttcgt ttacccagca ggcccctgga ggtgtgtagt
     1501 cactctgccc ccactggctc aggcccctgt cacgcttctc tgtgcccacg tttctgacct
     1561 ggtgctgcca ctgttgtcag tccctgggcc tgagtccctg gttggacagg aatggaccca
     1621 aagaatggtg ttggtatgtg ggtggtccca ctcgctttgg tcagtgggct tctgggtccc
     1681 cctttccctc accggccctg tgtgggtgga gaggcgtgag caccctatct cagctgctat
     1741 tcgggcatga tgctttgtag agggtagagt agacagcccc ctcccctact caccatggta
     1801 tttctccttg aattcctctt tcttgttttc tttcctggtt gtgtgaacca gttgctgctg
     1861 tcatacccct ggcagggcca ggggacctct ctttggtcat ctctgtcctt tcactggctg
     1921 ctgccccagg aagactcctc taggctctcc atctttccct tgagagctgg ctccccaccc
     1981 caacctgctc aggcaccaca gaggatctag gtctctggct ccccatacct ggacccacat
     2041 gggtgggtgc ctgttgcatg tttaagagag aggggctgtg aggtgacagg gcactagggc
     2101 cttcactcct ttctcccctt ccatcctttc tttaccagtg ccacccatgt ccctagctcc
     2161 cgggtattgg ggctgaggct ctggggcctg tctccctgcc agcgtgaggg caagacccca
     2221 gagccttagc tgagcaagcc cagaggggca gcgtggcccc tccctcccct tttcctgccc
     2281 cgtcccatgc ctcagcttgc tgcttgtgcc agttgcctgt ttcgcttcag tgtttgattc
     2341 tagcacttac atgtgtcctc cccaccaagc cctctatctc cttctaatcc ttcaacccct
     2401 ggccccctcc ccgtaacagt gacttttcca gggaggaaga ggcagcagga gctgttggcc
     2461 ttggtttgca cagagcgggt agggctgtag ggaaagcggg tgagctgttg tgctgctggg
     2521 cctccctttg gccctcgctt cccaccctac gatgtatgaa atgtatgtac agaccagaga
     2581 tgtttataca gccgataaag atggagtttc cgtatttatc agtatggccg gaaccaggag
     2641 cctttctagt ccactgggct aggaacagga ctgctggatg ggggcagccg aaggcagctt
     2701 gctcatgggg agatgtggac caatgttggg ccagggatgg gaatcatatg ttccatgggc
     2761 ctggctacag gcctgagcac agatacgtcc cctgggagat gaggctttga ccttcctgtg
     2821 aataagtgtt gactccaatt tcggctaaag tttatagaaa ttctttatta ttagacaaaa
     2881 atagactctc ttttttcccc ta
//
